Tumor rejection induced by CD70-mediated quantitative and qualitative effects on effector CD8+ T cell formation

Journal of Experimental Medicine

Volumn 199, Issue 11, 2004, Pages 1595-1605

  Arens, Ramon ^a   Schepers, Koen ^b   Nolte, Martijn A ^a   Van Oosterwijk, Michiel F ^a   Van Lier, René A W ^a   Schumacher, Ton N M ^b   Van Oers, Marinus H J ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

Costimulation; Influenza virus; MHC tetramer; TNF family member; Tumor immunity

Indexed keywords

CD27 ANTIGEN; CD4 ANTIGEN; CD70 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR;

ADOPTIVE TRANSFER; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CYTOTOXICITY; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; IMMUNOSTIMULATION; INFLUENZA VIRUS; LYMPHOCYTE DIFFERENTIATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TUMOR IMMUNITY; VIRUS INFECTION;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD27; ANTIGENS, CD70; CD8-POSITIVE T-LYMPHOCYTES; GRAFT REJECTION; INTERFERON TYPE II; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; ORTHOMYXOVIRIDAE INFECTIONS;

EID: 2942661949     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20031111     Document Type: Article

References (47)

1. Sprent, J., and C.D. Surh. 2002. T cell memory. Annu. Rev. Immunol. 20:551-579.
2. Wong, P., and E.G. Pamer. 2003. CD8 T cell responses to infectious pathogens. Annu. Rev. Immunol. 21:29-70.
3. Ahmed, R., and D. Gray. 1996. Immunological memory and protective immunity: understanding their relation. Science. 272:54-60.
4. Kaech, S.M., E.J. Wherry, and R. Ahmed. 2002. Effector and memory T-cell differentiation: implications for vaccine development. Nat. Rev. Immunol. 2:251-262.
5. Mercado, R., S. Vijh, S.E. Allen, K. Kerksiek, I.M. Pilip, and E.G. Pamer. 2000. Early programming of T cell populations responding to bacterial infection. J. Immunol. 165:6833-6839.
6. Kaech, S.M., and R. Ahmed. 2001. Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat. Immunol. 2:415-422.
7. Van Stipdonk, M.J., E.E. Lemmens, and S.P. Schoenberger. 2001. Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation. Nat. Immunol. 2:423-429.
8. Badovinac, V.P., B.B. Porter, and J.T. Harty. 2002. Programmed contraction of CD8(+) T cells after infection. Nat. Immunol. 3:619-626.
9. Van Stipdonk, M.J., G. Hardenberg, M.S. Bijker, E.E. Lemmens, N.M. Droin, D.R. Green, and S.P. Schoenberger. 2003. Dynamic programming of CD8(+) T lymphocyte responses. Nat. Immunol. 4:361-365.
10. Blattman, J.N., J.M. Grayson, E.J. Wherry, S.M. Kaech, K.A. Smith, and R. Ahmed. 2003. Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo. Nat. Med. 9:540-547.
11. Badovinac, V.P., A.R. Tvinnereim, and J.T. Harty. 2000. Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma. Science. 290:1354-1358.
12. van Lier, R.A., J. Borst, T.M. Vroom, H. Klein, P. Van Mourik, W.P. Zeijlemaker, and C.J. Melief. 1987. Tissue distribution and biochemical and functional properties of Tp55 (CD27), a novel T cell differentiation antigen. J. Immunol. 139:1589-1596.
13. + peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J. Exp. Med. 188:1679-1689.
14. Sugita, K., M.J. Robertson, Y. Torimoto, J. Ritz, S.F. Schlossman, and C. Morimoto. 1992. Participation of the CD27 antigen in the regulation of IL-2-activated human natural killer cells. J. Immunol. 149:1199-1203.
15. Wiesmann, A., R.L. Phillips, M. Mojica, L.J. Pierce, A.E. Searles, G.J. Spangrude, and I. Lemischka. 2000. Expression of CD27 on murine hematopoietic stem and progenitor cells. Immunity. 12:193-199.
16. Hintzen, R.Q., S.M. Lens, M.P. Beckmann, R.G. Goodwin, D. Lynch, and R.A. van Lier. 1994. Characterization of the human CD27 ligand, a novel member of the TNF gene family. J. Immunol. 152:1762-1773.
17. Oshima, H., H. Nakano, C. Nohara, T. Kobata, A. Nakajima, N.A. Jenkins, D.J. Gilbert, N.G. Copeland, T. Muto, H. Yagita, and K. Okumura. 1998. Characterization of murine CD70 by molecular cloning and mAb. Int. Immunol. 10:517-526.
18. Tesselaar, K., Y. Xiao, R. Arens, G.M. van Schijndel, D.H. Schuurhuis, R.E. Mebius, J. Borst, and R.A. van Lier. 2003. Expression of the murine CD27 ligand CD70 in vitro and in vivo. J. Immunol. 170:33-40.
19. Hintzen, R.Q., S.M. Lens, K. Lammers, H. Kuiper, M.P. Beckmann, and R.A. van Lier. 1995. Engagement of CD27 with its ligand CD70 provides a second signal for T cell activation. J. Immunol. 154:2612-2623.
20. Gravestein, L.A., J.D. Nieland, A.M. Kruisbeek, and J. Borst. 1995. Novel mAbs reveal potent co-stimulatory activity of murine CD27. Int. Immunol. 7:551-557.
21. Goodwin, R.G., M.R. Alderson, C.A. Smith, R.J. Armitage, T. VandenBos, R. Jerzy, T.W. Tough, M.A. Schoenborn, T. Davis-Smith, K. Hennen, et al. 1993. Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor. Cell. 73:447-456.
22. Brown, G.R., K. Meek, Y. Nishioka, and D.L. Thiele. 1995. CD27-CD27 ligand/CD70 interactions enhance alloantigen-induced proliferation and cytolytic activity in CD8+ T lymphocytes. J. Immunol. 154:3686-3695.
23. Yamada, S., K. Shinozaki, and K. Agematsu. 2002. Involvement of CD27/CD70 interactions in antigen-specific cytotoxic T-lymphocyte (CTL) activity by perforin-mediated cytotoxicity. Clin. Exp. Immunol. 130:424-430.
24. Hendriks, J., L.A. Gravestein, K. Tesselaar, R.A. van Lier, T.N. Schumacher, and J. Borst. 2000. CD27 is required for generation and long-term maintenance of T cell immunity. Nat. Immunol. 1:433-440.
25. Arens, R., K. Tesselaar, P.A. Baars, G.M. van Schijndel, J. Hendriks, S.T. Pals, P. Krimpenfort, J. Borst, M.H. van Oers, and R.A. van Lier. 2001. Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion. Immunity. 15:801-812.
26. Tesselaar, K., R. Arens, G.M. van Schijndel, P.A. Baars, M.A. van der Valk, J. Borst, M.H. van Oers, and R.A. van Lier. 2003. Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions. Nat. Immunol. 4:49-54.
27. Mamalaki, C., T. Norton, Y. Tanaka, A.R. Townsend, P. Chandler, E. Simpson, and D. Kioussis. 1992. Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice. Proc. Natl. Acad. Sci. USA. 89:11342-11346.
28. Dalton, D.K., S. Pitts-Meek, S. Keshav, I.S. Figari, A. Bradley, and T.A. Stewart. 1993. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science. 259:1739-1742.
29. Altman, J.D., P.A. Moss, P.J. Goulder, D.H. Barouch, M.G. McHeyzer-Williams, J.I. Bell, A.J. McMichael, and M.M. Davis. 1996. Phenotypic analysis of antigen-specific T lymphocytes. Science. 274:94-96.
30. Haanen, J.B., M. Toebes, T.A. Cordaro, M.C. Wolkers, A.M. Kruisbeek, and T.N. Schumacher. 1999. Systemic T cell expansion during localized viral infection. Eur. J. Immunol. 29:1168-1174.
31. Schepers, K., M. Toebes, G. Sotthewes, F.A. Vyth-Dreese, T.A. Dellemijn, C.J. Melief, F. Ossendorp, and T.N. Schumacher. 2002. Differential kinetics of antigen-specific CD4+ and CD8+ T cell responses in the regression of retrovirus-induced sarcomas. J. Immunol. 169:3191-3199.
32. van Elden, L.J., M. Nijhuis, P. Schipper, R. Schuurman, and A.M. van Loon. 2001. Simultaneous detection of influenza viruses A and B using real-time quantitative PCR. J. Clin. Microbiol. 39:196-200.
33. Wolkers, M.C., G. Stoetter, F.A. Vyth-Dreese, and T.N. Schumacher. 2001. Redundancy of direct priming and cross-priming in tumor-specific CD8+ T cell responses. J. Immunol. 167:3577-3584.
34. Liu, L., A. Chahroudi, G. Silvestri, M.E. Wernett, W.J. Kaiser, J.T. Safrit, A. Komoriya, J.D. Altman, B.Z. Packard, and M.B. Feinberg. 2002. Visualization and quantification of T cell-mediated cytotoxicity using cell-permeable fluorogenic caspase substrates. Nat. Med. 8:185-189.
35. Harrington, L.E., M. Galvan, L.G. Baum, J.D. Altman, and R. Ahmed. 2000. Differentiating between memory and effector CD8 T cells by altered expression of cell surface O-glycans. J. Exp. Med. 191:1241-1246.
36. Croft, M. 2003. Co-stimulatory members of the TNFR family: keys to effective T-cell immunity? Nat. Rev. Immunol. 3:609-620.
37. Cerwenka, A., T.M. Morgan, A.G. Harmsen, and R.W. Dutton. 1999. Migration kinetics and final destination of type 1 and type 2 CD8 effector cells predict protection against pulmonary virus infection. J. Exp. Med. 189:423-434.
38. Yewdell, J.W., and J.R. Bennink. 1999. Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses. Annu. Rev. Immunol. 17:51-88.
39. Rahemtulla, A., W.P. Fung-Leung, M.W. Schilham, T.M. Kundig, S.R. Sambhara, A. Narendran, A. Arabian, A. Wakeham, C.J. Paige, R.M. Zinkemagel, et al. 1991. Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4. Nature. 353:180-184.
40. Madoubian, M., R.J. Concepcion, and R. Ahmed. 1994. CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection. J. Virol. 68:8056-8063.
41. Janssen, E.M., E.E. Lemmens, T. Wolfe, U. Christen, M.G. von Herrath, and S.P. Schoenberger. 2003. CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes. Nature. 421:852-856.
42. Rogers, P.R., J. Song, I. Gramaglia, N. Killeen, and M. Croft. 2001. OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity. 15:445-455.
43. Lee, H.W., S.J. Park, B.K. Choi, H.H. Kim, K.O. Nam, and B.S. Kwon. 2002. 4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1. J. Immunol. 169:4882-4888.
44. Gamadia L.E., E.M. van Leeuwen, E.B. Remmerswaal, S.L. Yong, S. Surachno, P.M. Wertheim-van Dillen, I.J. Ten Berge, and R.A. Van Lier. 2004. The size and phenotype of virus-specific T cell populations is determined by repetitive antigenic stimulation and environmental cytokines. J. Immunol. 172:6107-6114.
45. Nieland, J.D., Y.F. Graus, Y.E. Dortmans, B.L. Kremers, and A.M. Kruisbeek. 1998. CD40 and CD70 co-stimulate a potent in vivo antitumor T cell response. J. Immunother. 21:225-236.
46. Couderc, B., L. Zitvogel, V. Douin-Echinard, L. Djennane, H. Tahara, G. Favre, M.T. Lotze, and P.D. Robbins. 1998. Enhancement of antitumor immunity by expression of CD70 (CD27 ligand) or CD154 (CD40 ligand) costimulatory molecules in tumor cells. Cancer Gene Ther. 5:163-175.
47. Lorenz, M.G., J.A. Kantor, J. Schlom, and J.W. Hodge. 1999. Anti-tumor immunity elicited by a recombinant vaccinia virus expressing CD70 (CD27L). Hum. Gene Ther. 10:1095-1103.