메뉴 건너뛰기




Volumn 10, Issue 3, 2013, Pages 235-243

HIV and neurocognitive dysfunction

Author keywords

Acute HIV infection; Antiretroviral therapy; Blood brain barrier; Central nervous system; Central nervous system penetration effectiveness; Cerebrospinal fluid; CNS reservoir; Compartmentalization; Efavirenz; HIV escape; HIV reservoir; HIV associated dementia; HIV associated neurocognitive disorder; HIV AIDS; Microglia; Monocyte efficacy; Neurotoxicity; Primary HIV infection; Viral load

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; EFAVIRENZ;

EID: 84881474722     PISSN: 15483568     EISSN: 15483576     Source Type: Journal    
DOI: 10.1007/s11904-013-0171-y     Document Type: Article
Times cited : (63)

References (95)
  • 1
    • 0022518134 scopus 로고
    • The AIDS dementia complex: I. Clinical features
    • Navia BA, Jordan BD, Price RW. The AIDS dementia complex: I. Clinical features. Ann Neurol. 1986;19:517-24. (Pubitemid 16085185)
    • (1986) Annals of Neurology , vol.19 , Issue.6 , pp. 517-524
    • Navia, B.A.1    Jordan, B.D.2    Price, R.W.3
  • 2
    • 78650834306 scopus 로고    scopus 로고
    • HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study
    • 21135382 10.1212/WNL.0b013e318200d727 This study examined over 1500 persons with chronic HIV infection with detailed neuropsychological testing and identified rates of forms of HAND in the overall cohort as well as in subgroups divded based on nadir CD4, plasma HIV suppression, and presence of comorbidities
    • •• Heaton RK, Clifford DB, Franklin Jr DR, et al. HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study. Neurology. 2010;75:2087-96. This study examined over 1500 persons with chronic HIV infection with detailed neuropsychological testing and identified rates of forms of HAND in the overall cohort as well as in subgroups divded based on nadir CD4, plasma HIV suppression, and presence of comorbidities.
    • (2010) Neurology , vol.75 , pp. 2087-2096
    • Heaton, R.K.1    Clifford, D.B.2    Franklin, Jr.D.R.3
  • 3
    • 79952921819 scopus 로고    scopus 로고
    • HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: Differences in rates, nature, and predictors
    • 21174240 10.1007/s13365-010-0006-1 1:CAS:528:DC%2BC3MXisVyrtb8%3D
    • Heaton RK, Franklin DR, Ellis RJ, et al. HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors. J Neurovirol. 2011;17:3-16.
    • (2011) J Neurovirol. , vol.17 , pp. 3-16
    • Heaton, R.K.1    Franklin, D.R.2    Ellis, R.J.3
  • 5
    • 79960034752 scopus 로고    scopus 로고
    • A neuropsychological investigation of multitasking in HIV infection: Implications for everyday functioning
    • 21401259 10.1037/a0022491
    • Scott JC, Woods SP, Vigil O, et al. A neuropsychological investigation of multitasking in HIV infection: implications for everyday functioning. Neuropsychology. 2011;25:511-9.
    • (2011) Neuropsychology , vol.25 , pp. 511-519
    • Scott, J.C.1    Woods, S.P.2    Vigil, O.3
  • 6
    • 79551703614 scopus 로고    scopus 로고
    • Medication and finance management among HIV-infected adults: The impact of age and cognition
    • 20694873 10.1080/13803395.2010.499357
    • Thames AD, Kim MS, Becker BW, et al. Medication and finance management among HIV-infected adults: the impact of age and cognition. J Clin Exp Neuropsychol. 2011;33:200-9.
    • (2011) J Clin Exp Neuropsychol , vol.33 , pp. 200-209
    • Thames, A.D.1    Kim, M.S.2    Becker, B.W.3
  • 8
    • 77952938752 scopus 로고    scopus 로고
    • Cognitive dysfunction in HIV patients despite long-standing suppression of viremia
    • 19996937
    • Simioni S, Cavassini M, Annoni JM, et al. Cognitive dysfunction in HIV patients despite long-standing suppression of viremia. AIDS. 2010;24:1243-50.
    • (2010) AIDS , vol.24 , pp. 1243-1250
    • Simioni, S.1    Cavassini, M.2    Annoni, J.M.3
  • 9
    • 33845473665 scopus 로고    scopus 로고
    • In HIV-1 pathogenesis the die is cast during primary infection
    • DOI 10.1097/QAD.0b013e3280117f7f, PII 0000203020070102000001
    • Centlivre M, Sala M, Wain-Hobson S, Berkhout B. In HIV-1 pathogenesis the die is cast during primary infection. AIDS. 2007;21:1-11. (Pubitemid 44912531)
    • (2007) AIDS , vol.21 , Issue.1 , pp. 1-11
    • Centlivre, M.1    Sala, M.2    Wain-Hobson, S.3    Berkhout, B.4
  • 10
    • 33745363316 scopus 로고    scopus 로고
    • Immunopathogenesis of acute AIDS virus infection
    • DOI 10.1016/j.coi.2006.05.001, PII S0952791506000951
    • Picker LJ. Immunopathogenesis of acute AIDS virus infection. Curr Opin Immunol. 2006;18:399-405. (Pubitemid 43947575)
    • (2006) Current Opinion in Immunology , vol.18 , Issue.4 , pp. 399-405
    • Picker, L.J.1
  • 11
    • 84859250847 scopus 로고    scopus 로고
    • Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection
    • 22479485 10.1371/journal.pone.0033948 1:CAS:528:DC%2BC38XlslegsLY%3D
    • Ananworanich J, Schuetz A, Vandergeeten C, et al. Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection. PLoS One. 2012;7:e33948.
    • (2012) PLoS One , vol.7 , pp. 33948
    • Ananworanich, J.1    Schuetz, A.2    Vandergeeten, C.3
  • 13
    • 0030450136 scopus 로고    scopus 로고
    • Neuroinvasion by simian immunodeficiency virus coincides with increased numbers of perivascular macrophages/microglia and intrathecal immune activation
    • Lane JH, Sasseville VG, Smith MO, et al. Neuroinvasion by simian immunodeficiency virus coincides with increased numbers of perivascular macrophages/microglia and intrathecal immune activation. J Neurovirol. 1996;2:423-32. (Pubitemid 27011096)
    • (1996) Journal of NeuroVirology , vol.2 , Issue.6 , pp. 423-432
    • Lane, J.H.1    Sasseville, V.G.2    Smith, M.O.3    Vogel, P.4    Pauley, D.R.5    Heyes, M.P.6    Lackner, A.A.7
  • 14
    • 0029042524 scopus 로고
    • Early intrathecal events in rhesus macaques (Macaca mulatta) infected with pathogenic or nonpathogenic molecular clones of simian immunodeficiency virus
    • 7745949 1:STN:280:DyaK2M3msVOjsQ%3D%3D
    • Smith MO, Heyes MP, Lackner AA. Early intrathecal events in rhesus macaques (Macaca mulatta) infected with pathogenic or nonpathogenic molecular clones of simian immunodeficiency virus. Lab Invest. 1995;72:547-58.
    • (1995) Lab Invest. , vol.72 , pp. 547-558
    • Smith, M.O.1    Heyes, M.P.2    Lackner, A.A.3
  • 15
    • 1542285320 scopus 로고    scopus 로고
    • Innate immune responses and control of acute simian immunodeficiency virus replication in the central nervous system
    • Barber SA, Herbst DS, Bullock BT, et al. Innate immune responses and control of acute simian immunodeficiency virus replication in the central nervous system. J Neurovirol. 2004;10 Suppl 1:15-20. (Pubitemid 38325088)
    • (2004) Journal of NeuroVirology , vol.10 , Issue.SUPPL. 1 , pp. 15-20
    • Barber, S.A.1    Herbst, D.S.2    Bullock, B.T.3    Gama, L.4    Clements, J.E.5
  • 16
    • 77954046747 scopus 로고    scopus 로고
    • Coordinated regulation of SIV replication and immune responses in the CNS
    • 20019816 10.1371/journal.pone.0008129
    • Witwer KW, Gama L, Li M, et al. Coordinated regulation of SIV replication and immune responses in the CNS. PLoS One. 2009;4:e8129.
    • (2009) PLoS One , vol.4 , pp. 8129
    • Witwer, K.W.1    Gama, L.2    Li, M.3
  • 17
    • 9644283128 scopus 로고    scopus 로고
    • Acute SIV infection of the brain leads to upregulation of IL6 and interferon-regulated genes: Expression patterns throughout disease progression and impact on neuroAIDS
    • DOI 10.1016/j.jneuroim.2004.08.030, PII S0165572804003376
    • Roberts ES, Burudi EM, Flynn C, et al. Acute SIV infection of the brain leads to upregulation of IL6 and interferon-regulated genes: expression patterns throughout disease progression and impact on neuroAIDS. J Neuroimmunol. 2004;157:81-92. (Pubitemid 39576641)
    • (2004) Journal of Neuroimmunology , vol.157 , Issue.1 , pp. 81-92
    • Roberts, E.S.1    Burudi, E.M.E.2    Flynn, C.3    Madden, L.J.4    Roinick, K.L.5    Watry, D.D.6    Zandonatti, M.A.7    Taffe, M.A.8    Fox, H.S.9
  • 18
    • 9644283129 scopus 로고    scopus 로고
    • Cerebrospinal fluid markers that predict SIV CNS disease
    • DOI 10.1016/j.jneuroim.2004.08.031, PII S0165572804003352
    • Mankowski JL, Queen SE, Clements JE, Zink MC. Cerebrospinal fluid markers that predict SIV CNS disease. J Neuroimmunol. 2004;157:66-70. (Pubitemid 39576639)
    • (2004) Journal of Neuroimmunology , vol.157 , Issue.1 , pp. 66-70
    • Mankowski, J.L.1    Queen, S.E.2    Clements, J.E.3    Zink, M.C.4
  • 19
    • 33645365759 scopus 로고    scopus 로고
    • Mechanism for the establishment of transcriptional HIV latency in the brain in a simian immunodeficiency Virus-Macaque Model
    • 16518758 10.1086/500983 1:CAS:528:DC%2BD28XjsVCgs7o%3D
    • Barber SA, Gama L, Dudaronek JM, et al. Mechanism for the establishment of transcriptional HIV latency in the brain in a simian immunodeficiency Virus-Macaque Model. J Infect Dis. 2006;193:963-70.
    • (2006) J Infect Dis , vol.193 , pp. 963-970
    • Barber, S.A.1    Gama, L.2    Dudaronek, J.M.3
  • 20
    • 77953724307 scopus 로고    scopus 로고
    • Simian immunodeficiency virus-infected macaques treated with highly active antiretroviral therapy have reduced central nervous system viral replication and inflammation but persistence of viral DNA
    • 20497048 10.1086/653213 1:CAS:528:DC%2BC3cXptlahsrg%3D This study reveals that systemically suppressive ART in an SIV macaque model reduces HIV RNA but does not affect viral DNA in the brain
    • • Zink MC, Brice AK, Kelly KM, et al. Simian immunodeficiency virus-infected macaques treated with highly active antiretroviral therapy have reduced central nervous system viral replication and inflammation but persistence of viral DNA. J Infect Dis. 2010;202:161-70. This study reveals that systemically suppressive ART in an SIV macaque model reduces HIV RNA but does not affect viral DNA in the brain.
    • (2010) J Infect Dis , vol.202 , pp. 161-170
    • Zink, M.C.1    Brice, A.K.2    Kelly, K.M.3
  • 22
    • 0022407895 scopus 로고
    • Isolation of HTLV-III from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome
    • Ho DD, Rota TR, Schooley RT, et al. Isolation of HTLV-III from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome. N Engl J Med. 1985;313:1493-7. (Pubitemid 16182477)
    • (1985) New England Journal of Medicine , vol.313 , Issue.24 , pp. 1493-1497
    • Ho, D.D.1    Rota, T.R.2    Schooley, R.T.3
  • 23
    • 0025775577 scopus 로고
    • Acute ataxia coincident with seroconversion for anti-HIV
    • 1940992 10.1007/BF00315340 1:STN:280:DyaK38%2FksVKnsw%3D%3D
    • Scarpini E, Sacilotto G, Lazzarin A, et al. Acute ataxia coincident with seroconversion for anti-HIV. J Neurol. 1991;238:356-7.
    • (1991) J Neurol , vol.238 , pp. 356-357
    • Scarpini, E.1    Sacilotto, G.2    Lazzarin, A.3
  • 24
    • 0029761952 scopus 로고    scopus 로고
    • Immediate immunosuppression caused by acute HIV-1 infection: A fulminant multisystemic disease 2 days post infection
    • Ben-Galim P, Shaked Y, Vonsover A, Garty M. Immediate immunosuppression caused by acute HIV-1 infection: a fulminant multisystemic disease 2 days post infection. Infection. 1996;24:332-5. (Pubitemid 26273303)
    • (1996) Infection , vol.24 , Issue.4 , pp. 332-335
    • Ben-Galim, P.1    Shaked, Y.2    Vonsover, A.3    Garty, M.4
  • 25
    • 68949165678 scopus 로고    scopus 로고
    • Acute encephalopathy and multi-organ involvement with rhabdomyolysis during primary HIV infection
    • 19324581 10.1016/j.ijid.2009.01.005
    • Douvoyiannis M, Litman N. Acute encephalopathy and multi-organ involvement with rhabdomyolysis during primary HIV infection. Int J Infect Dis. 2009;13:e299-304.
    • (2009) Int J Infect Dis , vol.13 , pp. 299-304
    • Douvoyiannis, M.1    Litman, N.2
  • 26
    • 34347327119 scopus 로고    scopus 로고
    • Acute demyelinizating encephalomyelitis (ADEM) as initial presentation of primary HIV infection
    • DOI 10.1080/00365540601137379, PII 779648602
    • Mogensen TH, Marinovskij E, Larsen CS. Acute demyelinizating encephalomyelitis (ADEM) as initial presentation of primary HIV infection. Scand J Infect Dis. 2007;39:630-4. (Pubitemid 47009181)
    • (2007) Scandinavian Journal of Infectious Diseases , vol.39 , Issue.6-7 , pp. 630-634
    • Mogensen, T.H.1    Marinovskij, E.2    Larsen, C.S.3
  • 27
    • 0023571269 scopus 로고
    • Acute infection with the human immunodeficiency virus (HIV) associated with acute brachial neuritis and exanthematous rash
    • 3688679 10.7326/0003-4819-107-6-849 1:STN:280:DyaL1c%2FnsFGgtw%3D%3D
    • Calabrese LH, Proffitt MR, Levin KH, et al. Acute infection with the human immunodeficiency virus (HIV) associated with acute brachial neuritis and exanthematous rash. Ann Intern Med. 1987;107:849-51.
    • (1987) Ann Intern Med , vol.107 , pp. 849-851
    • Calabrese, L.H.1    Proffitt, M.R.2    Levin, K.H.3
  • 28
    • 33847723955 scopus 로고    scopus 로고
    • Bilateral Bell palsy and acute HIV type 1 infection: Report of 2 cases and review
    • 17304442 10.1086/511876
    • Serrano P, Hernandez N, Arroyo JA, et al. Bilateral Bell palsy and acute HIV type 1 infection: report of 2 cases and review. Clin Infect Dis. 2007;44:e57-61.
    • (2007) Clin Infect Dis , vol.44 , pp. 57-61
    • Serrano, P.1    Hernandez, N.2    Arroyo, J.A.3
  • 30
    • 0028274583 scopus 로고
    • Ataxic neuropathy associated with human immunodeficiency virus seroconversion [3]
    • Castellanos F, Mallada J, Ricart C, Zabala JA. Ataxic neuropathy associated with human immunodeficiency virus seroconversion. Arch Neurol. 1994;51:236. (Pubitemid 24088405)
    • (1994) Archives of Neurology , vol.51 , Issue.3 , pp. 236
    • Castellanos, F.1    Mallada, J.2    Ricart, C.3    Zabala, J.A.4
  • 31
    • 0023156726 scopus 로고
    • Acute myelopathy associated with primary infection with human immunodeficiency virus
    • Denning DW, Anderson J, Rudge P, Smith H. Acute myelopathy associated with primary infection with human immunodeficiency virus. Br Med J (Clin Res Ed). 1987;294:143-4. (Pubitemid 17223862)
    • (1987) British Medical Journal , vol.294 , Issue.6565 , pp. 143-144
    • Denning, D.W.1    Anderson, J.2    Rudge, P.3    Smith, H.4
  • 32
    • 0036872328 scopus 로고    scopus 로고
    • Primary human immunodeficiency virus
    • Taiwo BO, Hicks CB. Primary human immunodeficiency virus. South Med J. 2002;95:1312-7. (Pubitemid 36109342)
    • (2002) Southern Medical Journal , vol.95 , Issue.11 , pp. 1312-1317
    • Taiwo, B.O.1    Hicks, C.B.2
  • 33
    • 24144485476 scopus 로고    scopus 로고
    • Primary HIV Infection
    • 16091225 10.1007/s11904-004-0010-2
    • Stekler J, Collier AC. Primary HIV Infection. Curr HIV/AIDS Rep. 2004;1:68-73.
    • (2004) Curr HIV/AIDS Rep. , vol.1 , pp. 68-73
    • Stekler, J.1    Collier, A.C.2
  • 34
    • 0026661095 scopus 로고
    • Early viral brain invasion in iatrogenic human immunodeficiency virus infection
    • 1513462 10.1212/WNL.42.9.1736 1:STN:280:DyaK38zot1Oluw%3D%3D
    • Davis LE, Hjelle BL, Miller VE, et al. Early viral brain invasion in iatrogenic human immunodeficiency virus infection. Neurology. 1992;42:1736-9.
    • (1992) Neurology , vol.42 , pp. 1736-1739
    • Davis, L.E.1    Hjelle, B.L.2    Miller, V.E.3
  • 37
    • 80051726729 scopus 로고    scopus 로고
    • Central nervous system immune activation characterizes primary human immunodeficiency virus 1 infection even in participants with minimal cerebrospinal fluid viral burden
    • 21844301 10.1093/infdis/jir387 1:CAS:528:DC%2BC3MXhtVyhu7rO
    • Spudich S, Gisslen M, Hagberg L, et al. Central nervous system immune activation characterizes primary human immunodeficiency virus 1 infection even in participants with minimal cerebrospinal fluid viral burden. J Infect Dis. 2011;204:753-60.
    • (2011) J Infect Dis , vol.204 , pp. 753-760
    • Spudich, S.1    Gisslen, M.2    Hagberg, L.3
  • 38
    • 84862885694 scopus 로고    scopus 로고
    • Central nervous system viral invasion and inflammation during acute HIV infection
    • 22551810 10.1093/infdis/jis326 1:CAS:528:DC%2BC38XpsVaiurk%3D This study shows that HIV enters the central nervous system within the first weeks of HIV infection and this viral entry is associated with CNS inflammation
    • • Valcour V, Chalermchai T, Sailasuta N, et al. Central nervous system viral invasion and inflammation during acute HIV infection. J Infect Dis. 2012;206:275-82. This study shows that HIV enters the central nervous system within the first weeks of HIV infection and this viral entry is associated with CNS inflammation.
    • (2012) J Infect Dis , vol.206 , pp. 275-282
    • Valcour, V.1    Chalermchai, T.2    Sailasuta, N.3
  • 42
    • 84872896614 scopus 로고    scopus 로고
    • Reduced basal transcriptional activity of central nervous system-derived HIV-1 long terminal repeats
    • 22924643 1:CAS:528:DC%2BC3sXhsVOjur0%3D
    • Gray L, Cowley D, Crespan E, et al. Reduced basal transcriptional activity of central nervous system-derived HIV-1 long terminal repeats. AIDS Res Hum Retroviruses. 2013;29(2):365-70.
    • (2013) AIDS Res Hum Retroviruses , vol.29 , Issue.2 , pp. 365-370
    • Gray, L.1    Cowley, D.2    Crespan, E.3
  • 43
    • 77649195668 scopus 로고    scopus 로고
    • Compartmentalization and clonal amplification of HIV-1 variants in the cerebrospinal fluid during primary infection
    • 20015984 10.1128/JVI.01863-09 1:CAS:528:DC%2BC3cXisVCjtbw%3D
    • Schnell G, Price RW, Swanstrom R, Spudich S. Compartmentalization and clonal amplification of HIV-1 variants in the cerebrospinal fluid during primary infection. J Virol. 2010;84(5):2395-407.
    • (2010) J Virol , vol.84 , Issue.5 , pp. 2395-2407
    • Schnell, G.1    Price, R.W.2    Swanstrom, R.3    Spudich, S.4
  • 44
    • 0024352431 scopus 로고
    • 2-microglobulin levels in blood and cerebrospinal fluid occur early in HIV-1 infection
    • Sonnerborg AB, von Stedingk LV, Hansson LO, Strannegard OO. Elevated neopterin and beta 2-microglobulin levels in blood and cerebrospinal fluid occur early in HIV-1 infection. AIDS. 1989;3:277-83. (Pubitemid 19167469)
    • (1989) AIDS , vol.3 , Issue.5 , pp. 277-283
    • Sonnerborg, A.B.1    Von Stedingk, L.-V.2    Hansson, L.-O.3    Strannegard, O.O.4
  • 45
    • 84869226441 scopus 로고    scopus 로고
    • Change in brain magnetic resonance spectroscopy after treatment during acute HIV infection
    • 23229129 10.1371/journal.pone.0049272 1:CAS:528:DC%2BC38XhvVShs7nE
    • Sailasuta N, Ross W, Ananworanich J, et al. Change in brain magnetic resonance spectroscopy after treatment during acute HIV infection. PLoS One. 2012;7:e49272.
    • (2012) PLoS One , vol.7 , pp. 49272
    • Sailasuta, N.1    Ross, W.2    Ananworanich, J.3
  • 47
    • 84879812284 scopus 로고    scopus 로고
    • HIV-1-related central nervous system disease: Current issues in pathogenesis, diagnosis, and treatment
    • 22675662 10.1101/cshperspect.a007120
    • Spudich S, Gonzalez-Scarano F. HIV-1-related central nervous system disease: current issues in pathogenesis, diagnosis, and treatment. Cold Spring Harb Perspect Med. 2012;2:a007120.
    • (2012) Cold Spring Harb Perspect Med. , vol.2 , pp. 007120
    • Spudich, S.1    Gonzalez-Scarano, F.2
  • 48
    • 79960027926 scopus 로고    scopus 로고
    • Alterations in brain metabolism during the first year of HIV infection
    • 21494901 10.1007/s13365-011-0030-9 1:CAS:528:DC%2BC3MXmtl2lsLc%3D
    • Lentz MR, Kim WK, Kim H, et al. Alterations in brain metabolism during the first year of HIV infection. J Neurovirol. 2011;17:220-9.
    • (2011) J Neurovirol. , vol.17 , pp. 220-229
    • Lentz, M.R.1    Kim, W.K.2    Kim, H.3
  • 49
    • 67549130940 scopus 로고    scopus 로고
    • Changes in MRS neuronal markers and T cell phenotypes observed during early HIV infection
    • 19398702 10.1212/WNL.0b013e3181a2e90a 1:CAS:528:DC%2BD1MXkslOjs78%3D
    • Lentz MR, Kim WK, Lee V, et al. Changes in MRS neuronal markers and T cell phenotypes observed during early HIV infection. Neurology. 2009;72:1465-72.
    • (2009) Neurology , vol.72 , pp. 1465-1472
    • Lentz, M.R.1    Kim, W.K.2    Lee, V.3
  • 50
    • 84871276520 scopus 로고    scopus 로고
    • Structural brain alterations can be detected early in HIV infection
    • 23197750 10.1212/WNL.0b013e318278b5b4 1:CAS:528:DC%2BC38XhvVeltbjF
    • Ragin AB, Du H, Ochs R, et al. Structural brain alterations can be detected early in HIV infection. Neurology. 2012;79:2328-34.
    • (2012) Neurology , vol.79 , pp. 2328-2334
    • Ragin, A.B.1    Du, H.2    Ochs, R.3
  • 51
    • 84872502378 scopus 로고    scopus 로고
    • Abnormalities in resting-state functional connectivity in early human immunodeficiency virus infection
    • 22433049 10.1089/brain.2011.0016 1:CAS:528:DC%2BC3MXhslyhsLw%3D
    • Wang X, Foryt P, Ochs R, et al. Abnormalities in resting-state functional connectivity in early human immunodeficiency virus infection. Brain Connect. 2011;1:207-17.
    • (2011) Brain Connect. , vol.1 , pp. 207-217
    • Wang, X.1    Foryt, P.2    Ochs, R.3
  • 52
    • 70349327989 scopus 로고    scopus 로고
    • Resting cerebral blood flow: A potential biomarker of the effects of HIV in the brain
    • 19720977 10.1212/WNL.0b013e3181b59a97 1:STN:280:DC%2BD1MrptlOgsw%3D%3D
    • Ances BM, Sisti D, Vaida F, et al. Resting cerebral blood flow: a potential biomarker of the effects of HIV in the brain. Neurology. 2009;73:702-8.
    • (2009) Neurology , vol.73 , pp. 702-708
    • Ances, B.M.1    Sisti, D.2    Vaida, F.3
  • 53
    • 84877252688 scopus 로고    scopus 로고
    • Cerebrospinal fluid and neuroimaging biomarker abnormalities suggest early neurological injury in a subset of individuals during primary hiv infection
    • 23460748 10.1093/infdis/jit088 1:CAS:528:DC%2BC3sXntVOrsL0%3D This analysis found elevated biomarkers of neuronal injury in the CSF in HIV infected subjects within the first year after infection. Biomarkers correlated with CNS inflammation
    • • Peluso MJ, Meyerhoff DJ, Price RW, et al. Cerebrospinal fluid and neuroimaging biomarker abnormalities suggest early neurological injury in a subset of individuals during primary hiv infection. J Infect Dis. 2013;207:1703-12. This analysis found elevated biomarkers of neuronal injury in the CSF in HIV infected subjects within the first year after infection. Biomarkers correlated with CNS inflammation.
    • (2013) J Infect Dis , vol.207 , pp. 1703-1712
    • Peluso, M.J.1    Meyerhoff, D.J.2    Price, R.W.3
  • 55
    • 72449140567 scopus 로고    scopus 로고
    • Psychiatric context of acute/early HIV infection. The NIMH Multisite Acute HIV Infection Study: IV
    • 19517225 10.1007/s10461-009-9585-3
    • Atkinson JH, Higgins JA, Vigil O, et al. Psychiatric context of acute/early HIV infection. The NIMH Multisite Acute HIV Infection Study: IV. AIDS Behav. 2009;13:1061-7.
    • (2009) AIDS Behav , vol.13 , pp. 1061-1067
    • Atkinson, J.H.1    Higgins, J.A.2    Vigil, O.3
  • 56
    • 79952936053 scopus 로고    scopus 로고
    • Neurocognitive functioning in acute or early HIV infection
    • 21165782 10.1007/s13365-010-0009-y
    • Moore DJ, Letendre SL, Morris S, et al. Neurocognitive functioning in acute or early HIV infection. J Neurovirol. 2011;17:50-7.
    • (2011) J Neurovirol. , vol.17 , pp. 50-57
    • Moore, D.J.1    Letendre, S.L.2    Morris, S.3
  • 57
    • 84873694141 scopus 로고    scopus 로고
    • Substance use is a risk factor for neurocognitive deficits and neuropsychiatric distress in acute and early HIV infection
    • 23250704 10.1007/s13365-012-0141-y 1:CAS:528:DC%2BC3sXisVahtLk%3D
    • Weber E, Morgan EE, Iudicello JE, et al. Substance use is a risk factor for neurocognitive deficits and neuropsychiatric distress in acute and early HIV infection. J Neurovirol. 2013;19:65-74.
    • (2013) J Neurovirol. , vol.19 , pp. 65-74
    • Weber, E.1    Morgan, E.E.2    Iudicello, J.E.3
  • 58
    • 39149143342 scopus 로고    scopus 로고
    • Immune activation of the central nervous system is still present after >4 years of effective highly active antiretroviral therapy
    • DOI 10.1086/523648
    • Eden A, Price RW, Spudich S, et al. Immune activation of the central nervous system is still present after >4 years of effective highly active antiretroviral therapy. J Infect Dis. 2007;196:1779-83. (Pubitemid 351411938)
    • (2007) Journal of Infectious Diseases , vol.196 , Issue.12 , pp. 1779-1783
    • Eden, A.1    Price, R.W.2    Spudich, S.3    Fuchs, D.4    Hagberg, L.5    Gisslen, M.6
  • 60
    • 79952452318 scopus 로고    scopus 로고
    • Persistence of HIV-associated cognitive impairment, inflammation, and neuronal injury in era of highly active antiretroviral treatment
    • 21297425 10.1097/QAD.0b013e3283427da7 1:CAS:528:DC%2BC3MXislOksL8%3D
    • Harezlak J, Buchthal S, Taylor M, et al. Persistence of HIV-associated cognitive impairment, inflammation, and neuronal injury in era of highly active antiretroviral treatment. AIDS. 2011;25:625-33.
    • (2011) AIDS , vol.25 , pp. 625-633
    • Harezlak, J.1    Buchthal, S.2    Taylor, M.3
  • 61
    • 84881477899 scopus 로고    scopus 로고
    • Microglial cell activation is visualized with [11C]-PK11195 positron emission tomography in neurologically asymptomatic hiv-infected subjects on effective ART
    • Seattle, WA, USA
    • Garvey L, Pavese N, Politis M, et al. Microglial cell activation is visualized with [11C]-PK11195 positron emission tomography in neurologically asymptomatic hiv-infected subjects on effective ART. In: 19th Conference for Retroviruses and Opportunistic Infections. Seattle, WA, USA; 2012.
    • (2012) 19th Conference for Retroviruses and Opportunistic Infections
    • Garvey, L.1    Pavese, N.2    Politis, M.3
  • 62
    • 78650338104 scopus 로고    scopus 로고
    • HIV-1 viral escape in cerebrospinal fluid of subjects on suppressive antiretroviral treatment
    • 21050119 10.1086/657342 1:CAS:528:DC%2BC3MXisFeqsw%3D%3D
    • Eden A, Fuchs D, Hagberg L, et al. HIV-1 viral escape in cerebrospinal fluid of subjects on suppressive antiretroviral treatment. J Infect Dis. 2010;202:1819-25.
    • (2010) J Infect Dis , vol.202 , pp. 1819-1825
    • Eden, A.1    Fuchs, D.2    Hagberg, L.3
  • 63
    • 33646703373 scopus 로고    scopus 로고
    • Variable benefit in neuropsychological function in HIV-infected HAART-treated patients
    • 16682686 10.1212/01.wnl.0000210477.63851.d3
    • Cysique LA, Maruff P, Brew BJ. Variable benefit in neuropsychological function in HIV-infected HAART-treated patients. Neurology. 2006;66:1447-50.
    • (2006) Neurology , vol.66 , pp. 1447-1450
    • Cysique, L.A.1    Maruff, P.2    Brew, B.J.3
  • 64
    • 80052412081 scopus 로고    scopus 로고
    • CD4 nadir is a predictor of HIV neurocognitive impairment in the era of combination antiretroviral therapy
    • 21750419 10.1097/QAD.0b013e32834a40cd 1:CAS:528:DC%2BC3MXhtFWksb%2FN
    • Ellis RJ, Badiee J, Vaida F, et al. CD4 nadir is a predictor of HIV neurocognitive impairment in the era of combination antiretroviral therapy. AIDS. 2011;25:1747-51.
    • (2011) AIDS , vol.25 , pp. 1747-1751
    • Ellis, R.J.1    Badiee, J.2    Vaida, F.3
  • 65
    • 84873669536 scopus 로고    scopus 로고
    • Low prevalence of neurocognitive impairment in early diagnosed and managed HIV-infected persons
    • 23303852 10.1212/WNL.0b013e31827f0776
    • Crum-Cianflone NF, Moore DJ, Letendre S, et al. Low prevalence of neurocognitive impairment in early diagnosed and managed HIV-infected persons. Neurology. 2013;80:371-9.
    • (2013) Neurology , vol.80 , pp. 371-379
    • Crum-Cianflone, N.F.1    Moore, D.J.2    Letendre, S.3
  • 68
    • 33845462114 scopus 로고    scopus 로고
    • Treatment benefit on cerebrospinal fluid HIV-1 levels in the setting of systemic virological suppression and failure
    • DOI 10.1086/508750
    • Spudich S, Lollo N, Liegler T, et al. Treatment benefit on cerebrospinal fluid HIV-1 levels in the setting of systemic virological suppression and failure. J Infect Dis. 2006;194:1686-96. (Pubitemid 44901999)
    • (2006) Journal of Infectious Diseases , vol.194 , Issue.12 , pp. 1686-1696
    • Spudich, S.1    Lollo, N.2    Liegler, T.3    Deeks, S.G.4    Price, R.W.5
  • 70
  • 71
    • 38349068747 scopus 로고    scopus 로고
    • Validation of the CNS penetration-effectiveness rank for quantifying antiretroviral penetration into the central nervous system
    • 18195140 10.1001/archneurol.2007.31
    • Letendre S, Marquie-Beck J, Capparelli E, et al. Validation of the CNS penetration-effectiveness rank for quantifying antiretroviral penetration into the central nervous system. Arch Neurol. 2008;65:65-70.
    • (2008) Arch Neurol , vol.65 , pp. 65-70
    • Letendre, S.1    Marquie-Beck, J.2    Capparelli, E.3
  • 72
    • 84872070473 scopus 로고    scopus 로고
    • Higher CNS penetration-effectiveness of long-term combination antiretroviral therapy is associated with better HIV-1 viral suppression in cerebrospinal fluid
    • 23018371 10.1097/QAI.0b013e318274e2b0 1:CAS:528:DC%2BC38XhvVykt73E
    • Cusini A, Vernazza PL, Yerly S, et al. Higher CNS penetration- effectiveness of long-term combination antiretroviral therapy is associated with better HIV-1 viral suppression in cerebrospinal fluid. J Acquir Immune Defic Syndr. 2013;62:28-35.
    • (2013) J Acquir Immune Defic Syndr , vol.62 , pp. 28-35
    • Cusini, A.1    Vernazza, P.L.2    Yerly, S.3
  • 73
    • 79952020252 scopus 로고    scopus 로고
    • Antiretroviral therapy CNS penetration and HIV-1-associated CNS disease
    • 21339496 10.1212/WNL.0b013e31820d8b0b 1:CAS:528:DC%2BC3MXit1artbg%3D
    • Garvey L, Winston A, Walsh J, et al. Antiretroviral therapy CNS penetration and HIV-1-associated CNS disease. Neurology. 2011;76:693-700.
    • (2011) Neurology , vol.76 , pp. 693-700
    • Garvey, L.1    Winston, A.2    Walsh, J.3
  • 74
    • 79551604850 scopus 로고    scopus 로고
    • Effects of central nervous system antiretroviral penetration on cognitive functioning in the ALLRT cohort
    • 21124201 10.1097/QAD.0b013e32834171f8
    • Smurzynski M, Wu K, Letendre S, et al. Effects of central nervous system antiretroviral penetration on cognitive functioning in the ALLRT cohort. AIDS. 2011;25:357-65.
    • (2011) AIDS , vol.25 , pp. 357-365
    • Smurzynski, M.1    Wu, K.2    Letendre, S.3
  • 75
    • 69549110328 scopus 로고    scopus 로고
    • Changes in cognition during antiretroviral therapy: Comparison of 2 different ranking systems to measure antiretroviral drug efficacy on HIV-associated neurocognitive disorders
    • 19731418 10.1097/QAI.0b013e3181af83d6 1:CAS:528:DC%2BD1MXhtVektbjP
    • Tozzi V, Balestra P, Salvatori MF, et al. Changes in cognition during antiretroviral therapy: comparison of 2 different ranking systems to measure antiretroviral drug efficacy on HIV-associated neurocognitive disorders. J Acquir Immune Defic Syndr. 2009;52:56-63.
    • (2009) J Acquir Immune Defic Syndr , vol.52 , pp. 56-63
    • Tozzi, V.1    Balestra, P.2    Salvatori, M.F.3
  • 76
    • 68449083930 scopus 로고    scopus 로고
    • Impact of combination antiretroviral therapy on cerebrospinal fluid HIV RNA and neurocognitive performance
    • 19424052 10.1097/QAD.0b013e32832c4152
    • Marra CM, Zhao Y, Clifford DB, et al. Impact of combination antiretroviral therapy on cerebrospinal fluid HIV RNA and neurocognitive performance. AIDS. 2009;23:1359-66.
    • (2009) AIDS , vol.23 , pp. 1359-1366
    • Marra, C.M.1    Zhao, Y.2    Clifford, D.B.3
  • 77
    • 84875657273 scopus 로고    scopus 로고
    • Revised central nervous system neuropenetration-effectiveness score is associated with cognitive disorders in HIV-infected patients with controlled plasma viraemia
    • 23486721 10.3851/IMP2560
    • Ciccarelli N, Fabbiani M, Colafigli M, et al. Revised central nervous system neuropenetration-effectiveness score is associated with cognitive disorders in HIV-infected patients with controlled plasma viraemia. Antivir Ther. 2013;18:153-60.
    • (2013) Antivir Ther , vol.18 , pp. 153-160
    • Ciccarelli, N.1    Fabbiani, M.2    Colafigli, M.3
  • 78
    • 64049093394 scopus 로고    scopus 로고
    • HIV DNA and cognition in a Thai longitudinal HAART initiation cohort: The SEARCH 001 Cohort Study
    • 19289739 10.1212/01.wnl.0000344404.12759.83 1:STN:280: DC%2BD1M3ht1agtQ%3D%3D
    • Valcour VG, Shiramizu BT, Sithinamsuwan P, et al. HIV DNA and cognition in a Thai longitudinal HAART initiation cohort: the SEARCH 001 Cohort Study. Neurology. 2009;72:992-8.
    • (2009) Neurology , vol.72 , pp. 992-998
    • Valcour, V.G.1    Shiramizu, B.T.2    Sithinamsuwan, P.3
  • 79
    • 84858691185 scopus 로고    scopus 로고
    • Cognitive performance related to HIV-1-infected monocytes
    • 10.1176/appi.neuropsych.11050109
    • Kusao I, Shiramizu B, Liang CY, et al. Cognitive performance related to HIV-1-infected monocytes. J Neuropsychiatr Clin Neurosci. 2012;24:71-80.
    • (2012) J Neuropsychiatr Clin Neurosci , vol.24 , pp. 71-80
    • Kusao, I.1    Shiramizu, B.2    Liang, C.Y.3
  • 80
    • 84870511138 scopus 로고    scopus 로고
    • Antiretroviral monocyte efficacy score linked to cognitive impairment in HIV
    • 23018140 10.3851/IMP2411 1:CAS:528:DC%2BC3sXhtFCqurY%3D
    • Shikuma CM, Nakamoto B, Shiramizu B, et al. Antiretroviral monocyte efficacy score linked to cognitive impairment in HIV. Antivir Ther. 2012;17:1233-42.
    • (2012) Antivir Ther , vol.17 , pp. 1233-1242
    • Shikuma, C.M.1    Nakamoto, B.2    Shiramizu, B.3
  • 81
    • 76749136667 scopus 로고    scopus 로고
    • Discordance between cerebral spinal fluid and plasma HIV replication in patients with neurological symptoms who are receiving suppressive antiretroviral therapy
    • 20100092 10.1086/650538 This is the first description of a series of patients with progressive neurologic disease on stable ART, found to have CSF HIV RNA levels higher than fairly controlled plasma HIV RNA
    • •• Canestri A, Lescure FX, Jaureguiberry S, et al. Discordance between cerebral spinal fluid and plasma HIV replication in patients with neurological symptoms who are receiving suppressive antiretroviral therapy. Clin Infect Dis. 2010;50:773-8. This is the first description of a series of patients with progressive neurologic disease on stable ART, found to have CSF HIV RNA levels higher than fairly controlled plasma HIV RNA.
    • (2010) Clin Infect Dis , vol.50 , pp. 773-778
    • Canestri, A.1    Lescure, F.X.2    Jaureguiberry, S.3
  • 82
    • 75749155819 scopus 로고    scopus 로고
    • Therapy failure following selection of enfuvirtide-resistant HIV-1 in cerebrospinal fluid
    • 20047481 10.1086/649874
    • van Lelyveld SF, Nijhuis M, Baatz F, et al. Therapy failure following selection of enfuvirtide-resistant HIV-1 in cerebrospinal fluid. Clin Infect Dis. 2010;50:387-90.
    • (2010) Clin Infect Dis , vol.50 , pp. 387-390
    • Van Lelyveld, S.F.1    Nijhuis, M.2    Baatz, F.3
  • 83
    • 80052265268 scopus 로고    scopus 로고
    • Reversible dementia in a patient with central nervous system escape of human immunodeficiency virus
    • 21658774 10.1016/j.jinf.2011.05.011
    • Bogoch II, Davis BT, Venna N. Reversible dementia in a patient with central nervous system escape of human immunodeficiency virus. J Infect. 2011;63:236-9.
    • (2011) J Infect , vol.63 , pp. 236-239
    • Bogoch, I.I.1    Davis, B.T.2    Venna, N.3
  • 84
    • 80054724214 scopus 로고    scopus 로고
    • HIV encephalitis despite suppressed viraemia: A case of compartmentalized viral escape
    • 21998185 10.1258/ijsa.2011.010507 1:STN:280:DC%2BC3MbhtFWmug%3D%3D
    • Bingham R, Ahmed N, Rangi P, et al. HIV encephalitis despite suppressed viraemia: a case of compartmentalized viral escape. Int J STD AIDS. 2011;22:608-9.
    • (2011) Int J STD AIDS , vol.22 , pp. 608-609
    • Bingham, R.1    Ahmed, N.2    Rangi, P.3
  • 85
    • 84855615123 scopus 로고    scopus 로고
    • HIV type 1 viral encephalitis after development of viral resistance to plasma suppressive antiretroviral therapy
    • 21504362 10.1089/aid.2011.0020
    • Tamarit Mdel P, Quereda C, Gonzalez-Rozas M, et al. HIV type 1 viral encephalitis after development of viral resistance to plasma suppressive antiretroviral therapy. AIDS Res Hum Retroviruses. 2012;28:83-6.
    • (2012) AIDS Res Hum Retroviruses. , vol.28 , pp. 83-86
    • Tamarit Mdel, P.1    Quereda, C.2    Gonzalez-Rozas, M.3
  • 86
    • 84866340305 scopus 로고    scopus 로고
    • Cerebrospinal fluid HIV escape associated with progressive neurologic dysfunction in patients on antiretroviral therapy with well controlled plasma viral load
    • 22614889 10.1097/QAD.0b013e328355e6b2 1:CAS:528:DC%2BC38XhtlaisrbP
    • Peluso MJ, Ferretti F, Peterson J, et al. Cerebrospinal fluid HIV escape associated with progressive neurologic dysfunction in patients on antiretroviral therapy with well controlled plasma viral load. AIDS. 2012;26:1765-74.
    • (2012) AIDS , vol.26 , pp. 1765-1774
    • Peluso, M.J.1    Ferretti, F.2    Peterson, J.3
  • 87
    • 84878873415 scopus 로고    scopus 로고
    • CD8 encephalitis in HIV-infected patients receiving cART: A treatable entity
    • 23515205 10.1093/cid/cit175 1:CAS:528:DC%2BC3sXptFeltb0%3D These authors describe a clinical syndrome of inflammatory encephalitis that may be a form of immune reconstitution inflammatory disease in the CNS
    • • Lescure FX, Moulignier A, Savatovsky J, et al. CD8 encephalitis in HIV-infected patients receiving cART: a treatable entity. Clin Infect Dis. 2013;57:101-8. These authors describe a clinical syndrome of inflammatory encephalitis that may be a form of immune reconstitution inflammatory disease in the CNS.
    • (2013) Clin Infect Dis , vol.57 , pp. 101-108
    • Lescure, F.X.1    Moulignier, A.2    Savatovsky, J.3
  • 88
    • 84882288035 scopus 로고    scopus 로고
    • Encephalitis with Infiltration by CD8+ lymphocytes in HIV patients receiving combination antiretroviral treatment
    • 10.1111/bpa.12038
    • Gray F, Lescure FX, Adle-Biassette H, et al. Encephalitis with Infiltration by CD8+ lymphocytes in HIV patients receiving combination antiretroviral treatment. Brain Pathol. 2013. doi: 10.1111/bpa.12038.
    • (2013) Brain Pathol
    • Gray, F.1    Lescure, F.X.2    Adle-Biassette, H.3
  • 90
    • 70450245268 scopus 로고    scopus 로고
    • Evidence for ongoing brain injury in human immunodeficiency virus-positive patients treated with antiretroviral therapy
    • 19499454 10.1080/13550280902973960 1:CAS:528:DC%2BD1MXht12gsr7J
    • Cardenas VA, Meyerhoff DJ, Studholme C, et al. Evidence for ongoing brain injury in human immunodeficiency virus-positive patients treated with antiretroviral therapy. J Neurovirol. 2009;15:324-33.
    • (2009) J Neurovirol. , vol.15 , pp. 324-333
    • Cardenas, V.A.1    Meyerhoff, D.J.2    Studholme, C.3
  • 91
    • 77951468353 scopus 로고    scopus 로고
    • Neurocognitive effects of treatment interruption in stable HIV-positive patients in an observational cohort
    • 20237308 10.1212/WNL.0b013e3181d9ed09 1:CAS:528:DC%2BC3cXkvV2qur8%3D
    • Robertson KR, Su Z, Margolis DM, et al. Neurocognitive effects of treatment interruption in stable HIV-positive patients in an observational cohort. Neurology. 2010;74:1260-6.
    • (2010) Neurology , vol.74 , pp. 1260-1266
    • Robertson, K.R.1    Su, Z.2    Margolis, D.M.3
  • 92
    • 84869223148 scopus 로고    scopus 로고
    • Dendritic spine injury induced by the 8-hydroxy metabolite of efavirenz
    • 22984227 10.1124/jpet.112.195701 1:CAS:528:DC%2BC38Xhslyjs7zP
    • Tovar-y-Romo LB, Bumpus NN, Pomerantz D, et al. Dendritic spine injury induced by the 8-hydroxy metabolite of efavirenz. J Pharmacol Exp Ther. 2012;343:696-703.
    • (2012) J Pharmacol Exp Ther , vol.343 , pp. 696-703
    • Tovar-Y-Romo, L.B.1    Bumpus, N.N.2    Pomerantz, D.3
  • 93
    • 84867288689 scopus 로고    scopus 로고
    • Antiretroviral neurotoxicity
    • 22811264 10.1007/s13365-012-0120-3 1:CAS:528:DC%2BC38XhsVyiu7fM
    • Robertson K, Liner J, Meeker RB. Antiretroviral neurotoxicity. J Neurovirol. 2012;18:388-99.
    • (2012) J Neurovirol , vol.18 , pp. 388-399
    • Robertson, K.1    Liner, J.2    Meeker, R.B.3
  • 94
    • 76749119501 scopus 로고    scopus 로고
    • Long-term impact of efavirenz on neuropsychological performance and symptoms in HIV-infected individuals (ACTG 5097s)
    • 20133265 10.1310/hct1006-343
    • Clifford DB, Evans S, Yang Y, et al. Long-term impact of efavirenz on neuropsychological performance and symptoms in HIV-infected individuals (ACTG 5097s). HIV Clin Trials. 2009;10:343-55.
    • (2009) HIV Clin Trials. , vol.10 , pp. 343-355
    • Clifford, D.B.1    Evans, S.2    Yang, Y.3
  • 95
    • 79955458684 scopus 로고    scopus 로고
    • Efavirenz associated with cognitive disorders in otherwise asymptomatic HIV-infected patients
    • 21502598 10.1212/WNL.0b013e31821670fb 1:CAS:528:DC%2BC3MXkvValtb0%3D
    • Ciccarelli N, Fabbiani M, Di Giambenedetto S, et al. Efavirenz associated with cognitive disorders in otherwise asymptomatic HIV-infected patients. Neurology. 2011;76:1403-9.
    • (2011) Neurology , vol.76 , pp. 1403-1409
    • Ciccarelli, N.1    Fabbiani, M.2    Di Giambenedetto, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.