Alterations in brain metabolism during the first year of HIV infection

Journal of NeuroVirology

Volumn 17, Issue 3, 2011, Pages 220-229

  Lentz, Margaret R ^a   Kim, Woong Ki ^b   Kim, Hyun ^a   Soulas, Caroline ^c   Lee, Vallent ^a   Venna, Nagagopal ^a   Halpern, Elkan F ^a   Rosenberg, Eric S ^a   Williams, Kenneth ^c   Gonzalez R G ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^c BOSTON COLLEGE   (United States)

Author keywords

CD14highCD16low; CD14lowCD16high; Choline; HIV; MRS; NAA

Indexed keywords

ABACAVIR PLUS LAMIVUDINE PLUS ZIDOVUDINE; CD16 ANTIGEN; CHOLINE; EFAVIRENZ; EFAVIRENZ PLUS EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; LAMIVUDINE; LAMIVUDINE PLUS ZIDOVUDINE; LOPINAVIR PLUS RITONAVIR; N ACETYLASPARTIC ACID; TENOFOVIR DISOPROXIL; VIRUS RNA;

ADULT; ARTICLE; BRAIN METABOLISM; BRAIN REGION; CLINICAL ARTICLE; CONTROLLED STUDY; DEMENTIA; FRONTAL CORTEX; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIPID MEMBRANE; LIPID METABOLISM; MALE; MONOCYTE; MOTOR DYSFUNCTION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; WESTERN BLOTTING; WHITE MATTER;

ADULT; ANTI-RETROVIRAL AGENTS; ANTIGENS, CD14; ASPARTIC ACID; BASAL GANGLIA; CHOLINE; FRONTAL LOBE; GPI-LINKED PROTEINS; HIV; HIV INFECTIONS; HUMANS; INOSITOL; LIPID METABOLISM; LONGITUDINAL STUDIES; MAGNETIC RESONANCE SPECTROSCOPY; MIDDLE AGED; MONOCYTES; RECEPTORS, IGG; RNA, VIRAL; VIRAL LOAD;

EID: 79960027926     PISSN: 13550284     EISSN: 15382443     Source Type: Journal    
DOI: 10.1007/s13365-011-0030-9     Document Type: Article

References (33)

1. Ances BM, Sisti D et al (2009) Resting cerebral blood flow: a potential biomarker of the effects of HIV in the brain. Neurology 73:702-708
2. Chakrabarti L, Hurtrel M et al (1991) Early viral replication in the brain of SIV-infected rhesus monkeys. Am J Pathol 139:1273-1280
3. Chang L, Ernst T et al (1999a) Cerebral metabolite abnormalities correlate with clinical severity of HIV-1 cognitive motor complex. Neurology 52:100-108 (Pubitemid 29044406)
4. Chang L, Ernst T et al (1999b) Highly active antiretroviral therapy reverses brain metabolite abnormalities in mild HIV dementia. Neurology 53:782-789 (Pubitemid 29448300)
5. Chang L, Lee PL et al (2004) A multicenter in vivo proton-MRS study of HIV-associated dementia and its relationship to age. Neuroimage 23:1336-1347 (Pubitemid 40260357)
6. Clay CC, Rodrigues DS et al (2007) Neuroinvastion of fluoresceinpositive monocytes in acute simian immunodeficiency virus infection. J Virol 81:12040-12048 (Pubitemid 47623834)
7. Ellery PJ, Tippett E et al (2007) The CD16+ monocyte subset is more permissive to infection and preferentially harbors HIV-1 in vivo. J Immunol 178:6581-6589 (Pubitemid 46717442)
8. Finzi D, Blankson J et al (1999) Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med 5:512-517 (Pubitemid 29220209)
9. Gray F, Scaravillio F et al (1996) Neuropathology of early HIV-1 infection. Brain Pathol 6:1-15 (Pubitemid 26078651)
10. Greco JB, Westmoreland SV et al (2004) In vivo 1 H MRS of brain injury and repair during acute SIV infection in the macaque model of neuroAIDS. Magn Reson Med 51:1108-1114 (Pubitemid 38796994)
11. Groeschel S, Brockmann K et al (2006) Magnetic resonance imaging and proton magnetic resonance spectroscopy of megalencephaly and dilated Virchow-Robin spaces. Pediatr Neurol 34:35-40 (Pubitemid 41821007)
12. Gruber S, Pinker K et al (2008) Metabolic changes in the normal ageing brain: consistent findings from short and long echo time proton spectroscopy. Eur J Radiol 68:320-327
13. Kassutto S, Maghsoudi K et al (2006) Longitudinal analysis of clinical markers following antiretroviral therapy initiated during acute or early HIV type 1 infection. Clin Infect Dis 42:1024-1031
14. Kaufmann DE, Walker BD (2007) Treatment interruption to boost specific HIV immunity in acute infection. Curr Opin HIV AIDS 2:21-25 (Pubitemid 46941137)
15. Kaul M, Lipton SA (2006) Mechanisms of neuroimmunity and neurodegeneration associated with HIV-1 infection and AIDS. J Neuroimmune Pharmacol 1:138-151 (Pubitemid 44257489)
16. Kim JP, Lentz MR et al (2005) Relationships between astrogliosis and 1H MR spectroscopic measures of brain choline/creatine and myo-inositol/creatine in a primate model. AJNR Am J Neuroradiol 26:752-759 (Pubitemid 43079764)
17. Kim WK, Sun Y et al (2009) Monocyte heterogeneity underlying phenotypic changes in monocytes according to SIV disease stage. J Leukoc Biol 87:557-567
18. Kreis R, Ross BD et al (1992) Metabolic disorders of the brain in chronic hepatic encephalopathy detected with H-1 MR spectroscopy. Radiology 182:19-27
19. Lentz MR, Kim WK et al (2009) Changes in MRS neuronal markers and T cell phenotypes observed during early HIV infection. Neurology 72:1465-1472
20. Mellors JW, Kingsley LA et al (1995) Quantitation of HIV-1 RNA in plasma predicts outcome after seroconversion. Ann Intern Med 122:573-579
21. Meyerhoff DJ, Bloomer C et al (1999) Elevated subcortical choline metabolites in cognitively and clinically asymptomatic HIV+ patients. Neurology 52:995-1003 (Pubitemid 29161610)
22. Mogensen TH, Marinovskij E et al (2007) Acute demyelinizating encephalomyelitis (ADEM) as initial presentation of primary HIV infection. Scand J Infect Dis 39:630-634 (Pubitemid 47009181)
23. Mohamad MSN, Sacktor NC, et al. (2007) 3 Tesla MR Spectroscopy Reveals Decreased Glutamate and Glutamine levels in frontal white matter in HIV-associated dementia. In: ISMRM 15: Berlin
24. Moore D, Letendre S, et al. (2010) HIV-associated Neurocognitive Disorder in Acute and Early HIV Infection. In: 17th Conference on Retroviruses and Opportunistic Infections: San Francisco, CA
25. Perelson AS, Essunger P et al (1997) Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 387:188-191 (Pubitemid 27209434)
26. Power C, Selnes OA et al (1995) HIV dementia scale: a rapid screening test. J Acquir Immune Defic Syndr Hum Retrovirol 8:273-278
27. Ratai EM, Pilkenton SJ et al (2009) In vivo proton magnetic resonance spectroscopy reveals region specific metabolic responses to SIV infection in the macaque brain. BMC Neurosci 10:63
28. Rosenberg ES, Altfeld M et al (2000) Immune control of HIV-1 after early treatment of acute infection. Nature 407:523-526
29. Ross BD, Jacobson S et al (1994) Subclinical hepatic encephalopathy: proton MR spectroscopic abnormalities. Radiology 193:457-463 (Pubitemid 24338334)
30. Schacker TW, Hughes JP et al (1998) Biological and virologic characteristics of primary HIV infection. Ann Intern Med 128:613-620 (Pubitemid 28169637)
31. Schnell G, Price RW et al (2010) Compartmentalization and clonal amplification of HIV-1 variants in the cerebrospinal fluid during primary infection. J Virol 84:2395-2407
32. Williams K, Westmoreland S et al (2005) Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS. J Clin Invest 115:2534-2545 (Pubitemid 41266216)
33. Yoshizawa T, Motonishi S et al (2007) Case of acute primary HIV infection with menigoencephalitis demonstrating high signal intensity of the bilateral globus pallidus in T2-weighted MRI. Rinsho Shinkeigaku 47:597-600 (Pubitemid 350071137)