Protective effects of hydrogen-rich saline on necrotizing enterocolitis in neonatal rats

Journal of Pediatric Surgery

Volumn 48, Issue 8, 2013, Pages 1697-1706

  Sheng, Qingfeng ^a,b   Lv, Zhibao ^a   Cai, Wei ^b   Song, Huanlei ^b   Qian, Linxi ^b   Wang, Xueli ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Shanghai Institute for Pediatric Research   (China)

Author keywords

Hydrogen rich saline; Inflammation; Necrotizing enterocolitis; Oxidative stress

Indexed keywords

AMINE OXIDASE (COPPER CONTAINING); ANTIOXIDANT; HYDROGEN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 6; MALONALDEHYDE; MESSENGER RNA; PROTECTIVE AGENT; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; ARTIFICIAL MILK; ASPHYXIA; BIRTH; BODY WEIGHT; COLD STRESS; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; DOWN REGULATION; ENZYME BLOOD LEVEL; GENE EXPRESSION; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; MEDIATOR; NECROTIZING ENTEROCOLITIS; NEWBORN; NEWBORN DISEASE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SURVIVAL RATE; SURVIVAL TIME;

HYDROGEN-RICH SALINE; INFLAMMATION; NECROTIZING ENTEROCOLITIS; OXIDATIVE STRESS;

AMINE OXIDASE (COPPER-CONTAINING); ANIMALS; ANIMALS, NEWBORN; ANTIOXIDANTS; ASPHYXIA; BODY WEIGHT; COLD TEMPERATURE; DRUG EVALUATION, PRECLINICAL; ENTEROCOLITIS, NECROTIZING; ENZYME INDUCTION; GENE EXPRESSION REGULATION; HYDROGEN; ILEUM; INFANT FOOD; INJECTIONS, INTRAPERITONEAL; INTERLEUKIN-10; INTERLEUKIN-6; INTESTINAL MUCOSA; LIPID PEROXIDATION; MALE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84881407128     PISSN: 00223468     EISSN: 15315037     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2012.11.038     Document Type: Article

References (34)

1. P.W. Lin, and B.J. Stoll Necrotising enterocolitis Lancet 368 2006 1271 1283 (Pubitemid 44485800)
2. M.C. Henry, and R.L. Moss Necrotizing enterocolitis Annu Rev Med 60 2009 111 124
3. J. Neu, and W.A. Walker Necrotizing enterocolitis N Engl J Med 364 2011 255 264
4. J.W. Lee, and J.M. Davis Future applications of antioxidants in premature infants Curr Opin Pediatr 23 2011 161 166
5. A. Guven, B. Uysal, and G. Gundogdu Melatonin ameliorates necrotizing enterocolitis in a neonatal rat model J Pediatr Surg 46 2011 2101 2107
6. C. Tayman, A. Tonbul, and A. Kosus N-acetylcysteine may prevent severe intestinal damage in necrotizing enterocolitis J Pediatr Surg 47 2012 540 550
7. I. Ohsawa, M. Ishikawa, and K. Takahashi Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals Nat Med 13 2007 688 694 (Pubitemid 46889750)
8. S. Ohta Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases Biochim Biophys Acta 1820 2012 586 594
9. B.M. Buchholz, D.J. Kaczorowski, and R. Sugimoto Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury Am J Transplant 8 2008 2015 2024
10. B.M. Buchholz, K. Masutani, and T. Kawamura Hydrogen-enriched preservation protects the isogeneic intestinal graft and amends recipient gastric function during transplantation Transplantation 92 2011 985 992
11. M.S. Caplan, E. Hedlund, and L. Adler Role of asphyxia and feeding in a neonatal rat model of necrotizing enterocolitis Pediatr Pathol 14 1994 1017 1028 (Pubitemid 24357149)
12. Y.F. Mao, X.F. Zheng, and J.M. Cai Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats Biochem Biophys Res Commun 381 2009 602 605
13. T method Nat Protoc 3 2008 1101 1108 (Pubitemid 351818697)
14. H. Ohkawa, N. Ohishi, and K. Yagi Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Anal Biochem 95 1979 351 358 (Pubitemid 9194347)
15. I.F. Benzie, and J.J. Strain The ferric reducing ability of plasma (FRAP) as a measure of «antioxidant power »: the FRAP assay Anal Biochem 239 1996 70 76
16. G.D. Luk, T.M. Bayless, and S.B. Baylin Diamine oxidase (histaminase). A circulating marker for rat intestinal mucosal maturation and integrity J Clin Invest 66 1980 66 70 (Pubitemid 10071349)
17. M.J. Morowitz, V. Poroyko, and M. Caplan Redefining the role of intestinal microbes in the pathogenesis of necrotizing enterocolitis Pediatrics 125 2010 777 785
18. J.H. Weitkamp, T. Koyama, and M.T. Rock Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)/effector (CD4, CD8) T cell ratios Gut 62 2013 73 82
19. O.D. Saugstad Oxidative stress in the newborn - a 30-year perspective Biol Neonate 88 2005 228 236 (Pubitemid 41433555)
20. J.S. Whitehouse, H. Xu, and Y. Shi Mesenteric nitric oxide and superoxide production in experimental necrotizing enterocolitis J Surg Res 161 2010 1 8
21. C. Aydemir, D. Dilli, and N. Uras Total oxidant status and oxidative stress are increased in infants with necrotizing enterocolitis J Pediatr Surg 46 2011 2096 2100
22. J.S. Cardinal, J. Zhan, and Y. Wang Oral hydrogen water prevents chronic allograft nephropathy in rats Kidney Int 77 2010 101 109
23. H. Sun, L. Chen, and W. Zhou The protective role of hydrogen-rich saline in experimental liver injury in mice J Hepatol 54 2011 471 480
24. E.P. Nadler, A. Stanford, and X.R. Zhang Intestinal cytokine gene expression in infants with acute necrotizing enterocolitis: interleukin-11 mRNA expression inversely correlates with extent of disease J Pediatr Surg 36 2001 1122 1129 (Pubitemid 32705688)
25. M.S. Caplan, D. Simon, and T. Jilling The role of PAF, TLR, and the inflammatory response in neonatal necrotizing enterocolitis Semin Pediatr Surg 14 2005 145 151 (Pubitemid 41111600)
26. B.L. Frost, T. Jilling, and M.S. Caplan The importance of pro-inflammatory signaling in neonatal necrotizing enterocolitis Semin Perinatol 32 2008 100 106 (Pubitemid 351381163)
27. A. Afrazi, C.P. Sodhi, and W. Richardson New insights into the pathogenesis and treatment of necrotizing enterocolitis: Toll-like receptors and beyond Pediatr Res 69 2011 183 188
28. K. Xie, Y. Yu, and Y. Pei Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release Shock 34 2010 90 97
29. C.N. Emami, N. Chokshi, and J. Wang Role of interleukin-10 in the pathogenesis of necrotizing enterocolitis Am J Surg 203 2012 428 435
30. R.J. Anand, C.L. Leaphart, and K.P. Mollen The role of the intestinal barrier in the pathogenesis of necrotizing enterocolitis Shock 27 2007 124 133 (Pubitemid 46105827)
31. K. Xie, Y. Yu, and Z. Zhang Hydrogen gas improves survival rate and organ damage in zymosan-induced generalized inflammation model Shock 34 2010 495 501
32. A. Guven, G. Gundogdu, and B. Uysal Hyperbaric oxygen therapy reduces the severity of necrotizing enterocolitis in a neonatal rat model J Pediatr Surg 44 2009 534 540
33. A. Guven, G. Gundogdu, and S. Vurucu Medical ozone therapy reduces oxidative stress and intestinal damage in an experimental model of necrotizing enterocolitis in neonatal rats J Pediatr Surg 44 2009 1730 1735
34. A. Nakao, Y. Toyoda, and P. Sharma Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study J Clin Biochem Nutr 46 2010 140 149