Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 32, 2013, Pages 12960-12965

  Leppänen, Veli Matti ^a   Tvorogov, Denis ^a   Kisko, Kaisa ^b   Prota, Andrea E ^b   Jeltsch, Michael ^a   Anisimov, Andrey ^a   Markovic Mueller, Sandra ^b   Stuttfeld, Edward ^b,c   Goldie, Kenneth N ^c   Ballmer Hofer, Kurt ^b   Alitalo, Kari ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b PAUL SCHERRER INSTITUTE   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Receptor tyrosine kinase; Signal transduction

Indexed keywords

HOMODIMER; VASCULOTROPIN C; VASCULOTROPIN RECEPTOR 3;

ARTICLE; AUTOPHOSPHORYLATION; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIMERIZATION; GLYCOSYLATION; HUMAN; HUMAN CELL; INSECT CELL; LIGAND BINDING; LIGHT SCATTERING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR BINDING; WESTERN BLOTTING; X RAY CRYSTALLOGRAPHY;

RECEPTOR TYROSINE KINASE; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; BINDING SITES; BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; LIGANDS; MICROSCOPY, ELECTRON; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; MUTATION; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; SCATTERING, SMALL ANGLE; SEQUENCE HOMOLOGY, AMINO ACID; THERMODYNAMICS; VASCULAR ENDOTHELIAL GROWTH FACTOR C; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3; X-RAY DIFFRACTION;

EID: 84881398446     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1301415110     Document Type: Article

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