Continuous hydrolysis and liquid-liquid phase separation of an active pharmaceutical ingredient intermediate using a miniscale hydrophobic membrane separator

Organic Process Research and Development

Volumn 16, Issue 5, 2012, Pages 888-900

  Cervera Padrell, Albert E ^a   Morthensen, Sofie T ^a   Lewandowski, Daniel J ^a   Skovby, Tommy ^b   Kiil, Søren ^a   Gernaey, Krist V ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC WATER; ACTIVE AREA; ACTIVE PHARMACEUTICAL INGREDIENTS; ALKOXIDES; AQUEOUS PHASIS; BACK PRESSURES; COALESCER; CONTINUOUS MODE; FLOW RATIOS; GRIGNARD REACTION; HYDROPHOBIC MEMBRANE; LAPLACE PRESSURE; LIQUID-LIQUID PHASE SEPARATION; LIQUID-LIQUIDS; LOW PRESSURE DROP; MEMBRANE SEPARATORS; MICRO POROUS MEMBRANES; MONITORING AND CONTROL; OPERATING WINDOWS; PER UNIT; PHARMACEUTICAL MANUFACTURING; PTFE MEMBRANES; SCALING-UP; SEPARATION DEVICES; SEPARATION EFFICIENCY; TUBE REACTORS;

FLOW RATE; HYDROLYSIS; HYDROPHOBICITY; LIQUIDS; PHASE SEPARATION; PRESSURE REGULATORS; SEPARATORS; SURFACE TENSION; TOLUENE;

MEMBRANES;

EID: 84862086433     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op200242s     Document Type: Article

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