Prevention of diet-induced obesity by apple polyphenols in Wistar rats through regulation of adipocyte gene expression and DNA methylation patterns

Molecular Nutrition and Food Research

Volumn 57, Issue 8, 2013, Pages 1473-1478

  Boqué, Noemi ^a   de la Iglesia, Rocío ^a   de la Garza, Ana L ^a   Milagro, Fermín I ^a,b   Olivares, Mónica ^c   Bañuelos, Óscar ^c   Soria, Ana Cristina ^d   Rodríguez Sánchez, Sonia ^d   Martínez, José Alfredo ^a,b   Campión, Javier ^a,b  

^a UNIVERSITY OF NAVARRA   (Spain)

^b Instituto de Salud Carlos III   (Spain)

^c Biosearch Life SA   (Spain)

^d INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

Author keywords

Adiposity; Epigenetics; High fat sucrose diet; Lipolysis; Nutrigenomics

Indexed keywords

MALUS X DOMESTICA; RATTUS; RATTUS NORVEGICUS;

ANTIOBESITY AGENT; AQP7 PROTEIN, RAT; AQUAPORIN; ISOPRENALINE; POLYPHENOL; PPARGC1A PROTEIN, RAT; SREBF1 PROTEIN, RAT; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTOR;

ADIPOCYTE; ANIMAL; ARTICLE; CHEMISTRY; DIET; DNA METHYLATION; DRUG EFFECT; EPIGENETICS; GENE EXPRESSION REGULATION; GENETICS; HIGH-FAT SUCROSE DIET; LIPID DIET; LIPOLYSIS; MALE; MALUS; NUTRIGENOMICS; OBESITY; PHYSIOLOGY; PROMOTER REGION; RAT; WISTAR RAT;

ADIPOSITY; EPIGENETICS; HIGH-FAT SUCROSE DIET; LIPOLYSIS; NUTRIGENOMICS;

ADIPOCYTES; ANIMALS; ANTI-OBESITY AGENTS; AQUAPORINS; DIET; DIET, HIGH-FAT; DNA METHYLATION; GENE EXPRESSION REGULATION; ISOPROTERENOL; MALE; MALUS; OBESITY; POLYPHENOLS; PROMOTER REGIONS, GENETIC; RATS; RATS, WISTAR; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTORS;

EID: 84881312296     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201200686     Document Type: Article

References (26)

1. Gerhauser, C., Cancer chemopreventive potential of apples, apple juice, and apple components. Planta Med. 2008, 74, 1608-1624.
2. Pandey, K. B., Rizvi, S. I., Plant polyphenols as dietary antioxidants in human health and disease. Oxid. Med. Cell. Longev. 2009, 2, 270-278.
3. Nakazato, K., Song, H., Waga, T., Effects of dietary apple polyphenol on adipose tissues weights in Wistar rats. Exp. Anim. 2006, 55, 383-389.
4. Ohta, Y., Sami M., Kanda, T., Saito, K. et al., Gene expression analysis of the anti-obesity effect by apple polyphenols in rats fed a high fat diet or a normal diet. J. Oleo. Sci. 2006, 55, 305-314.
5. Sugiyama, H., Akazome, Y., Shoji, T., Yamaguchi, A. et al., Oligomeric procyanidins in apple polyphenol are main active components for inhibition of pancreatic lipase and triglyceride absorption. J. Agric. Food. Chem. 2007, 55, 4604-4609.
6. Boqué, N., Campión, J., de la Iglesia, R., de la Garza, A. L. et al., Screening of polyphenolic plant extracts for anti-obesity properties in Wistar rats. J. Sci. Food. Agric. 2012, DOI: 10.1002/jsfa.5884.
7. Ogasawara, J., Kitadate, K., Nishioka, H., Fujii, H. et al., Comparison of the effect of oligonol, a new lychee fruit-derived low molecular form of polyphenol, and epigallocatechin-3-gallate on lipolysis in rat primary adipocytes. Phytother. Res. 2011, 25, 467-471.
8. Manzano, S., Williamson, G., Polyphenols and phenolic acids from strawberry and apple decrease glucose uptake and transport by human intestinal Caco-2 cells. Mol. Nutr. Food. Res. 2010, 54, 1773-1780.
9. Zhao, H., Yakar, S., Gavrilova, O., Sun, H. et al., Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes. Diabetes 2004, 53, 2901-2909.
10. Jernas, M., Palming, J., Sjöholm, K., Jennische, E. et al., Separation of human adipocytes by size: hypertrophic fat cells display distinct gene expression. FASEB J. 2006, 20, 1540-1542.
11. Salans, L. B., Dougherty, J. W., The effect of insulin upon glucose metabolism by adipose cells of different size. Influence of cell lipid and protein content, age and nutritional state. J. Clin. Invest. 1971, 50, 1399-1410.
12. Caimari, A., Del Bas, J. M., Crescenti, A., Arola, L., Low doses of grape seed procyanidins reduce adiposity and improve the plasma lipid profile in hamsters. Int. J. Obes. (Lond.) 2012, DOI: 10.1038/ijo.2012.75.
13. Wang, L., Yamasaki, M., Katsube, T., Sun, X. et al., Antiobesity effect of polyphenolic compounds from molokheiya (Corchorus olitorius L.) leaves in LDL receptor-deficient mice. Eur. J. Nutr. 2011, 50, 127-133.
14. Karamanlidis, G., Karamitri, A., Docherty, K., Hazlerigg, D. G. et al., C/EBPbeta reprograms white 3T3-L1 preadipocytes to a brown adipocyte pattern of gene expression. J. Biol. Chem. 2007, 282, 24660-24669.
15. Kim, S. W., Muise, A. M., Lyons, P. J., Ro, H. S., Regulation of adipogenesis by a transcriptional repressor that modulates MAPK activation. J. Biol. Chem. 2001, 276, 10199-10206.
16. Yamakawa, J., Ishigaki, Y., Takano, F., Takahashi, T. et al., The Kampo medicines Orengedokuto, Bofutsushosan and Boiogito have different activities to regulate gene expressions in differentiated rat white adipocytes: comprehensive analysis of genetic profiles. Biol. Pharm. Bull. 2008, 31, 2083-2089.
17. Park, H. J., Della-Fera, M. A., Hausman, D. B., Rayalam, S. et al., Genistein inhibits differentiation of primary human adipocytes. J. Nutr. Biochem. 2009, 20, 140-148.
18. Park, J. R., Jung, J. W., Seo, M. S., Kang, S. K. et al., DNER modulates adipogenesis of human adipose tissue-derived mesenchymal stem cells via regulation of cell proliferation. Cell. Prolif. 2010, 43, 19-28.
19. Masaki, T., Yoshimichi, G., Chiba, S., Yasuda, T. et al., Corticotropin-releasing hormone-mediated pathway of leptin to regulate feeding, adiposity and uncoupling protein expression in mice. Endocrinology 2003, 144, 3547-3554.
20. Campion, J., Milagro, F. I., Martinez, J. A., Individuality and epigenetics in obesity. Obes. Rev. 2009, 10, 383-392.
21. Fini, L., Piazzi, G., Daoud, Y., Selgrad, M. et al., Chemoprevention of intestinal polyps in ApcMin/+ mice fed with western or balanced diets by drinking annurca apple polyphenol extract. Cancer. Prev. Res. (Philadelphia) 2011, 4, 907-915.
22. Milagro, F. I., Campion, J., Garcia-Diaz, D. F., Goyenechea, E. et al., High fat diet-induced obesity modifies the methylation pattern of leptin promoter in rats. J. Physiol. Biochem. 2009, 65, 1-9.
23. Brons, C., Jacobsen, S., Nilsson, E., Ronn, T. et al., Deoxyribonucleic acid methylation and gene expression of PPARGC1A in human muscle is influenced by high-fat overfeeding in a birth-weight-dependent manner. J. Clin. Endocrinol. Metab. 2010, 95, 3048-3056.
24. Ngo, V., Gourdji, D., Laverriere, J. N., Site-specific methylation of the rat prolactin and growth hormone promoters correlates with gene expression. Mol. Cell. Biol. 1996, 16, 3245-3254.
25. Rodriguez, A., Catalan, V., Gomez-Ambrosi, J., Garcia-Navarro, S. et al., Insulin- and leptin-mediated control of aquaglyceroporins in human adipocytes and hepatocytes is mediated via the PI3K/Akt/mTOR signaling cascade. J. Clin. Endocrinol. Metab. 2011, 96, E586-E597.
26. Reagan-Shaw, S., Nihal, M., Ahmad, N., Dose translation from animal to human studies revisited. FASEB J. 2008, 22, 659-661.