메뉴 건너뛰기




Volumn 13, Issue 15, 2013, Pages 2351-2360

Proteomic approach toward molecular backgrounds of drug resistance of osteosarcoma cells in spheroid culture system

Author keywords

2DE; Cathepsin D; Chemotherapy; Osteosarcoma; Spheroid culture

Indexed keywords

CATHEPSIN D; DOXORUBICIN;

EID: 84881255714     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.201300053     Document Type: Article
Times cited : (46)

References (48)
  • 2
    • 0023125939 scopus 로고
    • Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial
    • Eilber, F., Giuliano, A., Eckardt, J., Patterson, K. et al., Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial. J. Clin. Oncol. 1987, 5, 21-26.
    • (1987) J. Clin. Oncol. , vol.5 , pp. 21-26
    • Eilber, F.1    Giuliano, A.2    Eckardt, J.3    Patterson, K.4
  • 3
    • 0022656434 scopus 로고
    • The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity
    • Link, M. P., Goorin, A. M., Miser, A. W., Green, A. A. et al., The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity. N. Engl. J. Med. 1986, 314, 1600-1606.
    • (1986) N. Engl. J. Med. , vol.314 , pp. 1600-1606
    • Link, M.P.1    Goorin, A.M.2    Miser, A.W.3    Green, A.A.4
  • 4
    • 45149133744 scopus 로고    scopus 로고
    • Osteosarcoma: ESMO clinical recommendations for diagnosis, treatment and follow-up
    • Bielack, S., Carrle, D., Jost, L., Osteosarcoma: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann. Oncol. 2008, 19(Suppl 2), ii94-96.
    • (2008) Ann. Oncol. , vol.19 , Issue.SUPPL 2
    • Bielack, S.1    Carrle, D.2    Jost, L.3
  • 5
    • 0020059356 scopus 로고
    • Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy
    • Rosen, G., Caparros, B., Huvos, A. G., Kosloff, C. et al., Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy. Cancer 1982, 49, 1221-1230.
    • (1982) Cancer , vol.49 , pp. 1221-1230
    • Rosen, G.1    Caparros, B.2    Huvos, A.G.3    Kosloff, C.4
  • 6
    • 77954333247 scopus 로고    scopus 로고
    • Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • Hogendoorn, P. C., Athanasou, N., Bielack, S., De Alava, E. et al., Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 2010, 21(Suppl 5), v204-213.
    • (2010) Ann. Oncol. , vol.21 , Issue.SUPPL 5
    • Hogendoorn, P.C.1    Athanasou, N.2    Bielack, S.3    De Alava, E.4
  • 7
    • 84863928403 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy with methotrexate, cisplatin, and doxorubicin with or without ifosfamide in nonmetastatic osteosarcoma of the extremity: an Italian sarcoma group trial ISG/OS-1
    • Ferrari, S., Ruggieri, P., Cefalo, G., Tamburini, A. et al., Neoadjuvant chemotherapy with methotrexate, cisplatin, and doxorubicin with or without ifosfamide in nonmetastatic osteosarcoma of the extremity: an Italian sarcoma group trial ISG/OS-1. J. Clin. Oncol. 2012, 30, 2112-2118.
    • (2012) J. Clin. Oncol. , vol.30 , pp. 2112-2118
    • Ferrari, S.1    Ruggieri, P.2    Cefalo, G.3    Tamburini, A.4
  • 8
    • 0036235429 scopus 로고    scopus 로고
    • Study of therapy resistance in cancer cells with functional proteome analysis
    • Poland, J., Schadendorf, D., Lage, H., Schnolzer, M. et al., Study of therapy resistance in cancer cells with functional proteome analysis. Clin. Chem. Lab. Med. 2002, 40, 221-234.
    • (2002) Clin. Chem. Lab. Med. , vol.40 , pp. 221-234
    • Poland, J.1    Schadendorf, D.2    Lage, H.3    Schnolzer, M.4
  • 9
    • 79955393326 scopus 로고    scopus 로고
    • Cancer drug-resistance and a look at specific proteins: Rho GDP-dissociation inhibitor 2, Y-box binding protein 1, and HSP70/90 organizing protein in proteomics clinical application
    • Skalnikova, H., Martinkova, J., Hrabakova, R., Halada, P. et al., Cancer drug-resistance and a look at specific proteins: Rho GDP-dissociation inhibitor 2, Y-box binding protein 1, and HSP70/90 organizing protein in proteomics clinical application. J. Proteome Res. 2011, 10, 404-415.
    • (2011) J. Proteome Res. , vol.10 , pp. 404-415
    • Skalnikova, H.1    Martinkova, J.2    Hrabakova, R.3    Halada, P.4
  • 10
  • 11
    • 11144242211 scopus 로고    scopus 로고
    • Timeline: chemotherapy and the war on cancer
    • Chabner, B. A., Roberts, T. G., Jr., Timeline: chemotherapy and the war on cancer. Nat. Rev. Cancer 2005, 5, 65-72.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 65-72
    • Chabner, B.A.1    Roberts Jr, T.G.2
  • 12
    • 0026506185 scopus 로고
    • Antineoplastic drug screening belongs in the laboratory, not in the clinic
    • Weisenthal, L. M., Antineoplastic drug screening belongs in the laboratory, not in the clinic. J. Natl. Cancer Inst. 1992, 84, 466-469.
    • (1992) J. Natl. Cancer Inst. , vol.84 , pp. 466-469
    • Weisenthal, L.M.1
  • 13
    • 77956287380 scopus 로고    scopus 로고
    • A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses
    • Harma, V., Virtanen, J., Makela, R., Happonen, A. et al., A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses. PLoS One 2010, 5, e10431.
    • (2010) PLoS One , vol.5
    • Harma, V.1    Virtanen, J.2    Makela, R.3    Happonen, A.4
  • 14
    • 80054972160 scopus 로고    scopus 로고
    • 3D tumour models: novel in vitro approaches to cancer studies
    • Nyga, A., Cheema, U., Loizidou, M., 3D tumour models: novel in vitro approaches to cancer studies. J. Cell. Commun. Signal 2011, 5, 239-248.
    • (2011) J. Cell. Commun. Signal , vol.5 , pp. 239-248
    • Nyga, A.1    Cheema, U.2    Loizidou, M.3
  • 15
    • 33644529130 scopus 로고    scopus 로고
    • Capturing complex 3D tissue physiology in vitro
    • Griffith, L. G., Swartz, M. A., Capturing complex 3D tissue physiology in vitro. Nat. Rev. Mol. Cell Biol. 2006, 7, 211-224.
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 211-224
    • Griffith, L.G.1    Swartz, M.A.2
  • 16
    • 34648834682 scopus 로고    scopus 로고
    • The third dimension bridges the gap between cell culture and live tissue
    • Pampaloni, F., Reynaud, E. G., Stelzer, E. H., The third dimension bridges the gap between cell culture and live tissue. Nat. Rev. Mol. Cell Biol. 2007, 8, 839-845.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 839-845
    • Pampaloni, F.1    Reynaud, E.G.2    Stelzer, E.H.3
  • 17
    • 34547931078 scopus 로고    scopus 로고
    • Modeling tissue morphogenesis and cancer in 3D
    • Yamada, K. M., Cukierman, E., Modeling tissue morphogenesis and cancer in 3D. Cell 2007, 130, 601-610.
    • (2007) Cell , vol.130 , pp. 601-610
    • Yamada, K.M.1    Cukierman, E.2
  • 18
    • 0024281372 scopus 로고
    • Cell and environment interactions in tumor microregions: the multicell spheroid model
    • Sutherland, R. M., Cell and environment interactions in tumor microregions: the multicell spheroid model. Science 1988, 240, 177-184.
    • (1988) Science , vol.240 , pp. 177-184
    • Sutherland, R.M.1
  • 19
    • 77953540958 scopus 로고    scopus 로고
    • HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment
    • Weigelt, B., Lo, A. T., Park, C. C., Gray, J. W. et al., HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment. Breast Cancer Res. Treat 2010, 122, 35-43.
    • (2010) Breast Cancer Res. Treat , vol.122 , pp. 35-43
    • Weigelt, B.1    Lo, A.T.2    Park, C.C.3    Gray, J.W.4
  • 20
    • 84862003156 scopus 로고    scopus 로고
    • Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system
    • Karlsson, H., Fryknas, M., Larsson, R., Nygren, P., Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system. Exp. Cell Res. 2012, 318, 1577-1585.
    • (2012) Exp. Cell Res. , vol.318 , pp. 1577-1585
    • Karlsson, H.1    Fryknas, M.2    Larsson, R.3    Nygren, P.4
  • 21
    • 84857763458 scopus 로고    scopus 로고
    • The resistance of intracellular mediators to doxorubicin and cisplatin are distinct in 3D and 2D endometrial cancer
    • Chitcholtan, K., Sykes, P. H., Evans, J. J., The resistance of intracellular mediators to doxorubicin and cisplatin are distinct in 3D and 2D endometrial cancer. J. Transl. Med. 2012, 10, 38, 1-16.
    • (2012) J. Transl. Med. , vol.10 , Issue.38 , pp. 1-16
    • Chitcholtan, K.1    Sykes, P.H.2    Evans, J.J.3
  • 22
    • 20144387214 scopus 로고    scopus 로고
    • An expression signature classifies chemotherapy-resistant pediatric osteosarcoma
    • Mintz, M. B., Sowers, R., Brown, K. M., Hilmer, S. C. et al., An expression signature classifies chemotherapy-resistant pediatric osteosarcoma. Cancer Res. 2005, 65, 1748-1754.
    • (2005) Cancer Res. , vol.65 , pp. 1748-1754
    • Mintz, M.B.1    Sowers, R.2    Brown, K.M.3    Hilmer, S.C.4
  • 23
    • 6044270577 scopus 로고    scopus 로고
    • Prediction of response to neoadjuvant chemotherapy for osteosarcoma by gene-expression profiles
    • Ochi, K., Daigo, Y., Katagiri, T., Nagayama, S. et al., Prediction of response to neoadjuvant chemotherapy for osteosarcoma by gene-expression profiles. Int. J. Oncol. 2004, 24, 647-655.
    • (2004) Int. J. Oncol. , vol.24 , pp. 647-655
    • Ochi, K.1    Daigo, Y.2    Katagiri, T.3    Nagayama, S.4
  • 24
    • 79958048319 scopus 로고    scopus 로고
    • Micro-RNA profiles in osteosarcoma as a predictive tool for ifosfamide response
    • Gougelet, A., Pissaloux, D., Besse, A., Perez, J. et al., Micro-RNA profiles in osteosarcoma as a predictive tool for ifosfamide response. Int. J. Cancer 2011, 129, 680-690.
    • (2011) Int. J. Cancer , vol.129 , pp. 680-690
    • Gougelet, A.1    Pissaloux, D.2    Besse, A.3    Perez, J.4
  • 25
    • 77953837479 scopus 로고    scopus 로고
    • Peroxiredoxin 2 as a chemotherapy responsiveness biomarker candidate in osteosarcoma revealed by proteomics
    • Kikuta, K., Tochigi, N., Saito, S., Shimoda, T. et al., Peroxiredoxin 2 as a chemotherapy responsiveness biomarker candidate in osteosarcoma revealed by proteomics. Proteomics Clin. Appl. 2010, 4, 560-567.
    • (2010) Proteomics Clin. Appl. , vol.4 , pp. 560-567
    • Kikuta, K.1    Tochigi, N.2    Saito, S.3    Shimoda, T.4
  • 26
    • 84867855432 scopus 로고    scopus 로고
    • P16 expression predicts necrotic response among patients with osteosarcoma receiving neoadjuvant chemotherapy
    • Borys, D., Canter, R. J., Hoch, B., Martinez, S. R. et al., P16 expression predicts necrotic response among patients with osteosarcoma receiving neoadjuvant chemotherapy. Hum. Pathol. 2012, 43, 1948-1954.
    • (2012) Hum. Pathol. , vol.43 , pp. 1948-1954
    • Borys, D.1    Canter, R.J.2    Hoch, B.3    Martinez, S.R.4
  • 27
    • 84863278104 scopus 로고    scopus 로고
    • Predicting chemosensitivity in osteosarcoma prior to chemotherapy: an investigational study of biomarkers with immunohistochemistry
    • Chen, Y., Yang, Y., Yuan, Z., Wang, C., Shi, Y., Predicting chemosensitivity in osteosarcoma prior to chemotherapy: an investigational study of biomarkers with immunohistochemistry. Oncol. Lett. 2012, 3, 1011-1016.
    • (2012) Oncol. Lett. , vol.3 , pp. 1011-1016
    • Chen, Y.1    Yang, Y.2    Yuan, Z.3    Wang, C.4    Shi, Y.5
  • 28
    • 84866343225 scopus 로고    scopus 로고
    • In vivo biomarker expression patterns are preserved in 3D cultures of Prostate Cancer
    • Windus, L. C., Kiss, D. L., Glover, T., Avery, V. M., In vivo biomarker expression patterns are preserved in 3D cultures of Prostate Cancer. Exp. Cell Res. 2012, 318, 2507-2519.
    • (2012) Exp. Cell Res. , vol.318 , pp. 2507-2519
    • Windus, L.C.1    Kiss, D.L.2    Glover, T.3    Avery, V.M.4
  • 29
    • 84867718106 scopus 로고    scopus 로고
    • 3D spheroid defects in NPHP knockdown cells are rescued by the somatostatin receptor agonist octreotide
    • Ghosh, A. K., Hurd, T., Hildebrandt, F., 3D spheroid defects in NPHP knockdown cells are rescued by the somatostatin receptor agonist octreotide. Am. J. Physiol. Renal. Physiol. 2012, 303, F1225-1229.
    • (2012) Am. J. Physiol. Renal. Physiol. , vol.303
    • Ghosh, A.K.1    Hurd, T.2    Hildebrandt, F.3
  • 30
    • 84858077204 scopus 로고    scopus 로고
    • Cancer-initiating cells derived from established cervical cell lines exhibit stem-cell markers and increased radioresistance
    • Lopez, J., Poitevin, A., Mendoza-Martinez, V., Perez-Plasencia, C., Garcia-Carranca, A., Cancer-initiating cells derived from established cervical cell lines exhibit stem-cell markers and increased radioresistance. BMC Cancer 2012, 12, 48, 1-14.
    • (2012) BMC Cancer , vol.12 , Issue.48 , pp. 1-14
    • Lopez, J.1    Poitevin, A.2    Mendoza-Martinez, V.3    Perez-Plasencia, C.4    Garcia-Carranca, A.5
  • 31
    • 0017412603 scopus 로고
    • One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice
    • Fogh, J., Fogh, J. M., Orfeo, T., One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. J. Natl. Cancer Inst. 1977, 59, 221-226.
    • (1977) J. Natl. Cancer Inst. , vol.59 , pp. 221-226
    • Fogh, J.1    Fogh, J.M.2    Orfeo, T.3
  • 32
  • 33
    • 0016440994 scopus 로고
    • Non-producer human cells induced by murine sarcoma virus
    • Rhim, J. S., Cho, H. Y., Huebner, R. J., Non-producer human cells induced by murine sarcoma virus. Int. J. Cancer 1975, 15, 23-29.
    • (1975) Int. J. Cancer , vol.15 , pp. 23-29
    • Rhim, J.S.1    Cho, H.Y.2    Huebner, R.J.3
  • 34
    • 0015012399 scopus 로고
    • Cultivation in vitro of cells derived from a human osteosarcoma
    • McAllister, R. M., Gardner, M. B., Greene, A. E., Bradt, C. et al., Cultivation in vitro of cells derived from a human osteosarcoma. Cancer 1971, 27, 397-402.
    • (1971) Cancer , vol.27 , pp. 397-402
    • McAllister, R.M.1    Gardner, M.B.2    Greene, A.E.3    Bradt, C.4
  • 35
    • 0017378001 scopus 로고
    • Human interferon: mass production in a newly established cell line, MG-63
    • Billiau, A., Edy, V. G., Heremans, H., Van Damme, J. et al., Human interferon: mass production in a newly established cell line, MG-63. Antimicrob. Agents Chemother. 1977, 12, 11-15.
    • (1977) Antimicrob. Agents Chemother. , vol.12 , pp. 11-15
    • Billiau, A.1    Edy, V.G.2    Heremans, H.3    Van Damme, J.4
  • 36
    • 0016719697 scopus 로고
    • Transformation of human cells in culture by N-methyl-N'-nitro-N-nitrosoguanidine
    • Rhim, J. S., Park, D. K., Arnstein, P., Huebner, R. J. et al., Transformation of human cells in culture by N-methyl-N'-nitro-N-nitrosoguanidine. Nature 1975, 256, 751-753.
    • (1975) Nature , vol.256 , pp. 751-753
    • Rhim, J.S.1    Park, D.K.2    Arnstein, P.3    Huebner, R.J.4
  • 37
    • 0024448458 scopus 로고
    • Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation
    • King, M. P., Attardi, G., Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation. Science 1989, 246, 500-503.
    • (1989) Science , vol.246 , pp. 500-503
    • King, M.P.1    Attardi, G.2
  • 38
    • 0025444075 scopus 로고
    • Establishment and characterization of a cell line, HS-Os-1 derived from an osteoblastic type of human osteosarcoma
    • Sonobe, H., Mizobuchi, H., Manabe, Y., Furihata, M. et al., Establishment and characterization of a cell line, HS-Os-1 derived from an osteoblastic type of human osteosarcoma. Hum. Cell 1990, 3, 148-151.
    • (1990) Hum. Cell , vol.3 , pp. 148-151
    • Sonobe, H.1    Mizobuchi, H.2    Manabe, Y.3    Furihata, M.4
  • 39
    • 0026563921 scopus 로고
    • Three human osteosarcoma cell lines exhibiting different phenotypic expressions
    • Hotta, T., Motoyama, T., Watanabe, H., Three human osteosarcoma cell lines exhibiting different phenotypic expressions. Acta Pathol. Jpn. 1992, 42, 595-603.
    • (1992) Acta Pathol. Jpn. , vol.42 , pp. 595-603
    • Hotta, T.1    Motoyama, T.2    Watanabe, H.3
  • 40
    • 79959887793 scopus 로고    scopus 로고
    • The use of nanoimprinted scaffolds as 3D culture models to facilitate spontaneous tumor cell migration and well-regulated spheroid formation
    • Yoshii, Y., Waki, A., Yoshida, K., Kakezuka, A. et al., The use of nanoimprinted scaffolds as 3D culture models to facilitate spontaneous tumor cell migration and well-regulated spheroid formation. Biomaterials 2011, 32, 6052-6058.
    • (2011) Biomaterials , vol.32 , pp. 6052-6058
    • Yoshii, Y.1    Waki, A.2    Yoshida, K.3    Kakezuka, A.4
  • 41
    • 0029072604 scopus 로고
    • Two-dimensional electrophoretic analysis of down-regulated proteins in human fibroblasts immortalized by treatment with either 4-nitroquinoline 1-oxide or 60Co gamma rays
    • Kondo, T., Mihara, K., Inoue, Y., Iijima, M. et al., Two-dimensional electrophoretic analysis of down-regulated proteins in human fibroblasts immortalized by treatment with either 4-nitroquinoline 1-oxide or 60Co gamma rays. Electrophoresis 1995, 16, 1067-1073.
    • (1995) Electrophoresis , vol.16 , pp. 1067-1073
    • Kondo, T.1    Mihara, K.2    Inoue, Y.3    Iijima, M.4
  • 42
    • 27744582416 scopus 로고    scopus 로고
    • Protein expression pattern distinguishes different lymphoid neoplasms
    • Fujii, K., Kondo, T., Yokoo, H., Yamada, T. et al., Protein expression pattern distinguishes different lymphoid neoplasms. Proteomics 2005, 5, 4274-4286.
    • (2005) Proteomics , vol.5 , pp. 4274-4286
    • Fujii, K.1    Kondo, T.2    Yokoo, H.3    Yamada, T.4
  • 43
    • 34147161968 scopus 로고    scopus 로고
    • Application of highly sensitive fluorescent dyes (CyDye DIGE Fluor saturation dyes) to laser microdissection and two-dimensional difference gel electrophoresis (2D-DIGE) for cancer proteomics
    • Kondo, T., Hirohashi, S., Application of highly sensitive fluorescent dyes (CyDye DIGE Fluor saturation dyes) to laser microdissection and two-dimensional difference gel electrophoresis (2D-DIGE) for cancer proteomics. Nature Protocols 2007, 1, 2940-2956.
    • (2007) Nature Protocols , vol.1 , pp. 2940-2956
    • Kondo, T.1    Hirohashi, S.2
  • 44
    • 77951625250 scopus 로고    scopus 로고
    • Cancer proteome-expression database: Genome Medicine Database of Japan Proteomics
    • Kondo, T., Cancer proteome-expression database: Genome Medicine Database of Japan Proteomics. Expert Rev. Proteomics 2010, 7, 21-27.
    • (2010) Expert Rev. Proteomics , vol.7 , pp. 21-27
    • Kondo, T.1
  • 45
    • 53349091482 scopus 로고    scopus 로고
    • Cathepsin D protects human neuroblastoma cells from doxorubicin-induced cell death
    • Sagulenko, V., Muth, D., Sagulenko, E., Paffhausen, T. et al., Cathepsin D protects human neuroblastoma cells from doxorubicin-induced cell death. Carcinogenesis 2008, 29, 1869-1877.
    • (2008) Carcinogenesis , vol.29 , pp. 1869-1877
    • Sagulenko, V.1    Muth, D.2    Sagulenko, E.3    Paffhausen, T.4
  • 46
    • 84859704103 scopus 로고    scopus 로고
    • A prognostic model to predict outcome of patients failing to achieve pathological complete response after anthracycline-containing neoadjuvant chemotherapy for breast cancer
    • Chen, S., Chen, C. M., Yu, K. D., Yang, W. T. et al., A prognostic model to predict outcome of patients failing to achieve pathological complete response after anthracycline-containing neoadjuvant chemotherapy for breast cancer. J. Surg. Oncol. 2012, 105, 577-585.
    • (2012) J. Surg. Oncol. , vol.105 , pp. 577-585
    • Chen, S.1    Chen, C.M.2    Yu, K.D.3    Yang, W.T.4
  • 47
    • 2942711855 scopus 로고    scopus 로고
    • Cathepsin D expression levels in nongynecological solid tumors: clinical and therapeutic implications
    • Leto, G., Tumminello, F. M., Crescimanno, M., Flandina, C. et al., Cathepsin D expression levels in nongynecological solid tumors: clinical and therapeutic implications. Clin. Exp. Metastasis 2004, 21, 91-106.
    • (2004) Clin. Exp. Metastasis , vol.21 , pp. 91-106
    • Leto, G.1    Tumminello, F.M.2    Crescimanno, M.3    Flandina, C.4
  • 48
    • 0024991432 scopus 로고
    • Comprehensive management of locally advanced breast cancer
    • Hortobagyi, G. N., Comprehensive management of locally advanced breast cancer. Cancer 1990, 66, 1387-1391.
    • (1990) Cancer , vol.66 , pp. 1387-1391
    • Hortobagyi, G.N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.