Predictive model for epoxide hydrolase-generated stereochemistry in the biosynthesis of nine-membered enediyne antitumor antibiotics

Biochemistry

Volumn 52, Issue 31, 2013, Pages 5217-5224

  Horsman, Geoffrey P ^a   Lechner, Anna ^b   Ohnishi, Yasuo ^c   Moore, Bradley S ^b   Shen, Ben ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITUMOR ANTIBIOTICS; DOUBLE MUTATION; EPOXIDE HYDROLASES; GENOME MINING; PHYLOGENETIC ANALYSIS; PREDICTIVE MODELS; STREPTOMYCES GRISEUS; VICINAL DIOLS;

ANTIBIOTICS; BIOSYNTHESIS; CELL IMMOBILIZATION; HYDROLYSIS; ORGANIC COMPOUNDS; REGIOSELECTIVITY; STEREOCHEMISTRY; STEREOSELECTIVITY; STYRENE;

BIOCHEMISTRY;

ANTIBIOTIC C 1027; ANTINEOPLASTIC ANTIBIOTIC; ENEDIYNE; EPOXIDE HYDROLASE; GENOMIC DNA; KEDARCIDIN; NATURAL PRODUCT; ZINOSTATIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOSYNTHESIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; DNA SEQUENCE; ENANTIOSELECTIVITY; ENZYME ACTIVITY; ENZYME ASSAY; GENE MUTATION; GENOME; GENOMICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MODEL; NONHUMAN; PHYLOGENY; POLYMERASE CHAIN REACTION; PREDICTION; PRIORITY JOURNAL; STEREOCHEMISTRY; STREPTOMYCES;

ANTIBIOTICS, ANTINEOPLASTIC; BACTERIAL PROTEINS; ENEDIYNES; EPOXIDE HYDROLASES; MODELS, MOLECULAR; PHYLOGENY; STEREOISOMERISM; STREPTOMYCES; SUBSTRATE SPECIFICITY;

EID: 84881238218     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi400572a     Document Type: Article

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