-
1
-
-
0036851863
-
The liver X receptor gene team: Potential new players in atherosclerosis
-
Repa JJ, Mangelsdorf DJ. The liver X receptor gene team: potential new players in atherosclerosis. Nat Med. 2002;8(11):1243-1248.
-
(2002)
Nat Med
, vol.8
, Issue.11
, pp. 1243-1248
-
-
Repa, J.J.1
Mangelsdorf, D.J.2
-
2
-
-
0037503924
-
Liver X receptor signaling pathways in cardiovascular disease
-
Tontonoz P, Mangelsdorf DJ. Liver X receptor signaling pathways in cardiovascular disease. Mol Endocrinol. 2003;17(6):985-993.
-
(2003)
Mol Endocrinol
, vol.17
, Issue.6
, pp. 985-993
-
-
Tontonoz, P.1
Mangelsdorf, D.J.2
-
3
-
-
33644651160
-
Liver X receptors as integrators of metabolic and inflammatory signaling
-
Zelcer N, Tontonoz P. Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest. 2006;116(3):607-614.
-
(2006)
J Clin Invest
, vol.116
, Issue.3
, pp. 607-614
-
-
Zelcer, N.1
Tontonoz, P.2
-
4
-
-
0035851188
-
Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism
-
Lu TT, Repa JJ, Mangelsdorf DJ. Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism. J Biol Chem. 2001;276(41):37735-37738.
-
(2001)
J Biol Chem
, vol.276
, Issue.41
, pp. 37735-37738
-
-
Lu, T.T.1
Repa, J.J.2
Mangelsdorf, D.J.3
-
5
-
-
0033524420
-
Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta
-
Janowski BA, et al. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc Natl Acad Sci U S A. 1999;96(1):266-271.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, Issue.1
, pp. 266-271
-
-
Janowski, B.A.1
-
6
-
-
0037188553
-
Synthetic LXR ligand inhibits the development of atherosclerosis in mice
-
Joseph SB, et al. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A. 2002;99(11):7604-7609.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, Issue.11
, pp. 7604-7609
-
-
Joseph, S.B.1
-
7
-
-
0037432165
-
T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice
-
Terasaka N, et al. T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice. FEBS Lett. 2003;536(1-3):6-11.
-
(2003)
FEBS Lett
, vol.536
, Issue.1-3
, pp. 6-11
-
-
Terasaka, N.1
-
8
-
-
79952378989
-
Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE3Leiden mice without affecting liver or plasma triglyceride levels
-
van der Hoorn J, et al. Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels. Br J Pharmacol. 2011; 162(7):1553-1563.
-
(2011)
Br J Pharmacol
, vol.162
, Issue.7
, pp. 1553-1563
-
-
Van Der Hoorn, J.1
-
9
-
-
0035976638
-
Nuclear receptors and lipid physiology: Opening the X-files
-
Chawla A, Repa JJ, Evans RM, Mangelsdorf DJ. Nuclear receptors and lipid physiology: opening the X-files. Science. 2001;294(5548):1866-1870.
-
(2001)
Science
, vol.294
, Issue.5548
, pp. 1866-1870
-
-
Chawla, A.1
Repa, J.J.2
Evans, R.M.3
Mangelsdorf, D.J.4
-
10
-
-
0037324340
-
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
-
Joseph SB, Castrillo A, Laffitte BA, Mangelsdorf DJ, Tontonoz P. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med. 2003;9(2):213-219.
-
(2003)
Nat Med
, vol.9
, Issue.2
, pp. 213-219
-
-
Joseph, S.B.1
Castrillo, A.2
Laffitte, B.A.3
Mangelsdorf, D.J.4
Tontonoz, P.5
-
11
-
-
21644487430
-
Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries
-
Blaschke F, et al. Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries. Circ Res. 2004;95(12):e110-e123.
-
(2004)
Circ Res
, vol.95
, Issue.12
-
-
Blaschke, F.1
-
12
-
-
0033552883
-
Atherosclerosis - An inflammatory disease
-
Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med. 1999;340(2):115-126.
-
(1999)
N Engl J Med
, vol.340
, Issue.2
, pp. 115-126
-
-
Ross, R.1
-
13
-
-
33644638521
-
Estrogen receptors and human disease
-
Deroo BJ, Korach KS. Estrogen receptors and human disease. J Clin Invest. 2006;116(3):561-570.
-
(2006)
J Clin Invest
, vol.116
, Issue.3
, pp. 561-570
-
-
Deroo, B.J.1
Korach, K.S.2
-
14
-
-
0033542402
-
The protective effects of estrogen on the cardiovascular system
-
Mendelsohn ME, Karas RH. The protective effects of estrogen on the cardiovascular system. N Engl J Med. 1999;340(23):1801-1811.
-
(1999)
N Engl J Med
, vol.340
, Issue.23
, pp. 1801-1811
-
-
Mendelsohn, M.E.1
Karas, R.H.2
-
15
-
-
0032945571
-
Protection against atherosclerosis by estrogen is independent of plasma cholesterol levels in LDL receptor- deficient mice
-
Marsh MM, Walker VR, Curtiss LK, Banka CL. Protection against atherosclerosis by estrogen is independent of plasma cholesterol levels in LDL receptor- deficient mice. J Lipid Res. 1999;40(5):893-900.
-
(1999)
J Lipid Res
, vol.40
, Issue.5
, pp. 893-900
-
-
Marsh, M.M.1
Walker, V.R.2
Curtiss, L.K.3
Banka, C.L.4
-
16
-
-
0035132187
-
Estrogen receptor alpha is a major mediator of 17beta-estradiol's atheroprotective effects on lesion size in Apoe-/- mice
-
Hodgin JB, Krege JH, Reddick RL, Korach KS, Smithies O, Maeda N. Estrogen receptor alpha is a major mediator of 17beta-estradiol's atheroprotective effects on lesion size in Apoe-/- mice. J Clin Invest. 2001;107(3):333-340.
-
(2001)
J Clin Invest
, vol.107
, Issue.3
, pp. 333-340
-
-
Hodgin, J.B.1
Krege, J.H.2
Reddick, R.L.3
Korach, K.S.4
Smithies, O.5
Maeda, N.6
-
17
-
-
0036798936
-
Estrogen modulation of endothelial nitric oxide synthase
-
Chambliss KL, Shaul PW. Estrogen modulation of endothelial nitric oxide synthase. Endocr Rev. 2002; 23(5):665-686.
-
(2002)
Endocr Rev
, vol.23
, Issue.5
, pp. 665-686
-
-
Chambliss, K.L.1
Shaul, P.W.2
-
18
-
-
13544260584
-
Dissecting the basis of nongenomic activation of endothelial nitric oxide synthase by estradiol: Role of ERalpha domains with known nuclear functions
-
Chambliss KL, Simon L, Yuhanna IS, Mineo C, Shaul PW. Dissecting the basis of nongenomic activation of endothelial nitric oxide synthase by estradiol: role of ERalpha domains with known nuclear functions. Mol Endocrinol. 2005;19(2):277-289.
-
(2005)
Mol Endocrinol
, vol.19
, Issue.2
, pp. 277-289
-
-
Chambliss, K.L.1
Simon, L.2
Yuhanna, I.S.3
Mineo, C.4
Shaul, P.W.5
-
19
-
-
77955006975
-
Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice
-
Chambliss KL, et al. Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice. J Clin Invest. 2010;120(7):2319-2330.
-
(2010)
J Clin Invest
, vol.120
, Issue.7
, pp. 2319-2330
-
-
Chambliss, K.L.1
-
20
-
-
0034711335
-
Estrogen receptor alpha and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae
-
Chambliss KL, et al. Estrogen receptor alpha and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae. Circ Res. 2000;87(11):E44-E52.
-
(2000)
Circ Res
, vol.87
, Issue.11
-
-
Chambliss, K.L.1
-
21
-
-
0036013436
-
ERbeta has nongenomic action in caveolae
-
Chambliss KL, Yuhanna IS, Anderson RG, Mendelsohn ME, Shaul PW. ERbeta has nongenomic action in caveolae. Mol Endocrinol. 2002; 16(5):938-946.
-
(2002)
Mol Endocrinol
, vol.16
, Issue.5
, pp. 938-946
-
-
Chambliss, K.L.1
Yuhanna, I.S.2
Anderson, R.G.3
Mendelsohn, M.E.4
Shaul, P.W.5
-
22
-
-
67649645087
-
Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice
-
Mouzat K, et al. Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice. Endocrinology. 2009; 150(7):3369-3375.
-
(2009)
Endocrinology
, vol.150
, Issue.7
, pp. 3369-3375
-
-
Mouzat, K.1
-
23
-
-
34547475143
-
Estrogen deprivation and inhibition of breast cancer growth in vivo through activation of the orphan nuclear receptor liver X receptor
-
Gong H, et al. Estrogen deprivation and inhibition of breast cancer growth in vivo through activation of the orphan nuclear receptor liver X receptor. Mol Endocrinol. 2007;21(8):1781-1790.
-
(2007)
Mol Endocrinol
, vol.21
, Issue.8
, pp. 1781-1790
-
-
Gong, H.1
-
24
-
-
27744513348
-
Estrogen regulation of adiposity and fuel partitioning
-
D'Eon TM, Souza SC, Aronovitz M, Obin MS, Fried SK, Greenberg AS. Estrogen regulation of adiposity and fuel partitioning. Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways. J Biol Chem. 2005;280(43):35983-35991.
-
(2005)
Evidence of Genomic and Non-genomic Regulation of Lipogenic and Oxidative Pathways. J Biol Chem
, vol.280
, Issue.43
, pp. 35983-35991
-
-
D'Eon, T.M.1
Souza, S.C.2
Aronovitz, M.3
Obin, M.S.4
Fried, S.K.5
Greenberg, A.S.6
-
25
-
-
79957971359
-
Cross-talk between the androgen receptor and the liver X receptor: Implications for cholesterol homeostasis
-
Krycer JR, Brown AJ. Cross-talk between the androgen receptor and the liver X receptor: implications for cholesterol homeostasis. J Biol Chem. 2011; 286(23):20637-20647.
-
(2011)
J Biol Chem
, vol.286
, Issue.23
, pp. 20637-20647
-
-
Krycer, J.R.1
Brown, A.J.2
-
26
-
-
34948820661
-
27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen
-
Umetani M, et al. 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. Nat Med. 2007;13(10):1185-1192.
-
(2007)
Nat Med
, vol.13
, Issue.10
, pp. 1185-1192
-
-
Umetani, M.1
-
27
-
-
0028234578
-
High-density lipoprotein stimulates endothelial cell movement by a mechanism distinct from basic fibroblast growth factor
-
Murugesan G, Sa G, Fox PL. High-density lipoprotein stimulates endothelial cell movement by a mechanism distinct from basic fibroblast growth factor. Circ Res. 1994;74(6):1149-1156.
-
(1994)
Circ Res
, vol.74
, Issue.6
, pp. 1149-1156
-
-
Murugesan, G.1
Sa, G.2
Fox, P.L.3
-
28
-
-
0036199988
-
Regulation of endothelial nitric oxide synthase: Location, location, location
-
Shaul PW. Regulation of endothelial nitric oxide synthase: location, location, location. Annu Rev Physiol. 2002;64:749-774.
-
(2002)
Annu Rev Physiol
, vol.64
, pp. 749-774
-
-
Shaul, P.W.1
-
29
-
-
0028820041
-
A detergent- free method for purifying caveolae membrane from tissue culture cells
-
Smart EJ, Ying YS, Mineo C, Anderson RG. A detergent- free method for purifying caveolae membrane from tissue culture cells. Proc Natl Acad Sci U S A. 1995;92(22):10104-10108.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, Issue.22
, pp. 10104-10108
-
-
Smart, E.J.1
Ying, Y.S.2
Mineo, C.3
Anderson, R.G.4
-
30
-
-
4644224284
-
Role of caveolae and caveolins in health and disease
-
Cohen AW, Hnasko R, Schubert W, Lisanti MP. Role of caveolae and caveolins in health and disease. Physiol Rev. 2004;84(4):1341-1379.
-
(2004)
Physiol Rev
, vol.84
, Issue.4
, pp. 1341-1379
-
-
Cohen, A.W.1
Hnasko, R.2
Schubert, W.3
Lisanti, M.P.4
-
31
-
-
0028886694
-
Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
-
Kato S, et al. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science. 1995;270(5241):1491-1494.
-
(1995)
Science
, vol.270
, Issue.5241
, pp. 1491-1494
-
-
Kato, S.1
-
32
-
-
0038648982
-
Ligand-independent interactions of p160/steroid receptor coactivators and CREB-binding protein (CBP) with estrogen receptor- alpha: Regulation by phosphorylation sites in the A/B region depends on other receptor domains
-
Dutertre M, Smith CL. Ligand-independent interactions of p160/steroid receptor coactivators and CREB-binding protein (CBP) with estrogen receptor- alpha: regulation by phosphorylation sites in the A/B region depends on other receptor domains. Mol Endocrinol. 2003;17(7):1296-1314.
-
(2003)
Mol Endocrinol
, vol.17
, Issue.7
, pp. 1296-1314
-
-
Dutertre, M.1
Smith, C.L.2
-
33
-
-
79958273729
-
Liganded and unliganded activation of estrogen receptor and hormone replacement therapies
-
Maggi A. Liganded and unliganded activation of estrogen receptor and hormone replacement therapies. Biochim Biophys Acta. 2011;1812(8):1054-1060.
-
(2011)
Biochim Biophys Acta
, vol.1812
, Issue.8
, pp. 1054-1060
-
-
Maggi, A.1
-
35
-
-
0034624062
-
Estrogen signals to the preservation of endothelial cell form and function
-
Razandi M, Pedram A, Levin ER. Estrogen signals to the preservation of endothelial cell form and function. J Biol Chem. 2000;275(49):38540-38546.
-
(2000)
J Biol Chem
, vol.275
, Issue.49
, pp. 38540-38546
-
-
Razandi, M.1
Pedram, A.2
Levin, E.R.3
-
36
-
-
45849096800
-
Liver X receptor activator downregulates angiotensin II type 1 receptor expression through dephosphorylation of Sp1
-
Imayama I, et al. Liver X receptor activator downregulates angiotensin II type 1 receptor expression through dephosphorylation of Sp1. Hypertension. 2008;51(6):1631-1636.
-
(2008)
Hypertension
, vol.51
, Issue.6
, pp. 1631-1636
-
-
Imayama, I.1
-
37
-
-
79954617449
-
Liver X receptor-retinoid X receptor (LXR-RXR) heterodimer cistrome reveals coordination of LXR and AP1 signaling in keratinocytes
-
Shen Q, et al. Liver X receptor-retinoid X receptor (LXR-RXR) heterodimer cistrome reveals coordination of LXR and AP1 signaling in keratinocytes. J Biol Chem. 2011;286(16):14554-14563.
-
(2011)
J Biol Chem
, vol.286
, Issue.16
, pp. 14554-14563
-
-
Shen, Q.1
-
38
-
-
38049008502
-
27-hydroxycholesterol is an endogenous selective estrogen receptor modulator
-
DuSell CD, Umetani M, Shaul PW, Mangelsdorf DJ, McDonnell DP. 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator. Mol Endocrinol. 2008;22(1):65-77.
-
(2008)
Mol Endocrinol
, vol.22
, Issue.1
, pp. 65-77
-
-
Dusell, C.D.1
Umetani, M.2
Shaul, P.W.3
Mangelsdorf, D.J.4
McDonnell, D.P.5
-
39
-
-
0037211754
-
Estrogen receptor phosphorylation
-
Lannigan DA. Estrogen receptor phosphorylation. Steroids. 2003;68(1):1-9.
-
(2003)
Steroids
, vol.68
, Issue.1
, pp. 1-9
-
-
Lannigan, D.A.1
-
40
-
-
0037399647
-
Nuclear receptors: Integration of multiple signalling pathways through phosphorylation
-
Rochette-Egly C. Nuclear receptors: integration of multiple signalling pathways through phosphorylation. Cell Signal. 2003;15(4):355-366.
-
(2003)
Cell Signal
, vol.15
, Issue.4
, pp. 355-366
-
-
Rochette-Egly, C.1
-
41
-
-
0037188941
-
Role of Akt signaling in vascular homeostasis and angiogenesis
-
Shiojima I, Walsh K. Role of Akt signaling in vascular homeostasis and angiogenesis. Circ Res. 2002; 90(12):1243-1250.
-
(2002)
Circ Res
, vol.90
, Issue.12
, pp. 1243-1250
-
-
Shiojima, I.1
Walsh, K.2
-
42
-
-
30744432102
-
Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo
-
Chen J, et al. Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Nat Med. 2005;11(11):1188-1196.
-
(2005)
Nat Med
, vol.11
, Issue.11
, pp. 1188-1196
-
-
Chen, J.1
-
43
-
-
77953158079
-
Distinct biological roles for the akt family in mammary tumor progression
-
Dillon RL, Muller WJ. Distinct biological roles for the akt family in mammary tumor progression. Cancer Res. 2010;70(11):4260-4264.
-
(2010)
Cancer Res
, vol.70
, Issue.11
, pp. 4260-4264
-
-
Dillon, R.L.1
Muller, W.J.2
-
44
-
-
0037440731
-
Endothelial nitric oxide synthase, caveolae and the development of atherosclerosis
-
Shaul PW. Endothelial nitric oxide synthase, caveolae and the development of atherosclerosis. J Physiol. 2003;547(pt 1):21-33.
-
(2003)
J Physiol
, vol.547
, Issue.PART 1
, pp. 21-33
-
-
Shaul, P.W.1
-
45
-
-
77951063806
-
Non-redundant roles for LXRα and LXRβ in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice
-
Bischoff ED, et al. Non-redundant roles for LXRα and LXRβ in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice. J Lipid Res. 2010;51(5):900-906.
-
(2010)
J Lipid Res
, vol.51
, Issue.5
, pp. 900-906
-
-
Bischoff, E.D.1
-
46
-
-
34547652884
-
Ligand activation of LXRβ reverses atherosclerosis and cellular cholesterol overload in mice lacking LXRα and apoE
-
Bradley MN, et al. Ligand activation of LXRβ reverses atherosclerosis and cellular cholesterol overload in mice lacking LXRα and apoE. J Clin Invest. 2007;117(8):2337-2346.
-
(2007)
J Clin Invest
, vol.117
, Issue.8
, pp. 2337-2346
-
-
Bradley, M.N.1
-
47
-
-
80255123405
-
Coupling of fcgamma receptor i to fcgamma receptor IIb by SRC kinase mediates C-reactive protein impairment of endothelial function
-
Sundgren NC, et al. Coupling of fcgamma receptor I to fcgamma receptor IIb by SRC kinase mediates C-reactive protein impairment of endothelial function. Circ Res. 2011;109(10):1132-1140.
-
(2011)
Circ Res
, vol.109
, Issue.10
, pp. 1132-1140
-
-
Sundgren, N.C.1
-
48
-
-
34250836804
-
Direct Interactions with Gαi and Gβγ mediate nongenomic signaling by estrogen receptor-α
-
Kumar P, et al. Direct Interactions with Gαi and Gβγ mediate nongenomic signaling by estrogen receptor-α. Mol Endocrinol. 2007;21(6):1370-1380.
-
(2007)
Mol Endocrinol
, vol.21
, Issue.6
, pp. 1370-1380
-
-
Kumar, P.1
-
49
-
-
0035936528
-
Estradiol accelerates reendothelialization in mouse carotid artery through estrogen receptor-alpha but not estrogen receptor-β
-
Brouchet L, Krust A, Dupont S, Chambon P, Bayard F, Arnal JF. Estradiol accelerates reendothelialization in mouse carotid artery through estrogen receptor-alpha but not estrogen receptor-β. Circulation. 2001;103(3):423-428.
-
(2001)
Circulation
, vol.103
, Issue.3
, pp. 423-428
-
-
Brouchet, L.1
Krust, A.2
Dupont, S.3
Chambon, P.4
Bayard, F.5
Arnal, J.F.6
-
50
-
-
33644844393
-
High-density lipoprotein promotes endothelial cell migration and reendothelialization via scavenger receptor-B type i
-
Seetharam D, et al. High-density lipoprotein promotes endothelial cell migration and reendothelialization via scavenger receptor-B type I. Circ Res. 2006; 98(1):63-72.
-
(2006)
Circ Res
, vol.98
, Issue.1
, pp. 63-72
-
-
Seetharam, D.1
-
51
-
-
78649758042
-
Biological and biochemical consequences of global deletion of exon 3 from the ER α gene
-
Hewitt SC, Kissling GE, Fieselman KE, Jayes FL, Gerrish KE, Korach KS. Biological and biochemical consequences of global deletion of exon 3 from the ER α gene. FASEB J. 2010;24(12):4660-4667.
-
(2010)
FASEB J
, vol.24
, Issue.12
, pp. 4660-4667
-
-
Hewitt, S.C.1
Kissling, G.E.2
Fieselman, K.E.3
Jayes, F.L.4
Gerrish, K.E.5
Korach, K.S.6
-
52
-
-
0013199471
-
Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα
-
Peet DJ, et al. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα. Cell. 1998;93(5):693-704.
-
(1998)
Cell
, vol.93
, Issue.5
, pp. 693-704
-
-
Peet, D.J.1
-
53
-
-
0034284918
-
Regulation of absorption and ABC1- mediated efflux of cholesterol by RXR heterodimers
-
Repa JJ, et al. Regulation of absorption and ABC1- mediated efflux of cholesterol by RXR heterodimers. Science. 2000;289(5484):1524-1529.
-
(2000)
Science
, vol.289
, Issue.5484
, pp. 1524-1529
-
-
Repa, J.J.1
|