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Volumn 123, Issue 8, 2013, Pages 3488-3497

LXRβ/estrogen receptor-α signaling in lipid rafts preserves endothelial integrity

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; CAVEOLIN 1; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ESTROGEN RECEPTOR ALPHA; LAMIN B; LIVER X RECEPTOR BETA; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SERINE;

EID: 84881233906     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI66533     Document Type: Article
Times cited : (45)

References (53)
  • 1
    • 0036851863 scopus 로고    scopus 로고
    • The liver X receptor gene team: Potential new players in atherosclerosis
    • Repa JJ, Mangelsdorf DJ. The liver X receptor gene team: potential new players in atherosclerosis. Nat Med. 2002;8(11):1243-1248.
    • (2002) Nat Med , vol.8 , Issue.11 , pp. 1243-1248
    • Repa, J.J.1    Mangelsdorf, D.J.2
  • 2
    • 0037503924 scopus 로고    scopus 로고
    • Liver X receptor signaling pathways in cardiovascular disease
    • Tontonoz P, Mangelsdorf DJ. Liver X receptor signaling pathways in cardiovascular disease. Mol Endocrinol. 2003;17(6):985-993.
    • (2003) Mol Endocrinol , vol.17 , Issue.6 , pp. 985-993
    • Tontonoz, P.1    Mangelsdorf, D.J.2
  • 3
    • 33644651160 scopus 로고    scopus 로고
    • Liver X receptors as integrators of metabolic and inflammatory signaling
    • Zelcer N, Tontonoz P. Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest. 2006;116(3):607-614.
    • (2006) J Clin Invest , vol.116 , Issue.3 , pp. 607-614
    • Zelcer, N.1    Tontonoz, P.2
  • 4
    • 0035851188 scopus 로고    scopus 로고
    • Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism
    • Lu TT, Repa JJ, Mangelsdorf DJ. Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism. J Biol Chem. 2001;276(41):37735-37738.
    • (2001) J Biol Chem , vol.276 , Issue.41 , pp. 37735-37738
    • Lu, T.T.1    Repa, J.J.2    Mangelsdorf, D.J.3
  • 5
    • 0033524420 scopus 로고    scopus 로고
    • Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta
    • Janowski BA, et al. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc Natl Acad Sci U S A. 1999;96(1):266-271.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.1 , pp. 266-271
    • Janowski, B.A.1
  • 6
    • 0037188553 scopus 로고    scopus 로고
    • Synthetic LXR ligand inhibits the development of atherosclerosis in mice
    • Joseph SB, et al. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A. 2002;99(11):7604-7609.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.11 , pp. 7604-7609
    • Joseph, S.B.1
  • 7
    • 0037432165 scopus 로고    scopus 로고
    • T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice
    • Terasaka N, et al. T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice. FEBS Lett. 2003;536(1-3):6-11.
    • (2003) FEBS Lett , vol.536 , Issue.1-3 , pp. 6-11
    • Terasaka, N.1
  • 8
    • 79952378989 scopus 로고    scopus 로고
    • Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE3Leiden mice without affecting liver or plasma triglyceride levels
    • van der Hoorn J, et al. Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels. Br J Pharmacol. 2011; 162(7):1553-1563.
    • (2011) Br J Pharmacol , vol.162 , Issue.7 , pp. 1553-1563
    • Van Der Hoorn, J.1
  • 9
    • 0035976638 scopus 로고    scopus 로고
    • Nuclear receptors and lipid physiology: Opening the X-files
    • Chawla A, Repa JJ, Evans RM, Mangelsdorf DJ. Nuclear receptors and lipid physiology: opening the X-files. Science. 2001;294(5548):1866-1870.
    • (2001) Science , vol.294 , Issue.5548 , pp. 1866-1870
    • Chawla, A.1    Repa, J.J.2    Evans, R.M.3    Mangelsdorf, D.J.4
  • 10
    • 0037324340 scopus 로고    scopus 로고
    • Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
    • Joseph SB, Castrillo A, Laffitte BA, Mangelsdorf DJ, Tontonoz P. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med. 2003;9(2):213-219.
    • (2003) Nat Med , vol.9 , Issue.2 , pp. 213-219
    • Joseph, S.B.1    Castrillo, A.2    Laffitte, B.A.3    Mangelsdorf, D.J.4    Tontonoz, P.5
  • 11
    • 21644487430 scopus 로고    scopus 로고
    • Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries
    • Blaschke F, et al. Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries. Circ Res. 2004;95(12):e110-e123.
    • (2004) Circ Res , vol.95 , Issue.12
    • Blaschke, F.1
  • 12
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis - An inflammatory disease
    • Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med. 1999;340(2):115-126.
    • (1999) N Engl J Med , vol.340 , Issue.2 , pp. 115-126
    • Ross, R.1
  • 13
    • 33644638521 scopus 로고    scopus 로고
    • Estrogen receptors and human disease
    • Deroo BJ, Korach KS. Estrogen receptors and human disease. J Clin Invest. 2006;116(3):561-570.
    • (2006) J Clin Invest , vol.116 , Issue.3 , pp. 561-570
    • Deroo, B.J.1    Korach, K.S.2
  • 14
    • 0033542402 scopus 로고    scopus 로고
    • The protective effects of estrogen on the cardiovascular system
    • Mendelsohn ME, Karas RH. The protective effects of estrogen on the cardiovascular system. N Engl J Med. 1999;340(23):1801-1811.
    • (1999) N Engl J Med , vol.340 , Issue.23 , pp. 1801-1811
    • Mendelsohn, M.E.1    Karas, R.H.2
  • 15
    • 0032945571 scopus 로고    scopus 로고
    • Protection against atherosclerosis by estrogen is independent of plasma cholesterol levels in LDL receptor- deficient mice
    • Marsh MM, Walker VR, Curtiss LK, Banka CL. Protection against atherosclerosis by estrogen is independent of plasma cholesterol levels in LDL receptor- deficient mice. J Lipid Res. 1999;40(5):893-900.
    • (1999) J Lipid Res , vol.40 , Issue.5 , pp. 893-900
    • Marsh, M.M.1    Walker, V.R.2    Curtiss, L.K.3    Banka, C.L.4
  • 16
    • 0035132187 scopus 로고    scopus 로고
    • Estrogen receptor alpha is a major mediator of 17beta-estradiol's atheroprotective effects on lesion size in Apoe-/- mice
    • Hodgin JB, Krege JH, Reddick RL, Korach KS, Smithies O, Maeda N. Estrogen receptor alpha is a major mediator of 17beta-estradiol's atheroprotective effects on lesion size in Apoe-/- mice. J Clin Invest. 2001;107(3):333-340.
    • (2001) J Clin Invest , vol.107 , Issue.3 , pp. 333-340
    • Hodgin, J.B.1    Krege, J.H.2    Reddick, R.L.3    Korach, K.S.4    Smithies, O.5    Maeda, N.6
  • 17
    • 0036798936 scopus 로고    scopus 로고
    • Estrogen modulation of endothelial nitric oxide synthase
    • Chambliss KL, Shaul PW. Estrogen modulation of endothelial nitric oxide synthase. Endocr Rev. 2002; 23(5):665-686.
    • (2002) Endocr Rev , vol.23 , Issue.5 , pp. 665-686
    • Chambliss, K.L.1    Shaul, P.W.2
  • 18
    • 13544260584 scopus 로고    scopus 로고
    • Dissecting the basis of nongenomic activation of endothelial nitric oxide synthase by estradiol: Role of ERalpha domains with known nuclear functions
    • Chambliss KL, Simon L, Yuhanna IS, Mineo C, Shaul PW. Dissecting the basis of nongenomic activation of endothelial nitric oxide synthase by estradiol: role of ERalpha domains with known nuclear functions. Mol Endocrinol. 2005;19(2):277-289.
    • (2005) Mol Endocrinol , vol.19 , Issue.2 , pp. 277-289
    • Chambliss, K.L.1    Simon, L.2    Yuhanna, I.S.3    Mineo, C.4    Shaul, P.W.5
  • 19
    • 77955006975 scopus 로고    scopus 로고
    • Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice
    • Chambliss KL, et al. Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice. J Clin Invest. 2010;120(7):2319-2330.
    • (2010) J Clin Invest , vol.120 , Issue.7 , pp. 2319-2330
    • Chambliss, K.L.1
  • 20
    • 0034711335 scopus 로고    scopus 로고
    • Estrogen receptor alpha and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae
    • Chambliss KL, et al. Estrogen receptor alpha and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae. Circ Res. 2000;87(11):E44-E52.
    • (2000) Circ Res , vol.87 , Issue.11
    • Chambliss, K.L.1
  • 22
    • 67649645087 scopus 로고    scopus 로고
    • Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice
    • Mouzat K, et al. Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice. Endocrinology. 2009; 150(7):3369-3375.
    • (2009) Endocrinology , vol.150 , Issue.7 , pp. 3369-3375
    • Mouzat, K.1
  • 23
    • 34547475143 scopus 로고    scopus 로고
    • Estrogen deprivation and inhibition of breast cancer growth in vivo through activation of the orphan nuclear receptor liver X receptor
    • Gong H, et al. Estrogen deprivation and inhibition of breast cancer growth in vivo through activation of the orphan nuclear receptor liver X receptor. Mol Endocrinol. 2007;21(8):1781-1790.
    • (2007) Mol Endocrinol , vol.21 , Issue.8 , pp. 1781-1790
    • Gong, H.1
  • 25
    • 79957971359 scopus 로고    scopus 로고
    • Cross-talk between the androgen receptor and the liver X receptor: Implications for cholesterol homeostasis
    • Krycer JR, Brown AJ. Cross-talk between the androgen receptor and the liver X receptor: implications for cholesterol homeostasis. J Biol Chem. 2011; 286(23):20637-20647.
    • (2011) J Biol Chem , vol.286 , Issue.23 , pp. 20637-20647
    • Krycer, J.R.1    Brown, A.J.2
  • 26
    • 34948820661 scopus 로고    scopus 로고
    • 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen
    • Umetani M, et al. 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. Nat Med. 2007;13(10):1185-1192.
    • (2007) Nat Med , vol.13 , Issue.10 , pp. 1185-1192
    • Umetani, M.1
  • 27
    • 0028234578 scopus 로고
    • High-density lipoprotein stimulates endothelial cell movement by a mechanism distinct from basic fibroblast growth factor
    • Murugesan G, Sa G, Fox PL. High-density lipoprotein stimulates endothelial cell movement by a mechanism distinct from basic fibroblast growth factor. Circ Res. 1994;74(6):1149-1156.
    • (1994) Circ Res , vol.74 , Issue.6 , pp. 1149-1156
    • Murugesan, G.1    Sa, G.2    Fox, P.L.3
  • 28
    • 0036199988 scopus 로고    scopus 로고
    • Regulation of endothelial nitric oxide synthase: Location, location, location
    • Shaul PW. Regulation of endothelial nitric oxide synthase: location, location, location. Annu Rev Physiol. 2002;64:749-774.
    • (2002) Annu Rev Physiol , vol.64 , pp. 749-774
    • Shaul, P.W.1
  • 29
    • 0028820041 scopus 로고
    • A detergent- free method for purifying caveolae membrane from tissue culture cells
    • Smart EJ, Ying YS, Mineo C, Anderson RG. A detergent- free method for purifying caveolae membrane from tissue culture cells. Proc Natl Acad Sci U S A. 1995;92(22):10104-10108.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , Issue.22 , pp. 10104-10108
    • Smart, E.J.1    Ying, Y.S.2    Mineo, C.3    Anderson, R.G.4
  • 30
    • 4644224284 scopus 로고    scopus 로고
    • Role of caveolae and caveolins in health and disease
    • Cohen AW, Hnasko R, Schubert W, Lisanti MP. Role of caveolae and caveolins in health and disease. Physiol Rev. 2004;84(4):1341-1379.
    • (2004) Physiol Rev , vol.84 , Issue.4 , pp. 1341-1379
    • Cohen, A.W.1    Hnasko, R.2    Schubert, W.3    Lisanti, M.P.4
  • 31
    • 0028886694 scopus 로고
    • Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
    • Kato S, et al. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science. 1995;270(5241):1491-1494.
    • (1995) Science , vol.270 , Issue.5241 , pp. 1491-1494
    • Kato, S.1
  • 32
    • 0038648982 scopus 로고    scopus 로고
    • Ligand-independent interactions of p160/steroid receptor coactivators and CREB-binding protein (CBP) with estrogen receptor- alpha: Regulation by phosphorylation sites in the A/B region depends on other receptor domains
    • Dutertre M, Smith CL. Ligand-independent interactions of p160/steroid receptor coactivators and CREB-binding protein (CBP) with estrogen receptor- alpha: regulation by phosphorylation sites in the A/B region depends on other receptor domains. Mol Endocrinol. 2003;17(7):1296-1314.
    • (2003) Mol Endocrinol , vol.17 , Issue.7 , pp. 1296-1314
    • Dutertre, M.1    Smith, C.L.2
  • 33
    • 79958273729 scopus 로고    scopus 로고
    • Liganded and unliganded activation of estrogen receptor and hormone replacement therapies
    • Maggi A. Liganded and unliganded activation of estrogen receptor and hormone replacement therapies. Biochim Biophys Acta. 2011;1812(8):1054-1060.
    • (2011) Biochim Biophys Acta , vol.1812 , Issue.8 , pp. 1054-1060
    • Maggi, A.1
  • 35
    • 0034624062 scopus 로고    scopus 로고
    • Estrogen signals to the preservation of endothelial cell form and function
    • Razandi M, Pedram A, Levin ER. Estrogen signals to the preservation of endothelial cell form and function. J Biol Chem. 2000;275(49):38540-38546.
    • (2000) J Biol Chem , vol.275 , Issue.49 , pp. 38540-38546
    • Razandi, M.1    Pedram, A.2    Levin, E.R.3
  • 36
    • 45849096800 scopus 로고    scopus 로고
    • Liver X receptor activator downregulates angiotensin II type 1 receptor expression through dephosphorylation of Sp1
    • Imayama I, et al. Liver X receptor activator downregulates angiotensin II type 1 receptor expression through dephosphorylation of Sp1. Hypertension. 2008;51(6):1631-1636.
    • (2008) Hypertension , vol.51 , Issue.6 , pp. 1631-1636
    • Imayama, I.1
  • 37
    • 79954617449 scopus 로고    scopus 로고
    • Liver X receptor-retinoid X receptor (LXR-RXR) heterodimer cistrome reveals coordination of LXR and AP1 signaling in keratinocytes
    • Shen Q, et al. Liver X receptor-retinoid X receptor (LXR-RXR) heterodimer cistrome reveals coordination of LXR and AP1 signaling in keratinocytes. J Biol Chem. 2011;286(16):14554-14563.
    • (2011) J Biol Chem , vol.286 , Issue.16 , pp. 14554-14563
    • Shen, Q.1
  • 39
    • 0037211754 scopus 로고    scopus 로고
    • Estrogen receptor phosphorylation
    • Lannigan DA. Estrogen receptor phosphorylation. Steroids. 2003;68(1):1-9.
    • (2003) Steroids , vol.68 , Issue.1 , pp. 1-9
    • Lannigan, D.A.1
  • 40
    • 0037399647 scopus 로고    scopus 로고
    • Nuclear receptors: Integration of multiple signalling pathways through phosphorylation
    • Rochette-Egly C. Nuclear receptors: integration of multiple signalling pathways through phosphorylation. Cell Signal. 2003;15(4):355-366.
    • (2003) Cell Signal , vol.15 , Issue.4 , pp. 355-366
    • Rochette-Egly, C.1
  • 41
    • 0037188941 scopus 로고    scopus 로고
    • Role of Akt signaling in vascular homeostasis and angiogenesis
    • Shiojima I, Walsh K. Role of Akt signaling in vascular homeostasis and angiogenesis. Circ Res. 2002; 90(12):1243-1250.
    • (2002) Circ Res , vol.90 , Issue.12 , pp. 1243-1250
    • Shiojima, I.1    Walsh, K.2
  • 42
    • 30744432102 scopus 로고    scopus 로고
    • Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo
    • Chen J, et al. Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Nat Med. 2005;11(11):1188-1196.
    • (2005) Nat Med , vol.11 , Issue.11 , pp. 1188-1196
    • Chen, J.1
  • 43
    • 77953158079 scopus 로고    scopus 로고
    • Distinct biological roles for the akt family in mammary tumor progression
    • Dillon RL, Muller WJ. Distinct biological roles for the akt family in mammary tumor progression. Cancer Res. 2010;70(11):4260-4264.
    • (2010) Cancer Res , vol.70 , Issue.11 , pp. 4260-4264
    • Dillon, R.L.1    Muller, W.J.2
  • 44
    • 0037440731 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase, caveolae and the development of atherosclerosis
    • Shaul PW. Endothelial nitric oxide synthase, caveolae and the development of atherosclerosis. J Physiol. 2003;547(pt 1):21-33.
    • (2003) J Physiol , vol.547 , Issue.PART 1 , pp. 21-33
    • Shaul, P.W.1
  • 45
    • 77951063806 scopus 로고    scopus 로고
    • Non-redundant roles for LXRα and LXRβ in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice
    • Bischoff ED, et al. Non-redundant roles for LXRα and LXRβ in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice. J Lipid Res. 2010;51(5):900-906.
    • (2010) J Lipid Res , vol.51 , Issue.5 , pp. 900-906
    • Bischoff, E.D.1
  • 46
    • 34547652884 scopus 로고    scopus 로고
    • Ligand activation of LXRβ reverses atherosclerosis and cellular cholesterol overload in mice lacking LXRα and apoE
    • Bradley MN, et al. Ligand activation of LXRβ reverses atherosclerosis and cellular cholesterol overload in mice lacking LXRα and apoE. J Clin Invest. 2007;117(8):2337-2346.
    • (2007) J Clin Invest , vol.117 , Issue.8 , pp. 2337-2346
    • Bradley, M.N.1
  • 47
    • 80255123405 scopus 로고    scopus 로고
    • Coupling of fcgamma receptor i to fcgamma receptor IIb by SRC kinase mediates C-reactive protein impairment of endothelial function
    • Sundgren NC, et al. Coupling of fcgamma receptor I to fcgamma receptor IIb by SRC kinase mediates C-reactive protein impairment of endothelial function. Circ Res. 2011;109(10):1132-1140.
    • (2011) Circ Res , vol.109 , Issue.10 , pp. 1132-1140
    • Sundgren, N.C.1
  • 48
    • 34250836804 scopus 로고    scopus 로고
    • Direct Interactions with Gαi and Gβγ mediate nongenomic signaling by estrogen receptor-α
    • Kumar P, et al. Direct Interactions with Gαi and Gβγ mediate nongenomic signaling by estrogen receptor-α. Mol Endocrinol. 2007;21(6):1370-1380.
    • (2007) Mol Endocrinol , vol.21 , Issue.6 , pp. 1370-1380
    • Kumar, P.1
  • 49
    • 0035936528 scopus 로고    scopus 로고
    • Estradiol accelerates reendothelialization in mouse carotid artery through estrogen receptor-alpha but not estrogen receptor-β
    • Brouchet L, Krust A, Dupont S, Chambon P, Bayard F, Arnal JF. Estradiol accelerates reendothelialization in mouse carotid artery through estrogen receptor-alpha but not estrogen receptor-β. Circulation. 2001;103(3):423-428.
    • (2001) Circulation , vol.103 , Issue.3 , pp. 423-428
    • Brouchet, L.1    Krust, A.2    Dupont, S.3    Chambon, P.4    Bayard, F.5    Arnal, J.F.6
  • 50
    • 33644844393 scopus 로고    scopus 로고
    • High-density lipoprotein promotes endothelial cell migration and reendothelialization via scavenger receptor-B type i
    • Seetharam D, et al. High-density lipoprotein promotes endothelial cell migration and reendothelialization via scavenger receptor-B type I. Circ Res. 2006; 98(1):63-72.
    • (2006) Circ Res , vol.98 , Issue.1 , pp. 63-72
    • Seetharam, D.1
  • 51
    • 78649758042 scopus 로고    scopus 로고
    • Biological and biochemical consequences of global deletion of exon 3 from the ER α gene
    • Hewitt SC, Kissling GE, Fieselman KE, Jayes FL, Gerrish KE, Korach KS. Biological and biochemical consequences of global deletion of exon 3 from the ER α gene. FASEB J. 2010;24(12):4660-4667.
    • (2010) FASEB J , vol.24 , Issue.12 , pp. 4660-4667
    • Hewitt, S.C.1    Kissling, G.E.2    Fieselman, K.E.3    Jayes, F.L.4    Gerrish, K.E.5    Korach, K.S.6
  • 52
    • 0013199471 scopus 로고    scopus 로고
    • Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα
    • Peet DJ, et al. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα. Cell. 1998;93(5):693-704.
    • (1998) Cell , vol.93 , Issue.5 , pp. 693-704
    • Peet, D.J.1
  • 53
    • 0034284918 scopus 로고    scopus 로고
    • Regulation of absorption and ABC1- mediated efflux of cholesterol by RXR heterodimers
    • Repa JJ, et al. Regulation of absorption and ABC1- mediated efflux of cholesterol by RXR heterodimers. Science. 2000;289(5484):1524-1529.
    • (2000) Science , vol.289 , Issue.5484 , pp. 1524-1529
    • Repa, J.J.1


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