The immunosuppressive drug azathioprine inhibits biosynthesis of the bacterial signal molecule cyclic-di-GMP by interfering with intracellular nucleotide pool availability

Applied Microbiology and Biotechnology

Volumn 97, Issue 16, 2013, Pages 7325-7336

  Antoniani, Davide ^a   Rossi, Elio ^a   Rinaldo, Serena ^b   Bocci, Paola ^c   Lolicato, Marco ^a   Paiardini, Alessandro ^b   Raffaelli, Nadia ^c   Cutruzzolà, Francesca ^b   Landini, Paolo ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

Antimetabolite drugs; Azathioprine; Biofilm formation; c di GMP; Crohn's disease; Diguanylate cyclase

Indexed keywords

ANTIMETABOLITE DRUGS; AZATHIOPRINE; BIOFILM FORMATION; C-DI-GMP; CROHN'S DISEASE; CYCLASES;

BACTERIA; BIOCHEMISTRY; BIOFILMS; BIOSYNTHESIS; DISEASES; ENZYME ACTIVITY; ESCHERICHIA COLI; LAKES; MOLECULES; NUCLEOTIDES;

ENZYME INHIBITION;

AZATHIOPRINE; BACTERIAL PROTEIN; CYCLIC GMP; NUCLEOTIDE; UNCLASSIFIED DRUG; VIRULENCE FACTOR; WSPR PROTEIN;

BIOFILM; DRUG; ENZYME; ENZYME ACTIVITY; INHIBITION; SIGNAL; VIRULENCE;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BACTERIAL CELL; BACTERIAL VIRULENCE; BIOFILM; CONTROLLED STUDY; ENZYMATIC ASSAY; ENZYME INHIBITION; ESCHERICHIA COLI; IN VITRO STUDY; MICROBIOLOGY; NONHUMAN; PROTEIN EXPRESSION;

ANTI-BACTERIAL AGENTS; AZATHIOPRINE; BIOFILMS; CYCLIC GMP; ESCHERICHIA COLI; NUCLEOTIDES; PSEUDOMONAS AERUGINOSA;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA; PSEUDOMONAS AERUGINOSA;

EID: 84881232457     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-013-4875-0     Document Type: Article

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