메뉴 건너뛰기




Volumn 18, Issue 8, 2012, Pages 1488-1492

Concomitant therapy with methotrexate and anti-TNF-α in pediatric patients with refractory crohn's colitis: A case series

Author keywords

adverse effects; Crohn's disease; inflammatory bowel diseases; methotrexate; tumor necrosis factor

Indexed keywords

ADALIMUMAB; ANTIBIOTIC AGENT; AZATHIOPRINE; CERTOLIZUMAB PEGOL; CORTICOSTEROID; INFLIXIMAB; MERCAPTOPURINE; METHOTREXATE; NATALIZUMAB; TACROLIMUS;

EID: 84863945010     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.21885     Document Type: Review
Times cited : (18)

References (36)
  • 1
    • 2442563304 scopus 로고    scopus 로고
    • Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences
    • Loftus EV Jr,. Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology. 2004; 126: 1504-1517.
    • (2004) Gastroenterology , vol.126 , pp. 1504-1517
    • Loftus Jr., E.V.1
  • 2
    • 36549001139 scopus 로고    scopus 로고
    • The prevalence and geographic distribution of Crohn's disease and ulcerative colitis in the United States
    • Kappelman MD, Rifas-Shiman SL, Kleinman K, et al. The prevalence and geographic distribution of Crohn's disease and ulcerative colitis in the United States. Clin Gastroenterol Hepatol. 2007; 5: 1424-1429.
    • (2007) Clin Gastroenterol Hepatol. , vol.5 , pp. 1424-1429
    • Kappelman, M.D.1    Rifas-Shiman, S.L.2    Kleinman, K.3
  • 3
    • 0018888679 scopus 로고
    • Treatment of Crohn's disease with 6-mercaptopurine
    • Present DH, Korelitz BI, Wisch N, et al. Treatment of Crohn's disease with 6-mercaptopurine. N Engl J Med. 1980; 302: 981-987.
    • (1980) N Engl J Med. , vol.302 , pp. 981-987
    • Present, D.H.1    Korelitz, B.I.2    Wisch, N.3
  • 4
    • 4444224484 scopus 로고    scopus 로고
    • Azathioprine, 6-mercaptopurine in inflammatory bowel disease: Pharmacology, efficacy, and safety
    • Dubinsky MC,. Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety. Clin Gastroenterol Hepatol. 2004; 2: 731-743.
    • (2004) Clin Gastroenterol Hepatol. , vol.2 , pp. 731-743
    • Dubinsky, M.C.1
  • 5
    • 16844365535 scopus 로고    scopus 로고
    • The bioavailability of oral methotrexate in children with inflammatory bowel disease
    • Stephens MC, Baldassano RN, York A, et al. The bioavailability of oral methotrexate in children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2005; 40: 445-449.
    • (2005) J Pediatr Gastroenterol Nutr. , vol.40 , pp. 445-449
    • Stephens, M.C.1    Baldassano, R.N.2    York, A.3
  • 6
    • 0037018761 scopus 로고    scopus 로고
    • Maintenance infliximab for Crohn's disease: The ACCENT i randomised trial
    • Hanauer SB, Feagan BG, Lichtenstein GR, et al. Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial. Lancet. 2002; 359: 1541-1549.
    • (2002) Lancet. , vol.359 , pp. 1541-1549
    • Hanauer, S.B.1    Feagan, B.G.2    Lichtenstein, G.R.3
  • 7
    • 33749436420 scopus 로고    scopus 로고
    • Medical therapy for refractory pediatric Crohn's disease
    • Faubion WA Jr, Bousvaros A,. Medical therapy for refractory pediatric Crohn's disease. Clin Gastroenterol Hepatol. 2006; 4: 1199-1213.
    • (2006) Clin Gastroenterol Hepatol. , vol.4 , pp. 1199-1213
    • Faubion Jr., W.A.1    Bousvaros, A.2
  • 8
    • 33751560426 scopus 로고    scopus 로고
    • A population-based study of the frequency of corticosteroid resistance and dependence in pediatric patients with Crohn's disease and ulcerative colitis
    • Tung J, Loftus EV, Freese DK, et al. A population-based study of the frequency of corticosteroid resistance and dependence in pediatric patients with Crohn's disease and ulcerative colitis. Inflamm Bowel Dis. 2006; 12: 1093-1100.
    • (2006) Inflamm Bowel Dis. , vol.12 , pp. 1093-1100
    • Tung, J.1    Loftus, E.V.2    Freese, D.K.3
  • 9
    • 33947397636 scopus 로고    scopus 로고
    • Induction and maintenance infliximab therapy for the treatment of moderate-to-severe Crohn's disease in children
    • Hyams J, Crandall W, Kugathasan S, et al. Induction and maintenance infliximab therapy for the treatment of moderate-to-severe Crohn's disease in children. Gastroenterology. 2007; 132: 863-873.
    • (2007) Gastroenterology , vol.132 , pp. 863-873
    • Hyams, J.1    Crandall, W.2    Kugathasan, S.3
  • 10
    • 34347369156 scopus 로고    scopus 로고
    • Hepatosplenic T-cell lymphoma in adolescents and young adults with Crohn's disease: A cautionary tale?
    • Rosh JR, Gross T, Mamula P, et al. Hepatosplenic T-cell lymphoma in adolescents and young adults with Crohn's disease: a cautionary tale? Inflamm Bowel Dis. 2007; 13: 1024-1030.
    • (2007) Inflamm Bowel Dis. , vol.13 , pp. 1024-1030
    • Rosh, J.R.1    Gross, T.2    Mamula, P.3
  • 11
    • 0028899859 scopus 로고
    • Methotrexate for the treatment of Crohn's disease
    • Feagan BG, Rochon J, Fedorak RN, et al. Methotrexate for the treatment of Crohn's disease. N Engl J Med. 1995; 332: 292-297.
    • (1995) N Engl J Med. , vol.332 , pp. 292-297
    • Feagan, B.G.1    Rochon, J.2    Fedorak, R.N.3
  • 12
    • 36549026839 scopus 로고    scopus 로고
    • Methotrexate following unsuccessful thiopurine therapy in pediatric Crohn's disease
    • Turner D, Grossman AB, Rosh J, et al. Methotrexate following unsuccessful thiopurine therapy in pediatric Crohn's disease. Am J Gastroenterol. 2007; 102: 2804-2812.
    • (2007) Am J Gastroenterol. , vol.102 , pp. 2804-2812
    • Turner, D.1    Grossman, A.B.2    Rosh, J.3
  • 13
    • 33750519460 scopus 로고    scopus 로고
    • Efficacy of methotrexate in pediatric Crohn's disease: A French multicenter study
    • Uhlen S, Belbouab R, Narebski K, et al. Efficacy of methotrexate in pediatric Crohn's disease: a French multicenter study. Inflamm Bowel Dis. 2006; 12: 1053-1057.
    • (2006) Inflamm Bowel Dis. , vol.12 , pp. 1053-1057
    • Uhlen, S.1    Belbouab, R.2    Narebski, K.3
  • 14
    • 0034214336 scopus 로고    scopus 로고
    • A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease
    • Feagan BG, Fedorak RN, Irvine EJ, et al. A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease. N Engl J Med. 2000; 342: 1627-1632.
    • (2000) N Engl J Med. , vol.342 , pp. 1627-1632
    • Feagan, B.G.1    Fedorak, R.N.2    Irvine, E.J.3
  • 15
    • 68949209778 scopus 로고    scopus 로고
    • Efficacy of methotrexate in Crohn's disease and ulcerative colitis patients unresponsive or intolerant to azathioprine/mercaptopurine
    • Wahed M, Louis-Auguste JR, Baxter LM, et al. Efficacy of methotrexate in Crohn's disease and ulcerative colitis patients unresponsive or intolerant to azathioprine/mercaptopurine. Aliment Pharmacol Ther. 2009; 30: 614-620.
    • (2009) Aliment Pharmacol Ther. , vol.30 , pp. 614-620
    • Wahed, M.1    Louis-Auguste, J.R.2    Baxter, L.M.3
  • 17
    • 67650882729 scopus 로고    scopus 로고
    • Methotrexate treatment in pediatric Crohn disease patients intolerant or resistant to purine analogues
    • Weiss B, Lerner A, Shapiro R, et al. Methotrexate treatment in pediatric Crohn disease patients intolerant or resistant to purine analogues. J Pediatr Gastroenterol Nutr. 2009; 48: 526-530.
    • (2009) J Pediatr Gastroenterol Nutr. , vol.48 , pp. 526-530
    • Weiss, B.1    Lerner, A.2    Shapiro, R.3
  • 18
    • 29344445925 scopus 로고    scopus 로고
    • Combining infliximab with methotrexate for the induction and maintenance of remission in refractory Crohn's disease: A controlled pilot study
    • Schröder O, Blumenstein I, Stein J,. Combining infliximab with methotrexate for the induction and maintenance of remission in refractory Crohn's disease: a controlled pilot study. Eur J Gastroenterol Hepatol. 2006; 18: 11-16.
    • (2006) Eur J Gastroenterol Hepatol. , vol.18 , pp. 11-16
    • Schröder, O.1    Blumenstein, I.2    Stein, J.3
  • 19
    • 78650098400 scopus 로고    scopus 로고
    • Short pediatric Crohn's disease activity index for quality improvement and observational research
    • Kappelman MD, Crandall WV, Colletti RB, et al. Short pediatric Crohn's disease activity index for quality improvement and observational research. Inflamm Bowel Dis. 2011; 17: 112-117.
    • (2011) Inflamm Bowel Dis. , vol.17 , pp. 112-117
    • Kappelman, M.D.1    Crandall, W.V.2    Colletti, R.B.3
  • 20
    • 78650108131 scopus 로고    scopus 로고
    • Recurrence rate of clostridium difficile infection in hospitalized pediatric patients with inflammatory bowel disease
    • Kelsen JR, Kim J, Latta D, et al. Recurrence rate of clostridium difficile infection in hospitalized pediatric patients with inflammatory bowel disease. Inflamm Bowel Dis. 2011; 17: 50-55.
    • (2011) Inflamm Bowel Dis. , vol.17 , pp. 50-55
    • Kelsen, J.R.1    Kim, J.2    Latta, D.3
  • 21
    • 1842425908 scopus 로고    scopus 로고
    • Bioavailability of higher dose methotrexate comparing oral and subcutaneous administration in patients with rheumatoid arthritis
    • Hoekstra M, Haagsma C, Neef C, et al. Bioavailability of higher dose methotrexate comparing oral and subcutaneous administration in patients with rheumatoid arthritis. J Rheumatol. 2004; 31: 645-648.
    • (2004) J Rheumatol. , vol.31 , pp. 645-648
    • Hoekstra, M.1    Haagsma, C.2    Neef, C.3
  • 22
    • 0024216625 scopus 로고
    • Pharmacokinetics of subcutaneous methotrexate
    • Balis FM, Mirro J Jr, Reaman GH, et al. Pharmacokinetics of subcutaneous methotrexate. J Clin Oncol. 1988; 6: 1882-1886.
    • (1988) J Clin Oncol. , vol.6 , pp. 1882-1886
    • Balis, F.M.1    Mirro Jr., J.2    Reaman, G.H.3
  • 23
    • 22944470530 scopus 로고    scopus 로고
    • Low-dose methotrexate: A mainstay in the treatment of rheumatoid arthritis
    • Cronstein BN,. Low-dose methotrexate: a mainstay in the treatment of rheumatoid arthritis. Pharmacol Rev. 2005; 57: 163-172.
    • (2005) Pharmacol Rev. , vol.57 , pp. 163-172
    • Cronstein, B.N.1
  • 24
    • 0032528186 scopus 로고    scopus 로고
    • Immunosuppressive properties of methotrexate: Apoptosis and clonal deletion of activated peripheral T cells
    • Genestier L, Paillot R, Fournel S, et al. Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells. J Clin Invest. 1998; 102: 322-328.
    • (1998) J Clin Invest. , vol.102 , pp. 322-328
    • Genestier, L.1    Paillot, R.2    Fournel, S.3
  • 25
    • 70349454135 scopus 로고    scopus 로고
    • Treatment with infliximab plus methotrexate improves anemia in patients with rheumatoid arthritis independent of improvement in other clinical outcome measuresa pooled analysis from three large, multicenter, double-blind, randomized clinical trials
    • Doyle MK, Rahman MU, Han C, et al. Treatment with infliximab plus methotrexate improves anemia in patients with rheumatoid arthritis independent of improvement in other clinical outcome measuresa pooled analysis from three large, multicenter, double-blind, randomized clinical trials. Semin Arthritis Rheum. 2009; 39: 123-131.
    • (2009) Semin Arthritis Rheum. , vol.39 , pp. 123-131
    • Doyle, M.K.1    Rahman, M.U.2    Han, C.3
  • 26
    • 57749180869 scopus 로고    scopus 로고
    • Infliximab and methotrexate in the treatment of rheumatoid arthritis: A systematic review and meta-analysis of dosage regimens
    • Zintzaras E, Dahabreh IJ, Giannouli S, et al. Infliximab and methotrexate in the treatment of rheumatoid arthritis: a systematic review and meta-analysis of dosage regimens. Clin Ther. 2008; 30: 1939-1955.
    • (2008) Clin Ther. , vol.30 , pp. 1939-1955
    • Zintzaras, E.1    Dahabreh, I.J.2    Giannouli, S.3
  • 27
    • 68049099274 scopus 로고    scopus 로고
    • Golimumab, a human anti-tumor necrosis factor α monoclonal antibody, injected subcutaneously every four weeks in methotrexate-naive patients with active rheumatoid arthritis: Twenty-four-week results of a phase III, multicenter, randomized, double-blind, placebo-controlled study of golimumab before methotrexate as first-line therapy for early-onset rheumatoid arthritis
    • Emery P, Fleischmann RM, Moreland LW, et al. Golimumab, a human anti-tumor necrosis factor α monoclonal antibody, injected subcutaneously every four weeks in methotrexate-naive patients with active rheumatoid arthritis: twenty-four-week results of a phase III, multicenter, randomized, double-blind, placebo-controlled study of golimumab before methotrexate as first-line therapy for early-onset rheumatoid arthritis. Arthritis Rheum. 2009; 60: 2272-2283.
    • (2009) Arthritis Rheum. , vol.60 , pp. 2272-2283
    • Emery, P.1    Fleischmann, R.M.2    Moreland, L.W.3
  • 28
    • 0037434552 scopus 로고    scopus 로고
    • Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease
    • Baert F, Noman M, Vermeire S, et al. Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease. N Engl J Med. 2003; 348: 601-608.
    • (2003) N Engl J Med. , vol.348 , pp. 601-608
    • Baert, F.1    Noman, M.2    Vermeire, S.3
  • 29
    • 34548130215 scopus 로고    scopus 로고
    • Effectiveness of concomitant immunosuppressive therapy in suppressing the formation of antibodies to infliximab in Crohn's disease
    • Vermeire S, Noman M, Van Assche G, et al. Effectiveness of concomitant immunosuppressive therapy in suppressing the formation of antibodies to infliximab in Crohn's disease. Gut. 2007; 56: 1226-1231.
    • (2007) Gut. , vol.56 , pp. 1226-1231
    • Vermeire, S.1    Noman, M.2    Van Assche, G.3
  • 30
    • 67650462325 scopus 로고    scopus 로고
    • Clinical trial: Benefits and risks of immunomodulators and maintenance infliximab for IBD-subgroup analyses across four randomized trials
    • Lichtenstein GR, Diamond RH, Wagner CL, et al. Clinical trial: benefits and risks of immunomodulators and maintenance infliximab for IBD-subgroup analyses across four randomized trials. Aliment Pharmacol Ther. 2009; 30: 210-226.
    • (2009) Aliment Pharmacol Ther. , vol.30 , pp. 210-226
    • Lichtenstein, G.R.1    Diamond, R.H.2    Wagner, C.L.3
  • 31
    • 80053649708 scopus 로고    scopus 로고
    • Methotrexate in the treatment of inflammatory bowel disease: An 8-year retrospective study in a Canadian pediatric IBD center
    • [Epub ahead of print]
    • Willot S, Noble A, Deslandres C,. Methotrexate in the treatment of inflammatory bowel disease: an 8-year retrospective study in a Canadian pediatric IBD center. Inflamm Bowel Dis. 2011 [Epub ahead of print].
    • (2011) Inflamm Bowel Dis.
    • Willot, S.1    Noble, A.2    Deslandres, C.3
  • 32
    • 43049108076 scopus 로고    scopus 로고
    • Methotrexate as single therapy in Crohn's disease: Is its long-term efficacy limited?
    • Charpignon C, Beau P,. Methotrexate as single therapy in Crohn's disease: is its long-term efficacy limited? Gastroenterol Clin Biol. 2008; 32: 153-157.
    • (2008) Gastroenterol Clin Biol. , vol.32 , pp. 153-157
    • Charpignon, C.1    Beau, P.2
  • 33
    • 34249873237 scopus 로고    scopus 로고
    • The risk of cancer in patients with Crohn's disease
    • von Roon A, Reese G, Teare J, et al. The risk of cancer in patients with Crohn's disease. Dis Colon Rectum. 2007; 50: 839-855.
    • (2007) Dis Colon Rectum. , vol.50 , pp. 839-855
    • Von Roon, A.1    Reese, G.2    Teare, J.3
  • 34
    • 70349314937 scopus 로고    scopus 로고
    • Inflammatory bowel disease and lymphoproliferative disorders: The dust is starting to settle
    • Sokol H, Beaugerie L,. Inflammatory bowel disease and lymphoproliferative disorders: the dust is starting to settle. Gut. 2009; 58: 1427-1436.
    • (2009) Gut. , vol.58 , pp. 1427-1436
    • Sokol, H.1    Beaugerie, L.2
  • 35
    • 56549085510 scopus 로고    scopus 로고
    • Hepatosplenic T cell lymphoma in inflammatory bowel disease
    • Shale M, Kanfer E, Panaccione R, et al. Hepatosplenic T cell lymphoma in inflammatory bowel disease. Gut. 2008; 57: 1639-1641.
    • (2008) Gut. , vol.57 , pp. 1639-1641
    • Shale, M.1    Kanfer, E.2    Panaccione, R.3
  • 36
    • 0031596842 scopus 로고    scopus 로고
    • Methotrexate in patients with Crohn's disease after 6-mercaptopurine
    • Mack DR, Young R, Kaufman SS, et al. Methotrexate in patients with Crohn's disease after 6-mercaptopurine. J Pediatr. 1998; 132: 830-835.
    • (1998) J Pediatr. , vol.132 , pp. 830-835
    • MacK, D.R.1    Young, R.2    Kaufman, S.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.