Osseointegration of biochemically modified implants in an osteoporosis rodent model

European Cells and Materials

Volumn 25, Issue , 2012, Pages 326-340

  Stadlinger, Bernd ^a   Korn, P ^b   Todtmann N ^b   Eckelt, U ^b   Range, U ^b   Burki A ^c   Ferguson, S J ^d   Kramer, I ^e   Kautz, A ^f   Schnabelrauch, M ^f   Kneissel, M ^e   Schlottig, F ^g  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c UNIVERSITY OF BERN   (Switzerland)

^d ETH ZURICH   (Switzerland)

^e NOVARTIS PHARMA AG   (Switzerland)

^f BIOMATERIALS DEPARTMENT   (Germany)

^g Thommen Medical AG   (Switzerland)

Author keywords

Animal model; Biomechanics; Histomorphometry; Implant; Osseointegration; Osteoporosis; Surface coating

Indexed keywords

ESTROGEN; SIMVASTATIN; ZOLEDRONIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOMECHANICS; BONE DENSITY; BONE IMPLANT; BONE MASS; BONE MINERALIZATION; BONE REGENERATION; CHEMICAL MODIFICATION; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FRACTURE HEALING; MICRO-COMPUTED TOMOGRAPHY; MORPHOMETRICS; NONHUMAN; OSSIFICATION; OSTEOPOROSIS; RAT;

EID: 84881228314     PISSN: 14732262     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Abtahi J, Tengvall P, Aspenberg P (2010) Bisphosphonate coating might improve fixation of dental implants in the maxilla: a pilot study. Int J Oral Maxillofac Surg 39: 673-677.
2. Abtahi J, Tengvall P, Aspenberg P (2012) A bisphosphonate-coating improves the fixation of metal implants in human bone. A randomized trial of dental implants. Bone 50: 1148-1151.
3. Alsaadi G, Quirynen M, Komarek A, van Steenberghe D (2007) Impact of local and systemic factors on the incidence of oral implant failures, up to abutment connection. J Clin Periodontol 34: 610-617.
4. Andersson T, Agholme F, Aspenberg P, Tengvall P (2010) Surface immobilized zoledronate improves screw fixation in rat bone: a new method for the coating of metal implants. Journal of materials science. Mater Med 21: 3029-3037.
5. Ayukawa Y, Ogino Y, Moriyama Y, Atsuta I, Jinno Y, Kihara M, Tsukiyama Y, Koyano K (2010) Simvastatin enhances bone formation around titanium implants in rat tibiae. J Oral Rehabil 37: 123-130.
6. Baron R, Kneissel M (2013) WNT signaling in bone homeostasis and disease: from human mutations to treatments. Nat Med 19: 179-192.
7. Becker D, Geissler U, Hempel U, Bierbaum S, Scharnweber D, Worch H, Wenzel KW (2002) Proliferation and differentiation of rat calvarial osteoblasts on type I collagen-coated titanium alloy. J Biomed Mater Res 59: 516-527.
8. Bernhardt R, van den Dolder J, Bierbaum S, Beutner R, Scharnweber D, Jansen J, Beckmann F, Worch H (2005) Osteoconductive modifications of Ti-implants in a goat defect model: characterization of bone growth with SR muCT and histology. Biomaterials 26: 3009-3019.
9. Bernhardt R, Kuhlisch E, Schulz MC, Eckelt U, Stadlinger B (2012) Comparison of bone-implant contact and bone-implant volume between 2D-histological sections and 3D-SRmicroCT slices. Eur Cells Mater 23: 237-248.
10. Bierbaum S, Douglas T, Hanke T, Scharnweber D, Tippelt S, Monsees TK, Funk RH, Worch H (2006) Collageneous matrix coatings on titanium implants modified with decorin and chondroitin sulfate: characterization and influence on osteoblastic cells. J Biomed Mater Res A 77: 551-562.
11. Bornstein MM, Cionca N, Mombelli A (2009) Systemic conditions and treatments as risks for implant therapy. Int J Oral Maxillofac Implants 24 Suppl: 12-27.
12. Branemark PI, Hansson BO, Adell R, Breine U, Lindstrom J, Hallen O, Ohman A (1977) Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period. Scand J Plast Reconstr Surg Suppl 16: 1-132.
13. Buser D, Broggini N, Wieland M, Schenk RK, Denzer AJ, Cochran DL, Hoffmann B, Lussi A, Steinemann SG (2004) Enhanced bone apposition to a chemically modified SLA titanium surface. J Dent Res 83: 529-533.
14. Butz F, Aita H, Wang CJ, Ogawa T (2006) Harder and stiffer bone osseointegrated to roughened titanium. J Dent Res 85: 560-565.
15. Calvo-Guirado JL, Ortiz-Ruiz AJ, Negri B, Lopez-Mari L, Rodriguez-Barba C, Schlottig F (2010) Histological and histomorphometric evaluation of immediate implant placement on a dog model with a new implant surface treatment. Clin Oral Implants Res 21: 308-315.
16. Davies JE (1998) Mechanisms of endosseous integration. Int J Prosthodont 11:391-401.
17. Donath K, Breuner G (1982) A method for the study of undecalcified bones and teeth with attached soft tissues. The Sage-Schliff (sawing and grinding) technique. J Oral Pathol 11: 318-326.
18. Douglas T, Heinemann S, Mietrach C, Hempel U, Bierbaum S, Scharnweber D, Worch H (2007) Interactions of collagen types I and II with chondroitin sulfates A-C and their effect on osteoblast adhesion. Biomacromolecules 8: 1085-1092.
19. Du Z, Chen J, Yan F, Xiao Y (2009) Effects of Simvastatin on bone healing around titanium implants in osteoporotic rats. Clin Oral Implants Res 20: 145-150.
20. Dvorak G, Arnhart C, Heuberer S, Huber CD, Watzek G, Gruber R (2011) Peri-implantitis and late implant failures in postmenopausal women: a cross-sectional study. J Clin Periodontol 38: 950-955.
21. Esposito M, Hirsch JM, Lekholm U, Thomsen P (1998) Biological factors contributing to failures of osseointegrated oral implants. (II). Etiopathogenesis. Eur J Oral Sci 106: 721-764.
22. Ferguson SJ, Broggini N, Wieland M, de Wild M, Rupp F, Geis-Gerstorfer J, Cochran DL, Buser D (2006) Biomechanical evaluation of the interfacial strength of a chemically modified sandblasted and acid-etched titanium surface. J Biomedi Mater Res A,78: 291-297.
23. Gallez B, Osinski P, Adline J, Dumont P (1988) Rapid and precise micro-methods for quantitating active components in commercial bone scintigraphy kits-II. Diphosphonates. Int J Rad Appl Instrum A 39: 1011-1014.
24. Gao Y, Luo E, Hu J, Xue J, Zhu S, Li J (2009) Effect of combined local treatment with zoledronic acid and basic fibroblast growth factor on implant fixation in ovariectomized rats. Bone 44: 225-232.
25. Holahan CM, Koka S, Kennel KA, Weaver AL, Assad DA, Regennitter FJ, Kademani D (2008) Effect of osteoporotic status on the survival of titanium dental implants. Int J Oral Maxillofac Implants 23: 905-910.
26. Jee WS, Yao W (2001) Overview: animal models of osteopenia and osteoporosis. J Musculoskel Neuronal Interact 1: 193-207.
27. Jeffcoat M (2005) The association between osteoporosis and oral bone loss. J Periodontol 76: 2125-2132.
28. Junker R, Dimakis A, Thoneick M, Jansen JA (2009) Effects of implant surface coatings and composition on bone integration: a systematic review. Clin Oral Implants Res 20(Suppl. 4): 185-206.
29. Li EC, Davis LE (2003) Zoledronic acid: a new parenteral bisphosphonate. Clin Ther 25: 2669-2708.
30. Martin W, Lewis E, Nicol A (2009) Local risk factors for implant therapy. Int J Oral Maxillofac Implants 24(Suppl): 28-38.
31. Marx RE (2003) Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg 61: 1115-1117.
32. Moriyama Y, Ayukawa Y, Ogino Y, Atsuta I, Todo M, Takao Y, Koyano K (2010) Local application of fluvastatin improves peri-implant bone quantity and mechanical properties: a rodent study. Acta Biomater 6: 1610-1618.
33. Moy PK, Medina D, Shetty V, Aghaloo TL (2005) Dental implant failure rates and associated risk factors. Int J Oral Maxillofac Implants 20: 569-577.
34. Mundy G, Garrett R, Harris S, Chan J, Chen D, Rossini G, Boyce B, Zhao M, Gutierrez G (1999) Stimulation of bone formation in vitro and in rodents by statins. Science 286: 1946-1949.
35. Oxlund H, Dalstra M, Andreassen TT (2001) Statin given perorally to adult rats increases cancellous bone mass and compressive strength. Calcif Tiss Int 69: 299-304.
36. Pei W, Bellows CG, Elsubeihi ES, Heersche JN (2003) Effect of ovariectomy on dexamethasone-and progesterone-dependent osteoprogenitors in vertebral and femoral rat bone cell populations. Bone 33:822-830.
37. Peter B, Gauthier O, Laib S, Bujoli B, Guicheux J, Janvier P, van Lenthe GH, Muller R, Zambelli PY, Bouler JM, Pioletti DP (2006) Local delivery of bisphosphonate from coated orthopedic implants increases implants mechanical stability in osteoporotic rats. J Biomed Mater Rest A 76: 133-143.
38. Rachner TD, Khosla S, Hofbauer LC (2011) Osteoporosis: now and the future. Lancet 377: 1276-1287.
39. Rammelt S, Illert T, Bierbaum S, Scharnweber D, Zwipp H, Schneiders W (2006) Coating of titanium implants with collagen, RGD peptide and chondroitin sulfate. Biomaterials 27: 5561-5571.
40. Rammelt S, Heck C, Bernhardt R, Bierbaum S, Scharnweber D, Goebbels J, Ziegler J, Biewener A, Zwipp H (2007) In vivo effects of coating loaded and unloaded Ti implants with collagen, chondroitin sulfate, and hydroxyapatite in the sheep tibia. J Orthop Res 25: 1052-1061.
41. Rebaudi A, Koller B, Laib A, Trisi P (2004) Microcomputed tomographic analysis of the peri-implant bone. Int J Periodontics Restorative Dent 24: 316-325.
42. Roberts WE, Simmons KE, Garetto LP, DeCastro RA (1992) Bone physiology and metabolism in dental implantology: risk factors for osteoporosis and other metabolic bone diseases. Implant Dent 1: 11-21.
43. Ruggiero SL, Dodson TB, Assael LA, Landesberg R, Marx RE, Mehrotra B (2009) American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws-2009 update. J Oral Maxillofac Surg 67: 2-12.
44. Schindeler A, McDonald MM, Bokko P, Little DG (2008) Bone remodeling during fracture repair: The cellular picture. Semin Cell Develop Biol 19: 459-466.
45. Sennerby L, Meredith N (2008) Implant stability measurements using resonance frequency analysis: biological and biomechanical aspects and clinical implications. Periodontol 2000 47: 51-66.
46. Skoglund B, Forslund C, Aspenberg P (2002) Simvastatin improves fracture healing in mice. J Bone Miner Res 17: 2004-2008.
47. Stadlinger B, Pilling E, Mai R, Bierbaum S, Berhardt R, Scharnweber D, Eckelt U (2008) Effect of biological implant surface coatings on bone formation, applying collagen, proteoglycans, glycosaminoglycans and growth factors. J Mater Sci Mater Med 19: 1043-1049.
48. Stadlinger B, Bierbaum S, Grimmer S, Schulz MC, Kuhlisch E, Scharnweber D, Eckelt U, Mai R (2009a) Increased bone formation around coated implants. J Clin Periodontol 36: 698-704.
49. Stadlinger B, Lode AT, Eckelt U, Range U, Schlottig F, Hefti T, Mai R (2009b) Surface-conditioned dental implants: an animal study on bone formation. J Clin Periodontol 36: 82-891.
50. Stadlinger B, Hintze V, Bierbaum S, Moller S, Schulz MC, Mai R, Kuhlisch E, Heinemann S, Scharnweber D, Schnabelrauch M, Eckelt U (2011) Biological functionalization of dental implants with collagen and glycosaminoglycans-A comparative study. J Biomed Mater Res B, in press.
51. Stadlinger B, Ferguson SJ, Eckelt U, Mai R, Lode AT, Loukota R, Schlottig F (2012) Biomechanical evaluation of a titanium implant surface conditioned by a hydroxide ion solution. Br J Oral Maxillofac Surg 50: 74-79.
52. Thompson DD, Simmons HA, Pirie CM, Ke HZ (1995) FDA Guidelines and animal models for osteoporosis. Bone 17: 125S-133S.
53. Thylin MR, McConnell JC, Schmid MJ, Reckling RR, Ojha J, Bhattacharyya I, Marx DB, Reinhardt RA (2002) Effects of simvastatin gels on murine calvarial bone. J Periodontol 73: 1141-1148.
54. Tugulu S, Lowe K, Scharnweber D, Schlottig F (2010) Preparation of superhydrophilic microrough titanium implant surfaces by alkali treatment. J Mater Sci Mater Med 21: 2751-2763.
55. Wactawski-Wende J, Hausmann E, Hovey K, Trevisan M, Grossi S, Genco RJ (2005) The association between osteoporosis and alveolar crestal height in postmenopausal women. J Periodontol 76: 2116-2124.
56. Wermelin K, Tengvall P, Aspenberg P (2007) Surface-bound bisphosphonates enhance screw fixation in rats - increasing effect up to 8 weeks after insertion. Acta Orthopaed 78: 385-392.
57. Wermelin K, Aspenberg P, Linderback P, Tengvall P (2008a) Bisphosphonate coating on titanium screws increases mechanical fixation in rat tibia after two weeks. J Biomed Mater Res A 86: 220-227.
58. Wermelin K, Suska F, Tengvall P, Thomsen P, Aspenberg P (2008b) Stainless steel screws coated with bisphosphonates gave stronger fixation and more surrounding bone. Histomorphometry in rats. Bone 42: 365-371.