A bisphosphonate-coating improves the fixation of metal implants in human bone. A randomized trial of dental implants

Bone

Volumn 50, Issue 5, 2012, Pages 1148-1151

  Abtahi, Jahan ^a,b   Tengvall, Pentti ^c   Aspenberg, Per ^b  

^a LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^b LINKÖPING UNIVERSITY   (Sweden)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Bone healing; Dental implant; Drug delivery; Mechanical test; Osseointegration bisphosphonates

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; FIBRINOGEN; IBANDRONIC ACID; PAMIDRONIC ACID; TITANIUM;

ARTICLE; BONE SCREW; CLINICAL ARTICLE; COMPOSITE MATERIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG RELEASE; EQUIPMENT DESIGN; FOLLOW UP; FRACTURE FIXATION; FREQUENCY ANALYSIS; HUMAN; MATERIAL COATING; MAXILLOFACIAL SURGERY; OSTEOLYSIS; PROSTHESIS FIXATION; RADIOFREQUENCY; SURFACE PROPERTY; TOOTH IMPLANTATION; TOOTH RADIOGRAPHY;

AGED; COATED MATERIALS, BIOCOMPATIBLE; DENTAL IMPLANTS; DENTAL PROSTHESIS RETENTION; DIPHOSPHONATES; FEMALE; HUMANS; MALE; MAXILLA; METALS;

EID: 84859308200     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2012.02.001     Document Type: Article

References (18)

1. Susin C., Qahash M., Polimeni G., Lu P.H., Prasad H.S., Rohrer M.D., et al. Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein-7 (rhBMP-7/rhOP-1): histological observations. J Clin Periodontol 2010, 37:574-581.
2. Tengvall P., Skoglund B., Askendal A., Aspenberg P. Surface immobilized bisphosphonate improves stainless-steel screw fixation in rats. Biomaterials 2004, 25:2133-2138.
3. Wermelin K., Suska F., Tengvall P., Thomsen P., Aspenberg P. Stainless steel screws coated with bisphosphonates gave stronger fixation and more surrounding bone. Histomorphometry in rats. Bone 2008, 42:365-371.
4. Bobyn J.D., McKenzie K., Karabasz D., Krygier J.J., Tanzer M. Locally delivered bisphosphonate for enhancement of bone formation and implant fixation. J Bone Joint Surg Am 2009, 91(Suppl 6):23-31.
5. Sennerby L., Meredith N. Implant stability measurements using resonance frequency analysis: biological and biomechanical aspects and clinical implications. Periodontol 2000 2000, 47(2008):51-66.
6. Wermelin K., Aspenberg P., Linderback P., Tengvall P. Bisphosphonate coating on titanium screws increases mechanical fixation in rat tibia after two weeks. J Biomed Mater Res A 2008, 86:220-227.
7. Wermelin K., Tengvall P., Aspenberg P. Surface-bound bisphosphonates enhance screw fixation in rats-increasing effect up to 8 weeks after insertion. Acta Orthop 2007, 78:385-392.
8. Cawood J.I., Howell R.A. A classification of the edentulous jaws. Int J Oral Maxillofac Surg 1988, 17:232-236.
9. J. Abtahi, P. Tengvall, P. Aspenberg. Bisphosphonate coating might improve fixation of dental implants in the maxilla: a pilot study. Int J Oral Maxillofac Surg; 39673-7.
10. Schatzle M., Mannchen R., Balbach U., Hammerle C.H., Toutenburg H., Jung R.E. Stability change of chemically modified sandblasted/acid-etched titanium palatal implants. A randomized-controlled clinical trial. Clin Oral Implants Res 2009, 20:489-495.
11. Andersson T., Agholme F., Aspenberg P., Tengvall P. Surface immobilized zoledronate improves screw fixation in rat bone: a new method for the coating of metal implants. J Mater Sci Mater Med 2010, 21:3029-3037.
12. Agholme F., Andersson T., Tengvall P., Aspenberg P. Local bisphosphonate release versus hydroxyapatite coating for stainless steel screw fixation in rat tibiae. J Mater Sci Mater Med 2011, [Epub ahead of print].
13. Hilding M., Aspenberg P. Postoperative clodronate decreases prosthetic migration: 4-year follow-up of a randomized radiostereometric study of 50 total knee patients. Acta Orthop 2006, 77:912-916.
14. Friedl G., Radl R., Stihsen C., Rehak P., Aigner R., Windhager R. The effect of a single infusion of zoledronic acid on early implant migration in total hip arthroplasty. A randomized, double-blind, controlled trial. J Bone Joint Surg Am 2009, 91:274-281.
15. Schilcher J., Michaelsson K., Aspenberg P. Bisphosphonate use and atypical fractures of the femoral shaft. N Engl J Med 2011, 364:1728-1737.
16. Russell R.G., Watts N.B., Ebetino F.H., Rogers M.J. Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy. Osteoporos Int 2008, 19:733-759.
17. McKenzie K., Dennis Bobyn J., Roberts J., Karabasz D., Tanzer M. Bisphosphonate remains highly localized after elution from porous implants. Clin Orthop Relat Res 2011, 469:514-522.
18. Dodson T.B., Raje N.S., Caruso P.A., Rosenberg A.E. Case records of the Massachusetts General Hospital. Case 9-2008. A 65-year-old woman with a nonhealing ulcer of the jaw. N Engl J Med 2008, 358:1283-1291.