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Volumn 50, Issue 2, 2013, Pages 161-171

Silymarin loaded liposomes for hepatic targeting: In vitro evaluation and HepG2 drug uptake

Author keywords

Hepatic targeting; HepG2; Silymarin; Targeting liposomes; Sitosterol D glucoside

Indexed keywords

4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; BETA DEXTRO GLUCOSIDE; CHOLESTEROL; GLUCOSIDE; LIPOSOME; PHOSPHATIDYLCHOLINE; PLASMA PROTEIN; POLYSORBATE 80; SILYMARIN; SITOSTEROL; UNCLASSIFIED DRUG;

EID: 84881181698     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.06.012     Document Type: Article
Times cited : (70)

References (58)
  • 1
    • 51049092308 scopus 로고    scopus 로고
    • Factors affecting the clearance and biodistribution of polymeric nanoparticles
    • Alexis, F., Pridgen, E., Molnar, L.K., Farokhzad, O.C., 2008. Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol. Pharm. 5, 505-515.
    • (2008) Mol. Pharm. , vol.5 , pp. 505-515
    • Alexis, F.1    Pridgen, E.2    Molnar, L.K.3    Farokhzad, O.C.4
  • 2
    • 0024551243 scopus 로고
    • Liposomes with prolonged circulation times: Factors affecting uptake by reticuloendothelial and other tissues
    • DOI 10.1016/0005-2736(89)90078-3
    • Allen, T.M., Hansen, C., Rutledge, J., 1989. Liposomes with prolonged circulation times: factors affecting uptake by reticuloendothelial and other tissues. Biochim. Biophys. Acta 981, 27-35. (Pubitemid 19127766)
    • (1989) Biochimica et Biophysica Acta - Biomembranes , vol.981 , Issue.1 , pp. 27-35
    • Allen, T.M.1    Hansen, C.2    Rutledge, J.3
  • 3
    • 33745044984 scopus 로고    scopus 로고
    • In vitro hemolysis: Guidance for the pharmaceutical scientist
    • DOI 10.1002/jps.20627
    • Amin, K., Dannenfelser, R.-M., 2006. In vitro hemolysis: guidance for the pharmaceutical scientist. J. Pharm. Sci. 95, 1173-1176. (Pubitemid 43874434)
    • (2006) Journal of Pharmaceutical Sciences , vol.95 , Issue.6 , pp. 1173-1176
    • Amin, K.1    Dannenfelser, R.-M.2
  • 4
    • 0034578764 scopus 로고    scopus 로고
    • Kinetics of surfactant-induced release from liposomes: A time-dependent permeability model
    • Annesini, M.C., Memoli, A., Petralito, S., 2000. Kinetics of surfactant-induced release from liposomes: a time-dependent permeability model. J. Membrane Sci. 180, 121-131.
    • (2000) J. Membrane Sci. , vol.180 , pp. 121-131
    • Annesini, M.C.1    Memoli, A.2    Petralito, S.3
  • 5
    • 0037427945 scopus 로고    scopus 로고
    • The influence of repeated injections on pharmacokinetics and biodistribution of different types of sterically stabilized immunoliposomes
    • DOI 10.1016/S0005-2736(02)00655-7, PII S0005273602006557
    • Bendas, G., Rothe, U., Scherphof, G.L., Kamps, J.A.A.M., 2003. The influence of repeated injections on pharmacokinetics and biodistribution of different types of sterically stabilized immunoliposomes. Biochim. Biophys. Acta 1609, 63-70. (Pubitemid 36044066)
    • (2003) Biochimica et Biophysica Acta - Biomembranes , vol.1609 , Issue.1 , pp. 63-70
    • Bendas, G.1    Rothe, U.2    Scherphof, G.L.3    Kamps, J.A.A.M.4
  • 6
    • 76549109113 scopus 로고    scopus 로고
    • A novel USP apparatus 4 based release testing method for dispersed systems
    • Bhardwaj, U., Burgess, D.J., 2010. A novel USP apparatus 4 based release testing method for dispersed systems. Int. J. Pharm. 388, 287-294.
    • (2010) Int. J. Pharm. , vol.388 , pp. 287-294
    • Bhardwaj, U.1    Burgess, D.J.2
  • 9
    • 0026643016 scopus 로고
    • Lipid peroxidationand irreversible damage in the rat hepatocyte model
    • Carini, R., Comogoliom, A., Albano, A., Poli, G., 1992. Lipid peroxidationand irreversible damage in the rat hepatocyte model. Biochem. Pharmacol. 43, 2111-2115.
    • (1992) Biochem. Pharmacol. , vol.43 , pp. 2111-2115
    • Carini, R.1    Comogoliom, A.2    Albano, A.3    Poli, G.4
  • 10
    • 84872436512 scopus 로고    scopus 로고
    • Influence of lipid composition on the phase transition temperature of liposomes composed of both DPPC and HSPC
    • Chen, J., Cheng, D., Li, J., Wang, Y., Guo, J.-X., Chen, Z.-P., Cai, B.-C., Yang, T., 2013. Influence of lipid composition on the phase transition temperature of liposomes composed of both DPPC and HSPC. Drug Dev. Ind. Pharm. 39, 197-204.
    • (2013) Drug Dev. Ind. Pharm. , vol.39 , pp. 197-204
    • Chen, J.1    Cheng, D.2    Li, J.3    Wang, Y.4    Guo, J.-X.5    Chen, Z.-P.6    Cai, B.-C.7    Yang, T.8
  • 11
    • 50249163680 scopus 로고    scopus 로고
    • Development and evaluation of novel itraconazole-loaded intravenous nanoparticles
    • Chen, W., Gu, B., Wang, H., Pan, J., Lu, W., Hou, H., 2008. Development and evaluation of novel itraconazole-loaded intravenous nanoparticles. Int. J. Pharm. 362, 133-140.
    • (2008) Int. J. Pharm. , vol.362 , pp. 133-140
    • Chen, W.1    Gu, B.2    Wang, H.3    Pan, J.4    Lu, W.5    Hou, H.6
  • 12
    • 0028829081 scopus 로고
    • Scavenging effect of silipide, a new silybin-phospholipid complex on ethanol-derived free radicals
    • Comoglio, A., Tomasi, A., Malandrino, S., Poli, G., Albano, E., 1995. Scavenging effect of silipide, a new silybin-phospholipid complex on ethanol-derived free radicals. Biochem. Pharm. 50, 1313-1316.
    • (1995) Biochem. Pharm. , vol.50 , pp. 1313-1316
    • Comoglio, A.1    Tomasi, A.2    Malandrino, S.3    Poli, G.4    Albano, E.5
  • 13
    • 0021914240 scopus 로고
    • Receptor-mediated uptake of asialoganglioside liposomes: Sub-cellular distrubition of the liposomal marker in isolated liver cell types
    • Dasgupta, P., Bachhawat, B.K., 1985. Receptor-mediated uptake of asialoganglioside liposomes: sub-cellular distribution of the liposomal marker in isolated liver cell types. Biochem. Int. 10, 327-336. (Pubitemid 15100213)
    • (1985) Biochemistry International , vol.10 , Issue.3 , pp. 327-336
    • Dasgupta, P.1    Bachhawat, B.K.2
  • 14
    • 35548971992 scopus 로고    scopus 로고
    • Silymarin: A review of pharmacological aspects and bioavailability enhancement approaches
    • Dixit, N., Baboota, S., Kohli, K., Ahmad, S., Ali, J., 2007. Silymarin: a review of pharmacological aspects and bioavailability enhancement approaches. Indian J. Pharmacol. 39, 171-179.
    • (2007) Indian J. Pharmacol. , vol.39 , pp. 171-179
    • Dixit, N.1    Baboota, S.2    Kohli, K.3    Ahmad, S.4    Ali, J.5
  • 15
    • 33745921477 scopus 로고    scopus 로고
    • Evaluation of hybrid liposomes-encapsulated silymarin regarding physical stability and in vivo performance
    • DOI 10.1016/j.ijpharm.2006.04.023, PII S0378517306003760
    • El-Samaligy, M.S., Afifi, N.N., Mahmoud, E.A., 2006a. Evaluation of hybrid liposomes encapsulated silymarin regarding physical stability and in vivo performance. Int. J. Pharm. 319, 121-129. (Pubitemid 44051811)
    • (2006) International Journal of Pharmaceutics , vol.319 , Issue.1-2 , pp. 121-129
    • El-Samaligy, M.S.1    Afifi, N.N.2    Mahmoud, E.A.3
  • 16
    • 30744437915 scopus 로고    scopus 로고
    • Increasing bioavailability of silymarin using a buccal liposomal delivery system: Preparation and experimental design investigation
    • DOI 10.1016/j.ijpharm.2005.11.006, PII S0378517305007398
    • El-Samaligy, M.S., Afifi, N.N., Mahmoud, E.A., 2006b. Increasing bioavailability of silymarin using a buccal liposomal delivery system: Preparation and experimental design investigation. Int. J. Pharm. 308, 140-148. (Pubitemid 43097245)
    • (2006) International Journal of Pharmaceutics , vol.308 , Issue.1-2 , pp. 140-148
    • El-Samaligy, M.S.1    Afifi, N.N.2    Mahmoud, E.A.3
  • 18
    • 18244374809 scopus 로고    scopus 로고
    • Silybin and its bioavailable phospholipid complex (IdB 1016) potentiate in vitro and in vivo the activity of cisplatin
    • DOI 10.1016/S0024-3205(01)01511-9, PII S0024320501015119
    • Giacomelli, S., Gallo, D., Apollonio, P., Ferlini, C., Distefano, M., Morazzoni, P., Riva, A., Bombardelli, E., Mancuso, S., Scambia, G., 2002. Silybin and its bioavailable phospholipid complex (IdB 1016) potentiate in vitro and in vivo the activity of cisplatin. Life Sci. 70, 1447-1459. (Pubitemid 34159100)
    • (2002) Life Sciences , vol.70 , Issue.12 , pp. 1447-1459
    • Giacomelli, S.1    Gallo, D.2    Apollonio, P.3    Ferlini, C.4    Distefano, M.5    Morazzoni, P.6    Riva, A.7    Bombardelli, E.8    Mancuso, S.9    Scambia, G.10
  • 21
    • 28444454536 scopus 로고    scopus 로고
    • Doxorubicin encapsulated thermosensitive liposome modified with poly (N-isopropylacrylamide-co-acrylamide): Drug release behavior and stability in presence of serum
    • Hee, H.D., Byung, S.C., Ho, C.S., 2006. Doxorubicin encapsulated thermosensitive liposome modified with poly (N-isopropylacrylamide-co- acrylamide): drug release behavior and stability in presence of serum. Eur. J. Pharm. Biopharm. 62, 110-116.
    • (2006) Eur. J. Pharm. Biopharm. , vol.62 , pp. 110-116
    • Hee, H.D.1    Byung, S.C.2    Ho, C.S.3
  • 22
    • 0344893332 scopus 로고
    • Mechanism of sustained action medication
    • Higuchi, T., 1963. Mechanism of sustained action medication. J. Pharm. Sci. 52, 1145-1149.
    • (1963) J. Pharm. Sci. , vol.52 , pp. 1145-1149
    • Higuchi, T.1
  • 23
    • 0029896222 scopus 로고    scopus 로고
    • Development and pharmacokinetics of galactosylated poly-L-glutamic acid as a bisdegradable carrier for liver-specific drug delivery
    • DOI 10.1023/A:1016053128569
    • Hirabayashi, H., Nishikawa, M., Takakura, Y., Hashida, M., 1996. Development and pharmacokinetics of galactosylated poly-L-glutamic acid as a biodegradable carrier for liver-specific drug delivery. Pharm. Res. 13, 880-884. (Pubitemid 26227745)
    • (1996) Pharmaceutical Research , vol.13 , Issue.6 , pp. 880-884
    • Hirabayashi, H.1    Nishikawa, M.2    Takakura, Y.3    Hashida, M.4
  • 24
    • 72149099574 scopus 로고    scopus 로고
    • The feasibility of antihypertensive oligopeptides encapsulated in liposomes prepared with phytosterols-βsitosterol or stigmasterol
    • Hwang, J.-S., Tsai, Y.-L., Hsu, K.-C., 2010. The feasibility of antihypertensive oligopeptides encapsulated in liposomes prepared with phytosterols-βsitosterol or stigmasterol. Food Res. Int. 43, 133-139.
    • (2010) Food Res. Int. , vol.43 , pp. 133-139
    • Hwang, J.-S.1    Tsai, Y.-L.2    Hsu, K.-C.3
  • 25
    • 0034889026 scopus 로고    scopus 로고
    • Liver-targeted gene transfer into a human hepatoblastoma cell line and in vivo by sterylglucoside-containing cationic liposomes
    • DOI 10.1038/sj.gt.3301510
    • Hwang, S.H., Hayashi, K., Takayama, K., Maitani, Y., 2001. Liver-targeted gene transfer into a human hepatoblastoma cell line and in vivo by sterylglucoside containing cationic liposomes. Gene Ther. 8, 1276-1280. (Pubitemid 32780817)
    • (2001) Gene Therapy , vol.8 , Issue.16 , pp. 1276-1280
    • Hwang, S.H.1    Hayashi, K.2    Takayama, K.3    Maitani, Y.4
  • 26
    • 0026087036 scopus 로고
    • Specific uptake of asialofetuin-tacked liposomes encapsulating interferon-gamma by human hepatoma cells and its inhibitory effect on hepatitis B virus replication
    • Ishihara, H., Hayashi, Y., Hara, T., Aramaki, Y., Tsuchiya, S., Koike, K., 1991. Specific uptake of asialofetuin-tacked liposomes encapsulating interferon-gamma by human hepatoma cells and its inhibitory effect on hepatitis B virus replication. Biochem. Biophys. Res. Commun. 174, 839-845.
    • (1991) Biochem. Biophys. Res. Commun. , vol.174 , pp. 839-845
    • Ishihara, H.1    Hayashi, Y.2    Hara, T.3    Aramaki, Y.4    Tsuchiya, S.5    Koike, K.6
  • 27
    • 0034902276 scopus 로고    scopus 로고
    • Characterization, stability and in - Vivo distribution of asialofetuin glycopeptide incorporating DSPC/CHOL liposomes prepared by mild cholate incubation
    • Kallinteri, P., Liao, W.Y., Antimisiaris, S.G., Hwang, K.H., 2001. Characterization, stability and in-vivo distribution of asialofetuin glycopeptide incorporating DSPC/CHOL liposomes prepared by mild cholate incubation. J. Drug Target. 9, 155-168. (Pubitemid 32725452)
    • (2001) Journal of Drug Targeting , vol.9 , Issue.2 , pp. 155-168
    • Kallinteri, P.1    Liao, W.-Y.2    Antimisiaris, S.G.3    Hwang, K.H.J.4
  • 28
    • 0036598864 scopus 로고    scopus 로고
    • Liver targeting liposomes containing beta-sitosterol glucoside with regard to penetration-enhancing effect on HepG2 cells
    • DOI 10.1248/bpb.25.766
    • Kawano, K., Nakamura, K., Hayashi, K., Nagai, T., Takayama, K., Maitani, Y., 2002. Liver targeting liposomes containing beta-sitosterol glucoside with regard to penetration-enhancing effect on HepG2 cells. Biol. Pharm. Bull. 25, 766-770. (Pubitemid 40036713)
    • (2002) Biological and Pharmaceutical Bulletin , vol.25 , Issue.6 , pp. 766-770
    • Kawano, K.1    Nakamura, K.2    Hayashi, K.3    Nagai, T.4    Takayama, K.5    Maitani, Y.6
  • 29
    • 84855776494 scopus 로고    scopus 로고
    • In vivo antitumor effect of cromolyn in PEGylated liposomes for pancreatic cancer
    • Kim, C.-E., Lim, S.-K., Kim, J.-S., 2012. In vivo antitumor effect of cromolyn in PEGylated liposomes for pancreatic cancer. J. Control. Release 157, 190-195.
    • (2012) J. Control. Release , vol.157 , pp. 190-195
    • Kim, C.-E.1    Lim, S.-K.2    Kim, J.-S.3
  • 31
    • 51049104302 scopus 로고    scopus 로고
    • Pharmacokinetics and biodistribution of nanoparticles
    • Li, S.-D., Huang, L., 2008. Pharmacokinetics and biodistribution of nanoparticles. Mol. Pharm. 5, 496-504.
    • (2008) Mol. Pharm. , vol.5 , pp. 496-504
    • Li, S.-D.1    Huang, L.2
  • 32
    • 0032239998 scopus 로고    scopus 로고
    • A review of plants used in the treatment of liver disease: Part 1
    • Luper, S., 1998. A review of plants used in the treatment of liver diseases: part 1. Altern. Med. Rev. 3, 410-421. (Pubitemid 128709687)
    • (1998) Alternative Medicine Review , vol.3 , Issue.6 , pp. 410-421
    • Luper, S.1
  • 34
    • 0035839216 scopus 로고    scopus 로고
    • Efficiency of liposomes surface-modified with soybean-derived sterylglucoside as a liver targeting carrier in HepG2 cells
    • DOI 10.1016/S0168-3659(01)00411-4, PII S0168365901004114
    • Maitani, Y., Kawanoa, K., Yamadab, K., Nagai, T., Takayama, K., 2001. Efficiency of liposomes surface-modified with soybean-derived sterylglucoside as a liver targeting carrier in HepG2 cells. J. Control. Release 75, 381-389. (Pubitemid 32727267)
    • (2001) Journal of Controlled Release , vol.75 , Issue.3 , pp. 381-389
    • Maitani, Y.1    Kawano, K.2    Yamada, K.3    Nagai, T.4    Takayama, K.5
  • 35
    • 0032851735 scopus 로고    scopus 로고
    • Immunoliposomes for the targeted delivery of antitumor drugs
    • DOI 10.1016/S0169-409X(99)00043-5, PII S0169409X99000435
    • Mastrobattistaa, E., Koning, G.A., Storma, G., 1999. Immunoliposomes for the targeted delivery of antitumor drugs. Adv. Drug Deliv. Rev. 40, 103-127. (Pubitemid 29486607)
    • (1999) Advanced Drug Delivery Reviews , vol.40 , Issue.1-2 , pp. 103-127
    • Mastrobattista, E.1    Koning, G.A.2    Storm, G.3
  • 36
    • 0027506564 scopus 로고
    • Differential scanning calorimetric study of the effect of cholesterol on the thermotropic phase behavior of a homologous series of linear saturated phosphatidylcholines
    • DOI 10.1021/bi00053a016
    • McMullen, T.P.W., Lewis, R.N.A.H., McElhaney, R.N., 1993. Differential scanning calorimetric study of the effect of cholesterol on the thermotropic phase behavior of a homologous series of linear saturated phosphatidylcholines. Biochemistry 32, 516-522. (Pubitemid 23034888)
    • (1993) Biochemistry , vol.32 , Issue.2 , pp. 516-522
    • McMullen, T.P.W.1    Lewis, R.N.A.H.2    McElhaney, R.N.3
  • 37
    • 0027403986 scopus 로고
    • Surface modification of I.V. Injectable biodegradable nanoparticles with poloxamer polymers and poloxamine
    • Muller, H., Willis, K.M., 1993. Surface modification of i.v. injectable biodegradable nanoparticles with poloxamer polymers and poloxamine. Int. J. Pharm. 89, 25-31.
    • (1993) Int. J. Pharm. , vol.89 , pp. 25-31
    • Muller, H.1    Willis, K.M.2
  • 39
    • 0000823463 scopus 로고
    • Dynamics of lipids in membranes: Heterogeneity and the role of cholesterol
    • Oldfield, E., Chapman, D., 1972. Dynamics of lipids in membranes: heterogeneity and the role of cholesterol. FEBS Lett. 23, 285-297.
    • (1972) FEBS Lett. , vol.23 , pp. 285-297
    • Oldfield, E.1    Chapman, D.2
  • 40
    • 28844488494 scopus 로고    scopus 로고
    • Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
    • DOI 10.1016/j.ijpharm.2005.10.010, PII S037851730500668X
    • Owens III, D.E., Peppas, N.A., 2006. Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int. J. Pharm. 307, 93-102. (Pubitemid 41773257)
    • (2006) International Journal of Pharmaceutics , vol.307 , Issue.1 , pp. 93-102
    • Owens III, D.E.1    Peppas, N.A.2
  • 41
    • 0036555092 scopus 로고    scopus 로고
    • Tumor-directed targeting of liposomes
    • DOI 10.1023/A:1020190606757
    • Park, Y.S., 2002. Tumor-directed Targeting of Liposomes. Biosci. Rep. 22, 267-281. (Pubitemid 35222735)
    • (2002) Bioscience Reports , vol.22 , Issue.2 , pp. 267-281
    • Park, Y.S.1
  • 42
    • 25444513974 scopus 로고    scopus 로고
    • A nanoparticle-based model delivery system to guide the rational design of gene delivery to the liver. 2. In vitro and in vivo uptake results
    • DOI 10.1021/bc0501146
    • Popielarski, S.R., Hu-Lieskovan, S., French, S.W., Triche, T.J., Davis, M.E., 2005. A nanoparticle-based model delivery system to guide the rational design of gene delivery to the liver. 2. In vitro and in vivo uptake results. Bioconjug. Chem. 16, 1071-1080. (Pubitemid 41368107)
    • (2005) Bioconjugate Chemistry , vol.16 , Issue.5 , pp. 1071-1080
    • Popielarski, S.R.1    Hu-Lieskovan, S.2    French, S.W.3    Triche, T.J.4    Davis, M.E.5
  • 43
    • 84861333908 scopus 로고    scopus 로고
    • Investigation on the stability of saquinavir loaded liposomes: Implication on stealth, release characteristics and cytotoxicity
    • Ramana, L.N., Sharma, S., Sethuraman, S., Ranga, U., Krishnan, U.M., 2012. Investigation on the stability of saquinavir loaded liposomes: implication on stealth, release characteristics and cytotoxicity. Int. J. Pharm. 431, 120-129.
    • (2012) Int. J. Pharm. , vol.431 , pp. 120-129
    • Ramana, L.N.1    Sharma, S.2    Sethuraman, S.3    Ranga, U.4    Krishnan, U.M.5
  • 44
    • 27644455955 scopus 로고    scopus 로고
    • Characteristics and biodistribution of soybean sterylglucoside and polyethylene glycol-modified cationic liposomes and their complexes with antisense oligodeoxynucleotide
    • DOI 10.1080/10717540590968215
    • Shi, J., Yan, W.W., Qi, X.R., Maitani, Y., Nagai, T., 2005. Characteristics and biodistribution of soybean sterylglucoside and polyethylene glycolmodified cationic liposomes and their complexes with antisense oligodeoxynucleotide. Drug Deliv. 12, 349-356. (Pubitemid 41572109)
    • (2005) Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents , vol.12 , Issue.6 , pp. 349-356
    • Shi, J.1    Yan, W.-W.2    Qi, X.-R.3    Maitani, Y.4    Nagai, T.5
  • 46
    • 1642362613 scopus 로고    scopus 로고
    • Targeted gene delivery into HepG2 cells using complexes containing DNA, cationized asialoorosomucoid and activated cationic liposomes
    • DOI 10.1016/S0168-3659(03)00360-2, PII S0168365903003602
    • Singh, M., Ariatti, M., 2003. Targeted gene delivery into HepG2 cells using complexes containing DNA, cationized asialoorosomucoid and activated cationic liposomes. J. Control. Release 92, 383-394. (Pubitemid 38366160)
    • (2003) Journal of Controlled Release , vol.92 , Issue.3 , pp. 383-394
    • Singh, M.1    Ariatti, M.2
  • 47
    • 0021066575 scopus 로고
    • Targeting of lactosylceramide-containing liposomes to hepatocytes in vivo
    • DOI 10.1016/0005-2736(83)90072-X
    • Spanjer, H.H., Scherphof, G.L., 1983. Targeting of lactosylceramide- containing liposomes to hepatocytes in vivo. Biochim. Biophys. Acta 734, 40-47. (Pubitemid 14236722)
    • (1983) Biochimica et Biophysica Acta - Biomembranes , vol.734 , Issue.1 , pp. 40-47
    • Spanjer, H.H.1    Scherphof, G.L.2
  • 48
    • 0006847485 scopus 로고
    • Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation
    • Szoka Jr., F., Papahadjopoulos, D., 1978. Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation. Proc. Natl. Acad. Sci. 75, 4194.
    • (1978) Proc. Natl. Acad. Sci. , vol.75 , pp. 4194
    • Szoka Jr., F.1    Papahadjopoulos, D.2
  • 50
    • 0027967151 scopus 로고
    • Enhanced delivery and antitumor activity of doxorubicin using long- circulating thermosensitive liposomes containing amphipathic polyethylene glycol in combination with local hyperthermia
    • DOI 10.1023/A:1018949218380
    • Unezaki, S., Maruyama, K., Takahashi, N., Koyama, M., Yuda, T., Suginaka, A., Iwatsuru, M., 1994. Enhanced delivery and antitumor activity of doxorubicin using long-circulating thermosensitive liposomes containing amphipathic polyethylene glycol in combination with local hyperthermia. Pharm. Res. 11, 1180-1185. (Pubitemid 24259860)
    • (1994) Pharmaceutical Research , vol.11 , Issue.8 , pp. 1180-1185
    • Unezaki, S.1    Maruyama, K.2    Takahashi, N.3    Koyama, M.4    Yuda, T.5    Suginaka, A.6    Iwatsuru, M.7
  • 52
    • 0021986662 scopus 로고
    • Inhibitory effect of the flavonoid silymarin on the erythrocyte hemolysis induced by phenylhydrazine
    • DOI 10.1016/0006-291X(85)90243-8
    • Valenzuela, A., Barría, T., Guerra, R., Garrido, A., 1985. Inhibitory effect of the flavonoid silymarin on the erythrocyte hemolysis induced by phenylhydrazine. Biochem. Biophys. Res. Commun. 126, 712-718. (Pubitemid 15130439)
    • (1985) Biochemical and Biophysical Research Communications , vol.126 , Issue.2 , pp. 712-718
    • Valenzuela, A.1    Barria, T.2    Guerra, R.3    Garrido, A.4
  • 54
    • 84862795685 scopus 로고    scopus 로고
    • A two-stage reverse dialysis in vitro dissolution testing method for passive targeted liposomes
    • Xu, X., Khan, M.A., Burgessa, D.J., 2012. A two-stage reverse dialysis in vitro dissolution testing method for passive targeted liposomes. Int. J. Pharm. 426, 211-218.
    • (2012) Int. J. Pharm. , vol.426 , pp. 211-218
    • Xu, X.1    Khan, M.A.2    Burgessa, D.J.3
  • 55
    • 33646000852 scopus 로고    scopus 로고
    • HPLC method for determination of SN-38 content and SN-38 entrapment efficiency in a novel liposome-based formulation, LE-SN38
    • Xuan, T., Zhang, J.A., Ahmad, I., 2006. HPLC method for determination of SN-38 content and SN-38 entrapment efficiency in a novel liposome-based formulation, LE-SN38. J. Pharm. Biomed. Anal. 41, 582-588.
    • (2006) J. Pharm. Biomed. Anal. , vol.41 , pp. 582-588
    • Xuan, T.1    Zhang, J.A.2    Ahmad, I.3
  • 56
    • 34248638766 scopus 로고    scopus 로고
    • Enhanced solubility and stability of PEGylated liposomal paclitaxel: In vitro and in vivo evaluation
    • DOI 10.1016/j.ijpharm.2007.02.011, PII S0378517307001639
    • Yang, T., Cui, F.D., Choi, M.K., Choc, J.W., Chungb, S.J., Shimb, C.K., Kimb, D.D., 2007. Enhanced solubility and stability of PEGylated liposomal paclitaxel. In vitro and in vivo evaluation. Int. J. Pharm. 338, 317-326. (Pubitemid 46777245)
    • (2007) International Journal of Pharmaceutics , vol.338 , Issue.1-2 , pp. 317-326
    • Yang, T.1    Cui, F.-D.2    Choi, M.-K.3    Cho, J.-W.4    Chung, S.-J.5    Shim, C.-K.6    Kim, D.-D.7
  • 57
    • 84862784904 scopus 로고    scopus 로고
    • The use of PEGylated liposomes to prolong the circulation lifetime of salvianolic acid B
    • Zhang, L., Han, L., Sun, X., Gao, D., Qin, J., Wang, J., 2012. The use of PEGylated liposomes to prolong the circulation lifetime of salvianolic acid B. Fitoterapia 83, 678-689.
    • (2012) Fitoterapia , vol.83 , pp. 678-689
    • Zhang, L.1    Han, L.2    Sun, X.3    Gao, D.4    Qin, J.5    Wang, J.6
  • 58
    • 33846547610 scopus 로고    scopus 로고
    • Mechanisms of co-modified liver-targeting liposomes as gene delivery carriers based on cellular uptake and antigens inhibition effect
    • DOI 10.1016/j.jconrel.2006.11.006, PII S016836590600616X
    • Zhang, Y., Qi, X.R., Gao, Y., Wei, L., Maitani, Y., Nagai, T., 2007. Mechanisms of comodified liver-targeting liposomes as gene delivery carriers based on cellular uptake and antigens inhibition effect. J. Control. Release 117, 281-290. (Pubitemid 46161882)
    • (2007) Journal of Controlled Release , vol.117 , Issue.2 , pp. 281-290
    • Zhang, Y.1    Rong Qi, X.2    Gao, Y.3    Wei, L.4    Maitani, Y.5    Nagai, T.6


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