Tumor necrosis factor receptor 1 associates with CD137 ligand and mediates its reverse signaling

FASEB Journal

Volumn 27, Issue 8, 2013, Pages 2957-2966

  Moh, Mei Chung ^a,b   Lorenzini, Paolo Alberto ^a,b   Gullo, Charles ^c,d   Schwarz, Herbert ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b Laboratory of Membrane Trafficking and Immunoregulation   (Singapore)

^c DUKE NUS MEDICAL SCHOOL   (Singapore)

^d Department of Microbiology ^*  (Singapore)

Author keywords

Monocytes; THP 1 cells; TNFR1

Indexed keywords

CD137 LIGAND; CD14 ANTIGEN; INTERLEUKIN 8; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; PROTEIN BINDING; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CELL ADHESION; CELL DEATH; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; CROSS LINKING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; CONFOCAL MICROSCOPY; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; MCF 7 CELL LINE; METABOLISM; MONOCYTE; TUMOR CELL LINE; WESTERN BLOTTING;

4-1BB LIGAND; ANTIGENS, CD14; APOPTOSIS; BLOTTING, WESTERN; CELL ADHESION; CELL LINE, TUMOR; CELL MEMBRANE; FLOW CYTOMETRY; HUMANS; INTERLEUKIN-8; MCF-7 CELLS; MICROSCOPY, CONFOCAL; MONOCYTES; PROTEIN BINDING; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84881176339     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.12-225250     Document Type: Article

References (38)

1. Goodwin, R. G., Din, W. S., vis-Smith, T., Anderson, D. M., Gimpel, S. D., Sato, T. A., Maliszewski, C. R., Brannan, C. I., Copeland, N. G., and Jenkins, N. A. (1993) Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. Eur. J. Immunol. 23, 2631-2641
2. Alderson, M. R., Smith, C. A., Tough, T. W., vis-Smith, T., Armitage, R. J., Falk, B., Roux, E., Baker, E., Sutherland, G. R., and Din, W. S. (1994) Molecular and biological characterization of human 4-1BB and its ligand. Eur. J. Immunol. 24, 2219-2227
3. Schwarz, H. (2005) Biological activities of reverse signal transduction through CD137 ligand. J. Leukoc.Biol. 77, 281-286
4. Schwarz, H., Valbracht, J., Tuckwell, J., von, K. J., and Lotz, M. (1995) ILA, the human 4-1BB homologue, is inducible in lymphoid and other cell lineages. Blood 85, 1043-1052
5. Shuford, W. W., Klussman, K., Tritchler, D. D., Loo, D. T., Chalupny, J., Siadak, A. W., Brown, T. J., Emswiler, J., Raecho, H., Larsen, C. P., Pearson, T. C., Ledbetter, J. A., Aruffo, A., and Mittler, R. S. (1997) 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J. Exp. Med. 186, 47-55
6. Wen, T., Bukczynski, J., and Watts, T. H. (2002) 4-1BB ligandmediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function. J. Immunol. 168, 4897-4906
7. Shao, Z., and Schwarz, H. (2011) CD137 ligand, a member of the tumor necrosis factor family, regulates immune responses via reverse signal transduction. J. Leukoc.Biol. 89, 21-29
8. Eissner, G., Kolch, W., and Scheurich, P. (2004) Ligands working as receptors: reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system. Cytokine Growth Factor Rev. 15, 353-366
9. Domonkos, A., Udvardy, A., Laszlo, L., Nagy, T., and Duda, E. (2001) Receptor-like properties of the 26 kDa transmembrane form of TNF. Eur. Cytokine Network 12, 411-419
10. Benslimane, N., Hassan, G. S., Yacoub, D., and Mourad, W. (2012) Requirement of transmembrane domain for CD154 association to lipid rafts and subsequent biological events. PloS One 7, e43070
11. Mitoma, H., Horiuchi, T., Tsukamoto, H., Tamimoto, Y., Kimoto, Y., Uchino, A., To, K., Harashima, S., Hatta, N., and Harada, M. (2008) Mechanisms for cytotoxic effects of antitumor necrosis factor agents on transmembrane tumor necrosis factor alpha-expressing cells: comparison among infliximab, etanercept, and adalimumab. Arthritis Rheum. 58, 1248-1257
12. Brenner, B., Koppenhoefer, U., Grassme, H., Kun, J., Lang, F., and Gulbins, E. (1997) Evidence for a novel function of the CD40 ligand as a signalling molecule in T-lymphocytes. FEBS Lett. 417, 301-306
13. Watts, A. D., Hunt, N. H., Wanigasekara, Y., Bloomfield, G., Wallach, D., Roufogalis, B. D., and Chaudhri, G. (1999) A casein kinase I motif present in the cytoplasmic domain of members of the tumour necrosis factor ligand family is implicated in "reverse signalling". EMBO J. 18, 2119-2126
14. Langstein, J., Michel, J., Fritsche, J., Kreutz, M., Andreesen, R., and Schwarz, H. (1998) CD137 (ILA/4-1BB), a member of the TNF receptor family, induces monocyte activation via bidirectional signaling. J. Immunol. 160, 2488-2494
15. Langstein, J., Michel, J., and Schwarz, H. (1999) CD137 induces proliferation and endomitosis in monocytes. Blood 94, 3161-3168
16. Langstein, J., and Schwarz, H. (1999) Identification of CD137 as a potent monocyte survival factor. J. Leukoc. Biol. 65, 829-833
17. Ju, S., Ge, Y., Qiu, H., Lu, B., Qiu, Y., Fu, J., Liu, G., Wang, Q., Hu, Y., Shu, Y., and Zhang, X. (2009) A novel approach to induce human DCs from monocytes by triggering 4-1BBL reverse signaling. Int. Immunol. 21, 1135-1144
18. Kwajah, M. M. S., and Schwarz, H. (2010) CD137 ligand signaling induces human monocyte to dendritic cell differentiation. Eur. J. Immunol. 40, 1938-1949
19. Drenkard, D., Becke, F. M., Langstein, J., Spruss, T., Kunz-Schughart, L. A., Tan, T. E., Lim, Y. C., and Schwarz, H. (2007) CD137 is expressed on blood vessel walls at sites of inflammation and enhances monocyte migratory activity. FASEB J. 21, 456-463
20. Gullo, C., Koh, L. K., Pang, W. L., Ho, K. T., Tan, S. H., and Schwarz, H. (2010) Inhibition of proliferation and induction of apoptosis in multiple myeloma cell lines by CD137 ligand signaling. PLoS One 5, e10845
21. Saito, K., Ohara, N., Hotokezaka, H., Fukumoto, S., Yuasa, K., Naito, M., Fujiwara, T., and Nakayama, K. (2004) Infectioninduced up-regulation of the costimulatory molecule 4-1BB in osteoblastic cells and its inhibitory effect on M-CSF/RANKLinduced in vitro osteoclastogenesis. J. Biol. Chem. 279, 13555-13563
22. Kim, J. D., Lee, E. A., Quang, N. N., Cho, H. R., and Kwon, B. (2011) Recombinant TAT-CD137 ligand cytoplasmic domain fusion protein induces the production of IL-6 and TNF-in peritoneal macrophages. Immune Network 11, 216-222
23. Won, E. Y., Cha, K., Byun, J. S., Kim, D. U., Shin, S., Ahn, B., Kim, Y. H., Rice, A. J., Walz, T., Kwon, B. S., and Cho, H. S. (2010) The structure of the trimer of human 4-1BB ligand is unique among members of the tumor necrosis factor superfamily. J. Biol. Chem. 285, 9202-9210
24. Kang, Y. J., Kim, S. O., Shimada, S., Otsuka, M., Seit-Nebi, A., Kwon, B. S., Watts, T. H., and Han, J. (2007) Cell surface 4-1BBL mediates sequential signaling pathways "downstream" of TLR and is required for sustained TNF production in macrophages. Nat. Immunol. 8, 601-609
25. Langstein, J., Becke, F. M., Sollner, L., Krause, G., Brockhoff, G., Kreutz, M., Andreesen, R., and Schwarz, H. (2000) Comparative analysis of CD137 and LPS effects on monocyte activation, survival, and proliferation. Biochem. Biophys. Res. Commun. 273, 117-122
26. Prive, G. G. (2007) Detergents for the stabilization and crystallization of membrane proteins. Methods 41, 388-397
27. Hsu, H., Huang, J., Shu, H. B., Baichwal, V., and Goeddel, D. V. (1996) TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4, 387-396
28. Hsu, H., Shu, H. B., Pan, M. G., and Goeddel, D. V. (1996) TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 84, 299-308
29. Jones, S. J., Ledgerwood, E. C., Prins, J. B., Galbraith, J., Johnson, D. R., Pober, J. S., and Bradley, J. R. (1999) TNF recruits TRADD to the plasma membrane but not the trans-Golgi network, the principal subcellular location of TNF-R1. J. Immunol. 162, 1042-1048
30. Baud, V., and Karin, M. (2001) Signal transduction by tumor necrosis factor and its relatives. Trends Cell. Biol. 11, 372-377
31. Boldin, M. P., Goncharov, T. M., Goltsev, Y. V., and Wallach, D. (1996) Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1-and TNF receptor-induced cell death. Cell 85, 803-815
32. Ho, W. T., Pang, W. L., Chong, S. M., Castella, A., Al-Salam, S., Tan, T. E., Moh, M. C., Koh, L. K., Gan, S. U., Cheng, C. K., and Schwarz, H. (2013) Expression of CD137 on Hodgkin and Reed-Sternberg cells inhibits T cell activation by eliminating CD137 ligand expression. Cancer Res 73, 652-661
33. Mosselmans, R., Hepburn, A., Dumont, J. E., Fiers, W., and Galand, P. (1988) Endocytic pathway of recombinant murine tumor necrosis factor in L-929 cells. J. Immunol. 141, 3096-3100
34. D'Alessio, A., Al-Lamki, R. S., Bradley, J. R., and Pober, J. S. (2005) Caveolae participate in tumor necrosis factor receptor 1 signaling and internalization in a human endothelial cell line. Am. J. Pathol. 166, 1273-1282
35. Schneider-Brachert, W., Tchikov, V., Neumeyer, J., Jakob, M., Winoto-Morbach, S., Held-Feindt, J., Heinrich, M., Merkel, O., Ehrenschwender, M., Adam, D., Mentlein, R., Kabelitz, D., and Schutze, S. (2004) Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles. Immunity 21, 415-428
36. Dri, P., Gasparini, C., Menegazzi, R., Cramer, R., Alberi, L., Presani, G., Garbisa, S., and Patriarca, P. (2000) TNF-induced shedding of TNF receptors in human polymorphonuclear leukocytes: role of the 55-kDa TNF receptor and involvement of a membrane-bound and non-matrix metalloproteinase. J. Immunol. 165, 2165-2172
37. Hawari, F. I., Rouhani, F. N., Cui, X., Yu, Z. X., Buckley, C., Kaler, M., and Levine, S. J. (2004) Release of full-length 55-kDa TNF receptor 1 in exosome-like vesicles: a mechanism for generation of soluble cytokine receptors. Proc. Natl. Acad. Sci. U. S. A. 101, 1297-1302
38. Aderka, D., Engelmann, H., Maor, Y., Brakebusch, C., and Wallach, D. (1992) Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors. J. Exp. Med. 175, 323-329