Transcriptional regulation of human MUC4 gene: Identification of a novel inhibitory element and its nuclear binding protein

Molecular Biology Reports

Volumn 40, Issue 8, 2013, Pages 4913-4920

  Zhang, Jing Jing ^a,b   Zhu, Yi ^a,b   Zhang, Xiong Fei ^c   Liang, Wen Biao ^d   Xie, Kun Ling ^e   Tao, Jin Qiu ^e   Peng, Yun Peng ^e   Xu, Ze Kuan ^a,b   Miao, Yi ^a,b  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b Jiangsu Province Academy of Clinical Medicine   (China)

^c WENZHOU MEDICAL UNIVERSITY   (China)

^d Jiangsu Province Hospital   (China)

^e NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Down regulation; Gene expression; MUC4; Transcription factors; Yin yang 1

Indexed keywords

LUCIFERASE; MUCIN 4; NUCLEOTIDE; TRANSCRIPTION FACTOR YY1;

ARTICLE; CANCER CELL CULTURE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GENE CONSTRUCT; GENE DELETION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC REGULATION; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MUC4 GENE; PANCREAS CANCER; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN PURIFICATION; TRANSCRIPTION REGULATION;

EID: 84881159835     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-013-2591-6     Document Type: Article

References (25)

1. Porchet N, Nguyen VC, Dufosse J, et al. (1991) Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs. Biochem Biophys Res Commun 175:414-422
2. Andrianifahanana M, Moniaux N, Schmied BM, et al. (2001) Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: a potential role of MUC4 as a tumor marker of diagnostic significance. Clin Cancer Res 7:4033-4040
3. Iacobuzio-Donahue CA, Ashfaq R, Maitra A, et al. (2003) Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies. Cancer Res 63:8614-8622
4. Swartz MJ, Batra SK, Varshney GC, et al. (2002) MUC4 expression increases progressively in pancreatic intraepithelial neoplasia. Am J Clin Pathol 117:791-796
5. Zhu Y, Zhang JJ, Zhu R, et al. (2011) The increase in the expression and hypomethylation of MUC4 gene with the progression of pancreatic ductal adenocarcinoma. Med Oncol 28:S175-S184
6. Singh AP, Moniaux N, Chauhan SC, et al. (2004) Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis. Cancer Res 64:622-630
7. Perrais M, Pigny P, Ducourouble MP, et al. (2001) Characterization of human mucin gene MUC4 promoter: importance of growth factors and proinflammatory cytokines for its regulation in pancreatic cancer cells. J Biol Chem 276:30923-30933
8. Andrianifahanana M, Singh AP, Nemos C, et al. (2007) IFN-γ-induced expression of MUC4 in pancreatic cancer cells is mediated by STAT-1 upregulation: a novel mechanism for IFN-gamma response. Oncogene 26:7251-7261
9. Mejías-Luque R, Peiró S, Vincent A, et al. (2008) IL-6 induces MUC4 expression through gp130/STAT3 pathway in gastric cancer cell lines. Biochim Biophys Acta 1783:1728-1736
10. Bai CH, Song SY, Kim YD (2007) Effect of glucocorticoid on the MUC4 gene in nasal polyps. Laryngoscope 117:2169-2173
11. Vincent A, Ducourouble MP, Van Seuningen I (2008) Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by DNA methyltransferases and histone deacetylases. FASEB J 22:3035-3045
12. Yamada N, Nishida Y, Tsutsumida H, et al. (2009) Promoter CpG methylation in cancer cells contributes to the regulation of MUC4. Br J Cancer 100:344-351
13. Zhang JJ, Zhang XF, Zhu Y, et al. (2010) Transcriptional regulation of human mucin gene MUC4 in pancreatic cancer cells. Mol Biol Rep 37:2797-2802
14. Fauquette V, Perrais M, Cerulis S, et al. (2005) The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells. Biochem J 386:35-45
15. Piessen G, Jonckheere N, Vincent A, et al. (2007) Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1α. Biochem J 402:81-91
16. Jonckheere N, Vincen A, Perrais M, et al. (2007) The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells. J Biol Chem 282:22638-22650
17. Fauquette V, Aubert S, Groux-Degroote S, et al. (2007) Transcription factor AP-2α represses both the mucin MUC4 expression and pancreatic cancer cell proliferation. Carcinogenesis 28:2305-2312
18. Shi Y, Seto E, Chang LS, et al. (1991) Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein. Cell 67:377-388
19. Thomas MJ, Seto E (1999) Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key? Gene 236:197-208
20. Shi Y, Lee JS, Galvin KM (1997) Everything you have ever wanted to know about Yin Yang 1. Biochim Biophys Acta 1332:F49-F66
21. Srinivasan L, Atchison ML (2004) YY1 DNA binding and PcG recruitment requires CtBP. Genes Dev 18:2596-2601
22. Sui G, el Affar B, Shi Y, et al. (2004) Yin Yang 1 is a negative regulator of p53. Cell 117:859-872
23. Yang WM, Inouye C, Zeng Y, et al. (1996) Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc Natl Acad Sci USA 93:12845-12850
24. Schug J, Schuller WP, Kappen C, et al. (2005) Promoter features related to tissue specificity as measured by Shannon entropy. Genome Biol 6:R33
25. Seto E, Lewis B, Shenk T (1993) Interaction between transcription factors Sp1 and YY1. Nature 365:462-464