Transcriptional regulation of human mucin gene MUC4 in pancreatic cancer cells

Molecular Biology Reports

Volumn 37, Issue 6, 2010, Pages 2797-2802

  Zhang, Jingjing ^a   Zhang, Xiongfei ^b   Zhu, Yi ^a   Chen, Zheng ^a   Xu, Zekuan ^a   Miao, Yi ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

CREB; Elk 1; Ets 1; MUC4; Promoter activity; STAT1

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; LUCIFERASE; MESSENGER RNA; MUCIN 4; STAT1 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ELK 1; TRANSCRIPTION FACTOR ETS 1; CREB1 PROTEIN, HUMAN; MUC4 PROTEIN, HUMAN; PROTEIN BINDING; STAT1 PROTEIN, HUMAN;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MOLECULAR BIOLOGY; PANCREAS CANCER; PROMOTER REGION; REPORTER GENE; TRANSCRIPTION REGULATION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PANCREAS TUMOR; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

CELL LINE, TUMOR; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MUCIN-4; PANCREATIC NEOPLASMS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTO-ONCOGENE PROTEIN C-ETS-1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STAT1 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 77955657718     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-009-9826-6     Document Type: Article

References (22)

1. N Porchet VC Nguyen J Dufosse, et al. 1991 Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs Biochem Biophys Res Commun 175 414 422 10.1016/0006-291X(91)91580-6 1:CAS:528:DyaK3MXlt1yku7w%3D 1673336
2. JP Audie A Janin N Porchet, et al. 1993 Expression of human mucin genes in respiratory, digestive, and reproductive tracts ascertained by in situ hybridization J Histochem Cytochem 41 1479 1485 1:CAS:528:DyaK3sXmsVKns7c%3D 8245407
3. JP Audie D Tetaert P Pigny, et al. 1995 Mucin gene expression in the human endocervix Hum Reprod 10 98 102 10.1093/humrep/10.1.98 1:CAS:528:DyaK2MXktlars7k%3D 7745080
4. MP Buisine L Devisme TC Savidge, et al. 1998 Mucin gene expression in human embryonic and fetal intestine Gut 43 519 524 10.1136/gut.43.4.519 1:STN:280:DyaK1M%2FntFahtw%3D%3D 9824580
5. MP Buisine L Devisme MC Copin, et al. 1999 Developmental mucin gene expression in the human respiratory tract Am J Respir Cell Mol Biol 20 209 218 1:CAS:528:DyaK1MXht1erurg%3D 9922211
6. M Andrianifahanana N Moniaux BM Schmied, et al. 2001 Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: a potential role of MUC4 as a tumor marker of diagnostic significance Clin Cancer Res 7 4033 4040 1:CAS:528:DC%2BD38XltFSisA%3D%3D 11751498
7. MJ Swartz SK Batra GC Varshney, et al. 2002 MUC4 expression increases progressively in pancreatic intraepithelial neoplasia Am J Clin Pathol 117 791 796 10.1309/7Y7N-M1WM-R0YK-M2VA 12090430 (Pubitemid 34457016)
8. AP Singh N Moniaux SC Chauhan, et al. 2004 Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis Cancer Res 64 622 630 10.1158/0008-5472.CAN-03-2636 1:CAS:528:DC%2BD2cXmsVaisA%3D%3D 14744777 (Pubitemid 38120902)
9. AP Singh SC Chauhan M Andrianifahanana, et al. 2006 MUC4 expression is regulated by cystic fibrosis transmembrane conductance regulator in pancreatic adenocarcinoma cells via transcriptional and post-translational mechanisms Oncogene 26 30 41 10.1038/sj.onc.1209764 16799633
10. M Perrais P Pigny MP Ducourouble, et al. 2001 Characterization of human mucin gene MUC4 promoter: importance of growth factors and proinflammatory cytokines for its regulation in pancreatic cancer cells J Biol Chem 276 30923 30933 10.1074/jbc.M104204200 1:CAS:528:DC%2BD3MXmsVaqtbc%3D 11418607
11. N Jonckheere A Vincen M Perrais, et al. 2007 The Human Mucin MUC4 Is Transcriptionally Regulated by Caudal-related Homeobox, Hepatocyte Nuclear Factors, Forkhead Box A, and GATA Endodermal Transcription Factors in Epithelial Cancer Cells J Biol Chem 282 22638 22650 10.1074/jbc.M700905200 1:CAS:528:DC%2BD2sXot1Wjtb0%3D 17553805 (Pubitemid 47267310)
12. G Piessen N Jonckheere A Vincent, et al. 2007 Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1α Biochem J 402 81 91 10.1042/BJ20061461 1:CAS:528:DC%2BD2sXosFOhsQ%3D%3D 17037983
13. CY Ren Y Akiyama S Miyake, et al. 2007 MUC4 expression is regulated by cystic fibrosis transmembrane conductance regulator in pancreatic adenocarcinoma cells via transcriptional and post-translational mechanisms Oncogene 26 30 41 10.1038/sj.onc.1209764 1:CAS:528:DC%2BD1cXhslSru78%3D (Pubitemid 46067329)
14. M Andrianifahanana AP Singh C Nemos, et al. 2007 IFN-gamma-induced expression of MUC4 in pancreatic cancer cells is mediated by STAT-1 upregulation: a novel mechanism for IFN-gamma response Oncogene 26 7251 7261 10.1038/sj.onc.1210532 1:CAS:528:DC%2BD2sXht1Oqsb3J 17525742 (Pubitemid 350085321)
15. AJ Shaywitz ME Greenberg 1999 CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals Annu Rev Biochem 68 821 861 10.1146/annurev.biochem.68.1.821 1:CAS:528:DyaK1MXlvFajt7g%3D 10872467 (Pubitemid 29449210)
16. B Mayr M Montminy 2001 Transcriptional regulation by the phosphorylation-dependent factor CREB Nat Rev Mol Cell Biol 2 599 609 10.1038/35085068 1:CAS:528:DC%2BD3MXlvVOqs70%3D 11483993 (Pubitemid 33674011)
17. V Iourgenko W Zhang C Mickanin, et al. 2003 Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells Proc Natl Acad Sci USA 100 12147 12152 10.1073/pnas.1932773100 1:CAS:528:DC%2BD3sXotlGlu7w%3D 14506290 (Pubitemid 37271529)
18. MD Conkright G Canettieri R Screaton, et al. 2003 TORCs: transducers of regulated CREB activity Mol Cell 12 413 423 10.1016/j.molcel.2003.08.013 1:CAS:528:DC%2BD3sXnt12qtLg%3D 14536081 (Pubitemid 37238928)
19. HA Al-Wadei MH Al-Wade HM Schuller 2009 Prevention of pancreatic cancer by the beta-blocker propranolol Anticancer Drugs 20 477 482 10.1097/CAD. 0b013e32832bd1e3 1:CAS:528:DC%2BD1MXnt12qt7s%3D 19387337
20. JS Yordy RC Muise-Helmericks 2000 Signal transduction and the Ets family of transcription factors Oncogene 19 6503 6513 10.1038/sj.onc.1204036 1:CAS:528:DC%2BD3MXptVelsg%3D%3D 11175366 (Pubitemid 32108440)
21. T Ito T Nakayama M Ito, et al. 1998 Expression of the ets-1 proto-oncogene in human pancreatic carcinoma Mod Pathol 11 209 215 1:STN:280:DyaK1c7mtlahsw%3D%3D 9504693
22. JS Rawlings KM Rosler DA Harrison 2004 The JAK/STAT signaling pathway J Cell Sci 117 1281 1283 10.1242/jcs.00963 1:CAS:528:DC%2BD2cXjs1ygtbo%3D 15020666 (Pubitemid 38559804)