The increase in the expression and hypomethylation of MUC4 gene with the progression of pancreatic ductal adenocarcinoma

Medical Oncology

Volumn 28, Issue SUPPL. 1, 2011, Pages

  Zhu, Yi ^a,b   Zhang, Jing Jing ^a,b   Zhu, Rong ^c   Zhu, Yan ^a   Liang, Wen Biao ^d   Gao, Wen Tao ^a,b   Yu, Jun Bo ^a   Xu, Ze Kuan ^a   Miao, Yi ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b Jiangsu Province Academy of Clinical Medicine   (China)

^c FUDAN UNIVERSITY   (China)

^d Jiangsu Province Blood Center   (China)

Author keywords

Gene expression; Methylation; Microdissection; MUC4; Pancreatic neoplasms

Indexed keywords

MESSENGER RNA; MUCIN 4;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER PROGNOSIS; CANCER STAGING; CARCINOGENESIS; DNA METHYLATION; EPIGENETICS; FEMALE; GENE EXPRESSION; GENE LOCUS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MICRODISSECTION; PANCREAS CARCINOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION;

EID: 84655164996     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-010-9683-0     Document Type: Article

References (42)

1. MA Hollingsworth BJ Swanson 2004 Mucins in cancer: protection and control of the cell surface Nat Rev Cancer 4 45 60 (Pubitemid 38082153)
2. N Porchet 1991 Molecular cloning and chromosomal localization of a novel human tracheobronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs Biochem Biophys Res Commun 175 414 422
3. MA Hollingsworth 1994 Expression of MUC1, MUC2, MUC3 and MUC4 mucin mRNAs in human pancreatic and intestinal tumor cell lines Int J Cancer 57 198 203 (Pubitemid 24144209)
4. C Balague 1994 Altered expression of MUC2, MUC4, and MUC5 mucin genes in pancreas tissues and cancer cell lines Gastroenterology 106 1054 1061
5. C Balague 1995 In situ hybridization shows distinct patterns of mucin gene expression in normal, benign, and malignant pancreas tissues Gastroenterology 109 953 964
6. M Andrianifahanana 2001 Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: a potential role of MUC4 as a tumor marker of diagnostic significance Clin Cancer Res 7 4033 4040 (Pubitemid 34044624)
7. MJ Swartz 2002 MUC4 expression increases progressively in pancreatic intraepithelial neoplasia Am J Clin Pathol 117 791 796 (Pubitemid 34457016)
8. HU Park 2003 Aberrant expression of MUC3 and MUC4 membrane-associated mucins and sialyl Le(x) antigen in pancreatic intraepithelial neoplasia Pancreas 26 e48 e54
9. A Bhardwaj 2007 Double immunohistochemical staining with MUC4/p53 is useful in the distinction of pancreatic adenocarcinoma from chronic pancreatitis: a tissue microarray-based study Arch Pathol Lab Med 131 556 562 (Pubitemid 46564427)
10. M Saitou 2005 MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas J Clin Pathol 58 845 852 (Pubitemid 41113392)
11. AP Singh N Moniaux SC Chauhan JL Meza SK Batra 2004 Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis Cancer Res 64 622 630 (Pubitemid 38120902)
12. P Chaturvedi 2007 MUC4 mucin potentiates pancreatic tumor cell proliferation, survival, and invasive properties and interferes with its interaction to extracellular matrix proteins Mol Cancer Res 5 309 320 (Pubitemid 46706993)
13. S Bafna S Kaur N Momi SK Batra 2009 Pancreatic cancer cells resistance to gemcitabine: the role of MUC4 mucin Br J Cancer 101 1155 1161
14. M Komatsu L Yee KL Carraway 1999 Overexpression of sialomucin complex, a rat homologue of MUC4, inhibits tumor killing by lymphokine-activated killer cells Cancer Res 59 2229 2236 (Pubitemid 29217690)
15. RH Hruban 2001 Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions Am J Surg Pathol 25 79 86
16. K Nagata 2007 Mucin expression profile in pancreatic cancer and the precursor lesions J Hepatobiliary Pancreat Surg 14 243 254 (Pubitemid 46863913)
17. CL Hattrup SJ Gendler 2008 Structure and function of the cell surface (tethered) mucins Annu Rev Physiol 70 431 457 (Pubitemid 351738187)
18. DJ Thornton K Rousseau MA [tmp] McGuckin 2008 Structure and function of the polymeric mucins in airways mucus Annu Rev Physiol 70 459 486 (Pubitemid 351738188)
19. A Walch 2001 Tissue microdissection techniques in quantitative genome and gene expression analyses Histochem Cell Biol 115 269 276 (Pubitemid 32323882)
20. R Grützmann 2004 Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarrays Neoplasia 6 611 622 (Pubitemid 39411099)
21. HS Erickson 2009 Quantitative RT-PCR gene expression analysis of laser microdissected tissue samples Nat Protoc 4 902 922
22. A Vincent MP Ducourouble I Van Seuningen 2008 Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by DNA methyltransferases and histone deacetylases FASEB J 22 3035 3045
23. N Yamada 2009 Promoter CpG methylation in cancer cells contributes to the regulation of MUC4 Br J Cancer 100 344 351
24. KY Bilimoria 2007 Validation of the 6th edition AJCC pancreatic cancer staging system: report from the national cancer database Cancer 110 738 744 (Pubitemid 47257648)
25. Hamilton SR, Aaltonen LA. Pathology and genetics of tumours of the digestive system. Lyon: IARC Press; 2000. p. 220-7.
26. GB Zhou 2006 Modified manual microdissection in procuring defined cells for high-quality RNA acquisition Chinese J Biochem Mol Biol 22 252 257
27. RH Hruban 2001 Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions Am J Surg Pathol 25 579 586 (Pubitemid 32423354)
28. RH Hruban 2004 An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms Am J Surg Pathol 28 977 987 (Pubitemid 38971421)
29. A Maitra 2003 Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray Mod Pathol 16 902 912 (Pubitemid 37152020)
30. SR Hustinx 2005 Concordant loss of MTAP and p16/CDKN2A expression in pancreatic intraepithelial neoplasia: evidence of homozygous deletion in a noninvasive precursor lesion Mod Pathol 18 959 963 (Pubitemid 41059957)
31. N Fukushima 2002 Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma Am J Pathol 160 1573 1581 (Pubitemid 34525637)
32. J Hanley 1989 Receiver operating characteristic (ROC) methodology: the state of the art Crit Rev Diagn Imaging 29 307 335 (Pubitemid 19236809)
33. A Spira DS Ettinger 2004 Multidisciplinary management of lung cancer N Engl J Med 350 379 392 (Pubitemid 38101633)
34. I Zlobec R Steele L Terracciano JR Jass A Lugli 2007 Selecting immunohistochemical cut-off scores for novel biomarkers of progression and survival in colorectal cancer J Clin Pathol 60 1112 1116 (Pubitemid 47612643)
35. J Zhang 2005 Presence of MUC4 in human milk and at the luminal surfaces of blood vessels J Cell Physiol 204 166 177 (Pubitemid 40776819)
36. J Zhang 2010 Transcriptional regulation of human mucin gene MUC4 in pancreatic cancer cells Mol Biol Rep 37 2797 2802
37. M Perrais 2001 Characterization of human mucin gene MUC4 promoter:importance of growth factors and proinflammatory cytokines for its regulation in pancreatic cancer cells J Biol Chem 276 30923 30933
38. A Choudhury 2004 MUC4 mucin expression in human pancreatic tumours is affected by organ environment: the possible role of TGFbeta2 Br J Cancer 90 657 664 (Pubitemid 38297207)
39. M Andrianifahanana 2005 Synergistic induction of the MUC4 mucin gene by interferon-gamma and retinoic acid in human pancreatic tumour cells involves a reprogramming of signalling pathways Oncogene 24 6143 6154 (Pubitemid 43080064)
40. C Mariette 2004 Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway Biochem J 377 701 708 (Pubitemid 38221841)
41. DG Altman B Lausen W Sauerbrei M Schumacher 1994 Dangers of using 'optimal' cutpoints in the evaluation of prognostic factors J Natl Cancer Inst 86 829 835 (Pubitemid 2100935)
42. PA Kyzas D Denaxa-Kyza JP Ioannidis 2007 Almost all articles on cancer prognostic markers report statistically significant results Eur J Cancer 43 2559 2579 (Pubitemid 350086938)