Two faces of vitamin e in the lung

American Journal of Respiratory and Critical Care Medicine

Volumn 188, Issue 3, 2013, Pages 279-284

  Cook Mills, Joan M ^a   Abdala Valencia, Hiam ^a   Hartert, Tina ^b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

A tocopherol; Asthma; G tocopherol; Human; Mouse

Indexed keywords

ALPHA TOCOPHEROL; GAMMA TOCOPHEROL; IMMUNOGLOBULIN E; SOYBEAN OIL;

ALLERGIC AIRWAY INFLAMMATION; ARTHRITIS; ARTICLE; ASTHMA; BODY MASS; CARDIOVASCULAR DISEASE; ETHNIC GROUP; FORCED EXPIRATORY VOLUME; GENETIC PREDISPOSITION; HEMATOPOIESIS; HUMAN; NONHUMAN; OSTEOARTHRITIS; OUTCOME ASSESSMENT; PREVALENCE; PRIORITY JOURNAL; RACE; RESPIRATORY TRACT ALLERGY; SMOKING; VITAMIN BLOOD LEVEL; WHEEZING;

ANTIOXIDANTS; ASTHMA; HUMANS; LUNG; PROGNOSIS; VITAMIN E;

EID: 84881158525     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201303-0503ED     Document Type: Article

References (85)

1. Martinez FD. Genes, environments, development and asthma: A reappraisal. Eur Respir J 2007;29:179-184.
2. Bousquet J, Bousquet PJ,Godard P,Daures JP. The public health implications of asthma. Bull World Health Organ 2005;83:548-554.
3. Vollmer WM, Osborne ML, Buist AS. 20-year trends in the prevalence of asthma and chronic airflow obstruction in an HMO. Am J Respir Crit Care Med 1998;157:1079-1084.
4. Friebele E. The attack of asthma. Environ Health Perspect 1996;104:22-25.
5. Uauy R, Hoffman DR, Birch EE, Birch DG, Jameson DM, Tyson J. Safety and efficacy of omega-3 fatty acids in the nutrition of very low birth weight infants: Soy oil and marine oil supplementation of formula. J Pediatr 1994;124:612-620.
6. Cook-Mills JM, McCary CA. Isoforms of vitamin E differentially regulate inflammation. Endocr Metab Immune Disord Drug Targets 2010;10:348-366.
7. McCary CA, Abdala-Valencia H, Berdnikovs S, Cook-Mills JM. Supplemental and highly elevated tocopherol doses differentially regulate allergic inflammation: Reversibility of alpha-tocopherol and gammatocopherol's effects. J Immunol 2011;186:3674-3685.
8. Berdnikovs S, Abdala-Valencia H, McCary C, Somand M, Cole R, Garcia A, Bryce P, Cook-Mills J. Isoforms of vitamin E have opposing immunoregulatory functions during inflammation by regulating leukocyte recruitment. J Immunol 2009;182:4395-4405.
9. Hunter SC, Cahoon EB. Enhancing vitamin E in oilseeds: Unraveling tocopherol and tocotrienol biosynthesis. Lipids 2007;42:97-108.
10. Leonard SW, Paterson E, Atkinson JK, Ramakrishnan R, Cross CE, Traber MG. Studies in humans using deuterium-labeled alpha-and gamma-tocopherols demonstrate faster plasma gamma-tocopherol disappearance and greater gamma-metabolite production. Free Radic Biol Med 2005;38:857-866.
11. Bella DL, Schock BC, Lim Y, Leonard SW, Berry C, Cross CE, Traber MG. Regulation of the alpha-tocopherol transfer protein in mice: Lack of response to dietary vitamin E or oxidative stress. Lipids 2006;41: 105-112.
12. Redlich CA, Grauer JN, Van Bennekum AM, Clever SL, Ponn RB, Blaner WS. Characterization of carotenoid, vitamin A, and alpha-tocopheral levels in human lung tissue and pulmonary macrophages. Am J Respir Crit Care Med 1996;154:1436-1443.
13. Zou W, Noh SK, Owen KQ, Koo SI. Dietary L-carnitine enhances the lymphatic absorption of fat and alpha-tocopherol in ovariectomized rats. J Nutr 2005;135:753-756.
14. Cavalier L, Ouahchi K, Kayden HJ, Di Donato S, Reutenauer L, Mandel JL, Koenig M. Ataxia with isolated vitamin E deficiency: Heterogeneity of mutations and phenotypic variability in a large number of families. Am J Hum Genet 1998;62:301-310.
15. Sundl I, Guardiola M, Khoschsorur G, Sola R, Vallve JC, Godas G, Masana L, Maritschnegg M, Meinitzer A, Cardinault N, et al. Increased concentrations of circulating vitamin E in carriers of the apolipoprotein A5 gene-1131T.C variant and associations with plasma lipids and lipid peroxidation. J Lipid Res 2007;48:2506-2513.
16. Guardiola M, Ribalta J, Gomez-Coronado D, Lasuncion MA, de OyaM, Garces C. The apolipoprotein A5 (ApoA5) gene predisposes Caucasian children to elevated triglycerides and vitamin E (four provinces study). Atherosclerosis 2010;212:543-547.
17. Huebbe P, Jofre-Monseny L, Rimbach G. Alpha-tocopherol transport in the lung is affected by the apoE genotype-studies in transgenic apoE3 and apoE4 mice. IUBMB Life 2009;61:453-456.
18. Yoshida Y, Saito Y, Jones LS, Shigeri Y. Chemical reactivities and physical effects in comparison between tocopherols and tocotrienols: Physiological significance and prospects as antioxidants. J Biosci Bioeng 2007;104:439-445.
19. Nishio K, Horie M, Akazawa Y, Shichiri M, Iwahashi H, Hagihara Y, Yoshida Y, Niki E. Attenuation of lipopolysaccharide (LPS)-induced cytotoxicity by tocopherols and tocotrienols. Redox Biology 2013;1: 97-103.
20. Huang PH, Chuang HC, Chou CC, Wang H, Lee SL, Yang HC, Chiu HC, Kapuriya N, Wang D, Kulp SK, et al. Vitamin E facilitates the inactivation of the kinase Akt by the phosphatase PHLPP1. Sci Signal 2013;6:ra19.
21. Patel A, Liebner F, Netscher T, Mereiter K, Rosenau T. Vitamin E chemistry. Nitration of non-alpha-tocopherols: Products and mechanistic considerations. J Org Chem 2007;72:6504-6512.
22. Fakhrzadeh L, Laskin JD, Laskin DL. Ozone-induced production of nitric oxide and TNF-alpha and tissue injury are dependent on NF-kappaB p50. Am J Physiol Lung Cell Mol Physiol 2004;287:L279-L285.
23. Hernandez ML, Wagner JG, Aline Kala R, Mills K, Wells HB, Alexis NE, Lay JC, Jiang Q, Zhang H, Zhou H, et al. Vitamin E, g-tocopherol, reduces airway neutrophil recruitment after inhaled endotoxin challenge in rats and in healthy volunteers. Free Radic Biol Med 2013;60:56-62.
24. Wiser J, Alexis NE, Jiang Q, Wu W, Robinette C, Roubey R, Peden DB. In vivo gamma-tocopherol supplementation decreases systemic oxidative stress and cytokine responses of human monocytes in normal and asthmatic subjects. Free Radic Biol Med 2008;45:40-49.
25. Wagner JG, Harkema JR, JiangQ, Illek B, Ames BN, PedenDB.Gammatocopherol attenuates ozone-induced exacerbation of allergic rhinosinusitis in rats. Toxicol Pathol 2009;37:481-491.
26. Wagner JG, Jiang Q, Harkema JR, Ames BN, Illek B, Roubey RA, Peden DB. Gamma-tocopherol prevents airway eosinophilia and mucous cell hyperplasia in experimentally induced allergic rhinitis and asthma. Clin Exp Allergy 2008;38:501-511.
27. Hamahata A, Enkhbaatar P, Kraft ER, Lange M, Leonard SW, Traber MG, Cox RA, Schmalstieg FC, Hawkins HK, Whorton EB, et al. Gamma-tocopherol nebulization by a lipid aerosolization device improves pulmonary function in sheep with burn and smoke inhalation injury. Free Radic Biol Med 2008;45:425-433.
28. Cook-Mills JM, Marchese ME, Abdala-Valencia H. Vascular cell adhesion molecule-1 expression and signaling during disease: Regulation by reactive oxygen species and antioxidants. Antioxid Redox Signal 2011;15:1607-1638.
29. Cook-Mills JM. Eosinophil-endothelial cell interactions during inflammation. In: Lee JJ, Rosenberg HF, editors. Eosinophils in health and disease. Oxford, UK: Elsevier; 2012. pp. 139-153.
30. Abdala-Valencia H, Berdnikovs S, Cook-Mills JM. Vitamin E isoforms differentially regulate intercellular adhesion molecule-1 activation of PKCa in human microvascular endothelial cells. PLoS ONE 2012;7: E41054.
31. McCary CA, Yoon Y, Panagabko C, ChoW, Atkinson J, Cook-Mills JM. Vitamin E isoforms directly bind PKCa and differentially regulate activation of PKCa. Biochem J 2012;441:189-198.
32. Okamoto N, Murata T, Tamai H, Tanaka H, Nagai H. Effects of alpha tocopherol and probucol supplements on allergen-induced airway inflammation and hyperresponsiveness in a mouse model of allergic asthma. Int Arch Allergy Immunol 2006;141:172-180.
33. Mabalirajan U, Aich J, Leishangthem GD, Sharma SK, Dinda AK, Ghosh B. Effects of vitamin E on mitochondrial dysfunction and asthma features in an experimental allergic murine model. J Appl Physiol 2009;107:1285-1292.
34. Suchankova J, Voprsalova M, Kottova M, Semecky V, Visnovsky P. Effects of oral alpha-tocopherol on lung response in rat model of allergic asthma. Respirology 2006;11:414-421.
35. Lim Y, Vasu VT, Valacchi G, Leonard S, Aung HH, Schock BC, Kenyon NJ, Li CS, Traber MG, Cross CE. Severe vitamin E deficiency modulates airway allergic inflammatory responses in the murine asthma model. Free Radic Res 2008;42:387-396.
36. Mahoney CW, Azzi A. Vitamin E inhibits protein kinase C activity. Biochem Biophys Res Commun 1988;154:694-697.
37. Weiss ST. Diet as a risk factor for asthma. Ciba Found Symp 1997;206: 244-257.
38. Troisi RJ,Willett WC, Weiss ST, Trichopoulos D, Rosner B, Speizer FE. A prospective study of diet and adult-onset asthma. Am J Respir Crit Care Med 1995;151:1401-1408.
39. Dow L, Tracey M, Villar A, Coggon D, Margetts BM, Campbell MJ, Holgate ST. Does dietary intake of vitamins C and E influence lung function in older people? Am J Respir Crit Care Med 1996;154:1401-1404.
40. Smit HA, Grievink L, Tabak C. Dietary influences on chronic obstructive lung disease and asthma: A review of the epidemiological evidence. Proc Nutr Soc 1999;58:309-319.
41. Tabak C, Smit HA, Rasanen L, Fidanza F, Menotti A, Nissinen A, Feskens EJ, Heederik D, Kromhout D. Dietary factors and pulmonary function: A cross sectional study in middle aged men from three European countries. Thorax 1999;54:1021-1026.
42. Hoskins A, Roberts JL II, Milne G, Choi L, Dworski R. Natural-source d-a-tocopheryl acetate inhibits oxidant stress and modulates atopic asthma in humans in vivo. Allergy 2012;67:676-682.
43. Pearson PJ, Lewis SA, Britton J, Fogarty A. Vitamin E supplements in asthma: A parallel group randomised placebo controlled trial. Thorax 2004;59:652-656.
44. Martindale S, McNeill G, Devereux G, Campbell D, Russell G, Seaton A. Antioxidant intake in pregnancy in relation to wheeze and eczema in the first two years of life. Am J Respir Crit Care Med 2005;171:121-128.
45. Devereux G. Early life events in asthma-diet. Pediatr Pulmonol 2007;42: 663-673.
46. Allen S, Britton JR, Leonardi-Bee JA. Association between antioxidant vitamins and asthma outcome measures: Systematic review and metaanalysis. Thorax 2009;64:610-619.
47. Kalayci O, Besler T, Kilinc K, Sekerel BE, Saraclar Y. Serum levels of antioxidant vitamins (alpha tocopherol, beta carotene, and ascorbic acid) in children with bronchial asthma. Turk J Pediatr 2000;42:17-21.
48. Kelly FJ, Mudway I, Blomberg A, Frew A, Sandstrom T. Altered lung antioxidant status in patients with mild asthma. Lancet 1999;354:482-483.
49. Schunemann HJ, Grant BJ, Freudenheim JL, Muti P, Browne RW, Drake JA, Klocke RA, Trevisan M. The relation of serum levels of antioxidant vitamins C and E, retinol and carotenoids with pulmonary function in the general population. Am J Respir Crit Care Med 2001; 163:1246-1255.
50. Al-Abdulla NO, Al Naama LM, Hassan MK. Antioxidant status in acute asthmatic attack in children. J Pak Med Assoc 2010;60:1023-1027.
51. Wu D, Han SN, MeydaniM,Meydani SN. Effect of concomitant consumption of fish oil and vitamin E on T cell mediated function in the elderly: A randomized double-blind trial. J Am Coll Nutr 2006;25:300-306.
52. Ratnasinghe D, Tangrea JA, Forman MR, Hartman T, Gunter EW, Qiao YL, Yao SX, Barett MJ, Giffen CA, Erozan Y, et al. Serum tocopherols, selenium and lung cancer risk among tin miners in China. Cancer Causes Control 2000;11:129-135.
53. Jiang Q, Christen S, Shigenaga MK, Ames BN. Gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr 2001;74:714-722.
54. Talegawkar SA, Johnson EJ, Carithers T, Taylor HA Jr, Bogle ML, Tucker KL. Total alpha-tocopherol intakes are associated with serum alpha-tocopherol concentrations in African American adults. J Nutr 2007;137:2297-2303.
55. Bieri JG, Evarts RP. Tocopherols and fatty acids in American diets. The recommended allowance for vitamin E. J Am Diet Assoc 1973;62:147-151.
56. Bieri JG, Evarts RP. Vitamin E adequacy of vegetable oils. J Am Diet Assoc 1975;66:134-139.
57. Meydani M, Cohn JS, Macauley JB, McNamara JR, Blumberg JB, Schaefer EJ. Postprandial changes in the plasma concentration of alpha-and gamma-tocopherol in human subjects fed a fat-rich meal supplemented with fat-soluble vitamins. J Nutr 1989;119:1252-1258.
58. Sanchez-Moreno C, Dorfman SE, Lichtenstein AH, Martin A. Dietary fat type affects vitamins C and E and biomarkers of oxidative status in peripheral and brain tissues of golden Syrian hamsters. J Nutr 2004; 134:655-660.
59. Gobel Y, Koletzko B, Bohles HJ, Engelsberger I, Forget D, Le Brun A, Peters J, Zimmermann A. Parenteral fat emulsions based on olive and soybean oils: A randomized clinical trial in preterm infants. J Pediatr Gastroenterol Nutr 2003;37:161-167.
60. Devereux G, Seaton A. Diet as a risk factor for atopy and asthma. J Allergy Clin Immunol 2005;115:1109-1117.
61. Schmitz G, Ecker J. The opposing effects of n-3 and n-6 fatty acids. Prog Lipid Res 2008;47:147-155.
62. Weylandt KH, Chiu CY, Gomolka B, Waechter SF, Wiedenmann B. Omega-3 fatty acids and their lipid mediators: Towards an understanding of resolvin and protectin formation. Prostaglandins Other Lipid Mediat 2012;97:73-82.
63. Junker R, Kratz M, Neufeld M, Erren M, Nofer JR, Schulte H, Nowak-Gottl U, Assmann G, Wahrburg U. Effects of diets containing olive oil, sunflower oil, or rapeseed oil on the hemostatic system. Thromb Haemost 2001;85:280-286.
64. McKeever TM, Lewis SA, Cassano PA, Ocke M, Burney P, Britton J, Smit HA. The relation between dietary intake of individual fatty acids, FEV1 and respiratory disease in Dutch adults. Thorax 2008; 63:208-214.
65. Zahran HS, Bailey C. Factors associated with asthma prevalence among racial and ethnic groups-united states, 2009-2010 behavioral risk factor surveillance system. J Asthma 2013;11:11.
66. Jordan JM, De Roos AJ, Renner JB, Luta G, Cohen A, Craft N, Helmick CG, Hochberg MC, Arab L. A case-control study of serum tocopherol levels and the alpha-to gamma-tocopherol ratio in radiographic knee osteoarthritis: The Johnston County Osteoarthritis Project. Am J Epidemiol 2004;159:968-977.
67. Brand C, Snaddon J, Bailey M, Cicuttini F. Vitamin E is ineffective for symptomatic relief of knee osteoarthritis: A six month double blind, randomised, placebo controlled study. Ann Rheum Dis 2001;60:946-949.
68. Dietrich M, Traber MG, Jacques PF, Cross CE, Hu Y, Block G. Does gamma-tocopherol play a role in the primary prevention of heart disease and cancer? A review. J Am Coll Nutr 2006;25:292-299.
69. Munteanu A, Zingg JM. Cellular, molecular and clinical aspects of vitamin E on atherosclerosis prevention. Mol Aspects Med 2007;28: 538-590.
70. Siekmeier R, Steffen C, Marz W. Role of oxidants and antioxidants in atherosclerosis: Results of in vitro and in vivo investigations. J Cardiovasc Pharmacol Ther 2007;12:265-282.
71. Meydani M. Vitamin E modulation of cardiovascular disease. Ann N Y Acad Sci 2004;1031:271-279.
72. Dutta A, Dutta SK. Vitamin E and its role in the prevention of atherosclerosis and carcinogenesis: A review. J Am Coll Nutr 2003;22:258-268.
73. Boyle SP, Dobson VL, Duthie SJ, Hinselwood DC, Kyle JA, Collins AR. Bioavailability and efficiency of rutin as an antioxidant: A human supplementation study. Eur J Clin Nutr 2000;54:774-782.
74. Johnstone AM, Lobley GE, Horgan GW, Bremner DM, Fyfe CL,Morrice PC, Duthie GG. Effects of a high-protein, low-carbohydrate v. highprotein, moderate-carbohydrate weight-loss diet on antioxidant status, endothelial markers and plasma indices of the cardiometabolic profile. Br J Nutr 2011;106:282-291.
75. Hodge AM, Simpson JA, Fridman M, Rowley K, English DR, Giles GG, Su Q, O'Dea K. Evaluation of an FFQ for assessment of antioxidant intake using plasma biomarkers in an ethnically diverse population. Public Health Nutr 2009;12:2438-2447.
76. Samman S, Sivarajah G, Man JC, Ahmad ZI, Petocz P, Caterson ID. A mixed fruit and vegetable concentrate increases plasma antioxidant vitamins and folate and lowers plasma homocysteine in men. J Nutr 2003;133:2188-2193.
77. Heinonen OP, Albanes D. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. The alpha-tocopherol, beta carotene cancer prevention study group. N Engl J Med 1994;330:1029-1035.
78. Zieden B, Kaminskas A, Kristenson M, Kucinskiene Z, Vessby B, Olsson AG, Diczfalusy U. Increased plasma 7 beta-hydroxycholesterol concentrations in a population with a high risk for cardiovascular disease. Arterioscler Thromb Vasc Biol 1999;19:967-971.
79. Gylling H, Hallikainen M, Nissinen MJ, Miettinen TA. The effect of a very high daily plant stanol ester intake on serum lipids, carotenoids, and fat-soluble vitamins. Clin Nutr 2010;29:112-118.
80. Valimaki IA, Vuorimaa T, Ahotupa M, Kekkonen R, Korpela R, Vasankari T. Decreased training volume and increased carbohydrate intake increases oxidized LDL levels. Int J Sports Med 2012;33:291-296.
81. Safronov ID, Trunov AN, Kokareva ED. Prooxidant-antioxidant factors in the blood of pregnant women with late gestosis of different severity. Bull Exp Biol Med 2008;146:800-802.
82. Ross MA, Crosley LK, Brown KM, Duthie SJ, Collins AC, Arthur JR, Duthie GG. Plasma concentrations of carotenoids and antioxidant vitamins in Scottish males: Influences of smoking. Eur J Clin Nutr 1995;49:861-865.
83. Wu LS, Sjakste T, Sakalauskas R, Sitkauskiene B, Paramonova N, Gasiuniene E, Jan RL, Wang JY. The burden of allergic asthma in children: A landscape comparison based on data from Lithuanian, Latvian, and Taiwanese populations. Pediatr Neonatol 2012;53:276-282.
84. Masoli M, Fabian D, Holt S, Beasley R. The global burden of asthma: Executive summary of the GINA dissemination committee report. Allergy 2004;59:469-478.
85. To T, Stanojevic S, Moores G, Gershon AS, Bateman ED, Cruz AA, Boulet LP. Global asthma prevalence in adults: Findings from the cross-sectional world health survey. BMC Public Health 2012;12:204.