A new self-microemulsifying mouth dissolving film to improve the oral bioavailability of poorly water soluble drugs

Drug Development and Industrial Pharmacy

Volumn 39, Issue 9, 2013, Pages 1284-1290

  Xiao, Lu ^a   Yi, Tao ^a,b   Liu, Ying ^c  

^a SOUTHWEST UNIVERSITY   (China)

^b MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Macao)

^c Wuhan Medical Treatment Center   (China)

Author keywords

Bioavailability; Indomethacin; Mouth dissolving film; Poorly water soluble drugs; Self microemulsifying

Indexed keywords

HYDROXYPROPYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; INDOMETACIN; MICROCRYSTALLINE CELLULOSE;

AREA UNDER THE CURVE; ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SOLUBILITY; FILM COATING; MAXIMUM PLASMA CONCENTRATION; MICROEMULSION; NONHUMAN; ORAL BIOAVAILABILITY; PARTICLE SIZE; RAT; SCANNING ELECTRON MICROSCOPY; SELF MICROEMULSIFYING MOUTH DISSOLVING FILM; SOLID STATE; TABLET; TIME TO MAXIMUM PLASMA CONCENTRATION; WATER IMMERSION; X RAY POWDER DIFFRACTION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; CELLULOSE; DRUG DELIVERY SYSTEMS; EMULSIONS; EXCIPIENTS; MALE; METHYLCELLULOSE; MICROSCOPY, ELECTRON, SCANNING; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PHYSICOCHEMICAL PHENOMENA; POWDER DIFFRACTION; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY;

EID: 84881125809     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2012.723716     Document Type: Article

References (34)

1. Liang AC, Chen LH. (2001). Fast-dissolving intraoral drug delivery systems. Expert Opin Ther Pat, 11:981-986. (Pubitemid 32536833)
2. Rathbone MJ, Hadgraft J. (1991). Absorption of drugs from the human oral cavity. Int J Pharm, 74:9-24.
3. Rojanasakul Y, Wang LY, Bhat M, Glover DD, Malanga CJ, Ma JK. (1992). The transport barrier of epithelia: A comparative study on membrane permeability and charge selectivity in the rabbit. Pharm Res, 9:1029-1034.
4. Gore AV, Liang AC, Chien YW. (1998). Comparative biomembrane permeation of tacrine using Yucatan minipigs and domestic pigs as the animal model. J Pharm Sci, 87:441-447. (Pubitemid 28175804)
5. Shojaei AH. (1998). Buccal mucosa as a route for systemic drug delivery: A review. J Pharm Pharm Sci, 1:15-30.
6. Dixit RP, Puthli SP. (2009). Oral strip technology: Overview and future potential. J Control Release, 139:94-107.
7. Hirani JJ, Rathod DA, Vadalia KR. (2009). Orally disintegrating tablets: A review. Trop J Pharm Res, 8:161-172.
8. Ciper M, Bodmeier R. (2006). Modified conventional hard gelatin capsules as fast disintegrating dosage form in the oral cavity. Eur J Pharm Biopharm, 62:178-184. (Pubitemid 43143270)
9. Cilurzo F, Cupone IE, Minghetti P, Selmin F, Montanari L. (2008). Fast dissolving films made of maltodextrins. Eur J Pharm Biopharm, 70:895-900.
10. Patel AR, Prajapat DS, Raval JA. (2010). Fast dissolving films (FDFs) as a newer venture in fast dissolving dosage forms. Int J Drug Dev & Res, 2:232-246.
11. Dahiya M, Saha S, Shahiwala AF. (2009). A review on mouth dissolving films. Curr Drug Deliv, 6:469-476.
12. Okabe H, Suzuki E, Sugiura Y, Yanagimoto K, Takanashi Y, Hoshi M et al. (2008). Development of an easily swallowed film formulation. Int J Pharm, 355:62-66.
13. Shimoda H, Taniguchi K, Nishimura M, Matsuura K, Tsukioka T, Yamashita H et al. (2009). Preparation of a fast dissolving oral thin film containing dexamethasone: A possible application to antiemesis during cancer chemotherapy. Eur J Pharm Biopharm, 73:361-365.
14. Nishimura M, Matsuura K, Tsukioka T, Yamashita H, Inagaki N, Sugiyama T et al. (2009). In vitro and in vivo characteristics of prochlorperazine oral disintegrating film. Int J Pharm, 368:98-102.
15. Rathbone MJ, Drummond BK, Tucker IG. (1994). The oral cavity as a site for systemic drug delivery. Adv Drug Deliv Rev, 13:1-22. (Pubitemid 24032039)
16. Gaisford S, Verma A, Saunders M, Royall PG. (2009). Monitoring crystallisation of drugs from fast-dissolving oral films with isothermal calorimetry. Int J Pharm, 380:105-111.
17. Humberstone AJ, Charman WN. (1997). Lipid based vehicles for the oral delivery of poorly water soluble drugs. Adv Drug Deliv Rev, 25:103-128.
18. Kohli K, Chopra S, Dhar D, Arora S, Khar RK. (2010). Selfemulsifying drug delivery systems: An approach to enhance oral bioavailability. Drug Discov Today, 15:958-965.
19. Franceschinis E, Voinovich D, Grassi M, Perissutti B, Filipovic-Grcic J, Martinac A et al. (2005). Self-emulsifying pellets prepared by wet granulation in high-shear mixer: Influence of formulation variables and preliminary study on the in vitro absorption. Int J Pharm, 291:87-97. (Pubitemid 40222000)
20. Tang B, Cheng G, Gu JC, Xu CH. (2008). Development of solid selfemulsifying drug delivery systems: Preparation techniques and dosage forms. Drug Discov Today, 13:606-612.
21. Wang Z, Sun J, Wang Y, Liu X, Liu Y, Fu Q et al. (2010). Solid selfemulsifying nitrendipine pellets: Preparation and in vitro/in vivo evaluation. Int J Pharm, 383:1-6.
22. Yi T, Wan J, Xu H, Yang X. (2008). A new solid self-microemulsifying formulation prepared by spray-drying to improve the oral bioavailability of poorly water soluble drugs. Eur J Pharm Biopharm, 70:439-444.
23. Yi T, Wan J, Xu H, Yang X. (2008). Controlled poorly soluble drug release from solid self-microemulsifying formulations with high viscosity hydroxypropylmethylcellulose. Eur J Pharm Sci, 34:274-280.
24. Xiao L, Yi T, Liu Y, Huan D, He JK. (2011). [Optimization of novel self-microemulsifying mouth dissolving films by response surface methodology]. Yao Xue Xue Bao, 46:586-591.
25. Xiao L, Yi T, Liu Y, Huan D, He JK. (2011). Preparation and characterization of self-microemulsifying oral fast dissolving films of total ginkgo flavonoid. Chin Trad Herb Drugs, 42:1517-1522.
26. Wu B, Deng D, Lu Y, Wu W. (2008). Biphasic release of indomethacin from HPMC/pectin/calcium matrix tablet: II. Influencing variables, stability and pharmacokinetics in dogs. Eur J Pharm Biopharm, 69:294-302. (Pubitemid 351467163)
27. Garg S, Goldman D, Krumme M, Rohan LC, Smoot S, Friend DR. (2010). Advances in development, scale-up and manufacturing of microbicide gels, films, and tablets. Antiviral Res, 88 Suppl 1:S19-S29.
28. Wollenweber C, Makievski AV, Miller R, Daniels R. (2000). Adsorption of hydroxypropyl methylcellulose at the liquid/liquid interface and the effect on emulsion stability. Colloids Surf A: Physicochem Eng Asp, 172:91-101. (Pubitemid 30618744)
29. Savolainen M, Kogermann K, Heinz A, Aaltonen J, Peltonen L, Strachan C et al. (2009). Better understanding of dissolution behaviour of amorphous drugs by in situ solid-state analysis using Raman spectroscopy. Eur J Pharm Biopharm, 71:71-79.
30. Loftsson T, FrioriksdóttirH. (1998). The effect of water-soluble polymers on the aqueous solubility and complexing abilities of β-cyclodextrin. Int J Pharm, 163:115-121. (Pubitemid 28162625)
31. Usui F, Maeda K, Kusai A, Nishimura K, Yamamoto K. (1997). Inhibitory effects of water-soluble polymers on precipitation of RS-8359. Int J Pharm, 154:59-66. (Pubitemid 27326820)
32. Raghavan SL, Trividic A, Davis AF, Hadgraft J. (2001). Crystallization of hydrocortisone acetate: Influence of polymers. Int J Pharm, 212:213-221. (Pubitemid 32119447)
33. Suzuki H, Sunada H. (1998). Influence of water-soluble polymers on the dissolution of nifedipine solid dispersions with combined carriers. Chem Pharm Bull, 46:482-487. (Pubitemid 28188567)
34. Cunha-Filho MS, Mart?ez-Pacheco R, Landin M. (2012). Fast dissolving ?-lapachone particles and tablets: An approach using surface adsorption technique. Drug Dev Ind Pharm, 38:866-871.