Monitoring crystallisation of drugs from fast-dissolving oral films with isothermal calorimetry

International Journal of Pharmaceutics

Volumn 380, Issue 1-2, 2009, Pages 105-111

  Gaisford, Simon ^a,b   Verma, Amit ^a   Saunders, Mark ^b   Royall, Paul G ^b,c  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b Synectix Pharmaceutical Solutions Ltd   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Crystallisation; Indomethacin; Polyvinylpyrrolidone; Stability testing; Thin polymer films

Indexed keywords

INDOMETACIN; POLYMER; POVIDONE;

AMPOULE; ARTICLE; CONTROLLED STUDY; CRYSTAL; CRYSTALLIZATION; DATA ANALYSIS; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DETERMINATION; DRUG SOLUBILITY; DRUG STABILITY; ISOTHERMAL TITRATION CALORIMETRY; MICROSCOPY; MOLECULAR WEIGHT; MONITORING; PRIORITY JOURNAL; TEMPERATURE;

ADMINISTRATION, ORAL; CALORIMETRY, DIFFERENTIAL SCANNING; CRYSTALLIZATION; DRUG COMPOUNDING; DRUG STABILITY; INDOMETHACIN; KINETICS; MODELS, STATISTICAL; MOLECULAR WEIGHT; POLYMERS; POVIDONE;

EID: 69549121638     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.07.006     Document Type: Article

References (17)

1. Andronis V., and Zografi G. Molecular mobility of supercooled amorphous indomethacin, determined by dynamic mechanical analysis. Pharm. Res. 14 (1997) 410-414
2. Andronis V., and Zografi G. The molecular mobility of supercooled amorphous indomethacin as a function of temperature and relative humidity. Pharm. Res. 15 (1998) 835-842
3. Andronis V., and Zografi G. Crystal nucleation and growth of indomethacin polymorphs from the amorphous state. J. Non-Cryst. Solids 271 (2000) 236-248
4. Andronis V., Yoshioka M., and Zografi G. Effects of sorbed water on the crystallization of indomethacin from the amorphous state. J. Pharm. Sci. 86 (1997) 346-351
5. Avrami M. Kinetics of phase change. I. General theory. J. Chem. Phys. 7 (1939) 1102-1103
6. Imaizumi H., Nambu N., and Nagai T. Stabilization of amorphous state of indomethacin by solid dispersion in polyvinylpolypyrrolidone. Chem. Pharm. Bull. 31 (1983) 2510-2512
7. Latsch S., Selzer T., Fink L., and Kreuter J. Crystallisation of estradiol containing TDDS determined by isothermal microcalorimetry, X-ray diffraction and optical microscopy. Eur. J. Pharm. Biopharm. 56 (2003) 43-52
8. Latsch S., Selzer T., Fink L., and Kreuter J. Determination of the physical state of norethindrone acetate containing transdermal drug delivery systems by isothermal microcalorimetry, X-ray diffraction and optical microscopy. Eur. J. Pharm. Biopharm. 57 (2004) 383-395
9. Latsch S., Selzer T., Fink L., Horstmann M., and Kreuter J. Use of isothermal microcalorimetry, X-ray diffraction and optical microscopy for characterisation of crystals grown in steroid-containing transdermal drug delivery systems. Eur. J. Pharm. Biopharm. 57 (2004) 397-410
10. Matsumoto T., and Zografi G. Physical properties of solid molecular dispersions of indomethacin with poly(vinylpyrrolidone) and poly(vinylpyrrolidone-co-vinyl-acetate) in relation to indomethacin crystallization. Pharm. Res. 16 (1999) 1722-1728
11. Ostwald W. Studien uber die bildung und umwandlung fester korper. Z. Phys. Chem. 22 (1897) 289-292
12. Sun N.X., Liu X.D., and Lu K. An explanation to the anomalous Avrami exponent. Scripta Mater. 34 (1996) 1201-1207
13. Supaphol P. Application of the Avrami, Tobin, Malkin and Urbanovici-Segal macrokinetic models to isothermal crystallization of syndiotactic polypropylene. Thermochim. Acta 370 (2001) 37-48
14. Tobin M.C. Theory of phase transition kinetics with growth site impingement. I. Homogeneous nucleation. J. Polym. Sci. Polym. Phys. 12 (1973) 399-406
15. Trofimov V.I., Trofimov I.V., and Kim J.I. The effect of finite film thickness on the crystallization kinetics of amorphous film and microstructure of crystallized film. Thin Solid Films 495 (2006) 398-403
16. Urbanovici E., and Segal E. New formal relationships to describe kinetics of crystallisation. Thermochim. Acta 171 (1990) 87-94
17. Yoshioka M., Hancock B., and Zografi G. Crystallization of indomethacin from the amorphous state below and above its glass transition temperature. J. Pharm. Sci. 83 (1994) 1700-1705