Self-emulsifying pellets prepared by wet granulation in high-shear mixer: Influence of formulation variables and preliminary study on the in vitro absorption

International Journal of Pharmaceutics

Volumn 291, Issue 1-2, 2005, Pages 87-97

  Franceschinis, Erica ^a   Voinovich, Dario ^a   Grassi, Mario ^b   Perissutti, Beatrice ^a   Filipovic Grcic, Jelena ^c   Martinac, Anita ^c   Meriani Merlo, Francesco ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

^b Eurand   (Italy)

^c UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

High shear mixer; Intestinal permeability; Mixture experimental design; Pelletisation; Self emulsifying pellets

Indexed keywords

DIACYLGLYCEROL; GRANULAC 200; LACTOSE; MICROCEL 101; MICROCRYSTALLINE CELLULOSE; MONOACYLGLYCEROL; NIMESULIDE; POLYSORBATE 80; WATER;

CHEMICAL COMPOSITION; CHEMICAL INTERACTION; CONFERENCE PAPER; DISSOLUTION; DRUG ABSORPTION; DRUG FORMULATION; DRUG PELLET; DRUG PENETRATION; DRUG SOLUBILITY; EMULSION; EVALUATION; EXPERIMENT; FEASIBILITY STUDY; IN VITRO STUDY; MODEL; POWDER; PRIORITY JOURNAL; SCALE UP; SCANNING ELECTRON MICROSCOPY; SOLUBILITY; TECHNIQUE;

EID: 13544270954     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2004.07.046     Document Type: Conference Paper

References (19)

1. B. Campisi, D. Chicco, D. Vojnovic, and R. Phan-Tan-Luu Experimental design for a pharmaceutical formulation: optimisation and robustness J. Pharm. Biomed. Anal. 18 1998 57 65
2. S.A. Charman, W.N. Charman, M.C. Rogge, T.D. Wilson, F.J. Dutko, and C.W. Pouton Self-emulsifying drug delivery systems: formulation and biopharmaceutical evaluation of an investigational lipophilic compound Pharm. Res. 9 1992 87 93
3. D. Chicco, I. Grabnar, A. Skerjanec, D. Vojnovic, V. Maurich, N. Realdon, E. Ragazzi, A. Belic, R. Karba, and A. Mrhar Correlation of in vitro and in vivo paracetamol availability from layered excipient suppositories Int. J. Pharm. 189 1999 147 160
4. E.E. Chiellini, B. Bellich, S. Macchiavelli, R. Fiannaca, D. Skrbec, G.C. Cadelli, and F. Carli Solid double microemulsions for improved absorption of scarcely bioavailable drugs Pharm. J. Slovenia 54 2003 469 470
5. P.P. Constantinides Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects Pharm. Res. 9 1995 87 93
6. M. Grassi, and G. Cadelli Theoretical considerations on the in vivo intestinal permeability determination by means of the single pass and recirculating techniques Int. J. Pharm. 229 2001 95 105
7. A.J. Humberstone, and W.N. Charman Lipid-based vehicles for the oral delivery for poorly water soluble drugs Adv. Drug Del. Rev. 25 1997 47 58
8. S.M. Khoo, A.J. Humberstone, C.J.H. Porter, G.A. Edwards, and W.N. Charman Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine Int. J. Pharm. 167 1998 155 164
9. G.A. Lewis, D. Mathieu, and R. Phan-Tan-Luu Pharmaceutical Experimental Design 1999 Marcel Dekker New York
10. Mathieu, D., Nony, J., Phan-Tan-Luu, R., 2003. NEMRODW (New Efficient Methodology for research using Optimal Design) software-L.P.R.A.I., Marseille.
11. F. Meriani, N. Coceani, D. Voinovich, and M. Grassi In vitro nimesulide absorption from different formulations J. Pharm. Sci. 93 2004 540 552
12. M. Newton, J. Petersson, F. Podczeck, A. Clarke, and S. Booth The influence of formulation variables on the properties of pellets containing a self-emulsifying mixture J. Pharm. Sci. 90 2001 987 995
13. C.M. O'Driscoll Lipid-based formulations for intestinal lymphatic delivery Eur. J. Pharm. Sci. 15 2002 405 415
14. C.W. Pouton Self-emulsifying drug delivery systems: assessment of the efficiency of emulsification Int. J. Pharm. 17 2000 335 348
15. R.J. Schilling, and A.K. Mira Intestinal mucosal transport of insulin Int. J. Pharm. 62 1990 53 64
16. N.H. Shah, M.T. Carvajal, C.I. Patel, M.H. Infield, and A.W. Malick Self-emulsifying drug delivery systems (SEDDS) with polyglycolized glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs Int. J. Pharm. 106 1994 15 23
17. D. Vojnovic, P. Rupena, M. Moneghini, F. Rubessa, S. Coslovich, R. Phan-Tan-Luu, and M. Sergent Experimental research methodology applied to wet peletisation in a high shear mixer. Part I. S. T. P Pharm. Sci. 3 1993 130 135
18. D. Vojnovic, M. Moneghini, F. Rubessa, and A. Zanchetta Simultaneous optimization of several response variables in a granulation process Drug. Dev. Ind. Pharm. 19 1993 1479 1496
19. D. Vojnovic, D. Chicco, and H. El Zenary Doehlert experimental design applied to optimisation and quality control of a granulation process in a high shear mixer Int. J. Pharm. 145 1996 203 213