Effects of spray drying process parameters on the solubility behavior and physical stability of solid dispersions prepared using a laboratory-scale spray dryer

Drug Development and Industrial Pharmacy

Volumn 39, Issue 9, 2013, Pages 1484-1493

  Kojima, Yuki ^a   Ohta, Tomoaki ^a   Shiraki, Kouji ^a   Takano, Ryusuke ^a   Maeda, Hiroyuki ^a   Ogawa, Yutaka ^b  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^b Chugai Pharma Manufacturing Co Ltd   (Japan)

Author keywords

Nano TA; Physical stability; Process parameter; Solid dispersion; Solubility behavior; Spray drying

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE; NIFEDIPINE; NILVADIPINE; NITROGEN;

ANALYTIC METHOD; ARTICLE; CONCENTRATION (PARAMETERS); DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DISSOLUTION; FLOW RATE; LABORATORY DEVICE; LABORATORY SCALE SPRAY DRYER; MORPHOLOGY; PARTICLE SIZE; PHASE SEPARATION; PHYSICAL CHEMISTRY; SCANNING ELECTRON MICROSCOPE; SOLUBILITY; SPRAY DRYING; STORAGE; THERMAL ANALYSIS; X RAY DIFFRACTION;

CALCIUM CHANNEL BLOCKERS; CALORIMETRY, DIFFERENTIAL SCANNING; DRUG COMPOUNDING; DRUG STABILITY; DRUG STORAGE; EXCIPIENTS; HOT TEMPERATURE; KINETICS; METHYLCELLULOSE; MICROSCOPY, ELECTRON, SCANNING; MODELS, CHEMICAL; NIFEDIPINE; POWDER DIFFRACTION; POWDERS; QUALITY CONTROL; SOLUBILITY; SUSPENSIONS; TRANSITION TEMPERATURE;

EID: 84881124464     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2012.692378     Document Type: Article

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