PLGF repairs myocardial ischemia through mechanisms of angiogenesis, cardioprotection and recruitment of myo-angiogenic competent marrow progenitors

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Iwasaki, Hiroto ^a,b   Kawamoto, Atsuhiko ^a   Tjwa, Marc ^c,d   Horii, Miki ^a   Hayashi, Saeko ^a   Oyamada, Akira ^a   Matsumoto, Tomoyuki ^a   Suehiro, Shigefumi ^b   Carmeliet, Peter ^c,d   Asahara, Takayuki ^a,e  

^a INSTITUTE OF BIOMEDICAL RESEARCH AND INNOVATION   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^e TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PLACENTAL GROWTH FACTOR; STROMAL CELL DERIVED FACTOR 1; GREEN FLUORESCENT PROTEIN; PLACENTA PROTEIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BONE MARROW CELL; CARDIOVASCULAR RESPONSE; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART PERFORMANCE; HEART PROTECTION; MALE; NONHUMAN; PHENOTYPE; RAT; UPREGULATION; VASCULARIZATION; ANIMAL; CHEMISTRY; CYTOLOGY; ELECTROCARDIOGRAPHY; FEMALE; HEART MUSCLE; HEART MUSCLE ISCHEMIA; HEMODYNAMICS; HUMAN; METABOLISM; METHODOLOGY; MOUSE; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; REGENERATION; SPRAGUE DAWLEY RAT; STEM CELL; TRANSGENIC MOUSE;

ANIMALS; BONE MARROW CELLS; CELL PROLIFERATION; ELECTROCARDIOGRAPHY; FEMALE; GENE TRANSFER TECHNIQUES; GREEN FLUORESCENT PROTEINS; HEMODYNAMICS; HUMANS; MALE; MICE; MICE, TRANSGENIC; MYOCARDIAL ISCHEMIA; MYOCARDIUM; NEOVASCULARIZATION, PATHOLOGIC; PHENOTYPE; PREGNANCY PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; REGENERATION; STEM CELLS;

EID: 80053276911     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024872     Document Type: Article

References (31)

1. Maglione D, Guerriero V, Viglietto G, Delli-Bovi P, Persico MG, (1991) Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. Proc Natl Acad Sci U S A 88: 9267-71.
2. Carmeliet P, Moons L, Luttun A, Vincenti V, Compernolle V, et al. (2001) Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat Med 7: 575-83.
3. Luttun A, Tjwa M, Moons L, Wu Y, Angelillo-Scherrer A, et al. (2002) Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med 8: 831-40.
4. Wei SC, Tsao PN, Yu SC, Shun CT, Tsai-Wu JJ, et al. (2005) Placenta growth factor expression is correlated with survival of patients with colorectal cancer. Gut 54: 666-72.
5. Odorisio T, Cianfarani F, Failla CM, Zambruno G, (2006) The placenta growth factor in skin angiogenesis. J Dermatol Sci 41: 11-9.
6. Lenderink T, Heeschen C, Fichtlscherer S, Dimmeler S, Hamm CW, et al. (2006) Elevated placental growth factor levels are associated with adverse outcomes at four-year follow-up in patients with acute coronary syndromes. J Am Coll Cardiol 47: 307-11.
7. Iwama H, Uemura S, Naya N, Imagawa K, Takemoto Y, et al. (2006) Cardiac expression of placental growth factor predicts the improvement of chronic phase left ventricular function in patients with acute myocardial infarction. J Am Coll Cardiol 47: 1559-67.
8. Autiero M, Luttun A, Tjwa M, Carmeliet P, (2003) Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders. J Thromb Haemost 1: 1356-70.
9. Losordo DW, Vale PR, Hendel RC, Milliken CE, Fortuin FD, et al. (2002) Phase 1/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia. Circulation 105: 2012-8.
10. Li B, Sharpe EE, Maupin AB, Teleron AA, Pyle AL, et al. (2006) VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization. Faseb J 20: 1495-7.
11. Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, et al. (2005) VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438: 820-7.
12. Roy H, Bhardwaj S, Babu M, Jauhiainen S, Herzig KH, et al. (2005) Adenovirus-mediated gene transfer of placental growth factor to perivascular tissue induces angiogenesis via upregulation of the expression of endogenous vascular endothelial growth factor-A. Hum Gene Ther 16: 1422-8.
13. Ninomiya M, Koyama H, Miyata T, Hamada H, Miyatake S, et al. (2003) Ex vivo gene transfer of basic fibroblast growth factor improves cardiac function and blood flow in a swine chronic myocardial ischemia model. Gene Ther 10: 1152-60.
14. Dor Y, Djonov V, Abramovitch R, Itin A, Fishman GI, et al. (2002) Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy. Embo J 21: 1939-47.
15. Mamluk R, Gechtman Z, Kutcher ME, Gasiunas N, Gallagher J, et al. (2002) Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain. J Biol Chem 277: 24818-25.
16. Kidoguchi K TM, Mizobe T, Koyama J, Kondoh T, Kohmura E, et al. (2006) In vivo X-ray angiography in the mouse brain using synchrotron radition. Stroke 37: 1856-1861.
17. Cianfarani F, Zambruno G, Brogelli L, Sera F, Lacal PM, et al. (2006) Placenta Growth Factor in Diabetic Wound Healing: Altered Expression and Therapeutic Potential. Am J Pathol 169: 1167-1182.
18. Janssens S, Dubois C, Bogaert J, Theunissen K, Deroose C, et al. (2006) Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial. Lancet 367: 113-21.
19. Jin DK, Shido K, Kopp HG, Petit I, Shmelkov SV, et al. (2006) Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4(+) hemangiocytes. Nat Med 12: 557-567.
20. Szukiewicz D, Szewczyk G, Watroba M, Kurowska E, Maslinski S, (2005) Isolated placental vessel response to vascular endothelial growth factor and placenta growth factor in normal and growth-restricted pregnancy. Gynecol Obstet Invest 59: 102-7.
21. Adini A, Kornaga T, Firoozbakht F, Benjamin LE, (2002) Placental growth factor is a survival factor for tumor endothelial cells and macrophages. Cancer Res 62: 2749-52.
22. Horio T, Maki T, Kishimoto I, Tokudome T, Okumura H, et al. (2005) Production and autocrine/paracrine effects of endogenous insulin-like growth factor-1 in rat cardiac fibroblasts. Regul Pept 124: 65-72.
23. Chintalgattu V, Nair DM, Katwa LC, (2003) Cardiac myofibroblasts: a novel source of vascular endothelial growth factor (VEGF) and its receptors Flt-1 and KDR. J Mol Cell Cardiol 35: 277-86.
24. Li Q, Li B, Wang X, Leri A, Jana KP, et al. (1997) Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. J Clin Invest 100: 1991-9.
25. Mehrhof FB, Muller FU, Bergmann MW, Li P, Wang Y, et al. (2001) In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein. Circulation 104: 2088-94.
26. Dallabrida SM, Ismail N, Oberle JR, Himes BE, Rupnick MA, (2005) Angiopoietin-1 promotes cardiac and skeletal myocyte survival through integrins. Circ Res 96: e8-24.
27. Takahashi M, Li TS, Suzuki R, Kobayashi T, Ito H, et al. (2006) Cytokines produced by bone marrow cells can contribute to functional improvement of the infarcted heart by protecting cardiomyocytes from ischemic injury. Am J Physiol Heart Circ Physiol 291: H886-93.
28. Ii M, Nishimura H, Iwakura A, Wecker A, Eaton E, et al. (2005) Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via "imported" nitric oxide synthase activity. Circulation 111: 1114-20.
29. Askari AT, Unzek S, Popovic ZB, Goldman CK, Forudi F, et al. (2003) Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy. Lancet 362: 697-703.
30. Laflamme MA, Gold J, Xu C, Hassanipour M, Rosler E, et al. (2005) Formation of human myocardium in the rat heart from human embryonic stem cells. Am J Pathol 167: 663-71.
31. Fukuhara S, Tomita S, Nakatani T, Ohtsu Y, Ishida M, et al. (2004) G-CSF promotes bone marrow cells to migrate into infarcted mice heart, and differentiate into cardiomyocytes. Cell Transplant 13: 741-8.