In vitro anti inflammatory activity of Aloe vera by down regulation of MMP-9 in peripheral blood mononuclear cells

Journal of Ethnopharmacology

Volumn 141, Issue 1, 2012, Pages 542-546

  Vijayalakshmi, Damodharan ^a   Dhandapani, Ramamurthy ^b   Jayaveni, Sivalingam ^a   Jithendra, Panneer Selvam ^a   Rose, Chellan ^a   Mandal, Asit Baran ^a  

^a CENTRAL LEATHER RESEARCH INSTITUTE   (India)

^b PERIYAR UNIVERSITY   (India)

Author keywords

Aloe vera gel; Antiinflammatory activity; Cytotoxicity; MMP 9; Peripheral blood mononuclear cells

Indexed keywords

ANTIINFLAMMATORY AGENT; DYE; GELATINASE B; HERBACEOUS AGENT; TETRAZOLIUM;

ALOE VERA; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL COUNT; CELL ISOLATION; CELL VIABILITY; CONCENTRATION RESPONSE; CYTOTOXICITY; DENSITY GRADIENT CENTRIFUGATION; DOWN REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VENOUS BLOOD; ZYMOGRAPHY;

ALOE; ANTI-INFLAMMATORY AGENTS; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GELS; GENE EXPRESSION REGULATION; HUMANS; LEUKOCYTES, MONONUCLEAR; MATRIX METALLOPROTEINASE 9; MICROSCOPY, ELECTRON, SCANNING; MOLECULAR WEIGHT; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; PLANTS, MEDICINAL; PROTEASE INHIBITORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

ALOE VERA;

EID: 84859765094     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2012.02.040     Document Type: Article

References (17)

1. P. Atherton Aloe vera: magic or medicine? Nursing Standard 41 1998 49 54
2. P. Borden, and R.A. Heller Transcriptional control of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases Critical Reviews in Eukaryotic Gene Expression 7 1997 159 178
3. A. Boyum Isolation of mononuclear cells and granulocytes from human blood. Isolation of mononuclear cells by one centrifugation and of granulocytes by combining centrifugation and sedimentation at 1 g Scandinavian Journal of Clinical and Laboratory Investigation Supplementum 97 1968 77 89
4. A.T. Chan, E.L. Giovannucci, J.A. Meyerhardt, E.S. Schernhammer, K. Wu, and C.S. Fuchs Aspirin dose and duration of use and risk of colorectal cancer in men Gastroenterology 134 1 2008 21 28
5. N.R. Cook, I.M. Lee, and D. Gaziano Low-dose aspirin in the primary prevention of cancer. The Women's Health Study: a randomized controlled trial Journal of the American Medical Association 294 1 2005 47 55
6. L.M. Coussens, and Z. Werb Inflammation and cancer Nature 420 2002 860 867
7. R.B. David, Senechal-Willis Patti, C.L. Linda, G.H. Brenda, and M.D. Sasha Suppression of lipopolysaccharide-induced inflammatory responses in RAW 264.7 murine macrophages by aqueous extract of Clinopodium vulgare L. (Lamiaceae) Journal of Ethnopharmacology 126 2009 397 405
8. R.H. Davis, M.G. Leitner, J.M. Russo, and M.E. Byrne Anti inflammatory activity of Aloe vera against a spectrum of irritants Journal of the American Podiatric Medical Association 79 1989 263 276
9. Fatema Habeeb, Graham Stables, Fiona Bradbury, Stephanie Nong, Pamela Cameron, Robin Plevin, Valerie, and A. Ferro The inner gel component of Aloe vera suppresses bacterial-induced pro-inflammatory cytokines from human immune cells Methods 42 2007 388 393
10. U.K. Laemmli Cleavage of structural proteins during the assembly of the bacteriophage T4 Nature 227 1970 680 685
11. T. Mossmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays Journal of Immunological Methods 65 1983 55 63
12. C. Nathan Points of control in inflammation Nature 420 2002 846 852
13. T. Reynolds, and A.C. Dweck Aloe vera leaf gel: a review update Journal of Ethnopharmacology 68 1999 3 37
14. D. Sarkar, A. Dutta, M. Das, K. Sarkar, C. Mandal, and M. Chatterjee Effect of Aloe vera on nitric oxide production by macrophages during inflammation Indian Journal of Pharmacology 37 6 2005 371 375
15. B. Vazquez, G. Avila, D. Segura, and B. Escalante Antiinflammatory activity of extracts from Aloe vera gel Journal of Ethnopharmacology 55 1996 69 75
16. B.A. Veld, A. Ruitenberg, and A. Hofman Nonsteroidal anti-inflammatory drugs and the risk of Alzheimer's disease New England Journal of Medicine 345 2001 1515 1521
17. H. Wong, H. Muzik, L.L. Groft, M.A. Lafleur, C. Matouk, and P.A. Forsyth Monitoring MMP and TIMP mRNA expression by RTPCR Methods in Molecular Biology 151 2001 305 320