Effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing in rats

World Journal of Gastroenterology

Volumn 12, Issue 13, 2006, Pages 2034-2039

  Eamlamnam, Kallaya ^a   Patumraj, Suthiluk ^a   Visedopas, Naruemon ^a   Thong Ngam, Duangporn ^a  

^a CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

Aloe vera; Gastric microcirculation; Gastric ulcer healing; IL 10; Sucralfate; TNF

Indexed keywords

ACETIC ACID; ALOE VERA EXTRACT; INTERLEUKIN 10; SUCRALFATE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; EPITHELIUM CELL; GASTRITIS; HISTOPATHOLOGY; LEUKOCYTE ADHERENCE; MALE; NONHUMAN; PROTEIN BLOOD LEVEL; RAT; RAT STRAIN; STATISTICAL SIGNIFICANCE; STOMACH BLOOD FLOW; STOMACH GLAND; STOMACH ULCER; ULCER HEALING; VENULE;

EID: 33646443703     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v12.i13.2034     Document Type: Article

References (55)

1. Szabo S, Trier JS, Brown A. Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology 1985; 88: 228-236
2. Feldman M, Walker P, Goldschmiedt M, Cannon D. Role of affect and personality in gastric acid secretion and serum gastrin concentration. Comparative studies in normal men and in male duodenal ulcer patients. Gastroenterology 1992; 102: 175-180
3. Konturek PC, Duda A, Brzozowski T, Konturek SJ, Kwiecien S, Drozdowicz D, Pajdo R, Meixner H, Hahn EG. Activation of genes for superoxide dismutase, interleukin-1beta, tumor necrosis factor-alpha, and intercellular adhesion molecule-1 during healing of ischemia-reperfusion-induced gastric injury. Scand J Gastroenterol 2000; 35: 452-463
4. Kwiecien S, Brzozowski T, Konturek SJ. Effects of reactive oxygen species action on gastric mucosa in various models of mucosal injury. J Physiol Pharmacol 2002; 53: 39-50
5. Moon EJ, Lee YM, Lee OH, Lee MJ, Lee SK, Chung MH, Park YI, Sung CK, Choi JS, Kim KW. A novel angiogenic factor derived from Aloe vera gel: beta- sitosterol, a plant sterol. Angiogenesis 1999; 3: 117-123
6. Capasso F, Gaginella TS. Laxatives: a practice guide. Milan: Springer Italia, 1997
7. Ghannam N, Kingston M, Al-Meshaal IA, Tariq M, Parman NS, Woodhouse N. The antidiabetic activity of aloes: prelimiary clinical and experimental observations. Horm Res 1986; 24: 288-294
8. Yagi A, Shibata S, Nishioka I, Iwadare S, Ishida Y. Cardiac stimulant action of constituents of Aloe saponaria. J Pharm Sci 1982; 71: 739-741
9. Davis RH, Leitner MG, Russo JM, Byrne ME. Wound healing. Oral and topical activity of Aloe vera. J Am Podiatr Med Assoc 1989; 79: 559-562
10. Parish LC, Witkoski JA, Millikan LE. Aloe vera: its chemical and therapeutic properties. Int J Dermatol 1991; 30: 679
11. Klein AD, Penneys NS. Aloe vera. J Am Acad Dermatol 1988; 18: 714-720
12. Lushbaugh CC, Hale DB. Experimental acute radioder-matitis following beta irradiation. V. Histopath-ological study of the mode of action of therapy with Aloe vera. Cancer 1953; 6: 690-698
13. Blitz JJ, Smith JW, Gerard JR. Aloe vera gel in peptic ulcer therapy: preliminary report. J Am Osteopath Assoc 1963; 62: 731-735
14. Bovik EG. Aloe vera. Panacea or old wives' tales? Texas Detal Journal 1966; 84: 13-16
15. Gjerstad G, Riner TD. Current status of aloe as a cure-all. Am J Pharm Sci Support Public Health 1968; 140: 58-64
16. Mahattanadul S. Antigastric ulcer properties of Aloe vera. Songklanakarin J Sci Technol 1995; 18: 49-57
17. Galal EE, Kandil A, Hegazy R, El Ghoroury M. and Gobran W. Aloe vera and gastrogenic ulceration. J Drug Res Egypt 1975; 7: 73-78
18. Kandil A, Gobran W. Protection gastric mucosa by aloe vera. Bull Islamic Med 1982; 2: 508-511
19. La-angphanich S. Ulcer-healing effect of Aloe vera gel, Aloe vera whole leaf extract and cimetidine on rat gastric ulcer induced by fasting, refeeding and cortisol injection. M.Sc. Thesis in Anatomy, Bangkok, Faculty of science. Mahidol University, 1987
20. Robert A, Nezamis JE, Lancaster C. and Hanchar AJ. Cytoprotection by prostaglandins in Rats. Gastroenterology 1979; 77: 433-443
21. Maze G, Terpolilli RN, Lee M. Aloe vera extract prevents aspirin- induced acute gastric mucosal injury in rats. Med Sci Res 1997; 25: 765-766
22. Suvitayavat W, Bunyapraphatsara. N, Thirawarapan SS, Watanabe K. Gastric acid secretion inbititory and gastric lesion protective effects of Aloe preparation. Thai J Phytopharm 1997; 4: 1-11
23. Teradaira R, Shinzato M, Bepp UH, Fujita K. Antigastric ulcer effects in rats of Aloe arborescens Miller var. natalensis Berger extract. Phytother Res 1993; 7: S34-S36
24. Visuthipanich W. Histochemical and pathological changes in rat gastric mucosa following Aloe vera gel and cortisol administration. M. Sc. Thesis in Anatomy, Bangkok, Faculty of science, Mahidol University, 1988
25. Lehr HA, Leunig M, Menger MD, Nolte D, Messmer K. Dorsal skinfold chamber technique for intravital microscopy in nude mice. Am J Pathol 1993; 143: 1055-1062
26. Kalia N, Brown NJ, Jacob S, Reed MW, Bardhan KD. Studies on gastric mucosal microcirculation. 1. The nature of regional variations induced by ethanol injury. Gut 1997; 40: 31-35
27. Konturek PC, Duda A, Brzozowski T, Konturek SJ, Kwiecien S, Drozdowicz D, Pajdo R, Meixner H, Hahn EG. Activation of genes for superoxide dismutase, interleukin-1beta, tumor necrosis factor-alpha, and intercellular adhesion molecule-1 during healing of ischemia-reperfusion-induced gastric injury. Scand J Gastroenterol 2000; 35: 452-463
28. Pober JS, Bevilacqua MP, Mendrick DL, Lapierre LA, Fiers W, Gimbrone MA Jr. Two distinct monokines, interleukin 1 and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells. J Immunol 1986; 136: 1680-1687
29. Pohlman TH, Stanness KA, Beatty PG, Ochs HD, Harlan JM. An endothelial cell surface factor(s) induced in vitro by lipopolysaccharide, interleukin 1, and tumor necrosis factor-alpha increases neutrophil adherence by a CDw18-dependent mechanism. J Immunol 1986; 136: 4548-4553
30. Watanabe T, Arakawa T, Fukuda T, Higuchi K, Kobayashi K. Role of neutrophils in a rat model of gastric ulcer recurrence caused by interleukin-1 beta. Am J Pathol 1997; 150: 971-979
31. Morise Z, Komatsu S, Fuseler JW, Granger DN, Perry M, Issekutz AC, Grisham MB. ICAM-1 and P-selectin expression in a model of NSAID-induced gastropathy. Am J Physiol 1998; 274: G246-G252
32. Wallace JL, McKnight W, Miyasaka M, Tamatani T, Paulson J, Anderson DC, Granger DN, Kubes P. Role of endothelial adhesion molecules in NSAID-induced gastric mucosal injury. Am J Physiol 1993; 265: G993-G998
33. Wallace JL, Arfors KE, McKnight GW. A monoclonal antibody against the CD18 leukocyte adhesion molecule prevents indomethacin-induced gastric damage in the rabbit. Gastroenterology 1991; 100: 878-883
34. Andrews FJ, Malcontenti-Wilson C, O'Brien PE. Effect of nonsteroidal anti- inflammatory drugs on LFA-1 and ICAM-1 expression in gastric mucosa. Am J Physiol 1994; 266: G657-G664
35. Wada K, Kamisaki Y, Kitano M, Kishimoto Y, Nakamoto K, Itoh T. A new gastric ulcer model induced by ischemia-reperfusion in the rat: role of leukocytes on ulceration in rat stomach. Life Sci 1996; 59: PL295-PL301
36. Dustin ML, Springer TA. T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature 1989; 341: 619-624
37. Va'zquez B, Avila G, Segura D, Escalante B. Antiinflammatory activity of extracts from Aloe vera gel. J Ethnopharmacol 1996; 55: 69-75
38. Somboonwong J, Thanamittramanee S, Jariryapongskul A, Patumraj S. Therapeutic effects of Aloe vera on cutaneous microcirculation and wound healing in second degree burn model in rats. J Med Assoc Thai 2000; 83: 417-425
39. Duansak D, Somboonwong J, Patumraj S. Effects of Aloe vera on leukocyte adhesion and TNF-alpha and IL-6 levels in burn wounded rats. Clin Hemorheol Microcirc 2003; 29: 239-246
40. Heggers JP, Loy G, Robson MC. Histological demonstration of prostaglandin and thromboxanes in burned tissue. J Surg Res 1979; 28: 110-117
41. Davis RH, Leitner MG, Russo JM, Byrne ME. Wound healing. Oral and topical activity of Aloe vera. J Am Podiatr Med Assoc 1989; 79: 559-562
42. Qu XF, Hayashi M, Yamaki K, Oh-ishi S. Assessment of vascular permeability increase in the mouse by dye leakage during paw edema. Jpn J Pharmacol 1990; 52: 500-503
43. Hollander D. Gastrointestinal complications of nonsteroidal anti-inflammatory drugs: prophylactic and therapeutic strategies. Am J Med 1994; 96: 274-281
44. Wallace JL, Mc Knight GW, Bell CJ. Adaptation of rat gastric mucosa to aspirin requires mucosal contact. Am J Physiol 1995; 268: G134-G138
45. Linder JD, Monkemuller KE, Davis JV, Wilcox CM. Cyclooxygenase-2 inhibitor celecoxib: a possible cause of gastropathy and hypoprothrombinemia. South Med J 2000; 93: 930-932
46. Watanabe S, Kobayashi T, Okuyama H. Regulation of lipopolysaccharide-induced tumor necrosis factor alpha production by endogenous prostaglandin E2 in rat resident and thioglycollate-elicited macrophages. J Lipid Mediat Cell Signal 1994; 10: 283-294
47. Ding SZ, Lam SK, Yuen ST, Wong BC, Hui WM, Ho J, Guo X, Cho CH. Prostaglandin, tumor necrosis factor alpha and neutrophils: causative relationship in indomethacin-induced stomach injuries. Eur J Pharmacol 1998; 348: 257-263
48. Fiorentino DF, Zlotnik A, Mosmann TR, Howard M, O'Garra A. IL-10 inhibits cytokine production by activated macrophages. J Immunol 1991; 147: 3815-3822
49. Ribbons KA, Thompson JH, Liu X, Pennline K, Clark DA, Miller MJ. Anti-inflammatory properties of interleukin-10 administration in hapten-induced colitis. Eur J Pharmacol 1997; 323: 245-254
50. Bodger K, Wyatt JI, Heatley RV. Gastric mucosal secretion of interleukin-10: relations to histopathology, Helicobacter pylori status, and tumur necrosis factor-alpha secretion. Gut 1997; 40: 739-744
51. Davis RH, Donato JJ, Hartman GM, Haas RC. Anti-inflammatory and wound healing activity of a growth substance in Aloe vera. J Am Podiatr Med Assoc 1994; 84: 77-81
52. Grindlay D, Reynolds T. The Aloe vera phenomenon: a review of the properties and modern uses of the leaf parenchyma gel. J Ethnopharmacol 1986; 16: 117-151
53. Barry LR. Possible mechanism of the healing action of Aloe vera gel. Cosmetic and Toileteries 1983; 98
54. Brzozowski T, Konturek PC, Konturek SJ, Drozdowicz D, Kwiecien S, Pajdo R, Bielanski W, Hahn EG. Role of gastric acid secretion in progression of acute gastric erosions induced by ischemia-reperfusion into gastric ulcers. Eur J Pharmacol 2000; 398: 147-158
55. Suvitayavat W, Sumrongkit C, Thirawarapan SS, Bunyaprahatsara N. Effects of Aloe preparation on the histamine-induced gastric secretion in rats. J Ethnopharmacol 2004; 90: 239-247