Knockdown of lipocalin-2 suppresses the growth and invasion of prostate cancer cells

Prostate

Volumn 73, Issue 12, 2013, Pages 1281-1290

  Tung, Min Che ^a   Hsieh, Shu Ching ^b   Yang, Shun Fa ^b   Cheng, Chun Wen ^b   Tsai, Rong Tzong ^b   Wang, Shao Chuan ^c   Huang, Min Hsien ^d   Hsieh, Yi Hsien ^b,c  

^a TUNGS' TAICHUNG METROHARBOR HOSPITAL   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d JEN TEH JUNIOR COLLEGE OF MEDICINE   (Taiwan)

Author keywords

invasion; lipocalin 2; migration; proliferation; prostate

Indexed keywords

GELATINASE A; GELATINASE B; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; SHORT HAIRPIN RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CANCER SIZE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; COLONY FORMING CELL; CONTROLLED STUDY; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PRIMARY TUMOR; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR INVASION; TUMOR XENOGRAFT; WESTERN BLOTTING; ZYMOGRAPHY;

INVASION; LIPOCALIN-2; MIGRATION; PROLIFERATION; PROSTATE;

ACUTE-PHASE PROTEINS; AGED; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; LIPOCALINS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MIDDLE AGED; NEOPLASM INVASIVENESS; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS;

EID: 84881083113     PISSN: 02704137     EISSN: 10970045     Source Type: Journal    
DOI: 10.1002/pros.22670     Document Type: Article

References (43)

1. Guess HA, Arrighi HM, Metter EJ, Fozard JL,. Cumulative prevalence of prostatism matches the autopsy prevalence of benign prostatic hyperplasia. Prostate 1990; 17 (3): 241-246.
2. Mimeault M, Batra SK,. Recent advances on multiple tumorigenic cascades involved in prostatic cancer progression and targeting therapies. Carcinogenesis 2006; 27 (1): 1-22.
3. Triebel S, Blaser J, Reinke H, Tschesche H,. A 25 kDa alpha 2-microglobulin-related protein is a component of the 125 kDa form of human gelatinase. FEBS Lett 1992; 314 (3): 386-388.
4. Nilsen-Hamilton M, Liu Q, Ryon J, Bendickson L, Lepont P, Chang Q,. Tissue involution and the acute phase response. Ann N Y Acad Sci 2003; 995: 94-108.
5. Leng X, Wu Y, Arlinghaus RB,. Relationships of lipocalin 2 with breast tumorigenesis and metastasis. J Cell Physiol 2011; 226 (2): 309-314.
6. Sun Y, Yokoi K, Li H, Gao J, Hu L, Liu B, Chen K, Hamilton SR, Fan D, Sun B, Zhang W,. NGAL expression is elevated in both colorectal adenoma-carcinoma sequence and cancer progression and enhances tumorigenesis in xenograft mouse models. Clin Cancer Res 2011; 17 (13): 4331-4340.
7. Cho H, Kim JH,. Lipocalin2 expressions correlate significantly with tumor differentiation in epithelial ovarian cancer. J Histochem Cytochem 2009; 57 (5): 513-521.
8. Mannelqvist M, Stefansson IM, Wik E, Kusonmano K, Raeder MB, Øyan AM, Kalland KH, Moses MA, Salvesen HB, Akslen LA,. Lipocalin 2 expression is associated with aggressive features of endometrial cancer. BMC Cancer 2012; 12 (1): 169.
9. Zhang H, Xu L, Xiao D, Xie J, Zeng H, Wang Z, Zhang X, Niu Y, Shen Z, Shen J, Wu X, Li E,. Upregulation of neutrophil gelatinase-associated lipocalin in oesophageal squamous cell carcinoma: Significant correlation with cell differentiation and tumour invasion. J Clin Pathol 2007; 60 (5): 555-561.
10. Tong Z, Kunnumakkara AB, Wang H, Matsuo Y, Diagaradjane P, Harikumar KB, Ramachandran V, Sung B, Chakraborty A, Bresalier RS, Logsdon C, Aggarwal BB, Krishnan S, Guha S,. Neutrophil gelatinase-associated lipocalin: A novel suppressor of invasion and angiogenesis in pancreatic cancer. Cancer Res 2008; 68 (15): 6100-6108.
11. Lee EK, Kim HJ, Lee KJ, Lee HJ, Lee JS, Kim DG, Hong SW, Yoon Y, Kim JS,. Inhibition of the proliferation and invasion of hepatocellular carcinoma cells by lipocalin 2 through blockade of JNK and PI3K/Akt signaling. Int J Oncol 2011; 38 (2): 325-333.
12. Leng X, Ding T, Lin H, Wang Y, Hu L, Hu J, Feig B, Zhang W, Pusztai L, Symmans WF, Wu Y, Arlinghaus RB,. Inhibition of lipocalin 2 impairs breast tumorigenesis and metastasis. Cancer Res 2009; 69 (22): 8579-8584.
13. Kubben FJ, Sier CF, Hawinkels LJ, Tschesche H, van Duijn W, Zuidwijk K, van der Reijden JJ, Hanemaaijer R, Griffioen G, Lamers CB, Verspaget HW,. Clinical evidence for a protective role of lipocalin-2 against MMP-9 autodegradation and the impact for gastric cancer. Eur J Cancer 2007; 43 (12): 1869-1876.
14. Playford RJ, Belo A, Poulsom R, Fitzgerald AJ, Harris K, Pawluczyk I, Ryon J, Darby T, Nilsen-Hamilton M, Ghosh S, Marchbank T,. Effects of mouse and human lipocalin homologues 24p3/lcn2 and neutrophil gelatinase-associated lipocalin on gastrointestinal mucosal integrity and repair. Gastroenterology 2006; 131 (3): 809-817.
15. Leng X, Lin H, Ding T, Wang Y, Wu Y, Klumpp S, Sun T, Zhou Y, Monaco P, Belmont J, Aderem A, Akira S, Strong R, Arlinghaus R,. Lipocalin 2 is required for BCR-ABL-induced tumorigenesis. Oncogene 2008; 27 (47): 6110-6119.
16. Iannetti A, Pacifico F, Acquaviva R, Lavorgna A, Crescenzi E, Vascotto C, Tell G, Salzano AM, Scaloni A, Vuttariello E, Chiappetta G, Formisano S, Leonardi A,. The neutrophil gelatinase-associated lipocalin (NGAL), a NF-kappaB-regulated gene, is a survival factor for thyroid neoplastic cells. Proc Natl Acad Sci USA 2008; 105 (37): 14058-14063.
17. Hu L, Hittelman W, Lu T, Ji P, Arlinghaus R, Shmulevich I, Hamilton SR, Zhang W,. NGAL decreases E-cadherin-mediated cell-cell adhesion and increases cell motility and invasion through Rac1 in colon carcinoma cells. Lab Invest 2009; 89 (5): 531-548.
18. Leung L, Radulovich N, Zhu CQ, Organ S, Bandarchi B, Pintilie M, To C, Panchal D, Tsao MS,. Lipocalin2 promotes invasion, tumorigenicity and gemcitabine resistance in pancreatic ductal adenocarcinoma. PLoS ONE 2012; 7 (10): e46677.
19. Chien MH, Ying TH, Yang SF, Yu JK, Hsu CW, Hsieh SC, Hsieh YH,. Lipocalin-2 induces apoptosis in human hepatocellular carcinoma cells through activation of mitochondria pathways. Cell Biochem Biophys 2012; 64 (3): 177-186.
20. Mahadevan NR, Rodvold J, Almanza G, Perez AF, Wheeler MC, Zanetti M,. ER stress drives Lipocalin 2 upregulation in prostate cancer cells in an NF-kappaB-dependent manner. BMC Cancer 2011; 11: 229.
21. Nadendla SK, Hazan A, Ward M, Harper LJ, Moutasim K, Bianchi LS, Naase M, Ghali L, Thomas GJ, Prowse DM, Philpott MP, Neill GW,. GLI1 confers profound phenotypic changes upon LNCaP prostate cancer cells that include the acquisition of a hormone independent state. PLoS ONE 2011; 6 (5): e20271.
22. Shrivastav A, Varma S, Senger A, Khandelwal RL, Carlsen S, Sharma RK,. Overexpression of Akt/PKB modulates N-myristoyltransferase activity in cancer cells. J Pathol 2009; 218 (3): 391-398.
23. Berger T, Cheung CC, Elia AJ, Mak TW,. Disruption of the Lcn2 gene in mice suppresses primary mammary tumor formation but does not decrease lung metastasis. Proc Natl Acad Sci USA 2010; 107 (7): 2995-3000.
24. Wu TT, Hsieh YH, Wu CC, Hsieh YS, Huang CY, Liu JY,. Overexpression of protein kinase C alpha mRNA in human hepatocellular carcinoma: A potential marker of disease prognosis. Clin Chim Acta 2007; 382 (1-2): 54-58.
25. Tsai SJ, Hwang JM, Hsieh SC, Ying TH, Hsieh YH,. Overexpression of myeloid zinc finger 1 suppresses matrix metalloproteinase-2 expression and reduces invasiveness of SiHa human cervical cancer cells. Biochem Biophys Res Commun 2012; 425 (2): 462-467.
26. Mitchell S, Abel P, Ware M, Stamp G, Lalani E,. Phenotypic and genotypic characterization of commonly used human prostatic cell lines. BJU Int 2000; 85 (7): 932-944.
27. Chakraborty S, Kaur S, Guha S, Batra SK,. The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer. Biochim Biophys Acta 2012; 1826 (1): 129-169.
28. Deryugina EI, Quigley JP,. Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev 2006; 25 (1): 9-34.
29. Bauer M, Eickhoff JC, Gould MN, Mundhenke C, Maass N, Friedl A,. Neutrophil gelatinase-associated lipocalin (NGAL) is a predictor of poor prognosis in human primary breast cancer. Breast Cancer Res Treat 2008; 108 (3): 389-397.
30. Mannelqvist M, Stefansson IM, Wik E, Kusonmano K, Raeder MB, Øyan AM, Kalland KH, Moses MA, Salvesen HB, Akslen LA,. Lipocalin 2 expression is associated with aggressive features of endometrial cancer. BMC Cancer 2012; 12: 169.
31. Sherr CJ, Roberts JM,. CDK inhibitors: Positive and negative regulators of G1-phase progression. Genes Dev 1999; 13 (12): 1501-1512.
32. Hui L, Zatloukal K, Scheuch H, Stepniak E, Wagner EF,. Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation. J Clin Invest 2008; 118 (12): 3943-3953.
33. Xu Y, Chen Q, Li W, Su X, Chen T, Liu Y, Zhao Y, Yu C,. Overexpression of transcriptional coactivator AIB1 promotes hepatocellular carcinoma progression by enhancing cell proliferation and invasiveness. Oncogene 2010; 29 (23): 3386-3397.
34. Wang PH, Yang SF, Tseng CJ, Ying TH, Ko JL, Lin LY,. The role of lipocalin 2 and its concernment with human nonmetastatic clone 23 type 1 and p53 in carcinogenesis of uterine cervix. Reprod Sci 2011; 18 (5): 447-455.
35. Bai J, Mei PJ, Liu H, Li C, Li W, Wu YP, Yu ZQ, Zheng JN,. BRG1 expression is increased in human glioma and controls glioma cell proliferation, migration and invasion in vitro. J Cancer Res Clin Oncol 2012; 138 (6): 991-998.
36. Gritsenko PG, Ilina O, Friedl P,. Interstitial guidance of cancer invasion. J Pathol 2012; 226 (2): 185-199.
37. Rabien A, Ergun B, Erbersdobler A, Jung K, Stephan C,. RECK overexpression decreases invasive potential in prostate cancer cells. Prostate 2012; 72 (9): 948-954.
38. Trudel D, Fradet Y, Meyer F, Harel F, Tetu B,. Membrane-type-1 matrix metalloproteinase, matrix metalloproteinase 2, and tissue inhibitor of matrix proteinase 2 in prostate cancer: Identification of patients with poor prognosis by immunohistochemistry. Hum Pathol 2008; 39 (5): 731-739.
39. Lee HJ, Lee EK, Lee KJ, Hong SW, Yoon Y, Kim JS,. Ectopic expression of neutrophil gelatinase-associated lipocalin suppresses the invasion and liver metastasis of colon cancer cells. Int J Cancer 2006; 118 (10): 2490-2497.
40. Hanai J, Mammoto T, Seth P, Mori K, Karumanchi SA, Barasch J, Sukhatme VP,. Lipocalin 2 diminishes invasiveness and metastasis of Ras-transformed cells. J Biol Chem 2005; 280 (14): 13641-13647.
41. Moses MA, Wiederschain D, Loughlin KR, Zurakowski D, Lamb CC, Freeman MR,. Increased incidence of matrix metalloproteinases in urine of cancer patients. Cancer Res 1998; 58 (7): 1395-1399.
42. Yan L, Borregaard N, Kjeldsen L, Moses MA,. The high molecular weight urinary matrix metalloproteinase (MMP) activity is a complex of gelatinase B/MMP-9 and neutrophil gelatinase-associated lipocalin (NGAL). Modulation of MMP-9 activity by NGAL. J Biol Chem 2001; 276 (40): 37258-37265.
43. Creighton CJ,. A gene transcription signature associated with hormone independence in a subset of both breast and prostate cancers. BMC Genomics 2007; 8: 199.