A gene transcription signature associated with hormone independence in a subset of both breast and prostate cancers

BMC Genomics

Volumn 8, Issue , 2007, Pages

  Creighton, Chad J ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTROGEN RECEPTOR; ANDROGEN RECEPTOR; HORMONE;

ARTICLE; BREAST CANCER; CANCER GROWTH; CANCER SURVIVAL; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; GENETIC TRANSCRIPTION; HORMONAL THERAPY; HUMAN; HUMAN CELL; PROSTATE CANCER; BREAST TUMOR; CELL CULTURE; DRUG RESISTANCE; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MALE; PROSTATE TUMOR; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

BREAST NEOPLASMS; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HORMONES; HUMANS; MALE; PROSTATIC NEOPLASMS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, ANDROGEN; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 34547792817     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-8-199     Document Type: Article

References (45)

1. Abate-Shen C Shen MM Molecular genetics of prostate cancer Genes Dev 2000, 14: 2410-34 10.1101/gad.819500 11018010
2. Elledge RM Fuqua SA Estrogen and progesterone receptors Diseases of the Breast Philadelphia: Lippincott, Williams and Wilkins Harris J, Lippman ME, Morrow M, Osborne C 2000, 471-488
3. Allred DC Brown P Medina D The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer Breast Cancer Res 2004, 6: 240-5 1064085 15535853 10.1186/bcr938
4. Feldman BJ Feldman D The development of androgen-independent prostate cancer Nat Rev Cancer 2001, 1: 34-45 10.1038/35094009 11900250
5. Clark GM McGuire WL Steroid receptors and other prognostic factors in primary breast cancer Semin Oncol 1988, 15: 20-25 3285482
6. Sorlie T Perou CM Tibshirani R Aas T Geisler S Johnsen H Hastie T Eisen MB van de Rijn M Jeffrey SS Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications Proc Natl Acad Sci USA 2001, 98: 10869-10874 58566 11553815 10.1073/ pnas.191367098
7. Sorlie T Tibshirani R Parker J Hastie T Marron JS Nobel A Deng S Johnsen H Pesich R Geisler S Repeated observation of breast tumor subtypes in independent gene expression data sets Proc Natl Acad Sci USA 2003, 100: 8418-23 166244 12829800 10.1073/pnas.0932692100
8. Zhao H Kim Y Wang P Lapointe J Tibshirani R Pollack JR Brooks JD Genome-wide characterization of gene expression variations and DNA copy number changes in prostate cancer cell lines Prostate 2005, 63: 187-197 10.1002/pros.20158 15486987
9. van de Vijver MJ He YD van't Veer LJ Dai H Hart AA Voskuil DW Schreiber GJ Peterse JL Roberts C Marton MJ A gene-expression signature as a predictor of survival in breast cancer N Engl J Med 2002, 347: 1999-2009 10.1056/NEJMoa021967 12490681
10. Wang Y Klijn JG Zhang Y Sieuwerts AM Look MP Yang F Talantov D Timmermans M Meijer-van Gelder ME Yu J Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer Lancet 2005, 365: 671-9 15721472
11. Bild AH Yao G Chang JT Wang Q Potti A Chasse D Joshi MB Harpole D Lancaster JM Berchuck A Oncogenic pathway signatures in human cancers as a guide to targeted therapies Nature 2006, 439: 353-7 10.1038/ nature04296 16273092
12. Neve RM Chin K Fridlyand J Yeh J Baehner FL Fevr T Clark L Bayani N Coppe JP Tong F A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes Cancer Cell 2006, 10: 515-27 10.1016/j.ccr.2006.10.008 17157791
13. Creighton CJ Cordero KE Larios JM Miller RS Johnson MD Chinnaiyan AM Marc E Lippman ME Rae JM Genes regulated by estrogen in breast tumor cells in vitro are similarly regulated in vivo in tumor xenografts and human breast tumors Genome Biol 2006, 7: R28 1557996 16606439 10.1186/ gb-2006-7-4-r28
14. Chen CD Welsbie DS Tran C Baek SH Chen R Vessella R Rosenfeld MG Sawyers CL Molecular determinants of resistance to antiandrogen therapy Nat Med 2004, 10: 33-9 10.1038/nm972 14702632
15. Tian L Greenberg SA Kong SW Altschuler J Kohane IS Park PJ Discovering statistically significant pathways in expression profiling studies Proc Natl Acad Sci USA 2005, 102: 13544-9 1200092 16174746 10.1073/ pnas.0506577102
16. Glinsky GV Glinskii AB Stephenson AJ Hoffman RM Gerald WL Gene expression profiling predicts clinical outcome of prostate cancer J Clin Invest 2004, 113: 913-23 362118 15067324 10.1172/JCI200420032
17. Yu YP Landsittel D Jing L Nelson J Ren B Liu L McDonald C Thomas R Dhir R Finkelstein S Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy J Clin Oncol 2004, 22: 2790-9 10.1200/JCO.2004.05.158 15254046
18. Lapointe J Li C Higgins JP van de Rijn M Bair E Montgomery K Ferrari M Egevad L Rayford W Bergerheim U Gene expression profiling identifies clinically relevant subtypes of prostate cancer Proc Natl Acad Sci USA 2004, 101: 811-6 321763 14711987 10.1073/pnas.0304146101
19. DePrimo SE Diehn M Nelson JB Reiter RE Matese J Fero M Tibshirani R Brown PO Brooks JD Transcriptional programs activated by exposure of human prostate cancer cells to androgen Genome Biol 2002, 3: R32 10.1186/ gb-2002-3-7-research0032
20. Majumder PK Febbo PG Bikoff R Berger R Xue Q McMahon LM Manola J Brugarolas J McDonnell TJ Golub TR mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways Nat Med 2004, 10: 594-601 10.1038/ nm1052 15156201
21. Lamb J Ramaswamy S Ford HL Contreras B Martinez RV Kittrell FS Zahnow CA Patterson N Golub TR Ewen ME A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer Cell 2003, 114: 323-34 10.1016/S0092-8674(03)00570-1 12914697
22. Creighton CJ Hilger AM Murthy S Rae JM Chinnaiyan AM El-Ashry D Activation of mitogen-activated protein kinase in estrogen receptor alpha-positive breast cancer cells in vitro induces an in vivo molecular phenotype of estrogen receptor alpha-negative human breast tumors Cancer Res 2006, 66: 3903-11 10.1158/0008-5472.CAN-05-4363 16585219
23. Visakorpi T Hyytinen E Koivisto P Tanner M Keinanen R Palmberg C Palotie A Tammela T Isola J Kallioniemi OP In vivo amplification of the androgen receptor gene and progression of human prostate cancer Nat Genet 1995, 9 :401-406 10.1038/ng0495-401 7795646
24. Veldscholte J Berrevoets CA Ris-Stalpers C Kuiper GG Jenster G Trapman J Brinkmann AO Mulder E The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens J Steroid Biochem Mol Biol 1992, 41: 665-669 10.1016/0960-0760(92)90401-4 1562539
25. Craft N Shostak Y Carey M Sawyers CL A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase Nat Med 1999, 5: 280-285 10.1038/6495 10086382
26. Vicentini C Festuccia C Gravina GL Angelucci A Marronaro A Bologna M Prostate cancer cell proliferation is strongly reduced by the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in vitro on human cell lines and primary cultures J Cancer Res Clin Oncol 2003, 129: 165-174 12712332
27. Di Lorenzo G Tortora G D'Armiento FP De Rosa G Staibano S Autorino R D'Armiento M De Laurentiis M De Placido S Catalano G Expression of epidermal growth factor receptor correlates with disease relapse and progression to androgen-independence in human prostate cancer Clin Cancer Res 2002, 8: 3438-3444 12429632
28. Bartlett JM Brawley D Grigor K Munro AF Dunne B Edwards J Type I receptor tyrosine kinases are associated with hormone escape in prostate cancer J Pathol 2005, 205: 522-529 10.1002/path.1735 15685688
29. Shah RB Ghosh D Elder JT Epidermal growth factor receptor (ErbB1) expression in prostate cancer progression: Correlation with androgen independence Prostate 2006, 66: 1437-1444 10.1002/pros.20460 16741920
30. Angelucci A Gravina GL Rucci N Millimaggi D Festuccia C Muzi P Teti A Vicentini C Bologna M Suppression of EGF-R signaling reduces the incidence of prostate cancer metastasis in nude mice Endocr Relat Cancer 2006, 13: 197-210 10.1677/erc.1.01100 16601288
31. Stanbrough M Bubley GJ Ross K Golub TR Rubin MA Penning TM Febbo PG Balk SP Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer Cancer Res 2006, 66: 2815-25 10.1158/0008-5472.CAN-05-4000 16510604
32. Tomlins SA Mehra R Rhodes DR Cao X Wang L Dhanasekaran SM Kalyana-Sundaram S Wei JT Rubin MA Pienta KJ Shah RB Chinnaiyan AM Integrative molecular concept modeling of prostate cancer progression Nat Genet 2007, 39: 41-51 10.1038/ng1935 17173048
33. Bubendorf L Kolmer M Kononen J Koivisto P Mousses S Chen Y Mahlamäki E Schraml P Moch H Willi N Elkahloun AG Pretlow TG Gasser TC Mihatsch MJ Sauter G Kallioniemi OP Hormone therapy failure is human prostate cancer: Analysis by complementary DNA and tissue microarrays J Natl Cancer Inst 1999, 91: 1758-1764 10.1093/jnci/91.20.1758 10528027
34. Mousses S Wagner U Chen Y Kim JW Bubendorf L Bittner M Pretlow T Elkahloun AG Trepel JB Kallioniemi OP Failure of hormone therapy in prostate cancer involves systematic restoration of androgen responsive genes and activation of rapamycin sensitive signaling Oncogene 2001, 20: 6718-6723 10.1038/sj.onc.1204889 11709706
35. Amler LC Agus DB LeDuc C Sapinoso ML Fox WD Kern S Lee D Wang V Leysens M Higgins B Martin J Gerald W Dracopoli N Cordon-Cardo C Scher HI Hampton GM Dysregulated expression of androgen-responsive and nonresponsive genes in the androgen-independent prostate cancer xenograft model CWR22-R Cancer Res 2000, 60: 6134-6141 11085537
36. Sirotnak FM She Y Khokhar NZ Hayes P Gerald W Scher HI Microarray analysis of prostate cancer progression to reduced androgen dependence: studies in unique models contrasts early and late molecular events Mol Carcinog 2004, 41: 150-163 10.1002/mc.20051 15390081
37. Doane AS Danso M Lal P Donaton M Zhang L Hudis C Gerald WL An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen Oncogene 2006, 25: 3994-4008 10.1038/sj.onc.1209415 16491124
38. Farmer P Bonnefoi H Becette V Tubiana-Hulin M Fumoleau P Larsimont D Macgrogan G Bergh J Cameron D Goldstein D Duss S Nicoulaz AL Brisken C Fiche M Delorenzi M Iggo R Identification of molecular apocrine breast tumours by microarray analysis Oncogene 2005, 24: 4660-71 10.1038/ sj.onc.1208561 15897907
39. Agrawal A Gutteridge E Gee JM Nicholson RI Robertson JF Overview of tyrosine kinase inhibitors in clinical breast cancer Endocr Relat Cancer 2005, 12 (Suppl 1): S135-44 10.1677/erc.1.01059 16113090
40. Hughes C Murphy A Martin C Sheils O O'Leary J Molecular pathology of prostate cancer J Clin Pathol 2005, 58: 673-84 10.1136/jcp.2002.003954 15976331
41. Rhodes DR Barrette TR Rubin MA Ghosh D Chinnaiyan AM Meta-analysis of microarrays: Interstudy validation of gene expression profiles reveals pathway dysregulation in prostate cancer Cancer Res 2002, 62: 4427-4433 12154050
42. Rae JM Creighton CJ Meck JM Haddad BR Johnson MD MDA-MB-435 cells are derived from M14 Melanoma cells - a loss for breast cancer, but a boon for melanoma research Breast Cancer Res Treat 104: 1-13 19 Epub Sep 27 2006 10.1007/s10549-006-9392-8 17004106
43. Eisen MB Spellman PT Brown PO Botstein D Cluster analysis and display of genome-wide expression patterns Proc Natl Acad Sci USA 1998, 95: 14863-14868 24541 9843981 10.1073/pnas.95.25.14863
44. Saldanha AJ Java Treeview - extensible visualization of microarray data Bioinformatics 2004, 20: 3246-8 10.1093/bioinformatics/bth349 15180930
45. Creighton CJ A gene transcription signature of the Akt/mTOR pathway in clinical breast tumors Oncogene E-pub Jan 8 2007, 17213801