BRG1 expression is increased in human glioma and controls glioma cell proliferation, migration and invasion in vitro

Journal of Cancer Research and Clinical Oncology

Volumn 138, Issue 6, 2012, Pages 991-998

  Bai, Jin ^a   Mei, Peng Jin ^b   Liu, Hui ^a   Li, Chen ^a   Li, Wang ^a   Wu, Yong Ping ^a   Yu, Zheng Quan ^b   Zheng, Jun Nian ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

BRG1; Glioma; Invasion; Migration; Proliferation

Indexed keywords

BRG1 PROTEIN; CHOLECYSTOKININ OCTAPEPTIDE; CYCLIN B1; CYCLIN D1; GELATINASE A; SMALL INTERFERING RNA;

ADULT; ARTICLE; BENIGN TUMOR; CANCER GRADING; CANCER INHIBITION; CANCER INVASION; CARCINOGENESIS; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; GENE SILENCING; GLIOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; MALIGNANT NEOPLASTIC DISEASE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TISSUE MICROARRAY; WESTERN BLOTTING;

BRAIN NEOPLASMS; CELL CYCLE; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CELL MOVEMENT; CYCLIN B1; CYCLIN D1; DNA HELICASES; FEMALE; G1 PHASE CELL CYCLE CHECKPOINTS; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; GLIOMA; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MATRIX METALLOPROTEINASE 2; MIDDLE AGED; NEOPLASM INVASIVENESS; NUCLEAR PROTEINS; RNA, SMALL INTERFERING; SINCALIDE; TRANSCRIPTION FACTORS;

EID: 84864352060     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-012-1172-8     Document Type: Article

References (34)

1. Asp P, Wihlborg M, Karlen M, Farrants AK (2002) Expression of BRG1, a human SWI/SNF component, affects the organisation of actin filaments through the RhoA signalling pathway. J Cell Sci 115(Pt 13):2735-2746
2. Bai J, Zhang J, Wu J, Shen L, Zeng J, Ding J, Wu Y, Gong Z, Li A, Xu S, Zhou J, Li G (2010) JWA regulates melanoma metastasis by integrin alphaVbeta3 signaling. Oncogene 29(8):1227-1237. doi:10.1038/onc.2009.408
3. Barcellos-Hoff MH, Newcomb EW, Zagzag D, Narayana A (2009) Therapeutic targets in malignant glioblastoma microenvironment. Semin Radiat Oncol 19(3):163-170. doi:10.1016/j.semradonc. 2009.02.004
4. Becker TM, Haferkamp S, Dijkstra MK, Scurr LL, Frausto M, Diefenbach E, Scolyer RA, Reisman DN, Mann GJ, Kefford RF, Rizos H (2009) The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a. Mol Cancer 8:4. doi:10.1186/1476-4598-8-4
5. Biegel JA, Tan L, Zhang F, Wainwright L, Russo P, Rorke LB (2002) Alterations of the hSNF5/INI1 gene in central nervous system atypical teratoid/rhabdoid tumors and renal and extrarenal rhabdoid tumors. Clin Cancer Res 8(11):3461-3467
6. Brooks PC, Stromblad S, Sanders LC, von Schalscha TL, Aimes RT, Stetler-Stevenson WG, Quigley JP, Cheresh DA (1996) Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3. Cell 85(5):683-693. doi:S0092-8674(00)81235-0
7. Carlson M, Osmond BC, Botstein D (1981) Mutants of yeast defective in sucrose utilization. Genetics 98(1):25-40
8. Decristofaro MF, Betz BL, Rorie CJ, Reisman DN, Wang W, Weissman BE (2001) Characterization of SWI/SNF protein expression in human breast cancer cell lines and other malignancies. J Cell Physiol 186(1):136-145. doi:10.1002/1097-4652(200101)186:1\136:AID-JCP1010[3.0.CO;2-4
9. Dinant C, Houtsmuller AB, Vermeulen W (2008) Chromatin structure and DNA damage repair. Epigenetics Chromatin 1(1):9. doi: 10.1186/1756-8935-1-9
10. Flowers S, Nagl NG Jr, Beck GR Jr, Moran E (2009) Antagonistic roles for BRM and BRG1 SWI/SNF complexes in differentiation. J Biol Chem 284(15):10067-10075. doi:10.1074/jbc. M808782200
11. Fukuoka J, Fujii T, Shih JH, Dracheva T, Meerzaman D, Player A, Hong K, Settnek S, Gupta A, Buetow K, Hewitt S, Travis WD, Jen J (2004) Chromatin remodeling factors and BRM/BRG1 expression as prognostic indicators in non-small cell lung cancer. Clin Cancer Res 10(13):4314-4324. doi:10.1158/1078-0432.CCR- 03-0489
12. Glaros S, Cirrincione GM, Muchardt C, Kleer CG, Michael CW, Reisman D (2007) The reversible epigenetic silencing of BRM: implications for clinical targeted therapy. Oncogene 26(49): 7058-7066. doi:10.1038/sj.onc.1210514
13. Grytsenko P, Ilina O, Friedl P (2011) Interstitial guidance of cancer invasion. J Pathol. doi:10.1002/path.3031
14. Hendricks KB, Shanahan F, Lees E (2004) Role for BRG1 in cell cycle control and tumor suppression. Mol Cell Biol 24(1): 362-376
15. Hill DA, Chiosea S, Jamaluddin S, Roy K, Fischer AH, Boyd DD, Nickerson JA, Imbalzano AN (2004) Inducible changes in cell size and attachment area due to expression of a mutant SWI/SNF chromatin remodeling enzyme. J Cell Sci 117(Pt 24):5847-5854. doi:10.1242/jcs.01502
16. Kang H, Cui K, Zhao K (2004) BRG1 controls the activity of the retinoblastoma protein via regulation of p21CIP1/WAF1/SDI. Mol Cell Biol 24(3):1188-1199
17. Keenen B, Qi H, Saladi SV, Yeung M, de la Serna IL (2010) Heterogeneous SWI/SNF chromatin remodeling complexes promote expression of microphthalmia-associated transcription factor target genes in melanoma. Oncogene 29(1):81-92. doi: 10.1038/onc.2009.304
18. Lee MH, Yang HY (2003) Regulators of G1 cyclin-dependent kinases and cancers. Cancer Metastasis Rev 22(4):435-449
19. Lin H, Wong RP, Martinka M, Li G (2010) BRG1 expression is increased in human cutaneous melanoma. Br J Dermatol 163(3): 502-510. doi:10.1111/j.1365- 2133.2010.09851.x
20. Mei PJ, Bai J, Liu H, Li C, Wu YP, Yu ZQ, Zheng JN (2011) RUNX3 expression is lost in glioma and its restoration causes drastic suppression of tumor invasion and migration. J Cancer Res Clin Oncol. doi:10.1007/s00432-011- 1063-4
21. Naidu SR, Love IM, Imbalzano AN, Grossman SR, Androphy EJ (2009) The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells. Oncogene 28(27):2492-2501. doi:10.1038/onc.2009.121
22. Ohgaki H, Kleihues P (2005) Epidemiology and etiology of gliomas. Acta Neuropathol 109(1):93-108. doi:10.1007/s00401-005-0991-y
23. Overall CM, Kleifeld O (2006) Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and antitargets for cancer therapy. Nat Rev Cancer 6(3):227-239. doi: 10.1038/nrc1821
24. Reardon DA, Desjardins A, Peters K, Gururangan S, Sampson J, Rich JN, McLendon R, Herndon JE II, Marcello J, Threatt S, Friedman AH, Vredenburgh JJ, Friedman HS (2011) Phase II study of metronomic chemotherapy with bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy. J Neurooncol 103(2):371-379. doi:10.1007/s11060-010-0403-6
25. Reisman DN, Sciarrotta J, Wang W, Funkhouser WK, Weissman BE (2003) Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis. Cancer Res 63(3):560-566
26. Reisman D, Glaros S, Thompson EA (2009) The SWI/SNF complex and cancer. Oncogene 28(14):1653-1668. doi:10.1038/onc. 2009.4
27. Saladi SV, Keenen B, Marathe HG, Qi H, Chin KV, de la Serna IL (2010) Modulation of extracellular matrix/adhesion molecule expression by BRG1 is associated with increased melanoma invasiveness. Mol Cancer 9:280. doi:10.1186/1476-4598-9-280
28. Sentani K, Oue N, Kondo H, Kuraoka K, Motoshita J, Ito R, Yokozaki H, Yasui W (2001) Increased expression but not genetic alteration of BRG1, a component of the SWI/SNF complex, is associated with the advanced stage of human gastric carcinomas. Pathobiology 69(6):315-320
29. Simone C (2006) SWI/SNF: the crossroads where extracellular signaling pathways meet chromatin. J Cell Physiol 207(2): 309-314. doi:10.1002/jcp.20514
30. Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352(10):987-996. doi:10.1056/NEJMoa043330
31. Sun A, Tawfik O, Gayed B, Thrasher JB, Hoestje S, Li C, Li B (2007) Aberrant expression of SWI/SNF catalytic subunits BRG1/BRM is associated with tumor development and increased invasiveness in prostate cancers. Prostate 67(2):203-213. doi:10.1002/pros. 20521
32. Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR (1996) differsity and specialization of mammalian SWI/SNF complexes. Genes Dev 10(17):2117-2130
33. Wang X, Sansam CG, Thom CS, Metzger D, Evans JA, Nguyen PT, Roberts CW (2009) Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent on activity of BRG1, the ATPase of the SWI/SNF chromatin remodeling complex. Cancer Res 69(20):8094-8101. doi:10.1158/0008-5472.CAN-09-0733
34. Wong AK, Shanahan F, Chen Y, Lian L, Ha P, Hendricks K, Ghaffari S, Iliev D, Penn B, Woodland AM, Smith R, Salada G, Carillo A, Laity K, Gupte J, Swedlund B, Tavtigian SV, Teng DH, Lees E (2000) BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines. Cancer Res 60(21): 6171-6177