Ethyl-pyruvate reduces lung injury matrix metalloproteinases and cytokines and improves survival in experimental model of severe acute pancreatitis

Acta Cirurgica Brasileira

Volumn 28, Issue 8, 2013, Pages 559-567

  Matone, Jacques ^a   Moretti, Ana Iochabel Soares ^b   Apodaca Torrez, Franz Robert ^a   Goldenberg, Alberto ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Acute necrotizing; Inflammation; Pancreatitis; Pyruvic acid; Rats

Indexed keywords

GELATINASE A; GELATINASE B; HEAT SHOCK PROTEIN 70; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 6; MALONALDEHYDE; MYELOPEROXIDASE; PYRUVIC ACID DERIVATIVE; PYRUVIC ACID ETHYL ESTER; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; LUNG PARENCHYMA; MALE; MORTALITY; NONHUMAN; OVERALL SURVIVAL; PROTEIN EXPRESSION; RAT; SPECTROPHOTOMETRY; ZYMOGRAPHY;

ACUTE LUNG INJURY; ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; IMMUNOBLOTTING; ISOTONIC SOLUTIONS; KAPLAN-MEIER ESTIMATE; MALE; MATRIX METALLOPROTEINASES; PANCREATITIS, ACUTE NECROTIZING; PYRUVATES; RANDOM ALLOCATION; RATS; RATS, WISTAR; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; TIME FACTORS; TREATMENT OUTCOME;

EID: 84881082260     PISSN: 01028650     EISSN: 16782674     Source Type: Journal    
DOI: 10.1590/S0102-86502013000800002     Document Type: Article

References (20)

1. McKay CJ, Imrie CW. The continuing challenge of early mortality in acute pancreatitis. Br J Surg. 2004;91:1243-4.
2. Gloor B, Müller CA, Worni M, Martignoni ME, Uhl W, Büchler MW. Late mortality in patients with severe acute pancreatitis. Br J Surg. 2001;88:975-9.
3. Chen YP, Ning JW, Ji F. Establishment of the critical period of severe acute pancreatitis-associated lung injury. Hepatobiliary Pancreat Dis Int. 2009;8(5):535-40.
4. Makhija R, Kingsnorth AN. Cytokine storm in acute pancreatitis. J Hepatobiliary Pancreat Surg. 2002;9:401-10.
5. Pereda J, Sabater L, Cassinello N, Gómez-Cambronero L, Closa D, Folch-Puy E, Aparisi L, Calvete J, Cerdá M, Lledó S, Viña J, Sastre J. Effect of simultaneous inhibition of TNF-alpha production and xanthine oxidase in experimental acute pancreatitis: the role of mitogen activated protein kinases. Ann Surg. 2004;240:108-16.
6. Gomez-Cambronero LG, Sabater L, Pereda J, Cassinello N, Camps B, Viña J, Sastre J. Role of cytokines and oxidative stress in the pathophysiology of acute pancreatitis: therapeutical implications. Curr Drug Targets Inflamm Allergy. 2002;1:393-403.
7. Okamoto T, Akuta T, Tamura F, van Der Vliet A, Akaike T. Molecular mechanism for activation and regulation of matrix metalloproteinases during bacterial infections and respiratory inflammation. Biol Chem. 2004;385(11):997-1006.
8. Muhs BE, Patel S, Yee H, Yee H, Marcus S, Shamamian P. Inhibition of matrix metalloproteinases reduces local and distant organ injury following experimental acute pancreatitis. J Surg Res. 2003;109(2):110-7.
9. Steinberg J, Halter J, Schiller HJ, Dasilva M, Landas S, Gatto LA, Maisi P, Sorsa T, Rajamaki M, Lee HM, Nieman GF. Metalloproteinase inhibition reduces lung injury and improves survival after cecal ligation and puncture in rats. J Surg Res. 2003;111(2):185-95.
10. Moretti AI, Rios EC, Soriano FG, de Souza HP, Abatepaulo F, Barbeiro DF, Velasco IT. Acute pancreatitis: hypertonic saline solution increases heat shock proteins 70 and 90 and reduces neutrophil infiltration in lung injury. Pancreas. 2009;38(5):507-14.
11. Tonsi AF, Bacchion M, Crippa S, Malleo G, Bassi C. Acute pancreatitis at the beginning of the 21st century: the state of the art. World J Gastroenterol. 2009;15:2945-59.
12. Kao KK, Fink MP. The biochemical basis for the anti-inflammatory and cytoprotective actions of ethyl pyruvate and related compounds. Biochem Pharmacol. 2010;80(2):151-9.
13. Fink MP. Ethyl pyruvate: a novel anti-inflammatory agent. J Intern Med. 2007;261(4):349-62.
14. Zingarelli B. Ethyl pyruvate: a simple solution? Crit Care Med. 2004;32(7):1603-4.
15. Machado MC, Coelho AM, Pontieri V, Sampietre SN, Molan NA, Soriano F, Matheus AS, Patzina RA, Cunha JE, Velasco IT. Local and systemic effects of hypertonic solution (NaCl 7.5%) in experimental acute pancreatitis. Pancreas. 2006;32:80-6.
16. Su KH, Cuthbertson C, Christophi C. Review of experimental animal models of acute pancreatitis. HPB (Oxford). 2006;8:264-86.
17. Kan SH, Huang F, Tang J, Gao Y, Yu CL. Role of intrapulmonary expression of inducible nitric oxide synthase gene and nuclear factor kappaB activation in severe pancreatitis-associated lung injury. Inflammation. 2010;33(5):287-94.
18. Davies MG, Hagen PO. Systemic inflammatory response syndrome. Br J Surg. 1997;84:920-35.
19. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med. 2000;342:1334-49.
20. Malangoni MA, Martin AS. Outcome of severe acute pancreatitis. Am J Surg. 2005;189:273-7.