Reaction pathway and free energy profile for papain-catalyzed hydrolysis of N-acetyl-phe-Gly 4-nitroanilide

Biochemistry

Volumn 52, Issue 30, 2013, Pages 5145-5154

  Wei, Donghui ^a,b   Huang, Xiaoqin ^b   Liu, Junjun ^b   Tang, Mingsheng ^a   Zhan, Chang Guo ^b  

^a ZHENGZHOU UNIVERSITY   (China)

^b University of Kentucky   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION FREE ENERGY; CATALYTIC REACTIONS; HYDROLYSIS PROCESS; NUCLEOPHILIC ATTACK; QUANTUM MECHANICAL; REACTION COORDINATES; REACTION PATHWAYS; ZWITTERIONIC FORMS;

ACYLATION; CALCULATIONS; CARBON; CATALYSIS; DISSOCIATION; ENERGY BARRIERS; HYDROLYSIS; MOLECULAR MODELING; PAPAIN;

FREE ENERGY;

ACETIC ACID DERIVATIVE; CARBON; PAPAIN; SULFUR; WATER;

ACYLATION AND DEACYLATION; ARTICLE; CATALYSIS; DEACYLATION; DISSOCIATION; ENERGY; HYDROLYSIS; NUCLEOPHILICITY; PRIORITY JOURNAL; PROTON TRANSPORT; QUANTUM MECHANICS; REACTION ANALYSIS;

ACYLATION; BINDING SITES; BIOCATALYSIS; DIPEPTIDES; HYDROLYSIS; INDICATORS AND REAGENTS; KINETICS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR DYNAMICS SIMULATION; PAPAIN; PLANT PROTEINS; PROTONS; QUANTUM THEORY;

EID: 84881061241     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi400629r     Document Type: Article

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