-
2
-
-
77954242530
-
Molecular circuits of solid tumors: Prognostic and predictive tools for bedside use
-
Ferté C, André F, and Soria JC (2010). Molecular circuits of solid tumors: prognostic and predictive tools for bedside use. Nat Rev Clin Oncol 7, 367-380.
-
(2010)
Nat Rev Clin Oncol
, vol.7
, pp. 367-380
-
-
Ferté, C.1
André, F.2
Soria, J.C.3
-
3
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, et al. (2002). Mutations of the BRAF gene in human cancer. Nature 417, 949-954.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
Teague, J.7
Woffendin, H.8
Garnett, M.J.9
Bottomley, W.10
-
4
-
-
72049114407
-
Understanding melanoma signaling networks as the basis for molecular targeted therapy
-
Smalley KS (2010). Understanding melanoma signaling networks as the basis for molecular targeted therapy. J Invest Dermatol 130, 28-37.
-
(2010)
J Invest Dermatol
, vol.130
, pp. 28-37
-
-
Smalley, K.S.1
-
5
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J, Dummer R, Garbe C, Testori A, Maio M, et al. (2011). Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 364, 2507-2516.
-
(2011)
N Engl J Med
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
Haanen, J.B.4
Ascierto, P.5
Larkin, J.6
Dummer, R.7
Garbe, C.8
Testori, A.9
Maio, M.10
-
6
-
-
78651446644
-
Hard times for oncogenic BRAF-expressing melanoma cells
-
Houslay MD (2011). Hard times for oncogenic BRAF-expressing melanoma cells. Cancer Cell 19, 3-4.
-
(2011)
Cancer Cell
, vol.19
, pp. 3-4
-
-
Houslay, M.D.1
-
7
-
-
79960027865
-
BRAF targeted therapy changes the treatment paradigm in melanoma
-
Ribas A and Flaherty KT (2011). BRAF targeted therapy changes the treatment paradigm in melanoma. Nat Rev Clin Oncol 8, 426-433.
-
(2011)
Nat Rev Clin Oncol
, vol.8
, pp. 426-433
-
-
Ribas, A.1
Flaherty, K.T.2
-
8
-
-
84868481873
-
Vemurafenib: The first drug approved for BRAF-mutant cancer
-
Bollag G, Tsai J, Zhang J, Zhang C, Ibrahim P, Nolop K, and Hirth P (2012). Vemurafenib: the first drug approved for BRAF-mutant cancer. Nat Rev Drug Discov 11, 873-886.
-
(2012)
Nat Rev Drug Discov
, vol.11
, pp. 873-886
-
-
Bollag, G.1
Tsai, J.2
Zhang, J.3
Zhang, C.4
Ibrahim, P.5
Nolop, K.6
Hirth, P.7
-
9
-
-
84857053657
-
Melanoma: New insights and new therapie
-
Nikolaou VA, Stratigos AJ, Flaherty KT, and Tsao H (2012). Melanoma: new insights and new therapies. J Invest Dermatol 132, 854-863.
-
(2012)
J Invest Dermatol
, vol.132
, pp. 854-863
-
-
Nikolaou, V.A.1
Stratigos, A.J.2
Flaherty, K.T.3
Tsao, H.4
-
10
-
-
77956045447
-
Melanoma-an unlikely poster child for personalized cancer therapy
-
Smalley KS and Sondak VK (2010). Melanoma-an unlikely poster child for personalized cancer therapy. N Engl J Med 363, 876-878.
-
(2010)
N Engl J Med
, vol.363
, pp. 876-878
-
-
Smalley, K.S.1
Sondak, V.K.2
-
11
-
-
78650303507
-
Melanomas acquire resistance to B-RAF (V600E) inhibition by RTK or N-RAS upregulation
-
Nazarian R, Shi H, Wang Q, Kong X, Koya RC, Lee H, Chen Z, Lee MK, Attar N, Sazegar H, et al. (2010). Melanomas acquire resistance to B-RAF (V600E) inhibition by RTK or N-RAS upregulation. Nature 468, 973-977.
-
(2010)
Nature
, vol.468
, pp. 973-977
-
-
Nazarian, R.1
Shi, H.2
Wang, Q.3
Kong, X.4
Koya, R.C.5
Lee, H.6
Chen, Z.7
Lee, M.K.8
Attar, N.9
Sazegar, H.10
-
12
-
-
78650309875
-
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
-
Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Cogdill AP, Barretina J, et al. (2010). COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature 468, 968-972.
-
(2010)
Nature
, vol.468
, pp. 968-972
-
-
Johannessen, C.M.1
Boehm, J.S.2
Kim, S.Y.3
Thomas, S.R.4
Wardwell, L.5
Johnson, L.A.6
Emery, C.M.7
Stransky, N.8
Cogdill, A.P.9
Barretina, J.10
-
13
-
-
83455254767
-
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
-
Poulikakos PI, Persaud Y, Janakiraman M, Kong X, Ng C, Moriceau G, Shi H, Atefi M, Titz B, Gabay MT, et al. (2011). RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature 480, 387-390.
-
(2011)
Nature
, vol.480
, pp. 387-390
-
-
Poulikakos, P.I.1
Persaud, Y.2
Janakiraman, M.3
Kong, X.4
Ng, C.5
Moriceau, G.6
Shi, H.7
Atefi, M.8
Titz, B.9
Gabay, M.T.10
-
14
-
-
84859183431
-
V600EB-RAF amplification-mediated acquired B-RAF inhibitor resistance
-
V600EB-RAF amplification-mediated acquired B-RAF inhibitor resistance. Nat Commun 3, 724.
-
(2012)
Nat Commun
, vol.3
, pp. 724
-
-
Shi, H.1
Moriceau, G.2
Kong, X.3
Lee, M.K.4
Lee, H.5
Koya, R.C.6
Ng, C.7
Chodon, T.8
Scolyer, R.A.9
Dahlman, K.B.10
-
15
-
-
73949083834
-
MEK1 mutations confer resistance to MEK and B-RAF inhibition
-
USA
-
Emery CM, Vijayendran KG, Zipser MC, Sawyer AM, Niu L, Kim JJ, Hatton C, Chopra R, Oberholzer PA, Karpova MB, et al. (2009). MEK1 mutations confer resistance to MEK and B-RAF inhibition. Proc Natl Acad Sci USA 106, 20411-20416.
-
(2009)
Proc Natl Acad Sci
, vol.106
, pp. 20411-20416
-
-
Emery, C.M.1
Vijayendran, K.G.2
Zipser, M.C.3
Sawyer, A.M.4
Niu, L.5
Kim, J.J.6
Hatton, C.7
Chopra, R.8
Oberholzer, P.A.9
Karpova, M.B.10
-
16
-
-
79953325104
-
PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression
-
Paraiso KH, Xiang Y, Rebecca VW, Abel EV, Chen YA, Munko AC, Wood E, Fedorenko IV, Sondak VK, Anderson AR, et al. (2011). PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression. Cancer Res 71, 2750-2760.
-
(2011)
Cancer Res
, vol.71
, pp. 2750-2760
-
-
Paraiso, K.H.1
Xiang, Y.2
Rebecca, V.W.3
Abel, E.V.4
Chen, Y.A.5
Munko, A.C.6
Wood, E.7
Fedorenko, I.V.8
Sondak, V.K.9
Anderson, A.R.10
-
17
-
-
78650008177
-
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
-
Villanueva J, Vultur A, Lee JT, Somasundaram R, Fukunaga-Kalabis M, Cipolla AK, Wubbenhorst B, Xu X, Gimotty PA, Kee D, et al. (2010). Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell 18, 683-695.
-
(2010)
Cancer Cell
, vol.18
, pp. 683-695
-
-
Villanueva, J.1
Vultur, A.2
Lee, J.T.3
Somasundaram, R.4
Fukunaga-Kalabis, M.5
Cipolla, A.K.6
Wubbenhorst, B.7
Xu, X.8
Gimotty, P.A.9
Kee, D.10
-
18
-
-
79951818749
-
V600E melanoma cells selected for resistance to apoptosis induced by the RAF inhibitor PLX4720
-
V600E melanoma cells selected for resistance to apoptosis induced by the RAF inhibitor PLX4720. Clin Cancer Res 17, 721-730.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 721-730
-
-
Jiang, C.C.1
Lai, F.2
Thorne, R.F.3
Yang, F.4
Liu, H.5
Hersey, P.6
Zhang, X.D.7
-
19
-
-
84858411005
-
NF-κB as potential target in the treatment of melanoma
-
Madonna G, Ullman CD, Gentilcore G, Palmieri G, and Ascierto PA (2012). NF-κB as potential target in the treatment of melanoma. J Transl Med 10, 53.
-
(2012)
J Transl Med
, vol.10
, pp. 53
-
-
Madonna, G.1
Ullman, C.D.2
Gentilcore, G.3
Palmieri, G.4
Ascierto, P.A.5
-
20
-
-
84868224906
-
Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
-
Flaherty KT, Infante JR, Daud A, Gonzalez R, Kefford RF, Sosman J, Hamid O, Schuchter L, Cebon J, Ibrahim N, et al. (2012). Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 367, 1694-1703.
-
(2012)
N Engl J Med
, vol.367
, pp. 1694-1703
-
-
Flaherty, K.T.1
Infante, J.R.2
Daud, A.3
Gonzalez, R.4
Kefford, R.F.5
Sosman, J.6
Hamid, O.7
Schuchter, L.8
Cebon, J.9
Ibrahim, N.10
-
21
-
-
84864371119
-
Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: A phase 1 dose-escalation trial
-
Falchook GS, Lewis KD, Infante JR, Gordon MS, Vogelzang NJ, DeMarini DJ, Sun P, Moy C, Szabo SA, Roadcap LT, et al. (2012). Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial. Lancet Oncol 13, 782-789.
-
(2012)
Lancet Oncol
, vol.13
, pp. 782-789
-
-
Falchook, G.S.1
Lewis, K.D.2
Infante, J.R.3
Gordon, M.S.4
Vogelzang, N.J.5
Demarini, D.J.6
Sun, P.7
Moy, C.8
Szabo, S.A.9
Roadcap, L.T.10
-
22
-
-
84864340896
-
Safety, pharmaco-kinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: A phase 1 dose-escalation trial
-
Infante JR, Fecher LA, Falchook GS, Nallapareddy S, Gordon MS, Becerra C, DeMarini DJ, Cox DS, Xu Y, Morris SR, et al. (2012). Safety, pharmaco-kinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial. Lancet Oncol 13, 773-781.
-
(2012)
Lancet Oncol
, vol.13
, pp. 773-781
-
-
Infante, J.R.1
Fecher, L.A.2
Falchook, G.S.3
Nallapareddy, S.4
Gordon, M.S.5
Becerra, C.6
Demarini, D.J.7
Cox, D.S.8
Xu, Y.9
Morris, S.R.10
-
23
-
-
84859874162
-
The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer
-
Shimizu T, Tolcher AW, Papadopoulos KP, Beeram M, Rasco DW, Smith LS, Gunn S, Smetzer L, Mays TA, Kaiser B, et al. (2012). The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer. Clin Cancer Res 18, 2316-2325.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 2316-2325
-
-
Shimizu, T.1
Tolcher, A.W.2
Papadopoulos, K.P.3
Beeram, M.4
Rasco, D.W.5
Smith, L.S.6
Gunn, S.7
Smetzer, L.8
Mays, T.A.9
Kaiser, B.10
-
24
-
-
0030907987
-
PI3K: Downstream AKTion blocks apoptosis
-
Franke TF, Kaplan DR, and Cantley LC (1997). PI3K: downstream AKTion blocks apoptosis. Cell 88, 435-437.
-
(1997)
Cell
, vol.88
, pp. 435-437
-
-
Franke, T.F.1
Kaplan, D.R.2
Cantley, L.C.3
-
25
-
-
0033574526
-
The role of phosphatases in inositol signaling reactions
-
Majerus PW, Kisseleva MV, and Norris FA (1999). The role of phosphatases in inositol signaling reactions. J Biol Chem 274, 10669-10672.
-
(1999)
J Biol Chem
, vol.274
, pp. 10669-10672
-
-
Majerus, P.W.1
Kisseleva, M.V.2
Norris, F.A.3
-
26
-
-
0035895910
-
Phosphatidylinositol 4-phosphate 5-kinase type I is regulated through phosphorylation response by extracellular stimuli
-
Park SJ, Itoh T, and Takenawa T (2001). Phosphatidylinositol 4-phosphate 5-kinase type I is regulated through phosphorylation response by extracellular stimuli. J Biol Chem 276, 4781-4787.
-
(2001)
J Biol Chem
, vol.276
, pp. 4781-4787
-
-
Park, S.J.1
Itoh, T.2
Takenawa, T.3
-
27
-
-
63749119765
-
PIKKing on PKB: Regulation of PKB activity by phosphorylation
-
Bozulic L and Hemmings BA (2009). PIKKing on PKB: regulation of PKB activity by phosphorylation. Curr Opin Cell Biol 21, 256-261.
-
(2009)
Curr Opin Cell Biol
, vol.21
, pp. 256-261
-
-
Bozulic, L.1
Hemmings, B.A.2
-
28
-
-
54949109808
-
PI3K/Akt: Getting it right matters
-
Franke TF (2008). PI3K/Akt: getting it right matters. Oncogene 27, 6473-6488.
-
(2008)
Oncogene
, vol.27
, pp. 6473-6488
-
-
Franke, T.F.1
-
29
-
-
15944406764
-
PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
-
Gao T, Furnari F, and Newton AC (2005). PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 18, 13-24.
-
(2005)
Mol Cell
, vol.18
, pp. 13-24
-
-
Gao, T.1
Furnari, F.2
Newton, A.C.3
-
30
-
-
0035895919
-
3-Phosphoinositide-dependent protein kinase 1, an Akt1 kinase, is involved in dephosphorylation of Thr-308 of Akt1 in Chinese hamster ovary cells
-
Yamada T, Katagiri H, Asano T, Inukai K, Tsuru M, Kodama T, Kikuchi M, and Oka Y (2001). 3-Phosphoinositide-dependent protein kinase 1, an Akt1 kinase, is involved in dephosphorylation of Thr-308 of Akt1 in Chinese hamster ovary cells. J Biol Chem 276, 5339-5345.
-
(2001)
J Biol Chem
, vol.276
, pp. 5339-5345
-
-
Yamada, T.1
Katagiri, H.2
Asano, T.3
Inukai, K.4
Tsuru, M.5
Kodama, T.6
Kikuchi, M.7
Oka, Y.8
-
31
-
-
0037155228
-
Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits Akt/protein kinase B phos-phorylation and leads to apoptotic cell death
-
Kisseleva MV, Cao L, and Majerus PW (2002). Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits Akt/protein kinase B phos-phorylation and leads to apoptotic cell death. J Biol Chem 277, 6266-6272.
-
(2002)
J Biol Chem
, vol.277
, pp. 6266-6272
-
-
Kisseleva, M.V.1
Cao, L.2
Majerus, P.W.3
-
32
-
-
39149097499
-
2 levels determine PKB activity
-
Ma K, Cheung SM, Marshall AJ, and Duronio V (2008). PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity. Cell Signal 20, 684-694.
-
(2008)
Cell Signal
, vol.20
, pp. 684-694
-
-
Ma, K.1
Cheung, S.M.2
Marshall, A.J.3
Duronio, V.4
-
33
-
-
31944442909
-
The inositol polyphosphate 5-phosphatase, PIPP, is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation
-
Ooms LM, Fedele CK, Astle MV, Ivetac I, Cheung V, Pearson RB, Layton MJ, Forrai A, Nandurkar HH, and Mitchell CA (2006). The inositol polyphosphate 5-phosphatase, PIPP, is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation. Mol Biol Cell 17, 607-622.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 607-622
-
-
Ooms, L.M.1
Fedele, C.K.2
Astle, M.V.3
Ivetac, I.4
Cheung, V.5
Pearson, R.B.6
Layton, M.J.7
Forrai, A.8
Nandurkar, H.H.9
Mitchell, C.A.10
-
34
-
-
78650675585
-
Inositol polyphos-phate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers
-
USA
-
Fedele CG, Ooms LM, Ho M, Vieusseux J, O'Toole SA, Millar EK, Lopez-Knowles E, Sriratana A, Gurung R, Baglietto L, et al. (2010). Inositol polyphos-phate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers. Proc Natl Acad Sci USA 107, 22231-22236.
-
(2010)
Proc Natl Acad Sci
, vol.107
, pp. 22231-22236
-
-
Fedele, C.G.1
Ooms, L.M.2
Ho, M.3
Vieusseux, J.4
O'Toole, S.A.5
Millar, E.K.6
Lopez-Knowles, E.7
Sriratana, A.8
Gurung, R.9
Baglietto, L.10
-
35
-
-
67651148274
-
Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling
-
Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, et al. (2009). Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell 16, 115-125.
-
(2009)
Cancer Cell
, vol.16
, pp. 115-125
-
-
Gewinner, C.1
Wang, Z.C.2
Richardson, A.3
Teruya-Feldstein, J.4
Etemadmoghadam, D.5
Bowtell, D.6
Barretina, J.7
Lin, W.M.8
Rameh, L.9
Salmena, L.10
-
36
-
-
78751535990
-
Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer
-
Hodgson MC, Shao LJ, Frolov A, Li R, Peterson LE, Ayala G, Ittmann MM, Weigel NL, and Agoulnik IU (2011). Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer. Cancer Res 71,572-582.
-
(2011)
Cancer Res
, vol.71
, pp. 572-582
-
-
Hodgson, M.C.1
Shao, L.J.2
Frolov, A.3
Li, R.4
Peterson, L.E.5
Ayala, G.6
Ittmann, M.M.7
Weigel, N.L.8
Agoulnik, I.U.9
-
37
-
-
79551542888
-
PTEN level in tumor suppression: How much is too little?
-
Carracedo A, Alimonti A, and Pandolfi PP (2011). PTEN level in tumor suppression: how much is too little? Cancer Res 71, 629-633.
-
(2011)
Cancer Res
, vol.71
, pp. 629-633
-
-
Carracedo, A.1
Alimonti, A.2
Pandolfi, P.P.3
-
38
-
-
84874634909
-
2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma
-
Ye Y, Jin L, Wilmott JS, Hu WL, Yosuf B, Thorne RF, Liu T, Rizos H, Yan XG, Dong L, et al. (2013). PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma. Nat Commun 4, 1508.
-
(2013)
Nat Commun
, vol.4
, pp. 1508
-
-
Ye, Y.1
Jin, L.2
Wilmott, J.S.3
Hu, W.L.4
Yosuf, B.5
Thorne, R.F.6
Liu, T.7
Rizos, H.8
Yan, X.G.9
Dong, L.10
-
39
-
-
36148954336
-
IAP antagonists target cIAP1 to induce TNFα-dependent apoptosis
-
Vince JE, Wong WW, Khan N, Feltham R, Chau D, Ahmed AU, Benetatos CA, Chunduru SK, Condon SM, McKinlay M, et al. (2007). IAP antagonists target cIAP1 to induce TNFα-dependent apoptosis. Cell 131, 682-693.
-
(2007)
Cell
, vol.131
, pp. 682-693
-
-
Vince, J.E.1
Wong, W.W.2
Khan, N.3
Feltham, R.4
Chau, D.5
Ahmed, A.U.6
Benetatos, C.A.7
Chunduru, S.K.8
Condon, S.M.9
McKinlay, M.10
-
40
-
-
42449154262
-
Multiplexed assays for detection of mutations in PIK3CA
-
Board RE, Thelwell NJ, Ravetto PF, Little S, Ranson M, Dive C, Hughes A, and Whitcombe D. (2008). Multiplexed assays for detection of mutations in PIK3CA. Clin Chem 54, 757-760.
-
(2008)
Clin Chem
, vol.54
, pp. 757-760
-
-
Board, R.E.1
Thelwell, N.J.2
Ravetto, P.F.3
Little, S.4
Ranson, M.5
Dive, C.6
Hughes, A.7
Whitcombe, D.8
-
41
-
-
79951818357
-
S
-
V600E involves preferential splicing of bimS. Cell Death Dis 1, e69.
-
(2010)
Cell Death Dis
, vol.1
-
-
Jiang, C.C.1
Lai, F.2
Tay, K.H.3
Croft, A.4
Rizos, H.5
Becker, T.M.6
Yang, F.7
Liu, H.8
Thorne, R.F.9
Hersey, P.10
-
42
-
-
34548096400
-
Apoptosis induction in human melanoma cells by inhibition of MEK is caspase-independent and mediated by the Bcl-2 family members PUMA, Bim, and Mcl-1
-
Wang YF, Jiang CC, Kiejda KA, Gillespie S, Zhang XD, and Hersey P (2007). Apoptosis induction in human melanoma cells by inhibition of MEK is caspase-independent and mediated by the Bcl-2 family members PUMA, Bim, and Mcl-1. Clin Cancer Res 13, 4934-4942.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 4934-4942
-
-
Wang, Y.F.1
Jiang, C.C.2
Kiejda, K.A.3
Gillespie, S.4
Zhang, X.D.5
Hersey, P.6
-
43
-
-
84863234102
-
Selumetinib (AZD6244; ARRY-142886) in the treatment of metastatic melanoma
-
Patel SP and Kim KB (2012). Selumetinib (AZD6244; ARRY-142886) in the treatment of metastatic melanoma. Expert Opin Investig Drugs 21, 531-539.
-
(2012)
Expert Opin Investig Drugs
, vol.21
, pp. 531-539
-
-
Patel, S.P.1
Kim, K.B.2
-
44
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, and Greenberg ME (1997). Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241.
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
Masters, S.4
Fu, H.5
Gotoh, Y.6
Greenberg, M.E.7
-
45
-
-
80052074729
-
Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress
-
Dong L, Jiang CC, Thorne RF, Croft A, Yang F, Liu H, de Bock CE, Hersey P, and Zhang XD (2011). Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress. Oncogene 30, 3716-3726.
-
(2011)
Oncogene
, vol.30
, pp. 3716-3726
-
-
Dong, L.1
Jiang, C.C.2
Thorne, R.F.3
Croft, A.4
Yang, F.5
Liu, H.6
de Bock, C.E.7
Hersey, P.8
Zhang, X.D.9
|