Intraperitoneal injection of ethanol results in drastic changes in bone metabolism not observed when ethanol is administered by oral gavage

Alcoholism: Clinical and Experimental Research

Volumn 37, Issue 8, 2013, Pages 1271-1277

  Iwaniec, Urszula T ^a   Turner, Russell T ^a  

^a OREGON STATE UNIVERSITY   (United States)

Author keywords

Gene Expression; Histomorphometry; Rat Model; Tibia

Indexed keywords

ALCOHOL; MESSENGER RNA;

ANIMAL EXPERIMENT; ARTICLE; AUTOPSY; BODY WEIGHT; BONE MATRIX; BONE METABOLISM; CONTROLLED STUDY; CORTICAL BONE; DIAPHYSIS; FEEDING; FEMALE; FEMUR; METAPHYSIS; MORPHOMETRICS; NONHUMAN; PERIOSTEUM; PRIORITY JOURNAL; RAT; TIBIA; TRABECULAR BONE; WEIGHT CHANGE; WEIGHT GAIN;

GENE EXPRESSION; HISTOMORPHOMETRY; RAT MODEL; TIBIA;

ADMINISTRATION, ORAL; ALCOHOLISM; ANIMALS; BONE MATRIX; BONE REMODELING; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DISEASE MODELS, ANIMAL; ETHANOL; FEMALE; INJECTIONS, INTRAPERITONEAL; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 84880990331     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.12105     Document Type: Article

References (42)

1. Bake S, Tingling JD, Miranda RC (2012) Ethanol exposure during pregnancy persistently attenuates cranially directed blood flow in the developing fetus: evidence from ultrasound imaging in a murine second trimester equivalent model. Alcohol Clin Exp Res 36:748-758.
2. Berg KM, Kunins HV, Jackson JL, Nahvi S, Chaudhry A, Harris KA Jr, Malik R, Arnsten JH (2008) Association between alcohol consumption and both osteoporotic fracture and bone density. Am J Med 121:406-418.
3. Boe DM, Richens TR, Horstmann SA, Burnham EL, Janssen WJ, Henson PM, Moss M, Vandivier RW (2010) Acute and chronic alcohol exposure impair the phagocytosis of apoptotic cells and enhance the pulmonary inflammatory response. Alcohol Clin Exp Res 34:1723-1732.
4. Cawthon PM, Harrison SL, Barrett-Connor E, Fink HA, Cauley JA, Lewis CE, Orwoll ES, Cummings SR (2006) Alcohol intake and its relationship with bone mineral density, falls, and fracture risk in older men. J Am Geriatr Soc 54:1649-1657.
5. Chon KS, Sartoris DJ, Brown SA, Clopton P (1992) Alcoholism-associated spinal and femoral bone loss in abstinent male alcoholics, as measured by dual X-ray absorptiometry. Skeletal Radiol 21:431-436.
6. Ciccocioppo R (1999) Conditioned taste aversion induced by ethanol in alcohol-preferring rats: influence of the method of ethanol administration. Pharmacol Biochem Behav 64:563-566.
7. Desimone DP, Greene VS, Hannon KS, Turner RT, Bell NH (1993) Prostaglandin E2 administered by subcutaneous pellets causes local inflammation and systemic bone loss: a model for inflammation-induced bone disease. J Bone Miner Res 8:625-634.
8. Devlin MJ, Cloutier AM, Thomas NA, Panus DA, Lotinun S, Pinz I, Baron R, Rosen CJ, Bouxsein ML (2010) Caloric restriction leads to high marrow adiposity and low bone mass in growing mice. J Bone Miner Res 25:2078-2088.
9. Emanuele NV, LaPaglia N, Kovacs EJ, Emanuele MA (2005) The impact of burn injury and ethanol on the cytokine network of the mouse hypothalamus: reproductive implications. Cytokine 30:109-115.
10. Gonzalez-Reimers E, Alvisa-Negrin J, Santolaria-Fernandez F, Ros-Vilamajo R, Martin-Gonzalez MC, Hernandez-Betancor I, Garcia-Valdecasas-Campelo E, Gonzalez-Diaz A (2011) Prognosis of osteopenia in chronic alcoholics. Alcohol 45:227-238.
11. Hogan HA, Sampson HW, Cashier E, Ledoux N (1997) Alcohol consumption by young actively growing rats: a study of cortical bone histomorphometry and mechanical properties. Alcohol Clin Exp Res 21:809-816.
12. Howe KS, Iwaniec UT, Turner RT (2011) The effects of low dose parathyroid hormone on lumbar vertebrae in a rat model for chronic alcohol abuse. Osteoporos Int 22:1175-1181.
13. Iwaniec UT, Wronski TJ, Turner RT (2008) Histological analysis of bone. Methods Mol Biol 447:325-341.
14. Kanis J, Johnell O, Gullberg B, Allander E, Elffors L, Ranstam J, Dequeker J, Dilsen G, Gennari C, Vaz AL, Lyritis G, Mazzuoli G, Miravet L, Passeri M, Perez Cano R, Rapado A, Ribot C (1999) Risk factors for hip fracture in men from southern Europe: the MEDOS study. Mediterranean Osteoporosis Study. Osteoporos Int 9:45-54.
15. Kidder LS, Turner RT (1998) Dietary ethanol does not accelerate bone loss in ovariectomized rats. Alcohol Clin Exp Res 22:2159-2164.
16. Knapp DJ, Braun CJ, Duncan GE, Qian Y, Fernandes A, Crews FT, Breese GR (2001) Regional specificity of ethanol and NMDA action in brain revealed with FOS-like immunohistochemistry and differential routes of drug administration. Alcohol Clin Exp Res 25:1662-1672.
17. Lauing K, Himes R, Rachwalski M, Strotman P, Callaci JJ (2008) Binge alcohol treatment of adolescent rats followed by alcohol abstinence is associated with site-specific differences in bone loss and incomplete recovery of bone mass and strength. Alcohol 42:649-656.
18. Lee S, Rivier C (2003) Long-term influence of an initial exposure to alcohol on the rat hypothalamic-pituitary axis. Alcohol Clin Exp Res 27:1463-1470.
19. Lieber CS, DeCarli LM, Sorrell MF (1989) Experimental methods of ethanol administration. Hepatology 10:501-510.
20. Luz J, Griggio MA, Plapler H, De-Meo-Bancher M, Carvalho-Kosmiskas JV (1996) Effects of ethanol on energy balance of rats and the inappropriateness of intraperitoneal injection. Alcohol 13:575-580.
21. Maddalozzo GF, Turner RT, Edwards CH, Howe KS, Widrick JJ, Rosen CJ, Iwaniec UT (2009) Alcohol alters whole body composition, inhibits bone formation, and increases bone marrow adiposity in rats. Osteoporos Int 20:1529-1538.
22. Marrone JA, Maddalozzo GF, Branscum AJ, Hardin K, Cialdella-Kam L, Philbrick KA, Breggia AC, Rosen CJ, Turner RT, Iwaniec UT (2012) Moderate alcohol intake lowers biochemical markers of bone turnover in postmenopausal women. Menopause 19:974-979.
23. McLernon DJ, Powell JJ, Jugdaohsingh R, Macdonald HM (2012) Do lifestyle choices explain the effect of alcohol on bone mineral density in women around menopause? Am J Clin Nutr 95:1261-1269.
24. Morales-Gonzalez JA, Gutierrez-Salinas J, Yanez L, Villagomez-Rico C, Badillo-Romero J, Hernandez-Munoz R (1999) Morphological and biochemical effects of a low ethanol dose on rat liver regeneration: role of route and timing of administration. Dig Dis Sci 44:1963-1974.
25. Ogilvie K, Lee S, Rivier C (1997) Effect of three different modes of alcohol administration on the activity of the rat hypothalamic-pituitary-adrenal axis. Alcohol Clin Exp Res 21:467-476.
26. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR (1987) Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 2:595-610.
27. Reed AH, McCarty HL, Evans GL, Turner RT, Westerlind KC (2002) The effects of chronic alcohol consumption and exercise on the skeleton of adult male rats. Alcohol Clin Exp Res 26:1269-1274.
28. Sampson HW, Chaffin C, Lange J, DeFee B II (1997) Alcohol consumption by young actively growing rats: a histomorphometric study of cancellous bone. Alcohol Clin Exp Res 21:352-359.
29. Sampson HW, Gallager S, Lange J, Chondra W, Hogan HA (1999) Binge drinking and bone metabolism in a young actively growing rat model. Alcohol Clin Exp Res 23:1228-1231.
30. Sampson HW, Hebert VA, Booe HL, Champney TH (1998) Effect of alcohol consumption on adult and aged bone: composition, morphology, and hormone levels of a rat animal model. Alcohol Clin Exp Res 22:1746-1753.
31. Santori C, Ceccanti M, Diacinti D, Attilia ML, Toppo L, D'Erasmo E, Romagnoli E, Mascia ML, Cipriani C, Prastaro A, Carnevale V, Minisola S (2008) Skeletal turnover, bone mineral density, and fractures in male chronic abusers of alcohol. J Endocrinol Invest 31:321-326.
32. Sommer I, Erkkilä AT, Järvinen R, Mursu J, Sirola J, Jurvelin JS, Kröger H, Tuppurainen M (2013) Alcohol consumption and bone mineral density in elderly women. Public Health Nutr 16:704-712.
33. Sripanyakorn S, Jugdaohsingh R, Mander A, Davidson SL, Thompson RP, Powell JJ (2009) Moderate ingestion of alcohol is associated with acute ethanol-induced suppression of circulating CTX in a PTH-independent fashion. J Bone Miner Res 24:1380-1388.
34. Tucker KL, Jugdaohsingh R, Powell JJ, Qiao N, Hannan MT, Sripanyakorn S, Cupples LA, Kiel DP (2009) Effects of beer, wine, and liquor intakes on bone mineral density in older men and women. Am J Clin Nutr 89:1188-1196.
35. Turner RT (2000) Skeletal response to alcohol. Alcohol Clin Exp Res 24:1693-1701.
36. Turner RT, Greene VS, Bell NH (1987) Demonstration that ethanol inhibits bone matrix synthesis and mineralization in the rat. J Bone Miner Res 2:61-66.
37. Turner RT, Kapelner SN, Spelsberg TC (1992) Tissue-specific expression of bone proteins in femora of growing rats. Am J Physiol 263:E724-E729.
38. Turner RT, Sibonga JD (2001) Effects of alcohol use and estrogen on bone. Alcohol Res Health 25:276-281.
39. Turner RT, Spelsberg TC (1991) Correlation between mRNA levels for bone cell proteins and bone formation in long bones of maturing rats. Am J Physiol 261:E348-E353.
40. Turner RT, Wronski TJ, Zhang M, Kidder LS, Bloomfield SA, Sibonga JD (1998) Effects of ethanol on gene expression in rat bone: transient dose-dependent changes in mRNA levels for matrix proteins, skeletal growth factors, and cytokines are followed by reductions in bone formation. Alcohol Clin Exp Res 22:1591-1599.
41. Walker BM, Ehlers CL (2009) Age-related differences in the blood alcohol levels of Wistar rats. Pharmacol Biochem Behav 91:560-565.
42. a N, Cooper GS, Einstadter D, Cebul R, Rimm AA (2001) Effects of alcohol-related disease on hip fracture and mortality: a retrospective cohort study of hospitalized Medicare beneficiaries. Am J Public Health 91:1089-1093.