Prognosis of osteopenia in chronic alcoholics

Alcohol

Volumn 45, Issue 3, 2011, Pages 227-238

  González Reimers, Emilio ^a   Alvisa Negrín, Julio ^a   Santolaria Fernández, Francisco ^a   Ros Vilamajó, Rosa ^a   Martín González, M Candelaria ^a   Hernández Betancor, Iván ^a   García Valdecasas Campelo, Elena ^a   González Díaz, Antonieta ^a  

^a HOSPITAL UNIVERSITARIO NUESTRA SEÑORA DE CANDELARIA   (Spain)

Author keywords

Alcoholism; Bone alterations; Osteopenia; Osteoprotegerin; Survival; Vitamin D

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE; HYDROCORTISONE; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PARATHYROID HORMONE; SOMATOMEDIN C; TELOPEPTIDE; TESTOSTERONE; VITAMIN D;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOLISM; ANALYTICAL EQUIPMENT; ARM; ARTICLE; ASCITES; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BONE DENSITOMETRY; BONE DENSITY; BRAIN DISEASE; CONTROLLED STUDY; FOLLOW UP; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HORMONE DETERMINATION; HUMAN; HYDROCORTISONE BLOOD LEVEL; LEG; LIVER CIRRHOSIS; LIVER FUNCTION; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; MALNUTRITION; NUTRITIONAL PARAMETERS; NUTRITIONAL STATUS; OSTEOLYSIS; OSTEOPENIA; PARATHYROID HORMONE BLOOD LEVEL; PELVIS; PROGNOSIS; PROTEIN BLOOD LEVEL; RIB; SURVIVAL RATE; TESTOSTERONE BLOOD LEVEL; THORACIC SPINE; VITAMIN BLOOD LEVEL;

ABSORPTIOMETRY, PHOTON; ADULT; ALCOHOLISM; BONE DENSITY; BONE DISEASES, METABOLIC; HUMANS; INSULIN-LIKE GROWTH FACTOR I; KAPLAN-MEIER ESTIMATE; LIVER CIRRHOSIS; MALE; MIDDLE AGED; NUTRITIONAL STATUS; OSTEOCALCIN; OSTEOPOROSIS; PROGNOSIS; REGRESSION ANALYSIS; VITAMIN D;

EID: 79953057036     PISSN: 07418329     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.alcohol.2010.09.002     Document Type: Article

References (59)

1. Addolorato G., Capristo E., Greco A.V., Stefani G.F., Gasbarrini G. Influence of chronic alcohol abuse on body weight and energy metabolism: is excess ethanol consumption a risk factor for obesity or malnutrition?. J. Intern. Med. 1998, 244:387-395.
2. Alvisa-Negrín J., González-Reimers E., Santolaria-Fernández F., García-Valdecasas-Campelo E., Alemán-Valls M.R., Pelazas-González R., et al. Osteopenia in alcoholics: effect of alcohol abstinence. Alcohol Alcohol. 2009, 44:468-475.
3. Amato G., Mazzioti G., Sorvillo F., Piscopo M., Lalli E., Biondi B., et al. High serum osteoprotegerin levels in patients with hyperthyroidism: effect of medical treatment. Bone 2004, 35:785-791.
4. Bourrin S., Amman P., Bonjour J.P., Rizzoli R. Dietary protein restriction lowers plasma insulin-like growth factor 1 (IGF-1), impairs cortical bone formation, and induces osteoblastic resistance to IGF-1 in adult female rats. Endocrinology 2000, 141:3149-3155.
5. Bourrin S., Toromanoff A., Amman P., Bonjour J.P., Rizzoli R. Dietary protein deficiency induces osteoporosis in aged male rats. J. Bone Miner. Res. 2000, 15:1555-1563.
6. Boyle W.J., Simonet W.S., Lacey D.L. Osteoclast differentiation and activation. Nature 2003, 423:337-342.
7. Bu R., Borysenko C.W., Li Y., Cao L., Sabokbar A., Blair H.C. Expression and function of TNF family proteins and receptors in human osteoblasts. Bone 2003, 33:760-770.
8. Callaci J.J., Himes R., Lauing K., Wezeman F.H., Brownson K. Binge alcohol-induced bone damage is accompanied by differential expression of bone remodeling-related genes in rat vertebral bone. Calcif. Tissue Int. 2009, 84:474-484.
9. Crawford B.A., Kam C., Donaghy A.J., McCaughan G.W. The heterogeneity of bone disease in cirrhosis: a multivariate analysis. Osteoporos. Int. 2003, 14:987-994.
10. Crilly R.G., Anderson C., Hogan D., Delaquerriere-Richardson L. Bone histomorphometry, bone mass, and related parameters in alcoholic males. Calcif. Tissue Int. 1988, 43:269-276.
11. Cummings S.R., Bates D., Black D.M. Clinical use of bone densitometry. JAMA 2002, 288:1889-1897.
12. Dai J., Lin D., Zhang J., Habib P., Smith P., Murtha J., et al. Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice. J. Clin. Invest. 2000, 106:887-895.
13. Diamond T., Stiel D., Lunzer M., Wilkinson M., Posen S. Ethanol reduces bone formation and may cause osteoporosis. Am. J. Med. 1989, 86:282-288.
14. Fabrega E., Orive A., García-Suárez C., García-Unzueta M., Amado J.A., Pons-Romero F. Osteoprotegerin and RANKL in alcoholic liver cirrhosis. Liver Int. 2005, 25:305-310.
15. Farley J.R., Fitzsimmons R., Taylor A.K., Jorch U.M., Lau K.H.W. Direct effects of ethanol on bone resorption and formation in vitro. Arch. Biochem. Biophys. 1985, 238:305-314.
16. Feitelberg S., Epstein S., Ismail F., D'Amanda C. Deranged bone metabolism in chronic alcoholism. Metabolism 1987, 36:322-326.
17. Feuerhern A.J., Borset M., Seidel C., Sundan A., Leistad L., Ostensen M., et al. Elevated levels of osteoprotegerin (OPG) and hepatocyte growth factor (HGF) in rheumatoid arthritis. Scand. J. Rheumatol. 2001, 30:229-234.
18. García-Valdecasas-Campelo E., González-Reimers E., Santolaria-Fernández F., de la Vega-Prieto M.J., Milena-Abril A., Sánchez-Pérez M.J., et al. Serum osteoprotegerin levels in chronic alcoholic liver disease. Alcohol Alcohol. 2006, 41:261-266.
19. George J., Ganesh H.K., Acharya S., Bandgar T.R., Shivane V., Karvat A., et al. Bone mineral density and disorders of mineral metabolism in chronic liver disease. World J. Gastroenterol. 2009, 15:3516-3522.
20. González-Calvín J.L., García-Sánchez A., Bellot V., Muñoz-Torres M., Raya-Alvarez E., Salvatierra-Ríos D. Mineral metabolism, osteoblastic function and bone mass in chronic alcoholism. Alcohol Alcohol. 1993, 28:571-579.
21. González-Reimers E., Pérez-Ramírez A., Santolaria-Fernández F., Rodríguez-Rodríguez E., Martínez-Riera A., Durán-Castellón Mdel C., et al. Association of Harris lines and shorter stature with ethanol consumption during growth. Alcohol 2007, 41:511-515.
22. Guañabens N., Enjuanes A., Alvarez L., Peris P., Caballería L., Jesus Martínez de Osaba M., et al. High osteoprotegerin serum levels in primary biliary cirrhosis are associated with disease severity but not with the mRNA gene expression in liver tissue. J. Bone Miner. Metab. 2009, 27:347-354.
23. Halsted C.H. Nutrition and alcoholic liver disease. Semin. Liver Dis. 2004, 24:289-304.
24. Hernández-Plasencia D., Santolaria-Fernández F., Hernández-García M., González-Reimers E., Batista-López N., Jorge-Hernández J., et al. Subjective nutritional assessment and short-term prognosis. J. Nutr. Environ. Med. 1991, 2:151-163.
25. Jorge-Hernández J.A., González-Reimers E., Torres-Ramírez A., Santolaria-Fernandez F., Gonzalez-Garcia C., Batista-Lopez J.N., et al. Bone changes in alcoholic liver cirrhosis: a histomorphometrical analysis of 52 cases. Dig. Dis. Sci. 1988, 33:1089-1095.
26. Kim M.J., Shim M.S., Kim M.K., Lee Y., Shin Y.G., Chung C.H., et al. Effect of chronic alcohol ingestion on bone mineral density in males without liver cirrhosis. Korean J. Intern. Med. 2003, 18:174-180.
27. Kondo T., Kitazawa R., Maeda S., Kitazawa S. 1 alpha,25 dihydroxyvitamin D3 rapidly regulates the mouse osteoprotegerin gene trough dual pathways. J. Bone Miner. Res. 2004, 19:1411-1419.
28. Lalor B.C., France M.W., Powell D., Adams P.H., Counihan T.B. Bone and mineral metabolism and chronic alcohol abuse. Q. J. Med. 1986, 59:497-511.
29. Lamberts S.W., Klijn J.G.M., De Jong F.H., Birkenhäger J.C. Hormone secretion in alcohol-induced pseudo-Cushing syndrome. JAMA 1979, 242:1640-1643.
30. Leevy C.M., Moroianu S.A. Nutritional aspects of alcoholic liver disease. Clin. Liver. Dis. 2005, 9:67-81.
31. Leslie W.D., Bernstein C.N., Leboff M.S. AGA technical review on osteoporosis in hepatic disorders. Gastroenterology 2003, 125:941-966.
32. Lindholm J., Steiniche T., Rasmussen E., Thamsborg G., Nielsen I.O., Brockestedt-Rasmussen H., et al. Bone disorders in men with chronic alcoholism: a reversible disease?. J. Clin. Endocrinol. Metab. 1991, 73:118-124.
33. Lindsell D.R.M., Wilson A.G., Maxwell J.D. Fractures in the chest radiograph in the detection of alcoholic liver disease. Br. Med. J. 1982, 285:597-599.
34. Lorenzo J. Interactions between immune and bone cells: new insights with many remaining questions. J. Clin. Invest. 2000, 106:749-752.
35. Malik P., Gasser R.W., Kemmler G., Moncayo R., Finkenstedt G., Hurz M., et al. Low bone mineral density and impaired bone metabolism in young alcoholic patients without liver cirrhosis: a cross-sectional study. Alcohol. Clin. Exp. Res. 2009, 33:375-381.
36. Merli M., Riggio O., Dally L. Does malnutrition affect survival in cirrhosis? PINC (Policentrica Italiana Nutrizione Cirrosi). Hepatology 1996, 23:1041-1046.
37. Molina-Pérez M., González-Reimers E., Santolaria-Fernández F., Martinez-Riera A., Rodriguez-Moreno F., Rodriguez-Rodriguez E., et al. Relative and combined effects of ethanol and protein deficiency on bone histology and mineral metabolism. Alcohol 2000, 20:1-8.
38. Monegal A., Navasa M., Peris P., Alvarez L., Pons F., Rodés J., et al. Serum osteoprotegerin and its ligand in cirrhotic patients referred for orthotopic liver transplantation: relationship with metabolic bone disease. Liver Int. 2007, 27:492-497.
39. Nagata N., Kitaura H., Yoshida N., Nakayama K. Inhibition of RANKL induced osteoclast formation in mouse bone marrow cells by IL-12: involvement of IFN-γ possibly induced from non T cell population. Bone 2003, 33:721-732.
40. Nicolas J.M., Fernández-Sola J., Estruch R., Parés J.C., Sacanella E., Urbano-Márquez A., et al. The effect of controlled drinking in alcoholic cardiomyopathy. Ann. Intern. Med. 2002, 136:192-200.
41. Nordström A., Eriksson M., Stegmayr B., Gustafson Y., Nordström P. Low bone mineral density is an independent risk factor for stroke and death. Cerebrovasc. Dis. 2010, 29:130-136.
42. Oppenheim W.L. The battered alcoholic syndrome. J. Trauma 1977, 17:850-856.
43. Peris P., Guañabens N., Parés A., Pons F., del Rio L., Monegal A., et al. Vertebral fractures and osteopenia in chronic alcoholic patients. Calcif. Tissue. Int. 1995, 57:111-114.
44. Peris P., Parés A., Guañabens N., Del Río L., Pons F., Martínez de Osaba M.J., et al. Bone mass improves in alcoholics after two years of abstinence. J. Bone Miner. Res. 1994, 10:1607-1612.
45. Peris P., Parés A., Guañabens N., Pons F., Martínez de Osaba M.J., Caballería J., et al. Reduced spinal and femoral bone mass and deranged bone mineral metabolism in chronic alcoholics. Alcohol Alcohol. 1992, 27:619-625.
46. Ricard-Blum S., Chossegros P., Guerret S., Trepo C., Grimaud J.A., Chevallier M. The carboxy-terminal cross-linked telopeptide of type I collagen (ICTP) is a potential serum marker of ongoing liver fibrosis. Clin. Chim. Acta 1996, 248:187-195.
47. Santolaria F., González-Reimers E., Pérez-Manzano J.L., Milena A., Gómez-Rodríguez M.A., González-Díaz A., et al. Osteopenia assessed by body composition analysis is related to malnutrition in alcoholic patients. Alcohol 2000, 22:147-157.
48. Santori C., Ceccanti M., Diacinti D., Attilia M.L., Toppo L., D'Erasmo E., et al. Skeletal turnover, bone mineral density, and fractures in male chronic abusers of alcohol. J. Endocrinol. Invest. 2008, 31:321-326.
49. Schnitzler C.M., Solomon L. Bone changes after alcohol abuse. S. Afr. Med. J. 1984, 66:730-734.
50. Spencer H., Rubio N., Rubio E., Indreika M., Seitam A. Chronic alcoholism. Frequently overlooked cause of osteoporosis in men. Am. J. Med. 1986, 80:393-397.
51. Stickel F., Hoehn B., Schuppan D., Seitz H.K. Nutritional therapy in alcoholic liver disease. Aliment. Pharmacol. Ther. 2003, 18:357-373.
52. Szalay F., Hegedus D., Lakatos P.L., Tornai I., Bajnok E., Dunkel K., et al. High serum osteoprotegerin and low RANKL in primary biliary cirrhosis. J. Hepatol. 2003, 38:395-400.
53. Szulc P., Hofbauer L.C., Heufelder A.E., Roth S., Delmas P.D. Osteoprotegerin serum levels in men: correlation with age, estrogen, and testosterone status. J. Clin. Endocrinol. Metab. 2001, 86:3162-3165.
54. Turner R.T., Kidder L.S., Kennedy A., Evans G.L., Sibonga J.D. Moderate alcohol consumption suppresses bone turnover in adult female rats. J. Bone Miner. Res. 2001, 16:589-594.
55. Ueland T., Bollerslev J., Godang K., Muller F., Froland S.S., Aukrust P. Increased serum osteoprotegerin in disorders characterized by persistent immune activation or glucocorticoid excess-possible role in bone homeostasis. Eur. J. Endocrinol. 2001, 145:685-690.
56. Vanderjagt D.J., Okeke E., Calvin C., Troncoso C., Crossey M., Glew R.H. Use of calcaneal ultrasound and biochemical markers to assess the density and metabolic state of the bones of adults with hepatic cirrhosis. J. Natl. Med. Assoc. 2007, 99:1024-1029.
57. Wezeman F.H., Emanuele M.A., Moskal S.F., Steiner J., Lapaglia N. Alendronate administration and skeletal response during chronic alcohol intake in the adolescent male rat. J. Bone Miner. Res. 2000, 15:2033-2041.
58. Wilkinson G., Cundy T., Parsons V., Lawson-Matthew P. Metabolic bone disease and fractures in male alcoholics: a pilot study. Br. J. Addict. 1985, 80:65-68.
59. Yamada N., Niwa S., Tsujimura T., Iwasaki T., Sugihara A., Futani H., et al. Interleukin 18 and interleukin 12 synergistically inhibit osteoclastic bone-resorbing activity. Bone 2002, 30:901-908.