Skeletal turnover, bone mineral density, and fractures in male chronic abusers of alcohol

Journal of Endocrinological Investigation

Volumn 31, Issue 4, 2008, Pages 321-326

  Santori, C ^a   Ceccanti, M ^a   Diacinti, D ^a   Attilia, M L ^a   Toppo, L ^a   D'Erasmo, E ^a   Romagnoli, E ^a   Mascia, M L ^a   Cipriani, C ^a   Prastaro, A ^a   Carnevale, V ^b   Minisola, Salvatore ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

Author keywords

Bone mineral density; Fractures; Male alcohol abusers

Indexed keywords

25 HYDROXYVITAMIN D; ALKALINE PHOSPHATASE BONE ISOENZYME; CALCIUM; CARBOXY TERMINAL TELOPEPTIDE; CREATININE; ESTRADIOL; LUTEINIZING HORMONE; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PARATHYROID HORMONE; PHOSPHATE; SOMATOMEDIN C; TESTOSTERONE;

ADULT; ALCOHOL ABUSE; ALCOHOL CONSUMPTION; ALCOHOLISM; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; BONE DENSITY; BONE INJURY; BONE METABOLISM; BONE TURNOVER; CALCIUM BLOOD LEVEL; CALCIUM METABOLISM; CONTROLLED STUDY; CORRELATION ANALYSIS; CREATININE BLOOD LEVEL; CYTOLYSIS; DUAL ENERGY X RAY ABSORPTIOMETRY; ESTRADIOL BLOOD LEVEL; FEMUR NECK; FRACTURE; HIGH RISK POPULATION; HIP; HUMAN; LEAN BODY WEIGHT; LIFESTYLE; LIVER FAILURE; LUMBAR SPINE; LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; OSSIFICATION; OSTEOPOROSIS; PARATHYROID HORMONE BLOOD LEVEL; PHOSPHATE BLOOD LEVEL; PROTEIN BLOOD LEVEL; RISK FACTOR; SPINE RADIOGRAPHY; TESTOSTERONE BLOOD LEVEL; THORACOLUMBAR SPINE; VERTEBRA FRACTURE; VITAMIN BLOOD LEVEL;

EID: 44849117798     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03346365     Document Type: Article

References (33)

1. Kanis JA, Johansson H, Johnell O, et al. Alcohol intake as a risk factor for fracture. Osteoparos Int 2005, 16: 737-42.
2. Santolaria F, Gonzàlez-Reimers E, Pérez-Manzano JL, et al. Osteopenia assessed by body composition analysis is related to malnutrition in alcoholic patients. Alcohol 2000, 22: 147-57.
3. Baron A Farahmand BY, Weiderpass E, et al. Cigarette smoking, alcohol consumption, and risk of hip fracture in women. Arch Intern Med 2001, 161: 983-8.
4. Bode C, Bode JC. Effect of alcohol consumption on the gut. Best Pract Res Clin Gastroenterol 2003, 17: 575-92.
5. Bannister P, Losowsky MS. Ethanol and hypogonadism. Alcohol Alcohol 1987, 22: 213-7.
6. Groote Veldman R, Meinders AE. On the mechanism of alcohol-induced pseudo-Cushing's syndrome. Endocr Rev 1996, 17: 262-8.
7. Lavigne JA, Baer DJ, Wimbrow HH, et al. Effects of alcohol 0on insulin-like growth factor I and insulin-like growth factor binding protein 3 in postmenopausal women. Am J Clin Nutr 2005, 81: 503-7.
8. Laitinen K, Lamberg-Allardt C, Tunninen R, et al. Transient hypoparathyroidism during acute alcohol intoxication. N Engl J Med 1991, 324: 721-7.
9. Friday KE, Howard GA. Ethanol inhibits human bone cell proliferation and function in vitro. Metabolism 1991, 40: 562-5.
10. Sampson HW. Effect of alcohol consumption on adult and aged bone: a histomorphometric study of the rat animal model. Alcohol Clin Exp Res 1998, 22: 2029-34.
11. Maran A, Zhang M, Spelsberg TC, Turner RT. The dose-response effects of ethanol on the human fetal osteoblastic cell line. J Bone Miner Res 2001, 16: 270-6.
12. Dai J, Lin D, Zhang J, et al. Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 mice. J Clin Invest 2000, 106: 887-95.
13. Law MR, Hackshaw AK. A meta-analysis of cigarette smoking, bone mineral density and risk of hip fracture: recognition of a major effect. BMJ 1997, 315: 841-6.
14. Barger-Lux MJ, Heaney RP. Caffeine and calcium economy revisited. Osteoporosis Int 1995, 5: 97-102.
15. Lloyd T, Johnson-Rollings N, Eggli DF, Kieselhorst K, Mauger EA, Cusatis DC. Bone status among post-menopausal women with different habitual caffeine intakes: a longitudinal investigation. J Am Coll Nutr 2000, 19: 256-61.
16. Fabbri A, Marchesini G, Morselli-Labate AM, et al. Positive blood alcohol concentration and road accidents. A prospective study in an Italian emergency department. Emerg Med J 2002, 19: 210-4.
17. Education Materials. National Institute on Alcohol Abuse and Alcoholism of the National Institute of Health. www.niaaa.nih.gov/guide
18. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: report of a WHO Study Group. World Health Organ Tech Rep Ser 1994, 843: 1-129.
19. Genant HK, Wu CY, van Kuijk C, Nevitt MC. Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 1993, 9: 1137-48.
20. Advisory Panel on Testosterone Replacement in Men. Report of the National Institute on Aging Advisory Panel on testosterone replacement in men. J Clin Endocrinol Metab 2001, 86: 4611-4.
21. Peris P, Guañabens N, Parés A, et al. Vertebral fractures and osteopenia in chronic alcoholic patients. Calcif Tissue Int 1995, 57: 111-4.
22. Santolaria F, Perez-Cejas A, Alemán MR, et al. Low serum leptin levels and malnutrition in chronic alcohol misusers hospitalized by somatic complications. Alcohol Alcohol 2003, 38: 60-6.
23. Jensen GF. Osteoporosis of slender smoker revisited by epidemiological approach. Eur J Clin Invest 1986, 16: 239-42.
24. Høidrup S, Prescott E, Sørensen TI, et al. Tobacco smoking and risk of hip fracture in men and women. Int J Epidemiol 2000, 29: 253-9.
25. Pedrazzoni M, Vescovi PP, Maninetti L, et al. Effect of chronic heroin abuse on bone and mineral metabolism. Acta Endocrinol (Copenh) 1993, 129: 42-5.
26. Idris Al, van't Hof RJ, Greig IR, et al. Regulation of bone mass, bone loss and osteoclast activity by cannabinoids receptors. Nature Med 2005, 11: 774-9.
27. Ofek O, Karsak M, Leclerc N, et al. Peripheral cannabinoid receptor, CB2, regulates bone mass. Proc Natl Acad Sci U S A 2006, 103: 696-701.
28. Kasukawa Y, Miyakoshi N, Mohan S. The anabolic effects of GH/IGF system on bone. Curr Pharm Des 2004, 10: 2577-92.
29. Gong Z, Wezeman FH. Inhibitory effect of alcohol on osteogenic differentiation in human bone marrow-derived mesenchymal stem cells. Alcohol Clin Exp Res 2004, 28: 468-79.
30. Garcia-Valdecasas-Campelo E, González-Reimers E, Santolaria-Fernández F, et al. Serum osteoprotegerin and RANKL levels in chronic alcoholic liver disease. Alcohol Alcohol 2006, 41: 261-6.
31. Monegal A, Navasa M, Peris P, et al. Serum osteoprotegerin and its ligand in cirrhotic patients referred for orthotopic liver transplantation: relationship with metabolic bone disease. Liver Int 2007, 27: 492-7.
32. Raisz LG. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest 2005, 115: 3318-25.
33. Khosla S, Arrighi HM, Melton LJ 3rd, et al. Correlates of osteoprotegerin levels in women and men. Osteoporos Int 2002, 13: 394-9.