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Volumn 8, Issue 8, 2013, Pages

TP53 and Let-7a micro-RNA Regulate K-Ras Activity in HCT116 Colorectal Cancer Cells

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; K RAS PROTEIN; LETHAL 7A MICRORNA; MESSENGER RNA; MICRORNA; PROTEIN P53; UNCLASSIFIED DRUG;

EID: 84880988462     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070604     Document Type: Article
Times cited : (23)

References (34)
  • 2
    • 0027509209 scopus 로고
    • Prognostic value of p53 overexpression and c-Ki-ras gene mutations in colorectal cancer
    • Bell SM, Scott N, Cross D, Sagar P, Lewis FA, et al. (1993) Prognostic value of p53 overexpression and c-Ki-ras gene mutations in colorectal cancer. Gastroenterology 104: 57-64.
    • (1993) Gastroenterology , vol.104 , pp. 57-64
    • Bell, S.M.1    Scott, N.2    Cross, D.3    Sagar, P.4    Lewis, F.A.5
  • 3
    • 84866981242 scopus 로고    scopus 로고
    • Expression of p53 and Ki-67 as prognostic factors for survival of men with colorectal cancer
    • Lumachi F, Orlando R, Marino F, Chiara GB, Basso SM, (2012) Expression of p53 and Ki-67 as prognostic factors for survival of men with colorectal cancer. Anticancer Res 32: 3965-3967.
    • (2012) Anticancer Res , vol.32 , pp. 3965-3967
    • Lumachi, F.1    Orlando, R.2    Marino, F.3    Chiara, G.B.4    Basso, S.M.5
  • 4
    • 84879685038 scopus 로고    scopus 로고
    • Poor prognosis of KRAS or BRAF mutant colorectal liver metastasis without microsatellite instability
    • Umeda Y, Nagasaka T, Mori Y, Sadamori H, Sun DS, et al. (2013) Poor prognosis of KRAS or BRAF mutant colorectal liver metastasis without microsatellite instability. J Hepatobiliary Pancreat Sci 20: 223-233.
    • (2013) J Hepatobiliary Pancreat Sci , vol.20 , pp. 223-233
    • Umeda, Y.1    Nagasaka, T.2    Mori, Y.3    Sadamori, H.4    Sun, D.S.5
  • 5
    • 79952258995 scopus 로고    scopus 로고
    • KRAS mutation is associated with lung metastasis in patients with curatively resected colorectal cancer
    • Tie J, Lipton L, Desai J, Gibbs P, Jorissen RN, et al. (2011) KRAS mutation is associated with lung metastasis in patients with curatively resected colorectal cancer. Clin Cancer Res 17: 1122-1130.
    • (2011) Clin Cancer Res , vol.17 , pp. 1122-1130
    • Tie, J.1    Lipton, L.2    Desai, J.3    Gibbs, P.4    Jorissen, R.N.5
  • 6
    • 40149088765 scopus 로고    scopus 로고
    • KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab
    • De Roock W, Piessevaux H, De Schutter J, Janssens M, De Hertogh G, et al. (2008) KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab. Ann Oncol 19: 508-515.
    • (2008) Ann Oncol , vol.19 , pp. 508-515
    • De Roock, W.1    Piessevaux, H.2    De Schutter, J.3    Janssens, M.4    De Hertogh, G.5
  • 8
    • 32544444419 scopus 로고    scopus 로고
    • The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation: influence of tumor site, type of mutation, and adjuvant treatment
    • Russo A, Bazan V, Lacopetta B, Kerr D, Soussi T, et al. (2005) The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation: influence of tumor site, type of mutation, and adjuvant treatment. J Clin Oncol 23: 7518-7528.
    • (2005) J Clin Oncol , vol.23 , pp. 7518-7528
    • Russo, A.1    Bazan, V.2    Lacopetta, B.3    Kerr, D.4    Soussi, T.5
  • 9
    • 33646228635 scopus 로고    scopus 로고
    • KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
    • Lievre A, Bachet JB, Le Corre D, Boige V, Landi B, et al. (2006) KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res 66: 3992-3995.
    • (2006) Cancer Res , vol.66 , pp. 3992-3995
    • Lievre, A.1    Bachet, J.B.2    Le Corre, D.3    Boige, V.4    Landi, B.5
  • 10
    • 80052287412 scopus 로고    scopus 로고
    • Identification of a biomarker profile associated with resistance to neoadjuvant chemoradiation therapy in rectal cancer
    • Garcia-Aguilar J, Chen Z, Smith DD, Li W, Madoff RD, et al. (2011) Identification of a biomarker profile associated with resistance to neoadjuvant chemoradiation therapy in rectal cancer. Ann Surg 254: 486-492.
    • (2011) Ann Surg , vol.254 , pp. 486-492
    • Garcia-Aguilar, J.1    Chen, Z.2    Smith, D.D.3    Li, W.4    Madoff, R.D.5
  • 11
    • 0037047057 scopus 로고    scopus 로고
    • Mutations in APC, Kirsten-ras, and p53-alternative genetic pathways to colorectal cancer
    • Smith G, Carey FA, Beattie J, Wilkie MJV, Lightfoot TJ, et al. (2002) Mutations in APC, Kirsten-ras, and p53-alternative genetic pathways to colorectal cancer. Proc Natl Acad Sci USA 99: 9433-9438.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 9433-9438
    • Smith, G.1    Carey, F.A.2    Beattie, J.3    Wilkie, M.J.V.4    Lightfoot, T.J.5
  • 12
    • 0032948553 scopus 로고    scopus 로고
    • p53 and K-ras gene mutations correlate with tumor aggressiveness but are not of routine prognostic value in colorectal cancer
    • Tortola S, Marcuello E, González I, Reyes G, Arribas R, et al. (1999) p53 and K-ras gene mutations correlate with tumor aggressiveness but are not of routine prognostic value in colorectal cancer. J Clin Oncol 17: 1375-1375.
    • (1999) J Clin Oncol , vol.17 , pp. 1375
    • Tortola, S.1    Marcuello, E.2    González, I.3    Reyes, G.4    Arribas, R.5
  • 13
    • 33846188098 scopus 로고    scopus 로고
    • microRNAs as oncogenes and tumor suppressors
    • Zhang B, Pan X, Cobb GP, Anderson TA, (2007) microRNAs as oncogenes and tumor suppressors. Dev Biol 302: 1-12.
    • (2007) Dev Biol , vol.302 , pp. 1-12
    • Zhang, B.1    Pan, X.2    Cobb, G.P.3    Anderson, T.A.4
  • 14
    • 38349169664 scopus 로고    scopus 로고
    • Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
    • Filipowicz W, Bhattacharyya SN, Sonenberg N, (2008) Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 9: 102-114.
    • (2008) Nat Rev Genet , vol.9 , pp. 102-114
    • Filipowicz, W.1    Bhattacharyya, S.N.2    Sonenberg, N.3
  • 16
    • 77953232823 scopus 로고    scopus 로고
    • The let-7a microRNA protects from growth of lung carcinoma by suppression of k-Ras and c-Myc in nude mice
    • He X, Chen J, Zhang Z, Li C, Peng Q, et al. (2010) The let-7a microRNA protects from growth of lung carcinoma by suppression of k-Ras and c-Myc in nude mice. J Cancer Res Clin Oncol 136: 1023-1028.
    • (2010) J Cancer Res Clin Oncol , vol.136 , pp. 1023-1028
    • He, X.1    Chen, J.2    Zhang, Z.3    Li, C.4    Peng, Q.5
  • 17
    • 84862877840 scopus 로고    scopus 로고
    • High let-7a microRNA levels in KRAS-mutated colorectal carcinomas may rescue anti-EGFR therapy effects in patients with chemotherapy-refractory metastatic disease
    • Ruzzo A, Graziano F, Vincenzi B, Canestrari E, Perrone G, et al. (2012) High let-7a microRNA levels in KRAS-mutated colorectal carcinomas may rescue anti-EGFR therapy effects in patients with chemotherapy-refractory metastatic disease. Oncologist 17: 823-829.
    • (2012) Oncologist , vol.17 , pp. 823-829
    • Ruzzo, A.1    Graziano, F.2    Vincenzi, B.3    Canestrari, E.4    Perrone, G.5
  • 18
    • 80054115192 scopus 로고    scopus 로고
    • Cellular stress induced alterations in microRNA let-7a and let-7b expression are dependent on p53
    • Saleh AD, Savage JE, Cao L, Soule BP, Ly D, et al. (2011) Cellular stress induced alterations in microRNA let-7a and let-7b expression are dependent on p53. PLoS One 6: e24429.
    • (2011) PLoS One , vol.6
    • Saleh, A.D.1    Savage, J.E.2    Cao, L.3    Soule, B.P.4    Ly, D.5
  • 19
    • 34547458550 scopus 로고    scopus 로고
    • p53-mediated activation of miRNA34 candidate tumor-suppressor genes
    • Bommer GT, Gerin I, Feng Y, Kaczorowski AJ, Kuick R, et al. (2007) p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol 17: 1298-1307.
    • (2007) Curr Biol , vol.17 , pp. 1298-1307
    • Bommer, G.T.1    Gerin, I.2    Feng, Y.3    Kaczorowski, A.J.4    Kuick, R.5
  • 20
    • 0032553485 scopus 로고    scopus 로고
    • Requirement for p53 and p21 to sustain G2 arrest after DNA damage
    • Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, et al. (1998) Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282: 1497-1501.
    • (1998) Science , vol.282 , pp. 1497-1501
    • Bunz, F.1    Dutriaux, A.2    Lengauer, C.3    Waldman, T.4    Zhou, S.5
  • 21
    • 80053039210 scopus 로고    scopus 로고
    • Mutations in the p53 tumor suppressor gene: Important milestones at the various steps of tumorigenesis
    • Rivlin N, Brosh R, Oren M, Rotter V, (2011) Mutations in the p53 tumor suppressor gene: Important milestones at the various steps of tumorigenesis. Genes Cancer 2: 466-474.
    • (2011) Genes Cancer , vol.2 , pp. 466-474
    • Rivlin, N.1    Brosh, R.2    Oren, M.3    Rotter, V.4
  • 23
    • 0036739336 scopus 로고    scopus 로고
    • Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype
    • Bazan V, Migliavacca M, Zanna I, Tubiolo C, Grassi N, et al. (2002) Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype. Ann Oncol 13: 1438-1446.
    • (2002) Ann Oncol , vol.13 , pp. 1438-1446
    • Bazan, V.1    Migliavacca, M.2    Zanna, I.3    Tubiolo, C.4    Grassi, N.5
  • 24
    • 34548012848 scopus 로고    scopus 로고
    • The let-7 microRNA represses cell proliferation pathways in human cells
    • Johnson CD, Esquela-Kerscher A, Stefani G, Byrom M, Kelnar K, et al. (2007) The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res 67: 7713-7722.
    • (2007) Cancer Res , vol.67 , pp. 7713-7722
    • Johnson, C.D.1    Esquela-Kerscher, A.2    Stefani, G.3    Byrom, M.4    Kelnar, K.5
  • 25
    • 33646444884 scopus 로고    scopus 로고
    • let-7 microRNA functions as a potential growth suppressor in human colon cancer cells
    • Akao Y, Nakagawa Y, Naoe T, (2006) let-7 microRNA functions as a potential growth suppressor in human colon cancer cells. Biol Pharm Bull 29: 903-906.
    • (2006) Biol Pharm Bull , vol.29 , pp. 903-906
    • Akao, Y.1    Nakagawa, Y.2    Naoe, T.3
  • 26
    • 35548957247 scopus 로고    scopus 로고
    • microRNAs join the p53 network-another piece in the tumour-suppression puzzle
    • He L, He X, Lowe SW, Hannon GJ, (2007) microRNAs join the p53 network-another piece in the tumour-suppression puzzle. Nat Rev Cancer 7: 819-822.
    • (2007) Nat Rev Cancer , vol.7 , pp. 819-822
    • He, L.1    He, X.2    Lowe, S.W.3    Hannon, G.J.4
  • 27
    • 34249822779 scopus 로고    scopus 로고
    • Transcriptional activation of miR-34a contributes to p53-mediated apoptosis
    • Raver-Shapira N, Marciano E, Meiri E, Spector Y, Rosenfeld N, et al. (2007) Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol Cell 26: 731-743.
    • (2007) Mol Cell , vol.26 , pp. 731-743
    • Raver-Shapira, N.1    Marciano, E.2    Meiri, E.3    Spector, Y.4    Rosenfeld, N.5
  • 28
    • 0032701521 scopus 로고    scopus 로고
    • Disruption of p53 in human cancer cells alters the responses to therapeutic agents
    • Bunz F, Hwang PM, Torrance C, Waldman T, Zhang Y, et al. (1999) Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest 104: 263-270.
    • (1999) J Clin Invest , vol.104 , pp. 263-270
    • Bunz, F.1    Hwang, P.M.2    Torrance, C.3    Waldman, T.4    Zhang, Y.5
  • 29
    • 34848868157 scopus 로고    scopus 로고
    • Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells
    • Tazawa H, Tsuchiya N, Izumiya M, Nakagama H, (2007) Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc Natl Acad Sci USA 104: 15472-15477.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 15472-15477
    • Tazawa, H.1    Tsuchiya, N.2    Izumiya, M.3    Nakagama, H.4
  • 30
    • 84855380396 scopus 로고    scopus 로고
    • MicroRNA-622 functions as a tumor suppressor by targeting K-Ras and enhancing the anticarcinogenic effect of resveratrol
    • Han Z, Yang Q, Liu B, Wu J, Li Y, et al. (2012) MicroRNA-622 functions as a tumor suppressor by targeting K-Ras and enhancing the anticarcinogenic effect of resveratrol. Carcinogenesis 33: 131-139.
    • (2012) Carcinogenesis , vol.33 , pp. 131-139
    • Han, Z.1    Yang, Q.2    Liu, B.3    Wu, J.4    Li, Y.5
  • 31
    • 81055144862 scopus 로고    scopus 로고
    • Y Galectin-3 mediates cross-talk between K-Ras and Let-7c tumor suppressor microRNA
    • Levy R, Biran A, Poirier F, Raz A, (2011) Kloog (2011) Y Galectin-3 mediates cross-talk between K-Ras and Let-7c tumor suppressor microRNA. PLoS One 6: e27490.
    • (2011) PLoS One , vol.6
    • Levy, R.1    Biran, A.2    Poirier, F.3    Raz, A.4
  • 32
    • 69249148349 scopus 로고    scopus 로고
    • Ras activity levels control the development of pancreatic diseases
    • Ji B, Tsou L, Wang H, Gaiser S, Chang DZ, et al. (2009) Ras activity levels control the development of pancreatic diseases. Gastroenterology 137: 1072-1082.e6.
    • (2009) Gastroenterology , vol.137 , pp. 1072-1082
    • Ji, B.1    Tsou, L.2    Wang, H.3    Gaiser, S.4    Chang, D.Z.5
  • 33
    • 0037339012 scopus 로고    scopus 로고
    • A pathologic complete response to preoperative chemoradiation is associated with lower local recurrence and improved survival in rectal cancer patients treated by mesorectal excision
    • García-Aguilar J, Hernandez de Anda E, Sirivongs P, Lee S-H, Madoff R, et al. (2003) A pathologic complete response to preoperative chemoradiation is associated with lower local recurrence and improved survival in rectal cancer patients treated by mesorectal excision. Dis Colon Rectum 46: 298-304.
    • (2003) Dis Colon Rectum , vol.46 , pp. 298-304
    • García-Aguilar, J.1    Hernandez de Anda, E.2    Sirivongs, P.3    Lee, S.-H.4    Madoff, R.5
  • 34
    • 0035045195 scopus 로고    scopus 로고
    • Improved overall survival among responders to preoperative chemoradiation for locally advanced rectal cancer
    • Janjan NA, Crane C, Feig BW, Cleary K, Dubrow R, et al. (2001) Improved overall survival among responders to preoperative chemoradiation for locally advanced rectal cancer. Am J Clin Oncol 24: 107-112.
    • (2001) Am J Clin Oncol , vol.24 , pp. 107-112
    • Janjan, N.A.1    Crane, C.2    Feig, B.W.3    Cleary, K.4    Dubrow, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.