Serotonin 2A receptors contribute to the regulation of risk-averse decisions

NeuroImage

Volumn 83, Issue , 2013, Pages 35-44

  Macoveanu, Julian ^a   Rowe, James B ^a,b   Hornboll, Bettina ^a   Elliott, Rebecca ^c   Paulson, Olaf B ^a,d   Knudsen, Gitte M ^a,d   Siebner, Hartwig R ^a  

^a Mental Health Center Glostrup   (Denmark)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d Rigshospitalet   (Denmark)

Author keywords

Decision making; Frontopolar cortex; Ketanserin; Pharmacological fMRI; Reward; Serotonin

Indexed keywords

KETANSERIN; SEROTONIN 2A RECEPTOR;

ADULT; ARTICLE; AVERSIVE BEHAVIOR; BRAIN CORTEX; CONTROLLED STUDY; CORPUS STRIATUM; DECISION MAKING; FEMALE; FRONTOPOLAR CORTEX; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GAMBLING; HIGH RISK BEHAVIOR; HUMAN; HUMAN EXPERIMENT; MALE; MENTAL TASK; NERVE POTENTIAL; NEUROMODULATION; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE SCANNER; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR BLOCKING; REGULATORY MECHANISM; REWARD; AVOIDANCE BEHAVIOR; BRAIN MAPPING; FRONTAL LOBE; METABOLISM; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSIOLOGY; RISK REDUCTION; SEROTONINERGIC NERVE CELL;

ADULT; AVOIDANCE LEARNING; BRAIN MAPPING; DECISION MAKING; FEMALE; FRONTAL LOBE; GAMBLING; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; RECEPTOR, SEROTONIN, 5-HT2A; REWARD; RISK REDUCTION BEHAVIOR; SEROTONERGIC NEURONS;

EID: 84880950962     PISSN: 10538119     EISSN: 10959572     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2013.06.063     Document Type: Article

References (49)

1. Abler B., Grön G., Hartmann A., Metzger C., Walter M. Modulation of frontostriatal interaction aligns with reduced primary reward processing under serotonergic drugs. J. Neurosci. 2012, 32:1329-1335.
2. Alex K.D., Pehek E.A. Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission. Pharmacol. Therapeut. 2007, 113:296-320.
3. Boorman E.D., Behrens T.E.J., Woolrich M.W., Rushworth M.F.S. How green is the grass on the other side? Frontopolar cortex and the evidence in favor of alternative courses of action. Neuron 2009, 62:733-743.
4. Boorman E.D., Behrens T.E., Rushworth M.F. Counterfactual choice and learning in a neural network centered on human lateral frontopolar cortex. PLoS Biol. 2011, 9:e1001093.
5. Boureau Y.-L., Dayan P. Opponency revisited: competition and cooperation between dopamine and serotonin. Neuropsychopharmacology 2011, 36:74-97.
6. Camille N., Coricelli G., Sallet J., Pradat-Diehl P., Duhamel J.-R., Sirigu A. The involvement of the orbitofrontal cortex in the experience of regret. Science 2004, 304:1167-1170.
7. Christopoulos G.I., Tobler P.N., Bossaerts P., Dolan R.J., Schultz W. Neural correlates of value, risk, and risk aversion contributing to decision making under risk. J. Neurosci. 2009, 29:12574-12583.
8. Cools R., Robinson O.J., Sahakian B. Acute tryptophan depletion in healthy volunteers enhances punishment prediction but does not affect reward prediction. Neuropsychopharmacology 2008, 33:2291-2299.
9. Cools R., Nakamura K., Daw N.D. Serotonin and dopamine: unifying affective, activational, and decision functions. Neuropsychopharmacology 2010, 36:98-113.
10. Crockett M.J., Clark L., Apergis-Schoute A.M., Morein-Zamir S., Robbins T.W. Serotonin modulates the effects of Pavlovian aversive predictions on response vigor. Neuropsychopharmacology 2012, 37:2244-2252.
11. Deichmann R., Gottfried J.A., Hutton C., Turner R. Optimized EPI for fMRI studies of the orbitofrontal cortex. NeuroImage 2003, 19:430-441.
12. Fisher P.M., Meltzer C.C., Price J.C., Coleman R.L., Ziolko S.K., Becker C., Moses-Kolko E.L., Berga S.L., Hariri A.R. Medial prefrontal cortex 5-HT(2A) density is correlated with amygdala reactivity, response habituation, and functional coupling. Cereb. Cortex 2009, 19:2499-2507.
13. Frokjaer V.G., Mortensen E.L., Nielsen F.A., Haugbol S., Pinborg L.H., Adams K.H., Svarer C., Hasselbalch S.G., Holm S., Paulson O.B., Knudsen G.M. Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder. Biol. Psychiatry 2008, 63:569-576.
14. Glennon R.A., Metwally K., Dukat M., Ismaiel A.M., De los Angeles, J., Herndon, J., Teitler, M., Khorana, N., Ketanserin and spiperone as templates for novel serotonin 5-HT(2A) antagonists. Curr. Top. Med. Chem. 2002, 2:539-558.
15. Glover G.H., Li T.Q., Ress D. Image-based method for retrospective correction of physiological motion effects in fMRI: RETROICOR. Magn. Reson. Med. 2000, 44:162-167.
16. Günther M., Oshio K., Feinberg D.A. Single-shot 3D imaging techniques improve arterial spin labeling perfusion measurements. Magn. Reson. Med. 2005, 54:491-498.
17. Haber S.N. Neuroanatomy of reward: a view from the ventral striatum. Neurobiology of Sensation and Reward 2011, CRC Press, Boca Raton (FL). J.A. Gottfried (Ed.).
18. Hsu M., Krajbich I., Zhao C., Camerer C. Neural response to reward anticipation under risk is nonlinear in probabilities. J. Neurosci. 2009, 29:2231-2237.
19. Huettel S.A., Stowe C.J., Gordon E.M., Warner B.T., Platt M.L. Neural signatures of economic preferences for risk and ambiguity. Neuron 2006, 49:765-775.
20. Kahneman D., Tversky A. Prospect theory: an analysis of decision under risk. Econometria 1979, 47:263-291.
21. Korstanje C., Sprenkels R., Doods H.N., Hugtenburg J.G., Boddeke E., Batink H.D., Thoolen M.J., Van Zwieten P.A. Characterization of flufylline, fluprofylline, ritanserin, butanserin and R 56413 with respect to in-vivo alpha 1-, alpha 2- and 5-HT2-receptor antagonism and in-vitro affinity for alpha 1-, alpha 2- and 5-HT2-receptors: comparison with ketanserin. J. Pharm. Pharmacol. 1986, 38:374-379.
22. Lamy M. For juice or money: the neural response to intertemporal choice of primary and secondary rewards. J. Neurosci. 2007, 27:12121-12122.
23. Liu X., Powell D.K., Wang H., Gold B.T., Corbly C.R., Joseph J.E. Functional dissociation in frontal and striatal areas for processing of positive and negative reward information. J. Neurosci. 2007, 27:4587-4597.
24. Liu X., Hairston J., Schrier M., Fan J. Common and distinct networks underlying reward valence and processing stages: a meta-analysis of functional neuroimaging studies. Neurosci. Biobehav. Rev. 2011, 35:1219-1236.
25. Long A.B., Kuhn C.M., Platt M.L. Serotonin shapes risky decision making in monkeys. Soc. Cogn. Affect. Neurosci. 2009, 4:346-356.
26. Ludvig E.A., Spetch M.L. Of black swans and tossed coins: is the description-experience gap in risky choice limited to rare events?. PLoS One 2011, 6:e20262.
27. Luh W.M., Wong E.C., Bandettini P.A., Hyde J.S. QUIPSS II with thin-slice TI1 periodic saturation: a method for improving accuracy of quantitative perfusion imaging using pulsed arterial spin labeling. Magn. Reson. Med. 1999, 41:1246-1254.
28. Lund T.E., Madsen K.H., Sidaros K., Luo W.-L., Nichols T.E. Non-white noise in fMRI: does modelling have an impact?. NeuroImage 2006, 29:54-66.
29. Macoveanu J., Rowe J.B., Hornboll B., Elliott R., Paulson O.B., Knudsen G.M., Siebner H.R. Playing it safe but losing anyway-serotonergic signaling of negative outcomes in dorsomedial prefrontal cortex in the context of risk-aversion. Eur. Neuropsychopharmacol. 2013, (in press), http://www.ncbi.nlm.nih.gov/pubmed/23051938.
30. Mata R., Hau R., Papassotiropoulos A., Hertwig R. DAT1 polymorphism is associated with risk taking in the Balloon Analogue Risk Task (BART). PLoS One 2012, 7:e39135.
31. McCabe C., Mishor Z., Cowen P.J., Harmer C.J. Diminished neural processing of aversive and rewarding stimuli during selective serotonin reuptake inhibitor treatment. Biol. Psychiatry 2010, 67:439-445.
32. McNair D.M., Lorr M., Droppleman L.F. Profile of Mood States Manual 1971, Educational and Industrial Testing Service, San Diego.
33. Murphy S.E., Longhitano C., Ayres R.E., Cowen P.J., Harmer C.J., Rogers R.D. The role of serotonin in nonnormative risky choice: the effects of tryptophan supplements on the "reflection effect" in healthy adult volunteers. J. Cogn. Neurosci. 2009, 21:1709-1719.
34. 2A receptor gene in impulsive behavior. Psychopharmacology (Berl.) 2006, 187:30-35.
35. O'Doherty J.P. Reward representations and reward-related learning in the human brain: insights from neuroimaging. Curr. Opin. Neurobiol. 2004, 14:769-776.
36. Pehek E.A., McFarlane H.G., Maguschak K., Price B., Pluto C.P. M100,907, a selective 5-HT(2A) antagonist, attenuates dopamine release in the rat medial prefrontal cortex. Brain Res. 2001, 888:51-59.
37. 2A receptors in the human brain using [18F]altanserin-PET and the bolus/infusion approach. J. Cereb. Blood Flow Metab. 2003, 23:985-996.
38. Rieskamp J. The probabilistic nature of preferential choice. J. Exp. Psychol. Learn. Mem. Cogn. 2008, 34:1446-1465.
39. Rogers R.D., Everitt B.J., Baldacchino A., Blackshaw A.J., Swainson R., Wynne K., Baker N.B., Hunter J., Carthy T., Booker E., London M., Deakin J.F., Sahakian B.J., Robbins T.W. Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: evidence for monoaminergic mechanisms. Neuropsychopharmacology 1999, 20:322-339.
40. Rogers R.D., Owen a M., Middleton H.C., Williams E.J., Pickard J.D., Sahakian B.J., Robbins T.W. Choosing between small, likely rewards and large, unlikely rewards activates inferior and orbital prefrontal cortex. J. Neurosci. 1999, 19:9029-9038.
41. Rogers R.D., Tunbridge E.M., Bhagwagar Z., Drevets W.C., Sahakian B.J., Carter C.S. Tryptophan depletion alters the decision-making of healthy volunteers through altered processing of reward cues. Neuropsychopharmacology 2003, 28:153-162.
42. Schoenbaum G., Roesch M.R., Stalnaker T.A., Takahashi Y.K. A new perspective on the role of the orbitofrontal cortex in adaptive behaviour. Nat. Rev. Neurosci. 2009, 10:885-892.
43. Shelton R.C., Sanders-Bush E., Manier D.H., Lewis D.A. Elevated 5-HT 2A receptors in postmortem prefrontal cortex in major depression is associated with reduced activity of protein kinase A. Neuroscience 2009, 158:1406-1415.
44. 1 receptors and nonlinear probability weighting in risky choice. J. Neurosci. 2010, 30:16567-16572.
45. Tanaka S.C., Shishida K., Schweighofer N., Okamoto Y., Yamawaki S., Doya K. Serotonin affects association of aversive outcomes to past actions. J. Neurosci. 2009, 29:15669-15674.
46. Tom S.M., Fox C.R., Trepel C., Poldrack R.A. The neural basis of loss aversion in decision-making under risk. Science 2007, 315:515-518.
47. 2A receptors in the human brain: a constant infusion paradigm with [18F]altanserin. J. Nucl. Med. 2000, 41:234-241.
48. Von Neumann J., Morgenstern O., Rubinstein A., Kuhn H.W. Theory of Games and Economic Behavior 2007, Greenwood Publishing Group.
49. Zink C.F., Pagnoni G., Martin-Skurski M.E., Chappelow J.C., Berns G.S. Human striatal responses to monetary reward depend on saliency. Neuron 2004, 42:509-517.