Genetic variation in the parasympathetic signaling pathway in patients with reflex syncope

Genetics and Molecular Research

Volumn 12, Issue 3, 2013, Pages 2601-2610

  Benn, M ^b   Holmegard, H N ^a   Mehlsen, J ^c   Haunso S ^a  

^a Rigshospitalet   (Denmark)

^b GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^c FREDERIKSBERG HOSPITAL   (Denmark)

Author keywords

Genetics; Parasympathetic; Reflex syncope; Translational medicine; Vagal signaling

Indexed keywords

ADULT; ARTICLE; CHOLINERGIC SYSTEM; CHRM2 GENE; CONTROLLED STUDY; DNA FLANKING REGION; DNA SEQUENCE; FAINTNESS; FEMALE; GENE; GENE FREQUENCY; GENETIC VARIABILITY; GNB1 GENE; GNG2 GENE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; INTRON; KCNJ3 GENE; KCNJ5 GENE; MAJOR CLINICAL STUDY; MALE; NEUROPATHOLOGY; POSTSYNAPTIC POTENTIAL; REFLEX SYNCOPE; VAGUS REFLEX;

ADULT; CASE-CONTROL STUDIES; FEMALE; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GTP-BINDING PROTEIN BETA SUBUNITS; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, MUSCARINIC M2; SYNCOPE, VASOVAGAL;

EID: 84880944259     PISSN: None     EISSN: 16765680     Source Type: Journal    
DOI: 10.4238/2013.January.30.6     Document Type: Article

References (30)

1. Bartoletti A, Alboni P, Ammirati F, Brignole M, et al. (2000). The Italian Protocol: a simplified head-up tilt testing potentiated with oral nitroglycerin to assess patients with unexplained syncope. Europace 2: 339-342.
2. Bettahi I, Marker CL, Roman MI and Wickman K (2002). Contribution of the Kir3.1 subunit to the muscarinic-gated atrial potassium channel IKACh. J. Biol. Chem. 277: 48282-48288.
3. Bizios AS and Sheldon RS (2009). Vasovagal syncope: state or trait? Curr. Opin. Cardiol. 24: 68-73.
4. Brignole M, Menozzi C, Del Rosso A, Costa S, et al. (2000). New classification of haemodynamics of vasovagal syncope: beyond the VASIS classification. Analysis of the pre-syncopal phase of the tilt test without and with nitroglycerin challenge. Vasovagal Syncope International Study. Europace 2: 66-76.
5. Camfield PR and Camfield CS (1990). Syncope in childhood: a case control clinical study of the familial tendency to faint. Can. J. Neurol. Sci. 17: 306-308.
6. Corey S, Krapivinsky G, Krapivinsky L and Clapham DE (1998). Number and stoichiometry of subunits in the native atrial G-protein-gated K+ channel, IKACh. J. Biol. Chem. 273: 5271-5278.
7. + channels. Cell Signal. 9: 551-573.
8. Hoffman EC, Reyes H, Chu FF, Sander F, et al. (1991). Cloning of a factor required for activity of the Ah (dioxin) receptor. Science 252: 954-958.
9. Hurowitz EH, Melnyk JM, Chen YJ, Kouros-Mehr H, et al. (2000). Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. DNA Res. 7: 111-120.
10. Kovoor P, Wickman K, Maguire CT, Pu W, et al. (2001). Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model. J. Am. Coll. Cardiol. 37: 2136-2143.
11. Lelonek M, Pietrucha T, Stanczyk A and Goch JH (2007). Vasovagal syncope patients and the C825T GNB3 polymorphism. Anadolu. Kardiyol. Derg. (Suppl 1) 7: 206-208.
12. Lelonek M, Pietrucha T, Matyjaszczyk M and Goch JH (2008). Mutation T/C,Ile 131 of the gene encoding the alfa subunit of the human Gs protein and predisposition to vasovagal syncope. Circ. J. 72: 558-562.
13. Lelonek M, Pietrucha T, Matyjaszczyk M and Goch JH (2009). Polymorphism C1114G of gene encoding the cardiac regulator of G-protein signaling 2 may be associated with number of episodes of neurally mediated syncope. Arch. Med. Res. 40: 191-195.
14. Logothetis DE, Kurachi Y, Galper J, Neer EJ, et al. (1987). The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart. Nature 325: 321-326.
15. + channels. Eur. J. Biochem. 267: 5830-5836.
16. Marquez MF, Hernandez-Pacheco G, Hermosillo AG, Gomez JR, et al. (2007). The Arg389Gly beta1-adrenergic receptor gene polymorphism and susceptibility to faint during head-up tilt test. Europace 9: 585-588.
17. Mathias CJ, Deguchi K, Bleasdale-Barr K and Kimber JR (1998). Frequency of family history in vasovagal syncope. Lancet 352: 33-34.
18. Newton JL, Donaldson P, Parry S, Kenny RA, et al. (2005). Angiotensin converting enzyme insertion/deletion polymorphisms in vasovagal syncope. Europace 7: 396-399.
19. Ng PC and Henikoff S (2003). SIFT: Predicting amino acid changes that affect protein function. Nucleic Acids Res. 31: 3812-3814.
20. Ramensky V, Bork P and Sunyaev S (2002). Human non-synonymous SNPs: server and survey. Nucleic Acids Res. 30: 3894-3900.
21. Rea RF and Thames MD (1993). Neural control mechanisms and vasovagal syncope. J. Cardiovasc. Electrophysiol. 4: 587-595.
22. Reuveny E, Slesinger PA, Inglese J, Morales JM, et al. (1994). Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits. Nature 370: 143-146.
23. Rose MS, Koshman ML, Spreng S and Sheldon R (2000). The relationship between health-related quality of life and frequency of spells in patients with syncope. J. Clin. Epidemiol. 53: 1209-1216.
24. Savage DD, Corwin L, McGee DL, Kannel WB, et al. (1985). Epidemiologic features of isolated syncope: the Framingham Study. Stroke 16: 626-629.
25. Sorrentino S, Forleo C, Iacoviello M, Guida P, et al. (2010). Lack of association between genetic polymorphisms affecting sympathetic activity and tilt-induced vasovagal syncope. Auton. Neurosci. 155: 98-103.
26. Thomas PD, Kejariwal A, Campbell MJ, Mi H, et al. (2003). PANTHER: a browsable database of gene products organized by biological function, using curated protein family and subfamily classification. Nucleic Acids Res. 31: 334-341.
27. van Dijk N, Sprangers MA, Boer KR, Colman N, et al. (2007). Quality of life within one year following presentation after transient loss of consciousness. Am. J. Cardiol. 100: 672-676.
28. van Lieshout JJ, Wieling W and Karemaker JM (1997). Neural circulatory control in vasovagal syncope. Pacing Clin. Electrophysiol. 20: 753-763.
29. Wickman K and Clapham DE (1995). Ion channel regulation by G proteins. Physiol. Rev. 75: 865-885.
30. Wickman KD, Iniguez-Lluhl JA, Davenport PA, Taussig R, et al. (1994). Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel. Nature 368: 255-257.