Nicotine increases lifespan and rescues olfactory and motor deficits in a Drosophila model of Parkinson's disease

Behavioural Brain Research

Volumn 253, Issue , 2013, Pages 95-102

  Chambers, Raegan P ^a   Call, Gerald B ^a   Meyer, David ^a   Smith, Justin ^a   Techau, Jared A ^a   Pearman, Krista ^a   Buhlman, Lori M ^a  

^a MIDWESTERN UNIVERSITY   (United States)

Author keywords

Drosophila; Nicotine; Parkin; Parkinson

Indexed keywords

NICOTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLIMBING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE SEVERITY; DOPAMINERGIC NERVE CELL; DROSOPHILA MELANOGASTER; DRUG RESPONSE; FLYING; GENE MUTATION; HETEROZYGOTE; HOMOZYGOTE; IN VITRO STUDY; IN VIVO STUDY; LIFESPAN; LONG TERM EXPOSURE; LOSS OF FUNCTION MUTATION; MORTALITY; MOTOR DYSFUNCTION; NEUROPROTECTION; NONHUMAN; PARKIN GENE; PARKINSON DISEASE; PHENOTYPE; PRIORITY JOURNAL; SMELLING DISORDER; SMOKING;

AR-JP; AUTOSOMAL RECESSIVE-JUVENILE PARKINSONISM; DROSOPHILA; DROSOPHILA THAT EXPRESS WILD-TYPE PARK; DROSOPHILA WITH HETEROZYGOUS PARKIN LOSS-OF-FUNCTION MUTATION; NICOTINE; PARK(25) HET; PARKIN; PARKINSON; PARKINSON'S DISEASE; PD; SEM; STANDARD ERROR OF THE MEAN; TH; TYROSINE HYDROXYLASE; W(1118), CONTROL;

ALLELES; ANIMALS; BRAIN; DISEASE PROGRESSION; DROSOPHILA MELANOGASTER; FEMALE; FLIGHT, ANIMAL; IMMUNOHISTOCHEMISTRY; LIFE EXPECTANCY; MALE; MOTOR ACTIVITY; MOVEMENT DISORDERS; MUTATION; NICOTINE; NICOTINIC AGONISTS; OLFACTION DISORDERS; PARKINSON DISEASE; SEX CHARACTERISTICS; SMELL; TYROSINE 3-MONOOXYGENASE; UBIQUITIN-PROTEIN LIGASES;

EID: 84880926601     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2013.07.020     Document Type: Article

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