Differences in circulating non-transferrin-bound iron after oral administration of ferrous sulfate, sodium iron EDTA, or iron polymaltose in women with marginal iron stores

Food and Nutrition Bulletin

Volumn 34, Issue 2, 2013, Pages 185-193

  Schümann, Klaus ^a   Solomons, Noel W ^b   Orozco, Monica ^b   Romero Abal, Maria Eugenia ^b   Weiss, Guenter ^c  

^a Life and Food Science Center Weihenstephan   (Germany)

^b Center for Studies of Sensory Impairment Aging and Metabolism Guatemala   (Guatemala)

^c INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Anemia; Guatemala; Iron polymaltose; Malaria; NaFeEDTA; Nontransferrin bound iron; Oral iron supplementation; Women

Indexed keywords

COMPARATIVE STUDY; CONCENTRATION (COMPOSITION); DRUG PRESCRIBING; HEALTH RISK; IRON; MALARIA; PLASMA; SAMPLING; SERUM; WOMENS HEALTH;

GUATEMALA [CENTRAL AMERICA];

EID: 84880907150     PISSN: 03795721     EISSN: None     Source Type: Journal    
DOI: 10.1177/156482651303400207     Document Type: Article

References (46)

1. Beard JL. Iron. In: Bowman BA, ed. Present knowledge in nutrition, 9th ed. Washington, DC: ILSI Press, 2006:430-44.
2. Schümann K. Safety aspects of iron in food. Ann Nutr Metab 2001;45:91-101.
3. Schümann K, Ettle T, Szegner B, Elsenhans B, Solomons NW. On risk and benefits of iron supplementation-recommendations for iron intake revisited. J Trace Elem Med Biol 2007;21:147-68.
4. Murray MJ, Murray AB, Murray MB, Murray CJ. The adverse effect of iron repletion on the course of certain infections. Br Med J 1978;21:1113-5.
5. Weinberg ED. Iron loading and disease surveillance. Emerg Infect Dis 1995;5:346-52.
6. Schaible UE, Kaufmann SH. Iron and microbial infection. Nat Rev Microbiol 2004;2:946-53.
7. Nairz M, Schroll A, Sonnweber T, Weiss G. The struggle for iron-A metal at the host-Athogen interface. Cell Microbiol 2010;12:1691-702.
8. Harvey PW, Heywood PF, Nesheim MC, Galme K, Zegans M, Habicht JP, Stephenson LS, Radimer KL, Brabin B, Forsyth K, Alpers MP. The effect of iron therapy on malarial infection in Papua New Guinean schoolchildren. Am J Trop Med Hyg 1989;40:12-8.
9. Smith AW, Hendrickse RG, Harrison C, Hayes RJ, Greenwood BM. The effects on malaria of treatment of iron-deficiency anaemia with oral iron in Gambian children. Ann Trop Paediatr 1989;9:17-23.
10. van den Hombergh J, Dalderop E, Smit Y. Does iron therapy benefit children with severe malaria-Associated anaemiä A clinical trial with 12 weeks supplementation of oral iron in young children from the Turiani Division, Tanzania. J Trop Pediatr 1996;42:220-7.
11. Berger J, Dyck JL, Galan P, Aplogan A, Schneider D, Traissac P, Hercberg S. Effect of daily iron supplementation on iron status, cell-mediated immunity, and incidence of infections in 6-36 month old Togolese children. Eur J Clin Nutr 2000;54:29-35.
12. Menendez C, Kahigwa E, Hirt R, Vounatsou P, Aponte JJ, Font F, Acosta CJ, Schellenberg DM, Galindo CM, Kimario J, Urassa H, Brabin B, Smith TA, Kitua AY, Tanner M, Alonso PL. Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants. Lancet 1997;350:844-50.
13. Ojukwu JU, Okebe JU, Yahav D, Paul M. Oral iron supplementation for preventing or treating anaemia among children in malaria-endemic areas. Cochrane Database Syst Rev 2011;(10):CD006589.
14. Sazawal S, Black RE, Ramsan M, Chwaya HM, Stoltzfus RJ, Dutta A, Dhingra U, Kabole I, Deb S, Othman MK, Kabole FM. Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial. Lancet 2006;367:133-43.
15. Conclusions and recommendations of the WHO consultation on prevention and control of iron deficiency in infants and young children in malaria-endemic areas. Food Nutr Bull 2007;28:S621-7.
16. Schumann K, Christ F. Did the iron age end in Pembä Sight Life Mag 2007;3:6-13.
17. Prentice AM. Iron metabolism, malaria, and other infections: what is all the fuss about? J Nutr 2008;138:2537-41.
18. Prentice AM, Ghattas H, Doherty C, Cox SE. Iron metabolism and malaria. Food Nutr Bull 2007;28:S524-39.
19. Sarkate P, Patil A, Parulekar S, Rege NN, Samant BD, Lokhande J, Gupta A, Kulkarni K. A randomised doubleblind study comparing sodium feredetate with ferrous fumarate in anaemia in pregnancy. J Indian Med Assoc 2007;105:278, 280-1, 284.
20. Andang'o PE, Osendarp SJ, Ayah R, West CE, Mwaniki DL, De Wolf CA, Kraaijenhagen R, Kok FJ, Verhoef H. Efficacy of iron-fortified whole maize flour on iron status of schoolchildren in Kenya: a randomised controlled trial. Lancet 2007;369:1799-806.
21. Longfils P, Monchy D, Weinheimer H, Chavasit V, Nakanishi Y, Schümann K. A comparative intervention trial on fish sauce fortified with NaFe-EDTA and FeSO4+citrate in iron deficiency anemic school children in Kampot, Cambodia. Asia Pac J Clin Nutr 2008;17:250-7.
22. Reddy PS, Adsul BB, Gandewar K, Korde KM, Desai A. Evaluation of efficacy and safety of iron polymaltose complex and folic acid (Mumfer) vs iron formulation (ferrous fumarate) in female patients with anaemia. J Indian Med Assoc 2001;99:154-5.
23. Saha L, Pandhi P, Gopalan S, Malhotra S, Saha PK. Comparison of efficacy, tolerability, and cost of iron polymaltose complex with ferrous sulphate in the treatment of iron deficiency anaemia in pregnant women. Med Gen Med 2007;9:1.
24. Haliotis FA, Papanastasiou DA. Comparative study of tolerability and efficacy of iron protein succinylate versus iron hydroxide polymaltose complex in the treatment of iron deficiency in children. Int J Clin Pharmacol Ther 1998;36:320-5.
25. Geisser P. Safety and efficacy of iron(III)-hydroxide polymaltose complex/a review of over 25 years experience. Arzneimittelforschung 2007;57:439-52.
26. Schümann K, Solomons NW, Romero-Abal M-E, Orozco M, Weiss G, Marx JJ. Oral administration of ferrous sulfate, but not of iron polymaltose and sodium iron EDTA, results in a substantial increase of nontransferrin-bound iron in healthy men. Food Nutr Bull 2012;33:128-36.
27. Hentze MW, Muckenhalter MU, Gaby B, Camaschella C. Two to tango: regulation of mammalian iron metabolism. Cell 2010;142:24-38.
28. Vanoaica L, Darshan D, Richman L, Schümann K, Kühn LC. Intestinal ferritin H is required for an accurate control of iron absorption. Cell 2010;12:273-82.
29. Breuer W, Cabantchik ZI. A fluorescence-based onestep assay for serum non transferrin-bound iron. Anal Biochem 2001;299:194-202.
30. Hider RC. Nature of nontransferrin-bound iron. Eur J Clin Nutr 2002;32:50-4.
31. Hutchinson C, Al-Ashgar W, Liu D, Hider RC, Powell JJ, Geissler CA. Oral ferrous sulphate leads to a marked increase in pro-oxidant non-Transferrin-bound iron. Eur J Clin Invest 2004;34:782-4.
32. Dresow B, Petersen D, Fischer R, Nielsen P. Non-Transferrin-bound iron in plasma followed administration of oral iron drugs. Biometals 2008;21:273-6.
33. Messner DJ, Kowdley KV. Neoplastic transformation of rat liver epithelial cells is enhanced by non-Transferrinbound iron. BMC Gastroenterol 2008;8:2.
34. Ozment CP, Turi JL. Iron overload following red blood cell transfusion and its impact on disease severity. Biochim Biophys Acta 2009;1790:694-701.
35. Porter JB. Pathophysiology of transfusional iron overload: contrasting patterns in thalassemia major and sickle cell disease. Haemoglobin 2009;33:S37-45.
36. Hershko C. Pathogenesis and management of iron toxicity in thalassemia. Ann N Y Acad Sci 2010;1202:1-9.
37. Kartikasari AER, Georgiou NA, Visseren FL, van Kats-Renaud H, van Asbeck BS, Marx JJ. Endothelial activation and induction of monocyte adhesion by nontransferrin-bound iron present in human sera. FASEB J 2005;20:353-5.
38. Gray C, McCormick C, Turner G, Craig A. ICAM-1 can play a major role in mediating P. falciparum adhesion to endothelium under flow. Mol Biochem Parasitol 2003; 128:187-93.
39. DeValk B, Addicks MA, Gosriwatana I, Lu S, Hider RC, Marx JJ. Non-Transferrin-bound iron is present in serum of hereditary haemochromatosis heterozygotes. Eur J Clin Invest 2000;30:248-51.
40. Rao BS, Vijayasarathy C. Fortification of common salt with iron: effect of chemical additives on stability and bioavailability. Am J Clin Nutr 1975;28:1395-401.
41. Rios E, Hunter RE, Cook JD, Smith NJ, Finch CA. The absorption of iron as supplements in infant cereal and infant formulas. Pediatrics 1975;55:686-93.
42. Hoppe M, Hulthén L, Hallberg L. The validation of using serum iron increase to measure iron absorption in human subjects. Br J Nutr 2004;92:485-8.
43. Hoppe M, Hulthén L, Hallberg L. The relative bioavailability in humans of elemental iron powders for use in food fortification. Eur J Nutr 2006;45:37-44.
44. Wallenburg HC, van Eijk HG. Effect of oral iron supplementation during pregnancy on maternal and fetal iron status. J Perinat Med 1984;12:7-12.
45. Chwang LC, Soemantri AG, Pollitt E. Iron supplementation and physical growth of rural Indonesian children. Am J Clin Nutr 1988;47:496-501.
46. Katz J, Khatry SK, Leclerq SC, Mullany LC, Yanik EL, Stoltzfus RJ, Siegel EH, Tielsch JM. Daily supplementation with iron plus folic acid, zinc, and their combination is not associated with younger age at first walking unassisted in malnourished preschool children from a deficient population in rural Nepal. J Nutr 2010;140:1317-21.