Does iron therapy benefit children with severe malaria-associated anaemia? A clinical trial with 12 weeks supplementation of oral iron in young children from the Turiani division, Tanzania

Journal of Tropical Pediatrics

Volumn 42, Issue 4, 1996, Pages 220-227

  Van Den Hombergh, J ^a,d   Dalderop, E ^b,c   Smit, Y ^a  

^a Diocesan Health Programme Morogoro   (Tanzania)

^b ST ANNA HOSPITAL   (Netherlands)

^c RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^d NONE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIANEMIC AGENT; ANTIMALARIAL AGENT; CHLOROQUINE; FANSIDAR; FERROUS SULFATE; FOLIC ACID; HEMOGLOBIN;

ANEMIA; ARTICLE; BLOOD SMEAR; BLOOD TRANSFUSION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HUMAN; IRON THERAPY; MAJOR CLINICAL STUDY; MALARIA; MALE; ORAL DRUG ADMINISTRATION; PATIENT COMPLIANCE; RANDOMIZED CONTROLLED TRIAL;

EID: 0029811848     PISSN: 01426338     EISSN: None     Source Type: Journal    
DOI: 10.1093/tropej/42.4.220     Document Type: Article

References (30)

1. WHO. Global Malaria Control Strategy. CTD/MAL/EXP/92.3. Ministerial Caonference on Malaria, Amsterdam, 1992.
2. Stürchler D. How much malaria is there worldwide. Parasitol Today 1989; 5(2): 39-40.
3. Bradley DJ. Malaria: old infections, changing epidemiology. Hlth Transit Rev 1992; 2 (suppl): 137-53.
4. Keuter M, et al. Parasitological, clinical and haematological response of children with plasmodium falciparum to 4-aminoquinolines and to pyrimethamine-sulfadoxine with quinine in western Kenya. Trop Geogr Med 1991; 44: 1-8.
5. Abdalla SH, Weatherall DJ, Wickramasinghe SN, Hughes M. The anaemia of P. falciparum malaria. Br J Haematol 1980; 46: 171-83.
6. Ho M, White NJ, Looaresuwan S. Splenic Fc receptor function in host defense and anaemia in acute Plasmodium falciparum malaria. J Inf Dis 1990; 161: 555-61.
7. Weatherall DJ, Abdalla S, Pippard MJ. The anaemia of Plasmodium falciparum malaria. In Evered D, Welan J (eds) Malaria and the red cell. Ciba Foundation Symposium 94. London, Pitman, 1983: 74-88.
8. Snow RW, et al. Severe childhood malaria in two areas of markedly different falciparum transmission in East Africa. Acta Tropica 1994; 57: 289-300.
9. Vos J, et al. Are some blood transfusions avoidable? A hospital record analysis in Mwanza Region, Tanzania. Trop Geogr Med 1993; 45: 301-3.
10. Craighead IB, Knowles JK. Prevention of transfusion associated HIV transmission with the use of a transfusion protocol for under 5s. Trop Doct 1993; 23: 59-61.
11. Trousseau A. Lectures on clinical medicine. London: New Sydenham Society, 1872.
12. Filteau SM, Tomkins AM. Micronutrients and tropical infections. Trans Roy Soc Med 1994; 88: 1-3.
13. Bullen JJ, Griffiths E (1987). Iron and infection, molecular, physiological and clinical aspects. Chichester: J. Wiley & Sons.
14. McGregor IA. Malaria: nutritional implications. Rev Inf Dis 1982; 4: 798-803.
15. Greenwood BM. Asymptomatic malaria infections, do they matter? Parasitol Today, 1987; 3: 206-13.
16. Byles AB, Avita D'Sa. Reduction of reaction due to iron-dextran infusion using chloroquine. Br Med J 1970; iii: 625-7.
17. Masawe AEJ, Muindi JM, Swai GBR. Infections in iron deficiency and other types of anaemia in the tropics. Lancet 1974; ii: 314-17.
18. Murray MJ, Murray NJ, Murray AB, Murray MB. Refeeding-malaria and hyperferraemia. Lancet 1975; i: 653-4.
19. Murray MJ, Murray AB, Murray MB, Murray CJ. The adverse effect of iron repletion on the course of certain infections. Br Med J 1978; 2: 1113-15.
20. Oppenheimer SJ, Cashiri P. Serum and red cell folatelevels associated with malarial parasitaemia. Trans Roy Soc Trop Med Hyg 1986; 80: 169.
21. Bates CJ, Powers HJ, Lamb WH, Gelman W, Webb E. Effect of supplementary vitamins and iron on malaria indices in rural Gambian children. Trans Roy Soc Trop Med Hyg 1987; 81: 286-91.
22. Harvey PWJ, et al. The effect of iron therapy on malarial infection in Papua New Guinean schoolchildren. Am J Trop Med Hyg 1989; 40: 12-18.
23. Smith AW, Hendrickse RG, Harrison C, Hayes RJ, Greenwood BM. The effects on malaria of treatment of iron-deficiency anaemia with oral iron in Gambian children. Ann Trop Paed 1989; 9: 17-23.
24. Snow RW, Byass P, Shenton FC, Greenwood BM. The relationship between anthropometic measurements and measurements of iron status and susceptibility to malaria in Gambian children. Trans Roy Soc Trop Med Hyg 1991; 85: 584-9.
25. Clyde DF. Malaria in Tanzania. Oxford: Oxford University Press, 1967.
26. Msuya FHM, Curtis CF. Trial of pyrethroid bednets in an area of Tanzania holoendemic for malaria. Part 4. Effects of incidence of malaria infection. Acta Tropica, 1991; 49: 165-71.
27. Premji Z, Minjas JN, Schiff CJ. Chloroquine resistant Plasmodium falciparum in coastal Tanzania. A challenge to the continued strategy of village based chemotherapy for malaria control. Trop Med Parasitol 1994; 45: 47-8.
28. Lines JD, Wilkes TJ, Lyimo EO. Human malaria infectiousness measured by age-specific sporozoite rates in Anopheles gambiae in Tanzania. Parasitology 1991; 102: 167-77.
29. De Boer IP, Dunk CP. Drug resistance of P. falciparum in children in Turiani. A field study on chloroquine and amodiaquine in Tanzania. 1992. University of Amsterdam (unpublished).
30. Van den Hombergh J. Malarial anaemia in infants and young children from the Morogoro Region in Tanzania. Epidemiology and clinical aspects. Thesis Msc. Communicable Diseases Epidemiology. London: School of Hygiene and Tropical Medicine, 1994.