The role of CNS in salt-sensitive hypertension

Current Hypertension Reports

Volumn 15, Issue 4, 2013, Pages 390-394

  Fujita, Megumi ^a   Fujita, Toshiro ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Aldosterone; Brain; Central nervous system; CNS; Mineralocorticoid receptor; Obesity; Oxidative stress; Salt sensitive hypertension; Sympathetic nerve activity

Indexed keywords

REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SODIUM CHLORIDE;

ACCURACY; ADRENERGIC TRANSMISSION; ARTICLE; BRAIN FUNCTION; BRAIN NERVE CELL; CENTRAL NERVOUS SYSTEM; DISEASE ASSOCIATION; DISEASE COURSE; ENZYME ACTIVITY; HUMAN; HYPERTENSION; MOLECULAR DYNAMICS; NERVE CONDUCTION; NONHUMAN; OBESITY; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PROTEIN EXPRESSION; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION;

ANIMALS; CENTRAL NERVOUS SYSTEM; HUMANS; HYPERTENSION; REACTIVE OXYGEN SPECIES; SODIUM CHLORIDE, DIETARY; SYMPATHETIC NERVOUS SYSTEM;

EID: 84880881146     PISSN: 15226417     EISSN: 15343111     Source Type: Journal    
DOI: 10.1007/s11906-013-0358-z     Document Type: Article

References (49)

1. • Esler MD, Krum H, Sobotka PA, et al. Renal sympathetic denervation in patients with treatment-resistant hypertension (the symplicity HTN-2 trial): A randomised controlled trial. Lancet. 2010;376:1903-09 This report reminds all doctors engaged in the management of hypertension of the importance of sympathetic nerve activity.
2. DiBona GF, Kopp UC. Neural control of renal function. Physiol Rev. 1997;77:75-197.
3. Converse Jr RL, Jacobsen TN, Toto RD, et al. Sympathetic overactivity in patients with chronic renal failure. N Engl J Med. 1992;327:1912-18.
4. Campese VM, Kogosov E. Renal afferent denervation prevents hypertension in rats with chronic renal failure. Hypertension. 1995;25:878-82.
5. • Simplicity HTN-1 Investigators. Catheter-based renal sympathetic denervation for resistant hypertension: Durability of blood pressure reduction out to 24 months. Hypertension. 2011;57:911-17 In this report, the durability of blood pressure reduction and the safety of the new strategy, catheter-based renal sympathetic denervation, are demonstrated.
6. Schlaich MP, Hering D, Sobotka PA, et al. Renal denervation in human hypertension: Mechanisms, current findings, and future prospects. Curr Hypertens Rep. 2012;14:247-53.
7. •• Fujita M, Ando K, Kawarazaki H, et al. Sympathoexcitation by brain oxidative stress mediates arterial pressure elevation in salt-induced chronic kidney disease. Hypertension. 2012;59:105-12 In this report, we demonstrated clearly that central antioxidant treatment decreased sympathetic nerve activity and arterial pressure, which, in turn, led to a decrease in renal damage in the acquired salt-sensitive hypertension model, the young salt-loaded uninephrectomized Sprague-Dawley rat.
8. Fujita M, Ando K, Nagae A, et al. Sympathoexcitation by oxidative stress in the brain mediates arterial pressure elevation in salt-sensitive hypertension. Hypertension. 2007;50:360-67.
9. •• Nagae A, Fujita M, Kawarazaki H, et al. Sympathoexcitation by oxidative stress in the brain mediates arterial pressure elevation in obesity-induced hypertension. Circulation. 2009;119:978-86 This report suggested a possible common pathogenic background - increased brain oxidative stress-mediated sympathoexcitation in obesity-induced and salt-sensitive hypertension - and proposed that a novel strategy such as administration of an antioxidant factor with a sympathoinhibitory effect may be useful for preventing and managing hypertension associated with metabolic disorder along with salt sensitivity.
10. Chen J, Gu D, Huang J, et al. Metabolic syndrome and salt sensitivity of blood pressure in non-diabetic people in China: A dietary intervention study. Lancet. 2009;373:829-35.
11. Uzu T, Kimura G, Yamauchi A, et al. Enhanced sodium sensitivity and disturbed circadian rhythm of blood pressure in essential hypertension. J Hypertens. 2006;24:1627-32.
12. Kishi T, Hirooka Y, Kimura Y, et al. Increased reactive oxygen species in rostral ventrolateral medulla contribute to neural mechanisms of hypertension in stroke-prone spontaneously hypertensive rats. Circulation. 2004;109:2357-62.
13. Koga Y, Hirooka Y, Araki S, et al. High salt intake enhances blood pressure increase during development of hypertension via oxidative stress in rostral ventrolateral medulla of spontaneously hypertensive rats. Hypertens Res. 2008;31:2075-83.
14. Ye S, Zhong H, Yanamadala S, et al. Oxidative stress mediates the stimulation of sympathetic nerve activity in the phenol renal injury model of hypertension. Hypertension. 2006;48:309-15.
15. Oliveira-Sales EB, Colombari DS, Davisson RL, et al. Kidney-induced hypertension depends on superoxide signaling in the rostral ventrolateral medulla. Hypertension. 2010;56:290-96.
16. Gomez-Sanchez EP, Gomez-Sanchez CM, Plonczynski M, et al. Aldosterone synthesis in the brain contributes to Dahl salt-sensitive rat hypertension. Exp Physiol. 2010;95:120-30.
17. Huang BS, White RA, Jeng AY, et al. Role of central nervous system aldosterone synthase and mineralocorticoid receptors in salt-induced hypertension in Dahl salt-sensitive rats. Am J Physiol Regul Integr Comp Physiol. 2009;296:R994-R1000.
18. Huang BS, Leenen FH. Mineralocorticoid actions in the brain and hypertension. Curr Hypertens Rep. 2011;13:214-20.
19. Ito K, Hirooka Y, Sunagawa K. Blockade of mineralocorticoid receptors improves salt-induced left-ventricular systolic dysfunction through attenuation of enhanced sympathetic drive in mice with pressure overload. J Hypertens. 2010;28:1449-58.
20. + channels in the choroid plexus are involved in hypertensive mechanisms in stroke-prone spontaneously hypertensive rats. Hypertens Res. 2013;36:277-84.
21. Van Huysse JW, Amin MS, Yang B, et al. Salt-induced hypertension in a mouse model of Liddle syndrome is mediated by epithelial sodium channels in the brain. Hypertension. 2012;60:691-96.
22. Huang BS, Leenen FH. Both brain angiotensin II and "ouabain" contribute to sympathoexcitation and hypertension in Dahl S rats on high salt intake. Hypertension. 1998;32:1028-33.
23. Leenen FH. The central role of the brain aldosterone-"ouabain" pathway in salt-sensitive hypertension. Biochim Biophys Acta. 1802;2010:1132-39.
24. Zimmerman MC, Lazartigues E, Sharma RV, et al. Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous system. Circ Res. 2004;95:210-16.
25. Kishi T, Hirooka Y, Sunagawa K. Sympathoinhibition caused by orally administered telmisartan through inhibition of the AT1 receptor in the rostral ventrolateral medulla of hypertensive rats. Hypertens Res. 2012;35:940-46.
26. Fujita T, Henry WL, Bartter FC, et al. Factors influencing blood pressure in salt-sensitive patients with hypertension. Am J Med. 1980;69:334-44.
27. Ono A, Kuwaki T, Kumada M, et al. Differential central modulation of the baroreflex by salt loading in normotensive and spontaneously hypertensive rats. Hypertension. 1997;29:808-14.
28. + in Dahl salt-sensitive vs. -resistant rats. Am J Physiol Heart Circ Physiol. 2001;281:H1881-89.
29. Fujita M, Kuwaki T, Ando K, et al. Sympatho-inhibitory action of endogenous adrenomedullin through inhibition of oxidative stress in the brain. Hypertension. 2005;45:1165-72.
30. Matsui H, Shimosawa T, Uetake Y, et al. Protective effect of potassium against the hypertensive cardiac dysfunction: Association with reactive oxygen species reduction. Hypertension. 2006;48:225-31.
31. Laffer CL, Bolterman RJ, Romero JC, et al. Effect of salt on isoprostanes in salt-sensitive essential hypertension. Hypertension. 2006;47:434-40.
32. Kim-Mitsuyama S, Yamamoto E, Tanaka T, et al. Critical role of angiotensin II in excess salt-induced brain oxidative stress of stroke-prone spontaneously hypertensive rats. Stroke. 2005;36:1083-88.
33. Ogihara T, Asano T, Ando K, et al. High-salt diet enhances insulin signaling and induces insulin resistance in Dahl salt-sensitive rats. Hypertension. 2002;40:83-9.
34. Zhang X, Dong F, Ren J, et al. High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex. Exp Neurol. 2005;191:318-25.
35. Purkayastha S, Zhang G, Cai D. Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-b and NF-kB. Nat Med. 2011;17:883-87.
36. Ye P, Kenyon CJ, Mackenzie SM, et al. Effects of ACTH, dexamethasone, and adrenalectomy on 11beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) gene expression in the rat central nervous system. J Endocrinol. 2008;196:305-11.
37. Zhang ZH, Yu Y, Kang YM, et al. Aldosterone acts centrally to increase brain renin-angiotensin system activity and oxidative stress in normal rats. Am J Physiol Heart Circ Physiol. 2008;294:H1067-74.
38. Huang BS, Zheng H, Tan J, et al. Regulation of hypothalamic renin-angiotensin system and oxidative stress by aldosterone. Exp Physiol. 2011;96:1028-38.
39. Kawarazaki H, Ando K, Fujita M, et al. Mineralocorticoid receptor activation: A major contributor to salt-induced renal injury and hypertension in young rats. Am J Physiol Renal Physiol. 2011;300:F1402-09.
40. Kawarazaki H, Ando K, Nagae A, et al. Mineralocorticoid receptor activation contributes to salt-induced hypertension and renal injury in prepubertal Dahl salt-sensitive rats. Nephrol Dial Transplant. 2010;25:2879-89.
41. Matsui H, Ando K, Kawarazaki H, et al. Salt excess causes left ventricular diastolic dysfunction in rats with metabolic disorder. Hypertension. 2008;52:287-94.
42. Ito K, Hirooka Y, Sunagawa K. Acquisition of brain Na sensitivity contributes to salt-induced sympathoexcitation and cardiac dysfunction in mice with pressure overload. Circ Res. 2009;104:1004-11.
43. Araki S, Hirooka Y, Kishi T, et al. Olmesartan reduces oxidative stress in the brain of stroke-prone spontaneously hypertensive rats assessed by an in vivo ESR method. Hypertens Res. 2009;32:1091-96.
44. Huang BS, Ahmadi S, Ahmad M, et al. Central neuronal activation and pressor responses induced by circulating ANG II: Role of the brain aldosterone-"ouabain" pathway. Am J Physiol Heart Circ Physiol. 2010;299:H422-30.
45. Gabor A, Leenen FH. Central mineralocorticoid receptors and the role of angiotensin II and glutamate in the paraventricular nucleus of rats with angiotensin II-induced hypertension. Hypertension. 2013;61:1083-90.
46. Zhang ZH, Kang YM, Yu Y, et al. 11beta-hydroxysteroid dehydrogenase type 2 activity in hypothalamic paraventricular nucleus modulates sympathetic excitation. Hypertension. 2006;48:127-33.
47. Rossi NF, Maliszewska-Scislo M, Chen H, et al. Neuronal nitric oxide synthase within paraventricular nucleus: Blood pressure and baroreflex in two-kidney, one-clip hypertensive rats. Exp Physiol. 2010;95:845-57.
48. Kimura Y, Hirooka Y, Sagara Y, et al. Overexpression of inducible nitric oxide synthase in rostral ventrolateral medulla causes hypertension and sympathoexcitation via an increase in oxidative stress. Circ Res. 2005;96:252-60.
49. Lob HE, Marvar PJ, Guzik TJ, et al. Induction of hypertension and peripheral inflammation by reduction of extracellular superoxide dismutase in the central nervous system. Hypertension. 2010;55:277-83.