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Volumn 14, Issue 3, 2012, Pages 247-253

Renal denervation in human hypertension: Mechanisms, current findings, and future prospects

Author keywords

Activation; Blood pressure; Cardiovascular; Glucose metabolism; Hypertension; Left ventricular hypertrophy; Renal denervation; Renal disease; Renal failure; Renal nerve ablation; Sympathetic

Indexed keywords

ANTIHYPERTENSIVE AGENT; CLONIDINE; MOXONIDINE;

EID: 84865679012     PISSN: 15226417     EISSN: 15343111     Source Type: Journal    
DOI: 10.1007/s11906-012-0264-9     Document Type: Article
Times cited : (38)

References (59)
  • 1
    • 0017874354 scopus 로고
    • Innervation of the renal cortex
    • Barajas L. Innervation of the renal cortex. Fed Proc. 1978;37 (5):1192-201. (Pubitemid 8314398)
    • (1978) Federation Proceedings , vol.37 , Issue.5 , pp. 1192-1201
    • Barajas, L.1
  • 2
    • 0017255111 scopus 로고
    • Effect of renal sympathetic nerve stimulation on proximal water and sodium reabsorption
    • Bell-Reuss E, Trevino DL, Gottschalk CW. Effect of renal sympathetic nerve stimulation on proximal water and sodium reabsorption. J Clin Invest. 1976;57(4):1104-7.
    • (1976) J Clin Invest , vol.57 , Issue.4 , pp. 1104-1107
    • Bell-Reuss, E.1    Trevino, D.L.2    Gottschalk, C.W.3
  • 3
    • 0024353093 scopus 로고
    • Sympathetic modulation of renal hemodynamics, renin release and sodium excretion
    • Kirchheim H, Ehmke H, Persson P. Sympathetic modulation of renal hemodynamics, renin release and sodium excretion. Klin Wochenschr. 1989;67(17):858-64. (Pubitemid 19208123)
    • (1989) Klinische Wochenschrift , vol.67 , Issue.17 , pp. 858-864
    • Kirchheim, H.1    Ehmke, H.2    Persson, P.3
  • 4
    • 0024538301 scopus 로고
    • Neural control of renal circulation
    • Kon V. Neural control of renal circulation. Miner Electrolyte Metab. 1989;15(1-2):33-43. (Pubitemid 19013523)
    • (1989) Mineral and Electrolyte Metabolism , vol.15 , Issue.1-2 , pp. 33-43
    • Kon, V.1
  • 5
    • 0017758276 scopus 로고
    • Neural regulation of renin release. Experimental evidence and clinical implications in arterial hypertension
    • Zanchetti AS. Neural regulation of renin release: experimental evidence and clinical implications in arterial hypertension. Circulation. 1977;56(5):691-8. (Pubitemid 8235170)
    • (1977) Circulation , vol.56 , Issue.5 , pp. 691-698
    • Zanchetti, A.S.1
  • 6
    • 0030844734 scopus 로고    scopus 로고
    • Neurogenic factors and hypertension in chronic renal failure
    • Campese VM. Neurogenic factors and hypertension in chronic renal failure. J Nephrol. 1997;10(4):184-7. (Pubitemid 27333193)
    • (1997) Journal of Nephrology , vol.10 , Issue.4 , pp. 184-187
    • Campese, V.M.1
  • 7
    • 0031864055 scopus 로고    scopus 로고
    • A limited renal injury may cause a permanent form of neurogenic hypertension
    • DOI 10.1016/S0895-7061(98)00030-2, PII S0895706198000302
    • Ye S, et al. A limited renal injury may cause a permanent form of neurogenic hypertension. Am J Hypertens. 1998;11(6 Pt 1):723- 8. (Pubitemid 28313692)
    • (1998) American Journal of Hypertension , vol.11 , Issue.6 , pp. 723-728
    • Ye, S.1    Gamburd, M.2    Mozayeni, P.3    Koss, M.4    Campese, V.M.5
  • 8
    • 0035997360 scopus 로고    scopus 로고
    • Renal injury caused by intrarenal injection of phenol increases afferent and efferent renal sympathetic nerve activity
    • DOI 10.1016/S0895-7061(02)02959-X, PII S089570610202959X
    • Ye S, et al. Renal injury caused by intrarenal injection of phenol increases afferent and efferent renal sympathetic nerve activity. Am J Hypertens. 2002;15(8):717-24. (Pubitemid 34804278)
    • (2002) American Journal of Hypertension , vol.15 , Issue.8 , pp. 717-724
    • Ye, S.1    Zhong, H.2    Yanamadala, V.3    Campese, V.M.4
  • 9
    • 0034087041 scopus 로고    scopus 로고
    • Neurogenic factors and hypertension in renal disease
    • Campese VM. Neurogenic factors and hypertension in renal disease. Kidney Int. 2000;57 Suppl 75:S2-6. (Pubitemid 30205432)
    • (2000) Kidney International, Supplement , vol.57 , Issue.75
    • Campese, V.M.1
  • 10
    • 0028953330 scopus 로고
    • Renal afferent denervation prevents hypertension in rats with chronic renal failure
    • Campese VM, Kogosov E. Renal afferent denervation prevents hypertension in rats with chronic renal failure. Hypertension. 1995;25(4 Pt 2):878-82.
    • (1995) Hypertension. , vol.25 , Issue.4 PART 2 , pp. 878-882
    • Campese, V.M.1    Kogosov, E.2
  • 11
    • 0028858468 scopus 로고
    • Renal afferent denervation prevents the progression of renal disease in the renal ablation model of chronic renal failure in the rat
    • Campese VM, Kogosov E, Koss M. Renal afferent denervation prevents the progression of renal disease in the renal ablation model of chronic renal failure in the rat. Am J Kidney Dis. 1995;26(5):861-5.
    • (1995) Am J Kidney Dis , vol.26 , Issue.5 , pp. 861-865
    • Campese, V.M.1    Kogosov, E.2    Koss, M.3
  • 12
    • 0036185588 scopus 로고    scopus 로고
    • Sympathetic nervous system and the kidney in hypertension
    • DOI 10.1097/00041552-200203000-00011
    • DiBona GF. Sympathetic nervous system and the kidney in hypertension. Curr Opin Nephrol Hypertens. 2002;11(2):197-200. (Pubitemid 34194740)
    • (2002) Current Opinion in Nephrology and Hypertension , vol.11 , Issue.2 , pp. 197-200
    • DiBona, G.F.1
  • 13
    • 0037338688 scopus 로고    scopus 로고
    • Neural control of the kidney: Past, present, and future
    • DOI 10.1161/01.HYP.0000047205.52509.8A
    • DiBona GF. Neural control of the kidney: past, present, and future. Hypertension. 2003;41(3 Pt 2):621-4. (Pubitemid 36314564)
    • (2003) Hypertension , vol.41 , Issue.3 , pp. 621-624
    • DiBona, G.F.1
  • 14
    • 0022537895 scopus 로고
    • Mechanism of elevated plasma noradrenaline in the course of essential hypertension
    • Esler M, et al. Mechanism of elevated plasma noradrenaline in the course of essential hypertension. J Cardiovasc Pharmacol. 1986;8 Suppl 5:S39-43. (Pubitemid 16039090)
    • (1986) Journal of Cardiovascular Pharmacology , vol.8 , Issue.5
    • Esler, M.1    Jennings, G.2    Biviano, B.3
  • 16
    • 0024519641 scopus 로고
    • Noradrenaline release and the pathophysiology of primary human hypertension
    • Esler M, Jennings G, Lambert G. Noradrenaline release and the pathophysiology of primary human hypertension. Am J Hypertens. 1989;2(3 Pt 2):140S-6S. (Pubitemid 19082354)
    • (1989) American Journal of Hypertension , vol.2 , Issue.3
    • Esler, M.1    Jennings, G.2    Lambert, G.3
  • 17
    • 0022492202 scopus 로고
    • Norepinephrine spillover to plasma in patients with congestive heart failure: Evidence of increased overall and cardiorenal sympathetic nervous activity
    • Hasking GJ, et al. Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity. Circulation. 1986;73 (4):615-21. (Pubitemid 16081418)
    • (1986) Circulation , vol.73 , Issue.4 , pp. 615-621
    • Hasking, G.J.1    Esler, M.D.2    Jennings, G.L.3
  • 18
    • 0037336614 scopus 로고    scopus 로고
    • Regional sympathetic effects of low-dose clonidine in heart failure
    • DOI 10.1161/01.HYP.0000055779.93635.A2
    • Aggarwal A, et al. Regional sympathetic effects of low-dose clonidine in heart failure. Hypertension. 2003;41(3):553-7. (Pubitemid 36314631)
    • (2003) Hypertension , vol.41 , Issue.3 , pp. 553-557
    • Aggarwal, A.1    Esler, M.D.2    Morris, M.J.3    Lambert, G.4    Kaye, D.M.5
  • 19
    • 18744401076 scopus 로고    scopus 로고
    • Long-term outcome in relation to renal sympathetic activity in patients with chronic heart failure
    • DOI 10.1093/eurheartj/ehi184
    • Petersson M, et al. Long-term outcome in relation to renal sympathetic activity in patients with chronic heart failure. Eur Heart J. 2005;26(9):906-13. (Pubitemid 40676571)
    • (2005) European Heart Journal , vol.26 , Issue.9 , pp. 906-913
    • Petersson, M.1    Friberg, P.2    Eisenhofer, G.3    Lambert, G.4    Rundqvist, B.5
  • 20
    • 0842267844 scopus 로고    scopus 로고
    • The sympathetic nervous system and hypertension recent developments
    • DOI 10.1161/01.HYP.0000113047.47711.fa
    • DiBona GF. The sympathetic nervous system and hypertension: recent developments. Hypertension. 2004;43(2):147-50. (Pubitemid 38174164)
    • (2004) Hypertension , vol.43 , Issue.2 , pp. 147-150
    • DiBona, G.F.1
  • 21
    • 0031015981 scopus 로고    scopus 로고
    • Neural control of renal function
    • DiBona GF, Kopp UC. Neural control of renal function. Physiol Rev. 1997;77(1):75-197. (Pubitemid 27069290)
    • (1997) Physiological Reviews , vol.77 , Issue.1 , pp. 75-197
    • Dibona, G.F.1    Kopp, U.C.2
  • 22
    • 15744405781 scopus 로고    scopus 로고
    • Renal denervation abolishes hypertension in low-birth-weight offspring from pregnant rats with reduced uterine perfusion
    • DOI 10.1161/01.HYP.0000153319.20340.2a
    • Alexander BT, et al. Renal denervation abolishes hypertension in low-birth-weight offspring from pregnant rats with reduced uterine perfusion. Hypertension. 2005;45(4):754-8. (Pubitemid 40418377)
    • (2005) Hypertension , vol.45 , Issue.4 SUPPL. , pp. 754-758
    • Alexander, B.T.1    Hendon, A.E.2    Ferril, G.3    Dwyer, T.M.4
  • 23
    • 0028920105 scopus 로고
    • Renal denervation attenuates the sodium retention and hypertension associated with obesity
    • Kassab S, et al. Renal denervation attenuates the sodium retention and hypertension associated with obesity. Hypertension. 1995;25(4 Pt 2):893-7.
    • (1995) Hypertension. , vol.25 , Issue.4 PART 2 , pp. 893-897
    • Kassab, S.1
  • 24
    • 0000220091 scopus 로고
    • Splanchnicectomy for essential hypertension; results in 1,266 cases
    • Smithwick RH, Thompson JE. Splanchnicectomy for essential hypertension; results in 1,266 cases. J Am Med Assoc. 1953;152 (16):1501-4.
    • (1953) J Am Med Assoc , vol.152 , Issue.16 , pp. 1501-1504
    • Smithwick, R.H.1    Thompson, J.E.2
  • 25
    • 50449148274 scopus 로고
    • Sympathectomy in the treatment of hypertension; review of 122 cases
    • Morrissey DM, Brookes VS, Cooke WT. Sympathectomy in the treatment of hypertension; review of 122 cases. Lancet. 1953;1 (6757):403-8.
    • (1953) Lancet , vol.1 , Issue.6757 , pp. 403-408
    • Morrissey, D.M.1    Brookes, V.S.2    Cooke, W.T.3
  • 26
    • 64049084640 scopus 로고    scopus 로고
    • Catheter-based renal sympathetic denervation for resistant hypertension: A multicentre safety and proof-of-principle cohort study
    • This study resents the first data on the safety and efficacy of a novel catheter based aroach to functionally denervate the human kidney demonstrating a favorable safety rofile and substantial and sustained reductions blood ressure
    • Krum H, et al. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet. 2009;373(9671):1275-81. This study presents the first data on the safety and efficacy of a novel catheter based approach to functionally denervate the human kidney demonstrating a favorable safety profile and substantial and sustained reductions blood pressure.
    • (2009) Lancet. , vol.373 , Issue.9671 , pp. 1275-81
    • Krum, H.1
  • 27
    • 78649876825 scopus 로고    scopus 로고
    • Renal sympathetic denervation in patients with treatment-resistant hypertension (the symplicity htn-2 trial): A randomised controlled trial
    • Initial proof-of-concept studies are now supported by this first randomized controlled clinical trial demonstrating that compared to an untreated control group there is substantial BP reduction associated with renal denervation.
    • Esler MD, et al. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet. 2010;376(9756):1903-9. Initial proof-of-concept studies are now supported by this first randomized controlled clinical trial demonstrating that compared to an untreated control group there is substantial BP reduction associated with renal denervation.
    • (2010) Lancet. , vol.376 , Issue.9756 , pp. 1903-1909
    • Esler, M.D.1
  • 28
    • 69349085170 scopus 로고    scopus 로고
    • Renal sympathetic-nerve ablation for uncontrolled hypertension
    • This study reorts on a atient treated with catheter based renal nerve ablation demonstrating a reduction in central symathetic outflow indicative of a otential invement of afferent nerve fibers in the sustained blood ressure reduction associated with the rocedure and additional benefit by regression of LV hyertrohy
    • Schlaich MP, et al. Renal sympathetic-nerve ablation for uncontrolled hypertension. N Engl J Med. 2009;361(9):932-4. This study reports on a patient treated with catheter based renal nerve ablation demonstrating a reduction in central sympathetic outflow indicative of a potential involvement of afferent nerve fibers in the sustained blood pressure reduction associated with the procedure and additional benefit by regression of LV hypertrophy.
    • (2009) N Engl J Med. , vol.361 , Issue.9 , pp. 932-934
    • Schlaich, M.P.1
  • 29
    • 0019014533 scopus 로고
    • Functional reinnervation and development of supersensitivity to ne after renal denervation in rats
    • R358
    • Kline RL, Mercer PF. Functional reinnervation and development of supersensitivity to NE after renal denervation in rats. Am J Physiol. 1980;238(5):R353-8.
    • (1980) Am J Physiol. , vol.238 , Issue.5
    • Kline, R.L.1    Mercer, P.F.2
  • 30
    • 0029160775 scopus 로고
    • Evidence against reinnervation of cardiac vagal afferents after human orthotopic cardiac transplantation
    • Arrowood JA, et al. Evidence against reinnervation of cardiac vagal afferents after human orthotopic cardiac transplantation. Circulation. 1995;92(3):402-8.
    • (1995) Circulation , vol.92 , Issue.3 , pp. 402-408
    • Arrowood, J.A.1
  • 31
    • 79955477242 scopus 로고    scopus 로고
    • Catheter-based renal sympathetic denervation for resistant hypertension. Durability of blood pressure reduction out to 24 months
    • This study demonstrates that the blood pressure effects achieved by renal denervation are sustained up to at least 2 years
    • Catheter-based renal sympathetic denervation for resistant hypertension. durability of blood pressure reduction out to 24 months. Hypertension. 2011;57(5):911-7. This study demonstrates that the blood pressure effects achieved by renal denervation are sustained up to at least 2 years.
    • (2011) Hypertension. , vol.57 , Issue.5 , pp. 911-7
  • 32
    • 77951091946 scopus 로고    scopus 로고
    • Sympathetic nervous activation in obesity and the metabolic syndrome-causes, consequences and therapeutic implications
    • Lambert GW, et al. Sympathetic nervous activation in obesity and the metabolic syndrome-causes, consequences and therapeutic implications. Pharmacol Ther. 2010;126(2):159-72.
    • (2010) Pharmacol Ther , vol.126 , Issue.2 , pp. 159-172
    • Lambert, G.W.1
  • 33
    • 84865682176 scopus 로고    scopus 로고
    • Baseline sympathetic nervous system activity predicts dietary weight loss in obese metabolic syndrome subjects
    • Straznicky, N.E., et al., Baseline Sympathetic Nervous System Activity Predicts Dietary Weight Loss in Obese Metabolic Syndrome Subjects. J Clin Endocrinol Metab, 2011.
    • (2011) J Clin Endocrinol Metab
    • Straznicky, N.E.1
  • 34
    • 73349115592 scopus 로고    scopus 로고
    • Renal denervation as a therapeutic approach for hypertension: Novel implications for an old concept
    • Schlaich MP, et al. Renal denervation as a therapeutic approach for hypertension: novel implications for an old concept. Hypertension. 2009;54(6):1195-201.
    • (2009) Hypertension , vol.54 , Issue.6 , pp. 1195-1201
    • Schlaich, M.P.1
  • 35
    • 65649109067 scopus 로고    scopus 로고
    • Sympathetic activation in chronic renal failure
    • Schlaich MP, et al. Sympathetic activation in chronic renal failure. J Am Soc Nephrol. 2009;20(5):933-9.
    • (2009) J Am Soc Nephrol , vol.20 , Issue.5 , pp. 933-939
    • Schlaich, M.P.1
  • 36
    • 79951589311 scopus 로고    scopus 로고
    • Exercise augments weight loss induced improvement in renal function in obese metabolic syndrome individuals
    • Straznicky, N.E., et al., Exercise augments weight loss induced improvement in renal function in obese metabolic syndrome individuals. J Hypertens. 2011;29(3):553-64.
    • (2011) J Hypertens , vol.29 , Issue.3 , pp. 553-564
    • Straznicky, N.E.1
  • 38
    • 0016795522 scopus 로고
    • Passage of glucose through the cell membrane of capillary endothelium
    • Rasio EA. Passage of glucose through the cell membrane of capillary endothelium. Am J Physiol. 1975;228(4):1103-7.
    • (1975) Am J Physiol , vol.228 , Issue.4 , pp. 1103-1107
    • Rasio, E.A.1
  • 39
    • 10244267463 scopus 로고    scopus 로고
    • Effect of central and peripheral body fat distribution on sympathetic and baroreflex function in obese normotensives
    • DOI 10.1097/00004872-200412000-00019
    • Grassi G, et al. Effect of central and peripheral body fat distribution on sympathetic and baroreflex function in obese normotensives. J Hypertens. 2004;22(12):2363-9. (Pubitemid 39620287)
    • (2004) Journal of Hypertension , vol.22 , Issue.12 , pp. 2363-2369
    • Grassi, G.1    Dell'Oro, R.2    Facchini, A.3    Trevano, F.Q.4    Bolla, G.B.5    Mancia, G.6
  • 40
    • 0026215840 scopus 로고
    • Neurohumoral, hemodynamic and microvascular changes as mechanisms of insulin resistance in hypertension: A provocative but partial picture
    • Egan BM. Neurohumoral, hemodynamic and microvascular changes as mechanisms of insulin resistance in hypertension: a provocative but partial picture. Int J Obes. 1991;15 Suppl 2:133-9.
    • (1991) Int J Obes. , vol.15 , Issue.SUPPL. 2 , pp. 133-139
    • Egan, B.M.1
  • 41
    • 0025292440 scopus 로고
    • Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance
    • Laakso M, et al. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance. J Clin Invest. 1990;85(6):1844-52. (Pubitemid 20192958)
    • (1990) Journal of Clinical Investigation , vol.85 , Issue.6 , pp. 1844-1852
    • Laakso, M.1    Edelman, S.V.2    Brechtel, G.3    Baron, A.D.4
  • 43
    • 0026307120 scopus 로고
    • Cardiovascular complications in renal failure [editorial]
    • Rostand SG, et al. Cardiovascular complications in renal failure [editorial]. J Am Soc Nephrol. 1991;2(6):1053-62.
    • (1991) J Am Soc Nephrol. , vol.2 , Issue.6 , pp. 1053-1062
    • Rostand, S.G.1
  • 44
    • 0032541672 scopus 로고    scopus 로고
    • Poor long-term survival after acute myocardial infarction among patients on long-term dialysis
    • DOI 10.1056/NEJM199809173391203
    • Herzog CA, Ma JZ, Collins AJ. Poor long-term survival after acute myocardial infarction among patients on long-term dialysis. N Engl J Med. 1998;339(12):799-805. (Pubitemid 28447453)
    • (1998) New England Journal of Medicine , vol.339 , Issue.12 , pp. 799-805
    • Herzog, C.A.1    Ma, J.Z.2    Collins, A.J.3
  • 45
    • 0034927743 scopus 로고    scopus 로고
    • Prevalence of high blood pressure and elevated serum creatinine level in the United States: Findings from the third national health and nutrition examination survey (1988-1994)
    • Coresh J, et al. Prevalence of high blood pressure and elevated serum creatinine level in the United States: findings from the third National Health and Nutrition Examination Survey (1988-1994). Arch Intern Med. 2001;161(9):1207-16. (Pubitemid 32691517)
    • (2001) Archives of Internal Medicine , vol.161 , Issue.9 , pp. 1207-1216
    • Coresh, J.1    Wei, G.L.2    McQuillan, G.3    Brancati, F.L.4    Levey, A.S.5    Jones, C.6    Klag, M.J.7
  • 47
    • 0016236826 scopus 로고
    • Hypertension in chronic renal failure. Treatment with hemodialysis and nephrectomy
    • Lazarus JM, Hampers C, Merrill JP. Hypertension in chronic renal failure. Treatment with hemodialysis and nephrectomy Arch Intern Med. 1974;133(6):1059-66.
    • (1974) Arch Intern Med , vol.133 , Issue.6 , pp. 1059-1066
    • Lazarus, J.M.1    Hampers, C.2    Merrill, J.P.3
  • 54
  • 55
    • 0016768306 scopus 로고
    • Blood pressure regulation in end-stage renal disease and anephric man
    • Onesti G, et al. Blood pressure regulation in end-stage renal disease and anephric man. Circ Res. 1975;36(6 Suppl 1):145-52.
    • (1975) Circ Res. , vol.36 , Issue.6 SUPPL. 1 , pp. 145-152
    • Onesti, G.1
  • 56
    • 33645294358 scopus 로고    scopus 로고
    • Regression of left ventricular hypertrophy after bilateral nephrectomy
    • Getts RT, et al. Regression of left ventricular hypertrophy after bilateral nephrectomy. Nephrol Dial Transplant. 2006;21(4):1089- 91.
    • (2006) Nephrol Dial Transplant , vol.21 , Issue.4 , pp. 1089-1091
    • Getts, R.T.1
  • 57
    • 0041572912 scopus 로고    scopus 로고
    • Relation between cardiac sympathetic activity and hypertensive left ventricular hypertrophy
    • DOI 10.1161/01.CIR.0000081775.72651.B6
    • Schlaich MP, et al. Relation between cardiac sympathetic activity and hypertensive left ventricular hypertrophy. Circulation. 2003;108(5):560-5. (Pubitemid 36961170)
    • (2003) Circulation , vol.108 , Issue.5 , pp. 560-565
    • Schlaich, M.P.1    Kaye, D.M.2    Lambert, E.3    Sommerville, M.4    Socratous, F.5    Esler, M.D.6
  • 58
    • 84865682177 scopus 로고    scopus 로고
    • Renal denervation in moderate to severe chronic kidney disease
    • in press. This pilot study provides first evidence that renal denervation is safe and effective in patients with moderate to severe chronic kidney disease
    • Hering D MF, Walton AS, Krum H, Lambert G, Lambert EA, Sobotka PA, Böhm M, Cremers B, Esler M, Schlaich MP. Renal denervation in moderate to severe chronic kidney disease. J Am Soc Nephrol. 2012;in press. This pilot study provides first evidence that renal denervation is safe and effective in patients with moderate to severe chronic kidney disease.
    • J Am Soc Nephrol. , vol.2012
    • Hering D, M.F.1    Walton, A.S.2    Krum, H.3    Lambert, G.4    Lambert, E.A.5    Sobotka, P.A.6    Böhm, M.7    Cremers, B.8    Esler, M.9    Schlaich, M.P.10
  • 59
    • 84857773847 scopus 로고    scopus 로고
    • Renal sympathetic denervation reduces left ventricular hypertrophy and improves cardiac function in patients with resistant hypertension
    • This study demonstrates that renal denervation is not only associated with BP reduction but also with a marked regression of LV hyertrohy in atients with resistant hyertension
    • Brandt MC, et al. Renal sympathetic denervation reduces left ventricular hypertrophy and improves cardiac function in patients with resistant hypertension. J Am Coll Cardiol. 2012;59(10): 901-9. This study demonstrates that renal denervation is not only associated with BP reduction but also with a marked regression of LV hypertrophy in patients with resistant hypertension.
    • (2012) J Am Coll Cardiol. , vol.59 , Issue.10 , pp. 901-909
    • Brandt, M.C.1


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