Characterization of enterococcus faecium with macrolide resistance and reduced susceptibility to quinupristin/dalfopristin in a japanese hospital: Detection of extensive diversity in erm(B)-regulator regions

Microbial Drug Resistance

Volumn 19, Issue 4, 2013, Pages 298-307

  Isogai, Nayuta ^a   Urushibara, Noriko ^a   Kawaguchiya, Mitsuyo ^a   Ghosh, Souvik ^a   Suzaki, Keisuke ^a   Watanabe, Naoki ^b   Quiñones, Dianelys ^c   Kobayashi, Nobumichi ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SAPPORO MEDICAL UNIVERSITY   (Japan)

^c INSTITUTO DE MEDICINA TROPICAL PEDRO KOURÍ   (Cuba)

Author keywords

[No Author keywords available]

Indexed keywords

CLINDAMYCIN; DALFOPRISTIN PLUS QUINUPRISTIN; ERYTHROMYCIN; LINCOSAMIDE; MACROLIDE; MIKAMYCIN B; RNA 23S;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENETICS; BACTERIUM ISOLATE; ENTEROCOCCUS FAECIUM; GENETIC VARIABILITY; GENOTYPE; HUMAN; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; TANDEM REPEAT;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BACTERIAL TYPING TECHNIQUES; BASE SEQUENCE; DRUG RESISTANCE, BACTERIAL; ENTEROCOCCUS FAECIUM; GENETIC VARIATION; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; JAPAN; MACROLIDES; METHYLTRANSFERASES; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; VIRGINIAMYCIN;

EID: 84880872112     PISSN: 10766294     EISSN: 19318448     Source Type: Journal    
DOI: 10.1089/mdr.2012.0176     Document Type: Article

References (54)

1. Arias, C.A., and B.E. Murray. 2012. The rise of the Enterococcus: beyond vancomycin resistance. Nat. Rev. Microbiol. 10:266-278.
2. Bozdogan, B., R. Leclercq, A. Lozniewski, and M. Weber. 1999. Plasmid-mediated coresistance to streptogramins and vancomycin in Enterococcus faecium HM1032. Antimicrob. Agents Chemother. 43:2097-2098. (Pubitemid 29395221)
3. Camargo, I.L., M.S. Gilmore, and A.L. Darini. 2006. Multilocus sequence typing and analysis of putative virulence factors in vancomycin-resistant and vancomycin-sensitive Enterococcus faecium isolates from Brazil. Clin. Microbiol. Infect. 12:1123-1130. (Pubitemid 44462848)
4. Caron, F., H.S. Gold, C.B. Wennersten, M.G. Farris, R.C. Moellering, Jr., and G.M. Eliopoulos. 1997. Influence of erythromycin resistance, inoculum growth phase, and incubation time on assessment of the bactericidal activity of RP 59500 (quinupristin-dalfopristin) against vancomycinresistant Enterococcus faecium. Antimicrob. Agents Chemother. 41:2749-2753. (Pubitemid 27524752)
5. [CLSI] Clinical and Laboratory Standards Institute. 2009. Methods for dilution susceptibility tests for bacteria that grow aerobically; approved standard. M7-A8, 8th edition. Clinical and Laboratory Standards Institute, Wayne, PA.
6. De Graef, E.M., A. Decostere, E. De Leener, H. Goossens, M. Baele, and F. Haesebrouck. 2007. Prevalence and mechanism of resistance against macrolides, lincosamides, and streptogramins among Enterococcus faecium isolates from food-producing animals and hospital patients in Belgium. Microb. Drug Resist. 13:135-141. (Pubitemid 47196047)
7. Donabedian, S.M., M.B. Perri, D. Vager, E. Hershberger, P. Malani, S. Simjee, J. Chow J, E.N. Vergis, R.R. Muder, K. Gay, F.J. Angulo, P. Bartlett, and M.J. Zervos. 2006. Quinupristin-dalfopristin resistance in Enterococcus faecium isolates from humans, farm animals, and grocery store meat in the United States. J. Clin. Microbiol. 44:3361-3365. (Pubitemid 44413777)
8. Depardieu, F., I. Podglajen, R. Leclercq, E. Collatz, and P. Courvalin. 2007. Modes and modulations of antibiotic resistance gene expression. Clin. Microbiol. Rev. 20:79-114. (Pubitemid 46167769)
9. Dipersio, L.P., and J.R. Dipersio. 2007. Identification of an erm(T) gene in strains of inducibly clindamycin-resistant group B Streptococcus. Diagn. Microbiol. Infect. Dis. 57: 189-193.
10. Eaton, T.J., and M.J. Gasson. 2001. Molecular screening of Enterococcus virulence determinants and potential for genetic exchange between food and medical isolates. Appl. Environ. Microbiol. 67:1628-1635. (Pubitemid 33644933)
11. Fantin, B., R. Leclercq, L. Garry, and C. Carbon. 1997. Influence of inducible cross-resistance to macrolides, lincosamides, and streptogramin B-type antibiotics in Enterococcus faecium on activity of quinupristin-dalfopristin in vitro and in rabbits with experimental endocarditis. Antimicrob. Agents Chemother. 41:931-935. (Pubitemid 27194163)
12. Homan, W.L., D. Tribe, S. Poznanski, M. Li, G. Hogg, E. Spalburg, J.D. Van Embden, and R.J. Willems. 2002. Multilocus sequence typing scheme for Enterococcus faecium. J. Clin. Microbiol. 40:1963-1971. (Pubitemid 34596369)
13. Horinouchi S., and B. Weisblum. 1980. Posttranscriptional modification of mRNA conformation: mechanism that regulates erythromycin-induced resistance. Proc. Natl. Acad. Sci. USA. 77:7079-7083. (Pubitemid 11190297)
14. Hoshuyama, T., H. Moriguchi, T. Muratani, and T. Matsumoto. 2008. Vancomycin-resistant enterococci (VRE) outbreak at a university hospital in Kitakyushu, Japan: casecontrol studies. J. Infect. Chemother. 14:354-360.
15. IDWR. Surveillance data table, category V (notifiable disease). Infectious Disease Surveillance Center, National Institute of Infectious Disease. Available at www.nih.go.jp/niid/ja/idwr/2085-ydata/1615-report-ja.html. (In Japanese) (Online.)
16. Jackson, C.R., P.J. Fedorka-Cray, J.B. Barrett, L.M. Hiott, and T.A. Woodley. 2007. Prevalence of streptogramin resistance in enterococci from animals: identification of vatD from animal sources in the USA. Int. J. Antimicrob. Agents. 30:60-66. (Pubitemid 46874907)
17. Jensen, L.B., A.M. Hammerum, F.M. Aerestrup, A.E. van den Bogaard, and E.E. Stobberingh. 1998. Occurrence of satA and vgb genes in streptogramin- resistant Enterococcus faecium isolates of animal and human origins in the Netherlands. Antimicrob. Agents Chemother. 42:3330-3331. (Pubitemid 28553769)
18. Jensen, L.B., A.M. Hammerum, F. Bager, and F.M. Aarestrup. 2002. Streptogramin resistance among Enterococcus faecium isolated from production animals in Denmark in 1997. Microb. Drug Resist. 8:369-374. (Pubitemid 36043704)
19. Karanika, M, A. Prati, M. Kiritsi, I. Spiliopoulou, I. Neonakis, M. Anifantaki, and E. Petinaki. 2008. Reduced susceptibility to quinupristin/dalfopristin in Enterococcus faecium in Greece without prior exposure to the agent. Int. J. Antimicrob. Agents. 31:55-57. (Pubitemid 350236722)
20. Kieke, A.L., M.A. Borchardt, B.A. Kieke, S.K. Spencer, M.F. Vandermause, K.E. Smith, S.L. Jawahir, and E.A. Belongia; Marshfield Enterococcal Study Group. 2006. Use of streptogramin growth promoters in poultry and isolation of streptogramin-resistant Enterococcus faecium from humans. J. Infect. Dis. 194:1200-1208. (Pubitemid 44630964)
21. Klare, K., G. Werner, and W. Witte. 2001. Enterococci. Habitats, infections, virulence factors, resistances to antibiotics, transfer of resistance determinants. In: I. Muhldorfer and K.P. Schafer (eds.), Emerging Bacterial Pathogens. Karger, Basel, pp.108-122.
22. Kobayashi, N., H. Wu, K. Kojima, K. Taniguchi, S. Urasawa, N. Uehara, Y. Omizu, Y. Kishi, A. Yagihashi, and I. Kurokawa. 1994. Detection of mecA, femA, and femB genes in clinical strains of staphylococci using polymerase chain reaction. Epidemiol. Infect. 113:259-266. (Pubitemid 24310314)
23. López, F., E. Culebras, C. Betriú , I. Rodríguez- Avial, M. Gómez, and J.J. Picazo. 2010. Antimicrobial susceptibility and macrolide resistance genes in Enterococcus faecium with reduced susceptibility to quinupristin-dalfopristin: level of quinupristin-dalfopristin resistance is not dependent on erm(B) attenuator region sequence. Diagn. Microbiol. Infect. Dis. 66:73-77.
24. Martin, B., G. Alloing, V. Méjean, and J.P. Claverys. 1987. Constitutive expression of erythromycin resistance mediated by the ermAM determinant of plasmid pAM beta 1 results from deletion of 5¢ leader peptide sequences. Plasmid 18:250-253.
25. Martineau, F., F.J. Picard, N. Lansac, C. Ménard, P.H. Roy, M. Ouellette, and M.G. Bergeron. 2000. Correlation between the resistance genotype determined by multiplex PCR assays and the antibiotic susceptibility patterns of Staphylococcus aureus and Staphylococcus epidermidis. Antimicrob. Agents Chemother. 44:231-238. (Pubitemid 30060711)
26. Min, Y-H., J-H. Jeong, Y-J. Choi, H-J. Yun, K. Lee, M-J. Shim, J-H. Kwak, and E-C. Choi. 2003. Heterogeneity of macrolide-lincosamide-streptogramin B resistance phenotypes in enterococci. Antimicrob. Agents Chemother. 47:3415-3420. (Pubitemid 37345698)
27. Min, Y-H., A-R., Kwon, J-M. Yoon, E-J.Yoon, M-J. Shim, and E-C. Choi. 2008. Molecular analysis of constitutive mutations in ermB and ermA selected in vitro from inducibly MLSB-resistant enterococci. Arch. Pharm. Res. 31:377-380.
28. Murray, B.E. 1998. Diversity among multidrug-resistant enterococci. Emerg. Infect. Dis. 4:37-47. (Pubitemid 28347414)
29. Nakajima, Y. 1999. Mechanisms of bacterial resistance to macrolide antibiotics. J. Infect. Chemother. 5:61-74. (Pubitemid 29317927)
30. Nishimoto, Y., N. Kobayashi, M.M. Alam, M. Ishino, N. Uehara, and N. Watanabe. 2005. Analysis of the prevalence of tetracycline resistance genes in clinical isolates of Enterococcus faecalis and Enterococcus faecium in a Japanese hospital. Microb. Drug Resist. 11:146-153. (Pubitemid 40705824)
31. Oh, W.-S., K.-S. Ko, J.-H. Song, M.-Y. Lee, S. Park, K.-R. Peck, N.-Y. Lee, C.-K. Kim, H. Lee, S.-W. Kim, H.-H. Chang, Y.-S. Kim, S.-I. Jung, J.-S. Son, J.-S. Yeom, H.-K. Ki, and G.-J. Woo. 2005. High rate of resistance to quinupristindalfopristin in Enterococcus faecium clinical isolates from Korea. Antimicrob. Agents Chemother. 49:5176-5178. (Pubitemid 41778946)
32. Pereira, G.H., P.R. Mü ller, R.C. Zanella, M. de Jesus Castro Lima, D.S. Torchio, and A.S. Levin. Outbreak of vancomycin-resistant enterococci in a tertiary hospital: the lack of effect of measures directed mainly by surveillance cultures and differences in response between Enterococcus faecium and Enterococcus faecalis. Am. J. Infect. Control. 38:406-409.
33. Portillo, A., F. Ruiz-Larrea, M. Zarazaga, A. Alonso, J.L. Martinez, and C. Torres. 2000. Macrolide resistance genes in Enterococcus spp. Antimicrob. Agents Chemother. 44:967-971. (Pubitemid 30165277)
34. Rende-Fournier, R., R. Leclercq,M. Galimand, J. Duval, and P. Courvalin. 1993. Identification of the satA gene encoding a streptogramin A acetyltransferase in Enterococcus faecium BM4145. Antimicrob. Agents Chemother. 37:2119-2125. (Pubitemid 23298199)
35. Reyes, J., M. Hidalgo, L. Díaz, S. Rincó n, J. Moreno, N. Vanegas, E. Castañ eda, and C.A. Arias. 2007. Characterization of macrolide resistance in Gram-positive cocci from Colombian hospitals: a countrywide surveillance. Int. J. Infect. Dis. 11:329-336. (Pubitemid 46990970)
36. Rosato, A., H. Vicarini, and R. Leclercq. 1999. Inducible or constitutive expression of resistance in clinical isolates of streptococci and enterococci cross-resistant to erythromycin and lincomycin. J. Antimicrob. Chemother. 43:559-562. (Pubitemid 29182307)
37. Schmitz, F.J., R. Sadurski, A. Kray, M. Boos, R. Geisel, K. Kö hrer, J. Verhoef, and A.C. Fluit. 2000. Prevalence of macrolide-resistance genes in Staphylococcus aureus and Enterococcus faecium isolates from 24 European university hospitals. J. Antimicrob. Chemother. 45:891-894. (Pubitemid 30348963)
38. Schmitz, F.J., J. Verhoef, A.C. Fluit, and Sentry Participants Group. 1999. Prevalence of resistance to MLS antibiotics in 20 European university hospitals participating in the European SENTRY surveillance programme. J. Antimicrob. Chemother. 43:783-792. (Pubitemid 29273728)
39. Schouten, M.A., A. Voss, J.A. Hoogkamp-Korstanje, and the European VRE Study Group. 1999. Antimicrobial susceptibility patterns of enterococci causing infections in Europe. Antimicrob. Agents Chemother. 43:2542-2546. (Pubitemid 29471244)
40. Singh, K.V., K. Malathum, and B.E. Murray. 2001. Disruption of an Enterococcus faecium species-specific gene, a homologue of acquired macrolide resistance genes of staphylococci, is associated with an increase in macrolide susceptibility. Antimicrob. Agents Chemother. 45:263-266. (Pubitemid 32039124)
41. Soltani, M., D. Beighton, J. Philpott-Howard, and N. Woodford. 2000. Mechanisms of resistance to quinupristindalfopristin among isolates of Enterococcus faecium from animals, raw meat, and hospital patients in Western Europe. Antimicrob. Agents Chemother. 44:433-436. (Pubitemid 30060747)
42. Tait-Kamradt, A., T. Davies, M. Cronan, M.R. Jacobs, P.C. Appelbaum, and J. Sutcliffe. 2000. Mutations in 23S rRNA and ribosomal protein L4 account for resistance in pneumococcal strains selected in vitro by macrolide passage. Antimicrob. Agents Chemother. 44:2118-2125. (Pubitemid 30484435)
43. Top, J., L.M. Schouls, M.J. Bonten, and R.J. Willems. 2004. Multiple-locus variable-number tandem repeat analysis, a novel typing scheme to the genetic relatedness and epidemiology of Enterococcus faecium isolates. J. Clin. Microbiol. 42:4503-4511. (Pubitemid 39362363)
44. Top, J., R. Willems, and M. Bonten. 2008. Emergence of CC17 Enterococcus faecium: from commensal to hospitaladapted pathogen. FEMS. Immunol. Med. Microbiol. 52: 297-308. (Pubitemid 351420752)
45. Watanabe, S., N. Kobayashi, D. Quiñ ones, S. Nagashima, N. Uehara, and N. Watanabe. 2009. Genetic diversity of enterococci harboring the high-level gentamicin resistance gene aac(6')-Ie-aph(2")-Ia or aph(2")-Ie in a Japanese hospital. Microb. Drug Resist. 15:185-194.
46. Werner, G., B. Hildebrandt, and W. Witte. 2001. The newly described msrC gene is not equally distributed among all isolates of Enterococcus faecium. Antimicrob. Agents Chemother. 45:3672-3673. (Pubitemid 33107906)
47. Werner, G., I. Klare, H. Heier, K.H. Hinz, G. Böhme, M. Wendt, and W. Witte. 2000. Quinupristin/dalfopristinresistant enterococci of the satA (vatD) and satG (vatE) genotypes from different ecological origins in Germany. Microb. Drug Resist. 6:37-47. (Pubitemid 30367849)
48. Werner, G., I. Klare, F.B. Spencker, and W. Witte. 2003. Intra-hospital dissemination of quinupristin/dalfopristin-and vancomycin-resistant Enterococcus faecium in a paediatric ward of a German hospital. J. Antimicrob. Chemother. 52:113-115. (Pubitemid 36850095)
49. Werner, G., I. Klare, and W. Witte. 2002. Molecular analysis of streptogramin resistance in enterococci. Int. J. Med. Microbiol. 292:81-94. (Pubitemid 34842179)
50. Werner, G., I. Klare, and W. Witte. 2007. The current MLVA typing scheme for Enterococcus faecium is less discriminatory than MLST and PFGE for epidemic-virulent, hospitaladapted clonal types. BMC Microbiol. 7:28.
51. Werner, G., and W. Witte. 1999. Characterization of a new enterococcal gene, satG, encoding a putative acetyltransferase conferring resistance to Streptogramin A compounds. Antimicrob. Agents Chemother. 43:1813-1814. (Pubitemid 29331278)
52. Wondrack, L., M. Massa, B.V. Yang, and J. Sutcliffe. 1996. Clinical strain of Staphylococcus aureus inactivates and causes efflux of macrolides. Antimicrob. Agents Chemother. 40:992-998. (Pubitemid 26117529)
53. Yamaguchi, K., A. Ohno, Y. Ishii, K. Tateda, M. Iwata, and levofloxacin-surveillance group. 2009. In vitro susceptibilities to levofloxacin and various antibacterial agents of 12,919 clinical isolates obtained from 72 centers in 2007. Jpn. J. Antibiot. 62:346-370.
54. Yilmaz, G., K. Aydin, S. Iskender, R. Caylan, and I. Koksal. 2007. Detection and prevalence of inducible clindamycin resistance in staphylococci. J. Med. Microbiol. 56:342-345. (Pubitemid 46363978)