Disruption of an Enterococcus faecium species-specific gene, a homologue of acquired macrolide resistance genes of staphylococci, is associated with an increase in macrolide susceptibility

Antimicrobial Agents and Chemotherapy

Volumn 45, Issue 1, 2001, Pages 263-266

  Singh, K V ^a   Malathum, K ^a   Murray, B E ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; ERYTHROMYCIN; MACROLIDE; QUINUPRISTIN; TYLOSIN;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM ISOLATION; DRUG SENSITIVITY; ENTEROCOCCUS FAECIUM; GENE EXPRESSION; GENE PROBE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SPECIES DIFFERENCE; STAPHYLOCOCCUS;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BASE SEQUENCE; DNA, BACTERIAL; DRUG RESISTANCE, MICROBIAL; ENTEROCOCCUS FAECIUM; ERYTHROMYCIN; GENES, BACTERIAL; MOLECULAR SEQUENCE DATA; MUTATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STAPHYLOCOCCUS;

EID: 0035165321     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.45.1.263-266.2001     Document Type: Article

References (32)

1. Sequence of a staphylococcal plasmid gene, vga, encoding a putative ATP-binding protein involved in resistance to virginiamycin A-like antibiotics
2. Characterization of a new staphylococcal gene, vgaB, encoding a putative ABC transporter conferring resistance to streptogramin A and related compounds
3. The ardl gene from Streptomyces capreolus encodes a polypeptide of the ABC-transporters superfamily which confers resistance to the amino-nucleoside antibiotic A201A
4. Evidence for natural gene transfer from gram-positive cocci to Escherichia coli
5. Vancomycin-resistant enterococci from nosocomial, community, and animal sources in the United States
6. Translational attenuation: The regulation of bacterial resistance to the macrolide-lincosamide-streptogramin B antibiotics
7. High-level resistance to gentamicin in clinical isolates of Streptococcus (Enterococcus) faecium
8. The identification of rofA, a positive-acting regulatory component of prtF expression: Use of a mγδ-based shuttle mutagenesis strategy in Streptococcus pyogenes
9. Genetic transformation of various species of Enterococcus by electroporation
10. Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport
11. Generation of auxotroph mutants of Enterococcus faecalis
12. In vitro activities of two ketolides, HMR 3647 and HMR 3004, against gram-positive bacteria
13. Cloning and sequences of inducible and constitutive macrolide resistance genes in Staphylococcus aureus that correspond to an ABC transporter
14. Cloning and sequencing of a plasmid-mediated erythromycin resistance determinant from Staphylococcus xylosus
15. DNA fingerprinting of Enterococcus faecium by pulsed-field gel electrophoresis may be a useful epidemiologic tool
16. Outbreak of vancomycin-, ampicillin-, and aminoglycoside-resistant Enterococcus faecium bacteremia in an adult oncology unit
17. Nucleotide sequence of ermA, a macrolide-licosamide-streptogramin B determinant in Staphylococcus aureus
18. Comparison of genomic DNAs of different enterococcal isolates using restriction endonucleases with infrequent recognition sites
19. Activity of macrolides against common pathogens in vitro
20. Macrolide resistance genes in Enterococcus spp
21. Replication properties of pJM13, a naturally occurring plasmid found in Bacillus subtilis, and of its close relative pE5, a plasmid native to Staphylococcus aureus
22. Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants
23. Inducible erythromycin resistance in staphylococci is encoded by a member of the ATP-binding transport super-gene family
24. In vivo testing of an Enterococcus faecalis efaA mutant and use of efaA homologs for species identification
25. Generation and testing of mutants of Enterococcus faecalis in a mouse peritonitis model
26. Detection of erythromycin-resistant determinants by PCR
27. Distantly related sequences in the α and β subunits of ATP synthase, myosin, kinase and other ATP-requiring enzymes and a common nucleotide binding fold
28. Inducible resistance to macrolides, lincosamides and streptogramin type B antibiotics: The resistance phenotype, its biological diversity, and structural elements that regulate expression - A review
29. Preparation of genomic DNA from bacteria