Genetic diversity of enterococci harboring the high-level gentamicin resistance gene aac(6′)-Ie-aph(2″)-Ia or aph(2″)-Ie in a japanese hospital

Microbial Drug Resistance

Volumn 15, Issue 3, 2009, Pages 185-194

  Watanabe, Shojiro ^a   Kobayashi, Nobumichi ^a   Quiñones, Dianelys ^b   Nagashima, Shigeo ^a   Uehara, Nobuyuki ^a   Watanabe, Naoki ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b INSTITUTO DE MEDICINA TROPICAL PEDRO KOURÍ   (Cuba)

Author keywords

[No Author keywords available]

Indexed keywords

GENTAMICIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; ENTEROCOCCUS; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; GENETIC VARIABILITY; HOSPITAL; JAPAN; MULTILOCUS SEQUENCE TYPING; NONHUMAN; PRIORITY JOURNAL;

ACETYLTRANSFERASES; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; DNA TRANSPOSABLE ELEMENTS; DRUG RESISTANCE, BACTERIAL; ENTEROCOCCUS; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; GENETIC VARIATION; GENTAMICINS; GRAM-POSITIVE BACTERIAL INFECTIONS; HOSPITALS; HUMANS; JAPAN; MICROBIAL SENSITIVITY TESTS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR);

ENTEROCOCCUS FAECALIS;

EID: 69949124477     PISSN: 10766294     EISSN: None     Source Type: Journal    
DOI: 10.1089/mdr.2009.0917     Document Type: Article

References (41)

1. Alam, M.M., N. Kobayashi, M. Ishino, A. Sumi, K. Kobayashi, N. Uehara, and N. Watanabe. 2005. Detection of a novel aph(200) allele (aph[200]-Ie) conferring high-level gen-tamicin resistance and a spectinomycin resistance gene ant(9)-Ia (aad 9) in clinical isolates of enterococci. Microb. Drug Resist. 11:239-247.
2. Camargo, I.L., M.S. Gilmore, and A.L. Darini. 2006. Mul-tilocus sequence typing and analysis of putative virulence factors in vancomycin-resistant and vancomycin-sensitive Enterococcus faecium isolates from Brazil. Clin. Microbiol. Infect. 12:1123-1130.
3. Casetta, A., A.B. Hoï, G. de Cespédés, and T. Horaud. 1998. Diversity of structures carrying the high-level gentamicin resistance gene (aac6-aph2) in Enterococcus faecalis strains isolated in France. Antimicrob. Agents Chemother. 42:2889-2892.
4. Chen, Y.G., T.T. Qu, Y.S. Yu, J.L. Zhou, and L.J. Li. 2006. Insertion sequence ISEcp1-like element connected with a novel aph(200) allele [aph(2'')-Ie] conferring high-level gentamicin resistance and a novel streptomycin adenylyl-transferase gene in Enterococcus. J. Med. Microbiol. 55:1521-1525.
5. Chow, J.W. 2000. Aminoglycoside resistance in enterococci. Clin. Infect. Dis. 31:586-589.
6. Clinical and Laboratory Standards Institute. 2007. Performance standards for antimicrobial susceptibility testing; 17th informational supplement. CLSI document M100-S17. Clinical and Laboratory Standards Institute, Wayne, PA.
7. Donabedian, S.M., L.A. Thal, E. Hershberger, M.B. Perri, J.W. Chow, P. Bartlett, R. Jones, K. Joyce, S. Rossiter, K. Gay, J. Johnson, C. Mackinson, E. Debess, J. Madden, F. Angulo, and M.J. Zervos. 2003. Molecular characterization of gentamicin-resistant Enterococci in the United States: evidence of spread from animals to humans through food. J. Clin. Microbiol. 41:1109-1113.
8. Duh, R.W., K.V. Singh, K. Malathum, and B.E. Murray. 2001. In vitro activity of 19 antimicrobial agents against enterococci from healthy subjects and hospitalized patients and use of an ace gene probe from Enterococcus faecalis for species identification. Microb. Drug Resist. 7:39-46.
9. Eaton, T.J., and M.J. Gasson. 2001. Molecular screening of Enterococcus virulence determinants and potential for genetic exchange between food and medical isolates. Appl. Environ Microbiol. 67:1628-1635.
10. Ferretti, J.J., K.S. Gilmore, and P. Courvalin. 1986. Nucleotide sequence analysis of the gene specifying the bifunctional 60-aminoglycoside acetyltransferase 200-aminoglycoside phosphotransferase enzyme in Streptococcus faecalis and identification and cloning of gene regions specifying the two activities. J. Bacteriol. 167:631-638.
11. Hällgren, A., B. Saeedi, M. Nilsson, H.J. Monstein, B. Isaksson, H. Hanberger, and L.E. Nilsson. 2003. Genetic relatedness among Enterococcus faecalis with transposon-mediated high-level gentamicin resistance in Swedish intensive care units. J. Antimicrob. Chemother. 52:162-167.
12. Hodel-Christian, S.L., and B.E. Murray. 1991. Characterization of the gentamicin resistance transposon Tn5281 from Enterococcus faecalis and comparison to staphylococcal transposons Tn4001 and Tn4031. Antimicrob. Agents Che-mother. 35:1147-1152.
13. Homan, W.L., D. Tribe, S. Poznanski, M. Li, G. Hogg, E. Spalburg, J.D. Van Embden, and R.J. Willems. 2002. Multilocus sequence typing scheme for Enterococcus faecium. J. Clin. Microbiol. 40:1963-1971.
14. Huycke, M.M., D.F. Sahm, and M.S. Gilmore. 1998. Multiple-drug resistant enterococci: the nature of the problem and an agenda for the future. Emerg. Infect. Dis. 4:239-249.
15. Jackson, C.R., P.J. Fedorka-Cray, J.B. Barrett, and S.R. Ladely. 2005. High-level aminoglycoside resistant entero-cocci isolated from swine. Epidemiol. Infect. 133:367-371.
16. Kawalec, M., Z. Pietras, E. Danilowicz, A. Jakubczak, M. Gniadkowski, W. Hryniewicz, and R.J. Willems. 2006. Clonal structure of Enterococcus faecalis isolated from Polish hospitals: characterization of epidemic clones. J. Clin. Mi-crobiol. 45:147-153.
17. Klibi, N., K. Ben Slama, A. Masmoudi, S. Gharbi, F. Ruiz-Larrea, C. Fendri, A. Boudabous, and C. Torres. 2006. Diversity of structures carrying the aac(60)-aph(200) gene in clinical Enterococcus faecalis and Enterococcus faecium strains isolated in Tunisia. J. Chemother. 18:353-359.
18. Kobayashi, N., H. Wu, K. Kojima, K. Taniguchi, S. Urasawa, N. Uehara, Y. Omizu, Y. Kishi, A. Yagihashi, and I. Kurokawa. 1994. Detection of mecA, femA, and femB genes in clinical strains of staphylococci using polymerase chain reaction. Epidemiol. Infect. 113:259-266.
19. Lavery, A., A.S. Rossney, D. Morrison, A. Power, and C.T. Keane. 1997. Incidence and detection of multi-drug-resistant enterococci in Dublin hospitals. J. Med. Microbiol. 46:150-156.
20. Leelaporn, A., K. Yodkamol, D. Waywa, and S. Pattanachaiwit. 2008. A novel structure of Tn4001-truncated element, type V, in clinical enterococcal isolates and multiplex PCR for detecting aminoglycoside resistance genes. Int. J. Antimicrob. Agents 31:250-254.
21. Lester, C.H., D. Sandvang, S.S. Olsen, H.C. Schønheyder, J.O. Jarløv, J. Bangsborg, D.S. Hansen, T.G. Jensen, N. Frimodt-Møller, A.M. Hammerum, and DANRES Study Group. 2008. Emergence of ampicillin-resistant Enterococcus faecium in Danish hospitals. J. Antimicrob. Chemother. 62:1203-1206.
22. Lopes, M.de F., T. Ribeiro, M.P. Martins, R. Tenreiro, and M.T. Crespo. 2003. Gentamicin resistance in dairy and clinical enterococcal isolates and in reference strains. J. Antimicrob. Chemother. 52:214-219.
23. Lyon, B.R., J.W. May, and R.A. Skurray. 1984. Tn4001: a gentamicin and kanamycin resistance transposon in Staphylococcus aureus. Mol. Gen. Genet. 193:554-556.
24. Marcus, N., N. Peled, and P. Yagupsky. 1997. Rapid increase in the prevalence of antimicrobial drug resistance among enterococcal blood isolates in southern Israel. Eur. J. Clin. Microbiol. Infect. Dis. 16:913-915. (Pubitemid 28046148)
25. Martin, B., M. Garriga, M. Hugas, and T. Aymerich. 2005. Genetic diversity and safety aspects of enterococci from slightly fermented sausages. J. Appl. Microbiol. 98:1177-1190.
26. Murray, B.E. 1990. The life and times of the Enterococcus. Clin. Microbiol. Rev. 3:46-65.
27. Ruiz-Garbajosa, P., M.J. Bonten, D.A. Robinson, J. Top, S.R. Nallapareddy, C. Torres, T.M. Coque, R. Cantón, F. Baquero, B.E. Murray, R. del Campo, and R.J. Willems. 2006. Multilocus sequence typing scheme for Enterococcus faecalis reveals hospital-adapted genetic complexes in a background of high rates of recombination. J. Clin. Micro-biol. 44:2220-2228.
28. Simjee, S., A.P. Fraise, and M.J. Gill. 1999. Plasmid heterogeneity and identification of a Tn5281-like element in clinical isolates of high-level gentamicin-resistant Enterococcus fae-cium isolated in the UK. J. Antimicrob. Chemother. 43:625-635.
29. Simjee, S., and M.J. Gill. 1997. Gene transfer, gentamicin resistance and enterococci. J. Hosp. Infect. 36:249-259.
30. Simjee, S., S.E. Manzoor, A.P. Fraise, and M.J. Gill. 2000. Nature of transposon-mediated high-level gentamicin resistance in Enterococcus faecalis isolated in the United Kingdom. J. Antimicrob. Chemother. 45:565-575.
31. Stampone, L., M. Del Grosso, D. Boccia, and A. Pantosti. 2005. Clonal spread of a vancomycin-resistant Enterococcus faecium strain among bloodstream-infecting isolates in Italy. J. Clin. Microbiol. 43:1575-1580.
32. Straut, M., G. de Cespédés, F. Delbos, and T. Horaud. 1997. Molecular typing of Enterococcus faecalis strains resistant to high levels of gentamicin and isolated in Romania. J. Anti-microb. Chemother. 39:483-491. (Pubitemid 27196946)
33. Suzuki, E., K. Kuwahara-Arai, J.F. Richardson, and K. Hiramatsu. 1993. Distribution of mec regulator genes in methicillin-resistant Staphylococcus clinical strains. Anti-microb. Agents Chemother. 37:1219-1226.
34. Thomas, W.D., Jr. and G.L. Archer. 1989. Mobility of gen-tamicin resistance genes from staphylococci isolated in the United States: identification of Tn4031, a gentamicin resistance transposon from Staphylococcus epidermidis. Anti-microb. Agents Chemother. 33:1335-1341.
35. Top, J., R. Willems, S. van der Velden, M. Asbroek, and M. Bonten. 2008. Emergence of clonal complex 17 Entero-coccus faecium in The Netherlands. J. Clin. Microbiol. 46:214-219.
36. Tsai, S.F., M.J. Zervos, D.B. Clewell, S.M. Donabedian, D.F. Sahm, and J.W. Chow. 1998. A new high-level genta-micin resistance gene, aph(200)-Id, in Enterococcus spp. An-timicrob. Agents Chemother. 42:1229-1232.
37. Tsakris, A., S. Pournaras, A.N. Maniatis, J. Douboyas, and A. Antoniadis. 2001. Increasing prevalence of high-level gentamicin resistance among Enterococci isolated in Greece. Chemotherapy 47:86-89.
38. Udo, E.E., N. Al-Sweih, P. John, L.E. Jacob, and S. Mohanakrishnan. 2004. Characterization of high-level aminoglycoside-resistant enterococci in Kuwait hospitals. Microb. Drug Resist. 10:139-145.
39. Vankerckhoven, V., T. Van Autgaerden, C. Vael, C. Lam-mens, S. Chapelle, R. Rossi, D. Jabes, and H. Goossens. 2004. Development of a multiplex PCR for the detection of asa1, gelE, cylA, esp, and hyl genes in enterococci and survey for virulence determinants among European hospital isolates of Enterococcus faecium. J. Clin. Microbiol. 42:4473-4479.
40. Werner, G., K.H. Dahl, and R.J.L. Willems. 2006. Composite elements encoding antibiotic resistance in Enterococcus faecium and Enterococcus faecalis. In N. Kobayashi (ed.), Drug Resistance of Enterococci: Epidemiology and Molecular Mechanisms. Research Signpost, Trivandrum, pp. 157-208.
41. Zheng, B., H. Tomita, Y.H. Xiao, S. Wang, Y. Li, and Y. Ike. 2007. Molecular characterization of vancomycin-resistant Enterococcus faecium isolates from mainland China. J. Clin. Microbiol. 45:2813-2818.