-
1
-
-
77954122580
-
Will DNA methylation inhibitors work in solid tumors? A review of the clinical experience with azacitidine and decitabine in solid tumors
-
Cowan LA, Talwar S, Yang AS, (2010) Will DNA methylation inhibitors work in solid tumors? A review of the clinical experience with azacitidine and decitabine in solid tumors. Epigenomics 2: 71-86.
-
(2010)
Epigenomics
, vol.2
, pp. 71-86
-
-
Cowan, L.A.1
Talwar, S.2
Yang, A.S.3
-
2
-
-
29144467606
-
In vivo effects of decitabine in myelodysplasia and acute myeloid leukemia: review of cytogenetic and molecular studies
-
Hackanson B, Robbel C, Wijermans P, Lubbert M, (2005) In vivo effects of decitabine in myelodysplasia and acute myeloid leukemia: review of cytogenetic and molecular studies. Ann Hematol 84 Suppl 1: 32-38.
-
(2005)
Ann Hematol
, vol.84
, Issue.SUPPL.
, pp. 32-38
-
-
Hackanson, B.1
Robbel, C.2
Wijermans, P.3
Lubbert, M.4
-
3
-
-
77956924038
-
Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia
-
Goodyear O, Agathanggelou A, Novitzky-Basso I, Siddique S, McSkeane T, et al. (2010) Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia. Blood 116: 1908-1918.
-
(2010)
Blood
, vol.116
, pp. 1908-1918
-
-
Goodyear, O.1
Agathanggelou, A.2
Novitzky-Basso, I.3
Siddique, S.4
McSkeane, T.5
-
4
-
-
0037108309
-
Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2′-deoxycytidine (decitabine) treatment
-
Daskalakis M, Nguyen TT, Nguyen C, Guldberg P, Kohler G, et al. (2002) Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2′-deoxycytidine (decitabine) treatment. Blood 100: 2957-2964.
-
(2002)
Blood
, vol.100
, pp. 2957-2964
-
-
Daskalakis, M.1
Nguyen, T.T.2
Nguyen, C.3
Guldberg, P.4
Kohler, G.5
-
5
-
-
34548529948
-
Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia
-
Blum W, Klisovic RB, Hackanson B, Liu Z, Liu S, et al. (2007) Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia. J Clin Oncol 25: 3884-3891.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3884-3891
-
-
Blum, W.1
Klisovic, R.B.2
Hackanson, B.3
Liu, Z.4
Liu, S.5
-
6
-
-
84863337757
-
Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells
-
Tsai HC, Li H, Van Neste L, Cai Y, Robert C, et al. (2012) Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells. Cancer Cell 21: 430-446.
-
(2012)
Cancer Cell
, vol.21
, pp. 430-446
-
-
Tsai, H.C.1
Li, H.2
van Neste, L.3
Cai, Y.4
Robert, C.5
-
7
-
-
80051992418
-
Outcome of high-risk myelodysplastic syndrome after azacitidine treatment failure
-
Prebet T, Gore SD, Esterni B, Gardin C, Itzykson R, et al. (2011) Outcome of high-risk myelodysplastic syndrome after azacitidine treatment failure. J Clin Oncol 29: 3322-3327.
-
(2011)
J Clin Oncol
, vol.29
, pp. 3322-3327
-
-
Prebet, T.1
Gore, S.D.2
Esterni, B.3
Gardin, C.4
Itzykson, R.5
-
8
-
-
60249094793
-
Mechanisms of resistance to 5-aza-2′-deoxycytidine in human cancer cell lines
-
Qin T, Jelinek J, Si J, Shu J, Issa JP, (2009) Mechanisms of resistance to 5-aza-2′-deoxycytidine in human cancer cell lines. Blood 113: 659-667.
-
(2009)
Blood
, vol.113
, pp. 659-667
-
-
Qin, T.1
Jelinek, J.2
Si, J.3
Shu, J.4
Issa, J.P.5
-
9
-
-
80051718182
-
Mechanisms of resistance to decitabine in the myelodysplastic syndrome
-
Qin T, Castoro R, El Ahdab S, Jelinek J, Wang X, et al. (2011) Mechanisms of resistance to decitabine in the myelodysplastic syndrome. PLoS One 6: e23372.
-
(2011)
PLoS One
, vol.6
-
-
Qin, T.1
Castoro, R.2
El Ahdab, S.3
Jelinek, J.4
Wang, X.5
-
10
-
-
77955459115
-
Long-term stability of demethylation after transient exposure to 5-aza-2′-deoxycytidine correlates with sustained RNA polymerase II occupancy
-
Kagey JD, Kapoor-Vazirani P, McCabe MT, Powell DR, Vertino PM, (2010) Long-term stability of demethylation after transient exposure to 5-aza-2′-deoxycytidine correlates with sustained RNA polymerase II occupancy. Mol Cancer Res 8: 1048-1059.
-
(2010)
Mol Cancer Res
, vol.8
, pp. 1048-1059
-
-
Kagey, J.D.1
Kapoor-Vazirani, P.2
McCabe, M.T.3
Powell, D.R.4
Vertino, P.M.5
-
11
-
-
79951570106
-
Transcriptional repressive H3K9 and H3K27 methylations contribute to DNMT1-mediated DNA methylation recovery
-
Wong CM, Wong CC, Ng YL, Au SL, Ko FC, et al. (2011) Transcriptional repressive H3K9 and H3K27 methylations contribute to DNMT1-mediated DNA methylation recovery. PLoS One 6: e16702.
-
(2011)
PLoS One
, vol.6
-
-
Wong, C.M.1
Wong, C.C.2
Ng, Y.L.3
Au, S.L.4
Ko, F.C.5
-
12
-
-
33846444355
-
Inhibition of histone deacetylation does not block resilencing of p16 after 5-aza-2′-deoxycytidine treatment
-
Egger G, Aparicio AM, Escobar SG, Jones PA, (2007) Inhibition of histone deacetylation does not block resilencing of p16 after 5-aza-2′-deoxycytidine treatment. Cancer Res 67: 346-353.
-
(2007)
Cancer Res
, vol.67
, pp. 346-353
-
-
Egger, G.1
Aparicio, A.M.2
Escobar, S.G.3
Jones, P.A.4
-
13
-
-
77956288615
-
Chromatin remodeling is required for gene reactivation after decitabine-mediated DNA hypomethylation
-
Si J, Boumber YA, Shu J, Qin T, Ahmed S, et al. (2010) Chromatin remodeling is required for gene reactivation after decitabine-mediated DNA hypomethylation. Cancer Res 70: 6968-6977.
-
(2010)
Cancer Res
, vol.70
, pp. 6968-6977
-
-
Si, J.1
Boumber, Y.A.2
Shu, J.3
Qin, T.4
Ahmed, S.5
-
14
-
-
35748936148
-
Role of nucleosomal occupancy in the epigenetic silencing of the MLH1 CpG island
-
Lin JC, Jeong S, Liang G, Takai D, Fatemi M, et al. (2007) Role of nucleosomal occupancy in the epigenetic silencing of the MLH1 CpG island. Cancer Cell 12: 432-444.
-
(2007)
Cancer Cell
, vol.12
, pp. 432-444
-
-
Lin, J.C.1
Jeong, S.2
Liang, G.3
Takai, D.4
Fatemi, M.5
-
15
-
-
0033135049
-
Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression
-
Deng G, Chen A, Hong J, Chae HS, Kim YS, (1999) Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression. Cancer Res 59: 2029-2033.
-
(1999)
Cancer Res
, vol.59
, pp. 2029-2033
-
-
Deng, G.1
Chen, A.2
Hong, J.3
Chae, H.S.4
Kim, Y.S.5
-
16
-
-
0028867842
-
Mismatch repair: mechanisms and relationship to cancer susceptibility
-
Kolodner RD, (1995) Mismatch repair: mechanisms and relationship to cancer susceptibility. Trends Biochem Sci 20: 397-401.
-
(1995)
Trends Biochem Sci
, vol.20
, pp. 397-401
-
-
Kolodner, R.D.1
-
17
-
-
80051578149
-
Dominantly inherited constitutional epigenetic silencing of MLH1 in a cancer-affected family is linked to a single nucleotide variant within the 5′UTR
-
Hitchins MP, Rapkins RW, Kwok CT, Srivastava S, Wong JJ, et al. (2011) Dominantly inherited constitutional epigenetic silencing of MLH1 in a cancer-affected family is linked to a single nucleotide variant within the 5′UTR. Cancer Cell 20: 200-213.
-
(2011)
Cancer Cell
, vol.20
, pp. 200-213
-
-
Hitchins, M.P.1
Rapkins, R.W.2
Kwok, C.T.3
Srivastava, S.4
Wong, J.J.5
-
18
-
-
80052284848
-
OCT4 establishes and maintains nucleosome-depleted regions that provide additional layers of epigenetic regulation of its target genes
-
You JS, Kelly TK, De Carvalho DD, Taberlay PC, Liang G, et al. (2011) OCT4 establishes and maintains nucleosome-depleted regions that provide additional layers of epigenetic regulation of its target genes. Proc Natl Acad Sci U S A 108: 14497-14502.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 14497-14502
-
-
You, J.S.1
Kelly, T.K.2
De Carvalho, D.D.3
Taberlay, P.C.4
Liang, G.5
-
19
-
-
34848911602
-
Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4
-
Vermeulen M, Mulder KW, Denissov S, Pijnappel WW, van Schaik FM, et al. (2007) Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4. Cell 131: 58-69.
-
(2007)
Cell
, vol.131
, pp. 58-69
-
-
Vermeulen, M.1
Mulder, K.W.2
Denissov, S.3
Pijnappel, W.W.4
van Schaik, F.M.5
-
20
-
-
34547725157
-
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA
-
Ooi SK, Qiu C, Bernstein E, Li K, Jia D, et al. (2007) DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature 448: 714-717.
-
(2007)
Nature
, vol.448
, pp. 714-717
-
-
Ooi, S.K.1
Qiu, C.2
Bernstein, E.3
Li, K.4
Jia, D.5
-
21
-
-
58149395035
-
Bivalent domains enforce transcriptional memory of DNA methylated genes in cancer cells
-
Rodriguez J, Munoz M, Vives L, Frangou CG, Groudine M, et al. (2008) Bivalent domains enforce transcriptional memory of DNA methylated genes in cancer cells. Proc Natl Acad Sci U S A 105: 19809-19814.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 19809-19814
-
-
Rodriguez, J.1
Munoz, M.2
Vives, L.3
Frangou, C.G.4
Groudine, M.5
-
22
-
-
70350069495
-
The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands
-
Takeshima H, Yamashita S, Shimazu T, Niwa T, Ushijima T, (2009) The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands. Genome Res 19: 1974-1982.
-
(2009)
Genome Res
, vol.19
, pp. 1974-1982
-
-
Takeshima, H.1
Yamashita, S.2
Shimazu, T.3
Niwa, T.4
Ushijima, T.5
-
23
-
-
78650599981
-
De novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one
-
Goel A, Nguyen TP, Leung HC, Nagasaka T, Rhees J, et al. (2011) De novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one. Int J Cancer 128: 869-878.
-
(2011)
Int J Cancer
, vol.128
, pp. 869-878
-
-
Goel, A.1
Nguyen, T.P.2
Leung, H.C.3
Nagasaka, T.4
Rhees, J.5
-
24
-
-
54549103517
-
DNA methylation determination by liquid chromatography-tandem mass spectrometry using novel biosynthetic [U-15N]deoxycytidine and [U-15N]methyldeoxycytidine internal standards
-
Quinlivan EP, Gregory JF 3rd, (2008) DNA methylation determination by liquid chromatography-tandem mass spectrometry using novel biosynthetic [U-15N]deoxycytidine and [U-15N]methyldeoxycytidine internal standards. Nucleic Acids Res 36: e119.
-
(2008)
Nucleic Acids Res
, vol.36
-
-
Quinlivan, E.P.1
Gregory III, J.F.2
-
25
-
-
84866450369
-
Relative distribution of folate species is associated with global DNA methylation in human colorectal mucosa
-
Liu J, Hesson LB, Meagher AP, Bourke MJ, Hawkins NJ, et al. (2012) Relative distribution of folate species is associated with global DNA methylation in human colorectal mucosa. Cancer Prev Res (Phila) 5: 921-929.
-
(2012)
Cancer Prev Res (Phila)
, vol.5
, pp. 921-929
-
-
Liu, J.1
Hesson, L.B.2
Meagher, A.P.3
Bourke, M.J.4
Hawkins, N.J.5
-
26
-
-
34547400458
-
Active and repressive chromatin are interspersed without spreading in an imprinted gene cluster in the mammalian genome
-
Regha K, Sloane MA, Huang R, Pauler FM, Warczok KE, et al. (2007) Active and repressive chromatin are interspersed without spreading in an imprinted gene cluster in the mammalian genome. Mol Cell 27: 353-366.
-
(2007)
Mol Cell
, vol.27
, pp. 353-366
-
-
Regha, K.1
Sloane, M.A.2
Huang, R.3
Pauler, F.M.4
Warczok, K.E.5
-
27
-
-
77956931047
-
H2A.Z maintenance during mitosis reveals nucleosome shifting on mitotically silenced genes
-
Kelly TK, Miranda TB, Liang G, Berman BP, Lin JC, et al. (2010) H2A.Z maintenance during mitosis reveals nucleosome shifting on mitotically silenced genes. Mol Cell 39: 901-911.
-
(2010)
Mol Cell
, vol.39
, pp. 901-911
-
-
Kelly, T.K.1
Miranda, T.B.2
Liang, G.3
Berman, B.P.4
Lin, J.C.5
|