Relative distribution of folate species is associated with global DNA methylation in human colorectal mucosa

Cancer Prevention Research

Volumn 5, Issue 7, 2012, Pages 921-929

  Liu, Jia ^a   Hesson, Luke B ^a   Meagher, Alan P ^c   Bourke, Michael J ^d   Hawkins, Nicholas J ^b   Rand, Keith N ^e   Molloy, Peter L ^e   Pimanda, John E ^a   Ward, Robyn L ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c ST VINCENT S HOSPITAL   (Australia)

^d WESTMEAD HOSPITAL   (Australia)

^e CSIRO   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; FOLIC ACID; FOLINIC ACID; TETRAHYDROFOLIC ACID;

ADULT; AGED; ARTICLE; BLOOD; CANCER STAGING; COLON MUCOSA; COLORECTAL CANCER; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE MARKER; DNA METHYLATION; FEMALE; FOLIC ACID BLOOD LEVEL; HEMATOCRIT; HUMAN; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECTUM MUCOSA; SMOKING; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

AGED; ALU ELEMENTS; CASE-CONTROL STUDIES; CHROMATOGRAPHY, LIQUID; COLON; COLORECTAL NEOPLASMS; DNA METHYLATION; FEMALE; FOLIC ACID; HUMANS; LONG INTERSPERSED NUCLEOTIDE ELEMENTS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; PROSPECTIVE STUDIES; RECTUM; TANDEM MASS SPECTROMETRY;

EID: 84866450369     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-11-0577     Document Type: Article

References (46)

1. Nijhout HF, Reed MC, Budu P, Ulrich CM. A mathematical model of thefolate cycle: new insights into folate homeostasis. J Biol Chem2004;279:55008-16. (Pubitemid 40066492)
2. Quinlivan EP, Davis SR, Shelnutt KP, Henderson GN, Ghandour H,Shane B, et al. Methylenetetrahydrofolate reductase 677C->T polymorphismand folate status affect one-carbon incorporation intohuman DNA deoxynucleosides. J Nutr 2005;135:389-96. (Pubitemid 40365193)
3. Goelz SE, Vogelstein B, Hamilton SR, Feinberg AP. Hypomethylationof DNA from benign and malignant human colon neoplasms. Science1985;228:187-90. (Pubitemid 15117274)
4. Feinberg AP, Gehrke CW, Kuo KC, Ehrlich M. Reduced genomic 5-methylcytosine content in human colonic neoplasia. Cancer Res1988;48:1159-61. (Pubitemid 18075525)
5. Duthie SJ. Folic acid deficiency and cancer: mechanisms of DNAinstability. Br Med Bull 1999;55:578-92.
6. Kim YI. Folate and DNA methylation: a mechanistic link between folatede fi ciency and colorectal cancer? Cancer Epidemiol Biomarkers Prev2004;13:511-9.
7. Brockton NT. Localized depletion: the key to colorectal cancer riskmediated by MTHFR genotype and folate? Cancer Causes Control2006;17:1005-16. (Pubitemid 44290765)
8. Arcot J, Shrestha A. Folate: methods of analysis. Trends Food Sci Tech2005;16:253-66. (Pubitemid 40816807)
9. Liu JJ, Ward RL. Folate and one-carbon metabolismand its impact onaberrant DNA methylation in cancer. Adv Genet 2010;71:79-121.
10. Schernhammer ES, Giovannucci E, Kawasaki T, Rosner B, Fuchs CS,Ogino S. Dietary folate, alcohol and B vitamins in relation to LINE-1hypomethylation in colon cancer. Gut 2010;59:794-9.
11. Powers HJ, Hill MH, Welfare M, Spiers A, Bal W, Russell J, et al.Responses of biomarkers of folate and ribo fl avin status to folate andribo fl avin supplementation in healthy and colorectal polyp patients(the FAB2 Study). Cancer Epidemiol Biomarkers Prev 2007;16:2128-35. (Pubitemid 47621190)
12. Meenan J, O'Hallinan E, Lynch S, Molloy A, McPartlan J, Scott J, et al.Folate status of gastrointestinal epithelial cells is not predicted by serum and red cell folate values in replete subjects. Gut 1996;38:410-3. (Pubitemid 26074320)
13. Kim YI, Fawaz K, Knox T, Lee YM, Norton R, Arora S, et al. Colonicmucosal concentrations of folate correlate well with blood measurementsof folate status in persons with colorectal polyps.Am J Clin Nutr 1998;68:866- 72.
14. Kim YI, Fawaz K, Knox T, Lee YM, Norton R, Libby E, et al. Colonicmucosal concentrations of folate are accurately predicted by bloodmeasurements of folate status among individuals ingesting physiologicquantities of folate. Cancer Epidemiol Biomarkers Prev 2001;10:715-9. (Pubitemid 32703209)
15. Bagley PJ, Selhub J. A common mutation in the methylenetetrahydrofolatereductase gene is associated with an accumulation of formylatedtetrahydrofolates in red blood cells. Proc Natl Acad Sci U S A1998;95:13217-20. (Pubitemid 28509551)
16. Friso S, Choi SW,Girelli D, Mason JB, Dolnikowski GG, Bagley PJ, et al.A common mutation in the 5,10-methylenetetrahydrofolate reductasegene affects genomic DNA methylation through an interaction withfolate status. Proc Natl Acad Sci U S A 2002;99:5606-11. (Pubitemid 34411596)
17. Liu J, Pickford R, Meagher AP, Ward RL. Quantitative analysis of tissuefolate using ultra high-performance liquid chromatography tandemmass spectrometry. Anal Biochem 2011;411:210-7.
18. Yetley EA, Pfeiffer CM, Phinney KW, Fazili Z, Lacher DA, Bailey RL,et al. Biomarkers of folate status in NHANES: a roundtable summary.Am J Clin Nutr 2011;94:303S-12S.
19. Suter CM, Martin DI, Ward RL. Hypomethylation of L1 retrotransposonsin colorectal cancer and adjacent normal tissue. Int J ColorectalDis 2004;19:95-101. (Pubitemid 38239827)
20. Pufulete M, Al-Ghnaniem R, Khushal A, Appleby P, Harris N, Gout S,et al. Effect of folic acid supplementation on genomic DNA methylationin patients with colorectal adenoma. Gut 2005;54:648-53. (Pubitemid 40559249)
21. Irahara N, Nosho K, Baba Y, Shima K, Lindeman NI, Hazra A, et al.Precision of pyrosequencing assay to measure LINE-1 methylation incolon cancer, normal colonic mucosa, and peripheral blood cells. J MolDiagn 2010;12:177-83.
22. Weisenberger DJ, Campan M, Long TI, Kim M, Woods C, Fiala E, et al.Analysis of repetitive element DNA methylation by MethyLight. NucleicAcids Res 2005;33:6823-36. (Pubitemid 41830488)
23. Chalitchagorn K, Shuangshoti S, Hourpai N, Kongruttanachok N,Tangkijvanich P, Thong-ngam D, et al. Distinctive pattern of LINE-1methylation level in normal tissues and the association with carcinogenesis.Oncogene 2004;23:8841-6. (Pubitemid 39593298)
24. Estecio MR, Gharibyan V, Shen L, Ibrahim AE, Doshi K, He R, et al.LINE-1 hypomethylation in cancer is highly variable and inverselycorrelated with microsatellite instability. PLoS One 2007;2:e399.
25. Friso S, Girelli D, Trabetti E, Olivieri O, Guarini P, Pignatti PF, et al. TheMTHFR 1298A>C polymorphism and genomic DNA methylation inhuman lymphocytes. Cancer Epidemiol Biomarkers Prev 2005;14:938- 43.
26. Protiva P, Mason JB, Liu Z, Hopkins ME, Nelson C, Marshall JR, et al.Altered folate availability modi fies the molecular environment of thehuman colorectum: implications for colorectal carcinogenesis. CancerPrev Res 2011;4:530-43.
27. Wong JJ, Hawkins NJ, Ward RL, Hitchins MP. Methylation of the 3p22region encompassing MLH1 is representative of the CpG islandmethylator phenotype in colorectal cancer. Mod Pathol 2011;24:396- 411.
28. Ahmadian A, Gharizadeh B, Gustafsson AC, Sterky F, Nyren P, UhlenM, et al. Single-nucleotide polymorphismanalysis by pyrosequencing.Anal Biochem 2000;280:103-10.
29. Quinlivan EP, Gregory JF 3rd. DNA methylation determination by liquidchromatography-tandemmass spectrometry using novel biosynthetic[U-15N] deoxycytidine and [U-15N]methyldeoxycytidine internal standards.Nucleic Acids Res 2008;36:e119.
30. Rand KN, Molloy PL. Sensitive measurement of unmethylated repeatDNA sequences by end-specific PCR. Biotechniques 2010;49:xiii-vii.
31. Smith DE, Kok RM, Teerlink T, Jakobs C, Smulders YM. Quantitativedetermination of erythrocyte folate vitamer distribution by liquid chromatography-tandem mass spectrometry. Clin Chem Lab Med2006;44:450-9.
32. Rychlik M, Netzel M, Pfannebecker I, Frank T, Bitsch I. Application ofstable isotope dilution assays based on liquid chromatography-tandemmass spectrometry for assessment of folate bioavailability. JChromatogr 2003;792:167-76. (Pubitemid 36830867)
33. Huang Y, Khartulyari S, Morales ME, Stanislawska-Sachadyn A, VonFeldt JM, Whitehead AS, et al. Quantification of key red blood cellfolates from subjects with defined MTHFR 677C>T genotypes usingstable isotope dilution liquid chromatography/mass spectrometry.Rapid Commun Mass Spectrom 2008;22:2403-12.
34. Lamers Y, Prinz-Langenohl R, Bramswig S, Pietrzik K. Red blood cellfolate concentrations increase more after supplementation with [6S]-5- methyltetrahydrofolate than with folic acid in women of childbearingage. Am J Clin Nutr 2006;84:156-61. (Pubitemid 44699180)
35. Meenan J, O'Hallinan E, Scott J, Weir DG. Epithelial cell folate depletionoccurs in neoplastic but not adjacent normal colon mucosa. Gastroenterology 1997;112:1163-8. (Pubitemid 27157527)
36. Ghandour H, Chen Z, Selhub J, Rozen R. Mice deficient in methylenetetrahydrofolatereductase exhibit tissue-specific distribution offolates. J Nutr 2004;134:2975-8. (Pubitemid 39470071)
37. Choi SW, Friso S, Ghandour H, Bagley PJ, Selhub J, Mason JB.Vitamin B-12 de ficiency induces anomalies of base substitution andmethylation in the DNA of rat colonic epithelium. J Nutr 2004;134:750-5. (Pubitemid 38456239)
38. Cravo MJ, Pinto AG, Chaves P, Cruz JA, Lage P, Nobre Leitao C, et al.Effect of folate supplemention on DNA methylation of rectal mucosa inpatients with colonic adenomas: correlation with nutrient intake. ClinNutr 1998;17:45-9. (Pubitemid 28230839)
39. Bariol C, Suter C, Cheong K, Ku SL, Meagher A, Hawkins N, et al. Therelationship between hypomethylation and CpG island methylation incolorectal neoplasia. Am J Pathol 2003;162:1361-71. (Pubitemid 36350680)
40. Hiraoka S, Kato J, Horii J, Saito S, Harada K, Fujita H, et al. Methylationstatus of normal background mucosa is correlated with occurrenceand development of neoplasia in the distal colon. Hum Pathol2010;41:38-47.
41. Figueiredo JC, Grau MV, Wallace K, Levine AJ, Shen LL, Hamdan R,et al. Global DNA hypomethyation (LINE-1) in the normal colon andlifestyle characteristics and dietary and genetic factors. Cancer EpidemiolBiomarkers Prev 2009;18:1041-49.
42. Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, Issa JP, et al.Incidence and functional consequences of hMLH1 promoter hypermethylationin colorectal carcinoma. Proc Natl Acad Sci U S A1998;95:6870-5. (Pubitemid 28278073)
43. Ward R, Meagher A, Tomlinson I, O'Connor T, Norrie M, Wu R, et al.Microsatellite instability and the clinicopathological features of sporadiccolorectal cancer. Gut 2001;48:821-9. (Pubitemid 32476985)
44. Hawkins N, Norrie M, Cheong K, Mokany E, Ku SL, Meagher A, et al.CpG island methylation in sporadic colorectal cancers and its relationshipto microsatellite instability. Gastroenterology 2002;122:1376- 87.
45. Wallace K, Grau MV, Levine AJ, Shen L, Hamdan R, Chen X, et al.Association between folate levels and CpG Island hypermethylationin normal colorectal mucosa. Cancer Prev Res 2010;3:1552-64.
46. Kawakami K, Ruszkiewicz A, Bennett G, Moore J, Watanabe G,Iacopetta B. The folate pool in colorectal cancers is associated withDNA hypermethylation and with a polymorphism in methylenetetrahydrofolatereductase. Clin Cancer Res 2003;9:5860-5. (Pubitemid 38018068)