Antinociceptive, anti-inflammatory and antioxidant activities of eleagnine: An alkaloid isolated from Chrysophyllum albidum seed cotyledons

Journal of Biological Sciences

Volumn 6, Issue 6, 2006, Pages 1029-1034

  Idowu, T O ^a   Iwalewa, E O ^a   Aderogba, M A ^a   Akinpelu, B A ^a   Ogundaini, A O ^a  

^a OBAFEMI AWOLOWO UNIVERSITY   (Nigeria)

Author keywords

An isolated alkaloid; Anti inflammatory antioxidant effects; Antinociceptive; Chrysophyllum albidum; Eleagnine

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ACETIC ACID; ACETYLSALICYLIC ACID CALCIUM; ALKALOID; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; ASCORBIC ACID; CARRAGEENAN; CHRYSOPHYLLUM ALBIDUM EXTRACT; CYPROHEPTADINE; ELEAGNINE; HISTAMINE; INDOMETACIN; METHANOL; NALOXONE; PLANT EXTRACT; PROSTAGLANDIN; SEROTONIN; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ANTIOXIDANT ACTIVITY; ARTICLE; CHEMICAL COMPOSITION; CHRYSOPHYLLUM ALBIDUM; CONTROLLED STUDY; COTYLEDON; DRUG DOSE COMPARISON; DRUG ISOLATION; DRUG POTENCY; DRUG STRUCTURE; FEMALE; MALE; MOUSE; NONHUMAN; PAIN; PAW EDEMA; PHYTOCHEMISTRY; PLANT SEED; RAT; SAPOTACEAE;

CHRYSOPHYLLUM ALBIDUM;

EID: 33845905761     PISSN: 17273048     EISSN: 18125719     Source Type: Journal    
DOI: 10.3923/jbs.2006.1029.1034     Document Type: Article

References (34)

1. Adewusi, H.A., 1997. The African Star Apple Chrysophylum albidum Indigenous Knowledge from Ibadan, Southwestern Nigeria. In: Proceedings of a National Workshop on the Potentials of the Star Apple in Nigeria. (Eds.) Denton, O.A., D.O. Ladipo, M.A. Adetoro, Sarumi MB., pp: 25-33.
2. Adisa, S.A., 2000. Vitamin C, Protein and mineral contents of African Apple (Chrysophillum albidum) In: Proceedings of the 18th annual conference of NIST. (Eds.) Garba, S.A., I.F. Ijagbone, A.O. Iyagba, A.O. Iyamu, A.S. Kilani and N. Ufaruna, pp: 141-146.
3. Amusa, N.A., O.A. Ashaye, M.O. Oladapo, 2003. Biodeterioration of the African star apple (Chrysophylum albidum) in storage and the effect on its food value. Afr. J. Biotech., 2: 56-59.
4. Burits, M. and F. Bucar, 2002. Antioxidant activity of Nigella sativa essential oil. Phytothera. Res., 14: 323-328.
5. Dalziel, J.M., 1955. The Useful Plants of West Tropical Africa, Watmonghs, Idle, London, pp: 354-355.
6. Deamiyagala, S.A., W.D. Ramasooriya and C.L. Goonasekara, 2003. Antinociceptive effect and toxicological study of the aqueous bark extract of Barringtonia racemosa on rats. J. Ethnopharmacol., 86: 21-26.
7. Di Rosa, M., J.P. Giroud and D.A. Willoughby, 1971. Studies on the mediators of acute inflammatory response induced in rats in different sites by carrageenan and turpentine. J. Pathol., 104: 15-29.
8. Feghali, C.A. and T.M. Wright, 1997. Cytokines in acute and chronic inflammation. Frontiers Biosci., 2: 12-26.
9. Groff, J. and S. Gropper, 2000. Advanced Nutrition and human Metabolism, 3rd Edn., Belmont: Wadsworth.
10. Gupta, M., U.K. Mazumdar, T. Sivahkumar, M.L.M. Vamis, S. Karki, R. Sambathkumar and L. Manikandan, 2003. Antioxidant and Antiinflammatory activities of Acalypha fruticosa. Nig. J. Nat. Prod. Med., 7: 25-29.
11. Halliwell, B., 1994. Antioxidants Sense or Speculation, Nutrition Today, 29: 15.
12. Hosseinzadeh, H. and H.M. Younesi, 2002. Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. Bio. Med. Central Pharmacol., 2: 7-18.
13. Idowu, T.O., G.O. Onawunmi, A.O. Ogundaini and S.A. Adesanya, 2003. Antimicrobial constituents of Chrysophllum albidum seed cotyledons. Nig. J. Nat. Prod. Med. 7: 33-36.
14. Iwalewa, E.O., O.J. Iwalewa and J.O. Adeboye, 2003. Analgesic, Antipyretic, Anti-inflammatory Activities of the Chloroform, Methanolic and Ether Extracts of Vernonia cinerea leaf. J. Ethnopharmacol., 86: 229-234.
15. Iwalewa, E.O. and E.O. Agbani, 2004. Effect of autacoid inhibitors and of an antagonist on malaria infection in mice. Braz. J. Med. Biol. Res., 37: 1199-1204.
16. Iwalewa, E.O., C.O. Adewunmi, N.O.A. Omisore, O.A. Adebanji and C.K. Azike et al., 2005. Pro-and Antioxidant effects and Cytoprotective potentials of Nine Edible Vegetables in South West Nigeria. J. Med. Foods, 8: 539-544.
17. Kasahara, Y., K. Yasukawa, S. Kitanaka, M. Taufiq Khan and F.J. Evans, 2002. Effect of Methanol Extract from Flower Petals of Tagetes patulla L. on Acute and Chronic Inflammation Model. Phytother. Res., 16: 217-222.
18. Koster, R., M. Anderson and E.J. De-Beer, 1959. Acetic acid for analgesic screening. Fed. Proceed, 18: 412-418.
19. Mensor, L.L., F.S. Menezes, G.G. Leitao, A.S. Reis, T.C. Santos, C.S. Coube and S.G. Leitao, 2001. Screening of Brazilian Plant Extracts for Antioxidant Activity by the use of DPPH Free Radical Method, Phytother. Res., 15: 127-130.
20. Nwadinigwe, C.A., 1982. Nutrtional values and mineral contents of Chrysophllum albidum fruit. J. Sci. Food. Agricul., 33: 283-286.
21. Okamura, H. A. Mimura, Y. Yakou, M. Niwano and Y. Takahara, 1993. Antioxidant activity of tannins and flavonoids in Eucalyptus rostrata. Phytochemistry, 33: 557-561.
22. Omisore, N.O.A., C.O. Adewunmi, E.O. Iwalewa, B.T. Ngadjui, B.M. Abegaz, J. Watchueng, J.A.O. Ojewole, 2004. Antinociceptive and anti-inflammatory effects of Dorstenia barteri (leaves and twigs) extracts in mice. J. Ethnopharmacol., 95: 7-12.
23. Omisore, N.O.A., C.O. Adewunmi, E.O. Iwalewa, B.T. Ngadjui, T.K. Adenowo, B.M. Abegaz, J. Watchuen and J.A.O. Ojewole, 2005. Anti-trichomonas and Antioxidant Activities of Dorstenia barteri and D. convexa Extracts. Braz. J. Med. Biol. Res., 38: 1087-1094.
24. Onabanjo, A.O. and B.G. Maegraith, 1970. Inflammatory changes in small blood vessels induced by kallikrein in Macaca mulatto infected with Plasmodium knowlesi. Ann. Trop. Med. Parasitol., 64: 227-236.
25. Onabanjo, A.O., O. Somorin and O. Sonola, 1979. The anti-inflammatory action of Chrysophyllum albidum Proceedings of the 4th OAU/STRC International African symposium on Traditional on Traditional Pharmacopoiea and Medicinal Plants. (Abidjan, Cote d'Ivoire, Sept 1979. Publication of OAU.STRC, Lagos, Cairo University Press 1983, pp: 581-584.
26. Parasakthy, K., S. Shanthi, P. Deepalokshmi, S.D. Niranjali, 1996. The antioxidant effect of eugenol and carbon tetrachloride induced erythrocyte damage in rats. J. Nutr. Biochem., 7: 23-28
27. Parimaladevi, B., R. Boominathan and S.C. Mandal, 2003. Studies on analgesic activity of Cleome viscosa in mice. Fitoterapia, 74: 262-266.
28. Pryor, W., W. Stahl and C. Rock, 2000. Beta Carotene: From Biochemistry to Clinical Trials. Nutr. Rev., 58: 39-53.
29. Randall, L.O. and J.J. Selitto, 1957. A method for measurement of an analgesic activity of inflammed tissue. Arch. Intl. Pharmacol. Therapeu, 3: 404-419.
30. Saskia, A.B.E.V. Acker, D.J. Van Den Berg, M. Njl and T. Desiriree et al., 1996. StructuraL aspects of antioxidant activity of flavonoids. Free Rad. Biol. Med., 20: 331-342.
31. Thabrew, MI., R.D. Hughes and I.G. McFarlane, 1998. Antioxidant activity of Osbeckia aspera, Phytother. Res., 12: 288-290.
32. Trouillas, P., C. Fagnère, R. Lazzaroni, C. Calliste, A. Marfak and J.A. Duroux, 2004. Theoretical study of the conformational behavior and electronic Structure of taxifolin correlated with the free radical-scavenging activity. Food Chem., 88: 571-582.
33. Vane, J.R., 1971. Inhibition prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol., 231: 232-235.
34. Winter, C.A., E.A. Risely and G.W. Nuss, 1962. Carrageenin induced oedema in hind paw of the rat as an assay for anti-inflammatory drugs. Proceedings of the Society of Experimental Biology and Medicine, 3: 544-547.